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    System and method providing directional ultrasound therapy to skeletal joints
    2.
    发明申请
    System and method providing directional ultrasound therapy to skeletal joints 审中-公开
    向骨骼关节提供定向超声治疗的系统和方法

    公开(公告)号：US20060241576A1

    公开(公告)日：2006-10-26

    申请号：US11364357

    申请日：2006-02-27

    申请人： Chris Diederich ,  Jeffrey Lotz ,  Will Nau ,  David Bradford

    发明人： Chris Diederich ,  Jeffrey Lotz ,  Will Nau ,  David Bradford

    IPC分类号： A61B18/04 ,  A61F7/00 ,  A61F7/12

    CPC分类号： A61N7/02 ,  A61B18/04 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0021 ,  A61N2007/003 ,  A61N2007/0056 ,  A61N2007/0078

    摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.

    摘要翻译： 提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

    SYSTEMS AND METHODS USING NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO EVALUATE PAIN AND DEGENERATIVE PROPERTIES OF TISSUE
    4.
    发明申请
    SYSTEMS AND METHODS USING NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO EVALUATE PAIN AND DEGENERATIVE PROPERTIES OF TISSUE 有权
    使用核磁共振（NMR）光谱评估组织的疼痛和变性特性的系统和方法

    公开(公告)号：US20080039710A1

    公开(公告)日：2008-02-14

    申请号：US11829847

    申请日：2007-07-27

    申请人： Sharmila Majumdar ,  John Kurhanewicz ,  Jeffrey Lotz ,  David Bradford ,  Kayvan Keshari

    发明人： Sharmila Majumdar ,  John Kurhanewicz ,  Jeffrey Lotz ,  David Bradford ,  Kayvan Keshari

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/4514 ,  A61B5/4528 ,  A61B5/4824 ,  G01N24/08 ,  G01R33/465 ,  G01R33/483 ,  G01R33/485

    摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3 T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3 T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain.

    摘要翻译： 对椎间盘组织进行NMR光谱。 基于NMR光谱测定退化程度。 NMR光谱区域与组织变性和疼痛中的至少一种之间的相关性。 因此，使用NMR光谱来确定与组织区域相关的变性或疼痛中的至少一种的位置和/或程度，例如特别是椎间盘变性或椎间盘性疼痛。 核磁共振光谱峰比例，如N-乙酰基/ cho和cho / carb之间，容易获得和分析，以预测组织变性和/或疼痛程度：组织样本使用HR-MAS光谱; 和较大部分的解剖结构，如关节节段如脊柱，使用具有表面头部或膝部线圈的临床3 T MRI系统; 和组织区域，例如使用具有表面脊髓线圈的3T MRI系统的活体患者脊柱内的椎间盘，从而提供完全无创的诊断工具和方法来成像和定位变性和/或疼痛。