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19 条记录 (耗时 0.018 秒)

    Composition for Topical Use
    1.
    发明申请
    Composition for Topical Use 审中-公开
    组合用于局部使用

    公开(公告)号：US20100324109A1

    公开(公告)日：2010-12-23

    申请号：US12863251

    申请日：2009-01-23

    申请人： Jean Hilaire Saurat

    发明人： Jean Hilaire Saurat

    IPC分类号： A61K31/405 ,  A61P17/02 ,  A61P17/10 ,  A61P31/04

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K31/00 ,  A61K31/407

    摘要： The use, as a dermatological or cosmetic medicament, of compounds capable of transiently interacting with the AhR receptor (aryl hydrocarbon receptor) as agents for modulating skin functions such as sebaceous function, skin healing, skin atrophy termed “dermatoporosis”, estrogen deprivation and defense against infection, without inducing other toxic effects of the TCDD type.The compounds that interact with the AhR receptor are chosen in that they have a metabolism favorable to the dissociation of these effects, in particular by virtue of in situ production from a precursor and/or metabolization modulated in situ.

    摘要翻译： 使用能够与AhR受体（芳烃受体）瞬时相互作用的化合物作为皮肤病学或化妆品药物，用作调节皮肤功能如皮脂腺功能，皮肤愈合，称为“皮肤病”的皮肤萎缩，雌激素剥夺和防御 免受感染，不引起TCDD类型的其他毒性作用。 选择与AhR受体相互作用的化合物，因为它们具有有利于这些作用的解离的代谢，特别是通过原位原位产生和/或原位调节的代谢。

    AGONISTS OF THE AhR RECEPTOR PATHWAY HAVING SEBOSUPPRESSIVE ACTIVITY AND A METHOD FOR IDENTIFYING SAID AGONISTS
    4.
    发明申请
    AGONISTS OF THE AhR RECEPTOR PATHWAY HAVING SEBOSUPPRESSIVE ACTIVITY AND A METHOD FOR IDENTIFYING SAID AGONISTS 有权
    具有抗栓活性的AhR受体途径的激素和鉴定激素的方法

    公开(公告)号：US20150057343A1

    公开(公告)日：2015-02-26

    申请号：US14536507

    申请日：2014-11-07

    申请人： Jean Hilaire SAURAT

    发明人： Jean Hilaire SAURAT

    IPC分类号： A61K31/352 ,  A61K45/06 ,  A61K9/00 ,  A61K47/10

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K45/06 ,  A61K47/10 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2800/20

    摘要： The subject invention provides a method of treating acne in a subject which comprises topically and periodically applying to the subject's acne a composition comprising 3-phenyl-1-benzo[f]chromen-1-one and a pharmaceutically acceptable carrier, wherein the 3-phenyl-1-benzo[f]chromen-1-one is present in an amount effective to treat the subject's acne. The subject invention also provides a method of treating a skin condition associated with abnormal sebum secretion or abnormal sebaceous gland function in a subject, compositions in such methods and a sorting method for identifying agonists of AhR pathway, useful in such methods and compositions.

    摘要翻译： 本发明提供一种治疗受试者的痤疮的方法，该方法包括局部地和周期性地向受试者的痤疮施用包含3-苯基-1-苯并[f]苯甲酸-1-酮和药学上可接受的载体的组合物，其中3- 苯基-1-苯并[f]苯甲酸-1-酮以有效治疗受试者的痤疮的量存在。 本发明还提供了一种治疗与受试者异常皮脂分泌或异常皮脂腺功能相关的皮肤病症的方法以及用于鉴定在这些方法和组合物中有用的这些方法的组合物和用于鉴定AhR通路激动剂的分选方法。

    Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same
    7.
    发明申请
    Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same 失效
    新型多不饱和化合物，其制备方法及其组合物

    公开(公告)号：US20100168045A1

    公开(公告)日：2010-07-01

    申请号：US12086625

    申请日：2006-12-14

    申请人： Pascal Bordat ,  Roger Tarroux ,  Jean-Hilaire Saurat ,  Olivier Sorg ,  Jean-Louis Brayer ,  Natacha Frison

    发明人： Pascal Bordat ,  Roger Tarroux ,  Jean-Hilaire Saurat ,  Olivier Sorg ,  Jean-Louis Brayer ,  Natacha Frison

    IPC分类号： A61K8/37 ,  C07H15/207 ,  A61K8/60 ,  C07C69/736 ,  C07C47/277 ,  C07C69/587 ,  C07D339/04 ,  A61K8/49 ,  C07D311/72 ,  A61K8/67 ,  C07C69/738 ,  A61K8/34 ,  A61K8/33 ,  A61Q5/00 ,  A61Q19/02

    CPC分类号： C07D339/04 ,  A61K8/33 ,  A61K8/37 ,  A61K8/4986 ,  A61K8/585 ,  A61K8/602 ,  A61Q19/02 ,  C07B2200/09 ,  C07C403/08 ,  C07C403/10 ,  C07C403/14 ,  C07C403/20 ,  C07C2601/16 ,  C07F7/081 ,  C07F7/0812 ,  C07H15/203

    摘要： The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R′1, -A-R′1 group, R′1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3, R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R′2—O—R6 group, wherein R′2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C1-C16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

    摘要翻译： 本发明涉及式（I）的新型多不饱和化合物，其中：R1表示R'1，-AR'1基团，R'1选自-COOH，-COOR3，-CONH2，-CONHR3，-CONR3，R4， - CHO，-CH2OH，-CH2OR5和A表示C2-C16亚烷基，亚烯基或亚炔基; R2表示：任选取代的芳基或任选取代的杂芳基; 糖残基或脂肪酸残基，优选在链末端，特别是羟基，乙酰氧基或任选被保护的氨基上任选地支链和/或取代; a -OC-（CH 2）n CO-生育酚（α，β或γ或δ）组，其中2 $ m（F）n $ m（F）10; -R'2-O-R6基团，其中R'2是任选取代的亚芳基或任选取代的亚杂芳基，R 6表示氢原子，直链或支链任选取代的C 1 -C 16烷基，直链或支链 任选取代的C 2 -C 16烯基，或直链或支链C 2 -C 16炔基，任选取代的生育酚基等，氨基酸残基或糖残基。 本发明还涉及组合物，特别是包含至少一种式（I）化合物的化妆品和/或皮肤病学组合物，以及它们作为增白剂和/或脱色素剂的用途，以及使用所述组合物的美容方法。

    METHOD AND COMPOSITION FOR TREATING ACNE
    10.
    发明申请
    METHOD AND COMPOSITION FOR TREATING ACNE 审中-公开
    用于治疗ACNE的方法和组合物

    公开(公告)号：US20170042856A1

    公开(公告)日：2017-02-16

    申请号：US15334987

    申请日：2016-10-26

    申请人： Jean Hilaire Saurat

    发明人： Jean Hilaire Saurat

    IPC分类号： A61K31/352 ,  A61K45/06 ,  A61K9/00 ,  A61K47/10

    CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K45/06 ,  A61K47/10 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2800/20

    摘要： The subject invention provides a method of treating acne in a subject which comprises topically and periodically applying to the subject's acne a composition comprising 3-phenyl-benzo[f]chromen-1-one and a pharmaceutically acceptable carrier, wherein the 3-phenyl-1-benzo[f]chromen-1-one is present in an amount effective to treat the subject's acne. The subject invention also provides a method of treating a skin condition associated with abnormal sebum secretion or abnormal sebaceous gland function in a subject, compositions in such methods and a sorting method for identifying agonists of AhR pathway useful in such methods and compositions.

    摘要翻译： 本发明提供一种治疗受试者的痤疮的方法，其包括局部地和周期性地向受试者的痤疮施用包含3-苯基 - 苯并[f]苯并菲-1-酮和药学上可接受的载体的组合物，其中所述3-苯基 - 1-苯并[f]苯并菲-1-酮以有效治疗受试者的痤疮的量存在。 本发明还提供了一种治疗与受试者异常皮脂分泌或异常皮脂腺功能相关的皮肤病症的方法以及用于鉴定在这些方法和组合物中有用的AhR通路激动剂的分类方法。