公开(公告)号：US07138133B2

公开(公告)日：2006-11-21

申请号：US09974347

申请日：2001-10-10

申请人： Douglas Joseph Dobrozsi ,  Jerry William Hayes, II ,  Francis Joseph David Bealin-Kelly ,  Jayant Eknath Khanolkar ,  Benoit Maurice Mullet ,  Shane Michael DE LA Harpe ,  Brian James Robbins

发明人： Douglas Joseph Dobrozsi ,  Jerry William Hayes, II ,  Francis Joseph David Bealin-Kelly ,  Jayant Eknath Khanolkar ,  Benoit Maurice Mullet ,  Shane Michael DE LA Harpe ,  Brian James Robbins

IPC分类号： A61K9/10 ,  A61K47/34

CPC分类号： A61K9/0095 ,  A61K9/0056 ,  A61K9/4858 ,  A61K9/4866 ,  Y10S514/85 ,  Y10S514/975

摘要： The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.

摘要翻译： 本发明是口服给药的液体药物组合物，其表现出优异的物理稳定性，同时提供浓度水平的药物活性物质。 具体地说，这些组合物长时间不允许活性物沉淀或沉淀出溶液。 本发明的优点之一是组合物在使用前不需要搅动/摇动作为重新悬浮或溶解活性药物材料以确保均匀和一致的给药的方法。

公开(公告)号：US06846495B2

公开(公告)日：2005-01-25

申请号：US09466950

申请日：1999-12-20

申请人： Douglas Joseph Dobrozsi ,  Jerry William Hayes, II ,  Kishor Jivanlal Desai ,  Brian James Robbins

发明人： Douglas Joseph Dobrozsi ,  Jerry William Hayes, II ,  Kishor Jivanlal Desai ,  Brian James Robbins

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K9/107 ,  A61K9/12 ,  A61K9/48 ,  A61K9/64 ,  A61K9/66 ,  A61K9/68 ,  A61K31/00 ,  A61K31/137 ,  A61K31/167 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/485 ,  A61K47/10 ,  A61K47/34 ,  A61P11/00 ,  A61P11/02 ,  A61P11/10 ,  A61P11/12 ,  A61P11/14 ,  A61K47/00 ,  A61K9/14

CPC分类号： A61K31/00 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/0095 ,  A61K31/485 ,  A61K47/10

摘要： The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.

摘要翻译： 本发明涉及具有改进的药物活性物质递送的组合物。 这些组合物在无水溶剂中包含药物活性物质。 这些组合物可以采取放置在口中并最终吞咽的液体酏剂的形式，或者可以通过液体填充的滴剂，计量液体剂量装置，雾化器和液体释放的可食用胶囊来递送。

公开(公告)号：US06503955B1

公开(公告)日：2003-01-07

申请号：US09658813

申请日：2000-09-11

申请人： Douglas Joseph Dobrozsi ,  Jerry William Hayes, II ,  Bjorn Olof Lindman ,  Rouja Hristova Ivanova ,  Paschalis Alexandridis

发明人： Douglas Joseph Dobrozsi ,  Jerry William Hayes, II ,  Bjorn Olof Lindman ,  Rouja Hristova Ivanova ,  Paschalis Alexandridis

IPC分类号： A61K4732

CPC分类号： A61K9/0095 ,  A61K8/345 ,  A61K8/90 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0043 ,  A61K47/10 ,  A61Q11/00

摘要： The present invention covers pourable liquid vehicles that can be combined with compositions, materials and substances. Among the benefits of such pourable liquid vehicles is the compositions are retained on the moistened surface for a period of time sufficient to allow compositions, materials and substances to act on said surface, resisting erosion or run-off from additional moisture being applied. Such pourable liquid vehicles have a number of utilities including but not limited to cleaning and treating surfaces of objects as well as biological or living organisms, including living creatures.

摘要翻译： 本发明涉及可与组合物，材料和物质组合的可倾倒液体载体。 这些可流动液体载体的益处之一是将组合物保留在湿润表面上足以允许组合物，材料和物质作用在所述表面上的时间，抵抗来自所施加的额外湿气的侵蚀或流出。 这种可流动的液体载体具有许多用途，包括但不限于清洁和处理物体以及包括活生物在内的生物或生物体的表面。

公开(公告)号：US06319513B1

公开(公告)日：2001-11-20

申请号：US09361533

申请日：1999-07-27

申请人： Douglas Joseph Dobrozsi

发明人： Douglas Joseph Dobrozsi

IPC分类号： A61F1302

CPC分类号： A61K9/0095 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/006 ,  A61K47/02

摘要： The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal or nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.

摘要翻译： 本发明涉及一种口服，口服或鼻内药物粘液性含水液体组合物，其包含按组合物重量计约2％至约50％的二氧化硅，二氧化钛，粘土及其混合物的胶体颗粒，以及 选自止痛剂，减充血剂，祛痰剂，镇咳药，抗组胺药，感觉剂，胃肠道药剂及其混合物的药物活性物质的安全有效量; 其中所述组合物具有大于约0.90的沉降体积比，并且其中所述组合物的触发粘度比为至少约1.2。 本发明还涉及一种涂敷消化道或鼻粘膜的方法，特别是通过施用安全有效量的预防或治疗上呼吸道感染或上呼吸道组织刺激或损伤的症状的方法 以上组成。

公开(公告)号：US09827314B2

公开(公告)日：2017-11-28

申请号：US10730346

申请日：2003-12-08

申请人： Edward Russell Cox ,  Douglas Joseph Dobrozsi ,  Thomas Edward Huetter ,  Allan John Lepine ,  Susan Ruth Ward

发明人： Edward Russell Cox ,  Douglas Joseph Dobrozsi ,  Thomas Edward Huetter ,  Allan John Lepine ,  Susan Ruth Ward

IPC分类号： A61K45/06 ,  A23K1/00 ,  A23K1/175 ,  A23K1/18 ,  A61K33/42 ,  A61K33/34 ,  A61K33/32 ,  A61K33/30 ,  A61K31/28 ,  A61K31/30 ,  A61K31/315 ,  A61K31/32 ,  A61K33/24

CPC分类号： A61K45/06 ,  A23K20/30 ,  A23K40/30 ,  A23K50/42 ,  A23K50/45 ,  A61K31/28 ,  A61K31/30 ,  A61K31/315 ,  A61K31/32 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K33/42 ,  A61K2300/00

摘要： Disclosed herein are a variety of embodiments of compositions and methods which are each adapted for use by a companion animal. In one embodiment, an edible composition comprising an amount of a soluble mineral component is disclosed, wherein the soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof, wherein the amount is an effective amount for use as an oral medicament. In further embodiments, a phosphate component is included. The edible compositions are advantageously companion animal foods or supplements. Further disclosed are methods selected from treating oral cavity tartar, oral cavity plaque, periodontal disease, gingivitis, breath odor and combinations thereof comprising orally administering a described composition to a companion animal.

公开(公告)号：US5670158A

公开(公告)日：1997-09-23

申请号：US558338

申请日：1995-11-15

申请人： Paula Denise Davis ,  Douglas Joseph Dobrozsi ,  Gary Robert Kelm ,  Kenneth Gary Mandel

发明人： Paula Denise Davis ,  Douglas Joseph Dobrozsi ,  Gary Robert Kelm ,  Kenneth Gary Mandel

IPC分类号： A61K9/24 ,  A61K9/14 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K9/66 ,  A61K31/44 ,  A61K31/4402 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/40 ,  A61K47/48 ,  A61P1/10 ,  A61P43/00 ,  A61K9/00 ,  A61K31/715 ,  A61K47/00

CPC分类号： B82Y5/00 ,  A61K31/44 ,  A61K31/4402 ,  A61K47/48969 ,  A61K9/145 ,  A61K9/146 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/4808 ,  A61K9/4891 ,  A61K9/5078

摘要： The subject invention involves pharmaceutical compositions in dosage unit form, for peroral administration of bisacodyl to a human or lower animal having a gastrointestinal tract, with a lumen therethrough, with a small intestine and a colon with a junction therebetween, comprising: (a) a safe and effective amount of rapidly-dissolving bisacodyl means; and (b) a delivery means which prevents the release of bisacodyl from the dosage form into the lumen of the gastrointestinal tract during transport of the dosage form through the lumen until the dosage form is near the junction between the small intestine and the colon or in the colon, and which then releases the bisacodyl in the lumen near the junction between the small intestine and the colon or within the colon, The subject invention also involves methods for providing laxation for humans and lower animals in need thereof by peroral administration of such compositions.

摘要翻译： 本发明涉及以剂量单位形式的药物组合物，其用于口服给予具有胃肠道的人或更低级动物，具有通过其中的腔的比索拉昔克，具有小肠和结肠之间的连接，包括：（a） 安全有效量的快速溶解的bisacodyl手段; 和（b）递送装置，其防止在将剂型运送到内腔期间直到剂型接近小肠和结肠之间的连接处时，剂型中的双醋酸从剂型释放到胃肠道的内腔中 结肠，然后在小肠和结肠之间或结肠内的接合处的内腔中释放双歧杆菌。本发明还涉及通过口服给予这种组合物来为有需要的人和低等动物提供泻药的方法 。

公开(公告)号：US5651983A

公开(公告)日：1997-07-29

申请号：US442915

申请日：1995-05-17

申请人： Gary Robert Kelm ,  Gary Lee Manring ,  Paula Denise Davis ,  Douglas Joseph Dobrozsi ,  Kenneth Gary Mandel ,  David Lee McCauley-Meyers

发明人： Gary Robert Kelm ,  Gary Lee Manring ,  Paula Denise Davis ,  Douglas Joseph Dobrozsi ,  Kenneth Gary Mandel ,  David Lee McCauley-Meyers

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/22 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K31/44 ,  A61K31/4402 ,  A61K47/48 ,  A61K9/20 ,  A61K31/715 ,  A61K47/40

CPC分类号： A61K9/145 ,  A61K31/44 ,  A61K31/4402 ,  A61K47/48969 ,  A61K9/146 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/4808 ,  A61K9/4891 ,  A61K9/5078 ,  B82Y5/00

摘要： The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.5; the rapidly dissolving bisacodyl is released at a point near the inlet to, or within the colon; the enteric polymer coating material begins to dissolve in an aqueous media at a pH between about 5 to about 6.3; and the enteric polymer coating material has a coating thickness of at least about 250 .mu.m.

摘要翻译： 本发明涉及一种用于人或低等动物口服给药的单位剂量形式的药物组合物，其具有胃肠道，该胃肠道包含小肠和结肠与其中具有从小肠到结肠入口的结肠，包括 ： 一个。 将安全有效量的快速溶解的双醋酸掺入或涂覆在选自球状基质，椭圆形基质，硬胶囊或压缩片剂的剂型的表面上，最大直径为约3 毫米至约10毫米; 和b。 肠溶性聚合物涂料; 其中所述剂型具有没有边缘或尖锐曲线的光滑表面; 椭圆形基底和硬胶囊具有长度与短径之比不大于约1.5; 快速溶解的bisacodyl在靠近入口处或结肠内的点处释放; 肠溶聚合物涂层材料开始在约5至约6.3之间的pH下溶于水性介质; 肠溶性聚合物涂层材料的涂层厚度为至少约250μm。

公开(公告)号：US06638521B2

公开(公告)日：2003-10-28

申请号：US10021327

申请日：2001-12-07

申请人： Douglas Joseph Dobrozsi

发明人： Douglas Joseph Dobrozsi

IPC分类号： A61K900

CPC分类号： A61K9/0095 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/0065 ,  A61K47/02 ,  Y10S977/915

摘要： The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.

公开(公告)号：US5656290A

公开(公告)日：1997-08-12

申请号：US442914

申请日：1995-05-17

申请人： Gary Robert Kelm ,  Gary Lee Manring ,  Paula Denise Davis ,  Douglas Joseph Dobrozsi ,  Kenneth Gary Mandel

发明人： Gary Robert Kelm ,  Gary Lee Manring ,  Paula Denise Davis ,  Douglas Joseph Dobrozsi ,  Kenneth Gary Mandel

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30 ,  A61K9/48 ,  A61K9/50 ,  A61K31/44 ,  A61K31/4402 ,  A61K47/48 ,  A61K9/32 ,  A61K9/36 ,  A61K9/58

CPC分类号： B82Y5/00 ,  A61K31/44 ,  A61K31/4402 ,  A61K47/48969 ,  A61K9/145 ,  A61K9/146 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/4808 ,  A61K9/4891 ,  A61K9/5078 ,  Y10S514/867 ,  Y10S514/892

摘要： The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material comprising at least one inner coating layer and one outer coating layer;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.5; the rapidly dissolving bisacodyl is released at a point near the inlet to, or within the colon; each of the inner coating layer(s) is an enteric polymer that begins to dissolve in an aqueous media at a pH between about 5 to about 6.3; and the outer coating layer is an enteric polymer that begins to dissolve in an aqueous media at a pH between about 6.8 to about 7.2.

摘要翻译： 本发明涉及一种用于人或低等动物口服给药的单位剂量形式的药物组合物，其具有胃肠道，该胃肠道包含小肠和结肠与其中具有从小肠到结肠入口的结肠，包括 ： 一个。 将安全有效量的快速溶解的双醋酸掺入或涂覆在选自球状基质，椭圆形基质，硬胶囊或压缩片剂的剂型的表面上，最大直径为约3 毫米至约10毫米; 和b。 肠溶性聚合物涂层材料，其包含至少一个内涂层和一个外涂层; 其中所述剂型具有没有边缘或尖锐曲线的光滑表面; 椭圆形基底和硬胶囊具有长度与短径之比不大于约1.5; 快速溶解的bisacodyl在靠近入口处或结肠内的点处释放; 每个内部涂层是在pH约5至约6.3之间开始溶解于水性介质中的肠溶性聚合物; 并且外涂层是在约6.8至约7.2之间的pH下开始溶解于水性介质中的肠溶性聚合物。