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公开(公告)号：US6060320A
公开(公告)日：2000-05-09
申请号：US985878
申请日：1997-12-05
CPC分类号： G01N35/1016 , G01N2035/1018 , G01N2035/1032 , Y10T436/115831 , Y10T436/119163 , Y10T436/2575
摘要： A nethod of verifying sample volume quantifies the fluid volume aspirated and verifies sample uniformity by detecting the presence of foam or clots in the sample. After aspiration, a pressure sensor is used to measure the vacuum needed to hold up the column of fluid in the probe tip. By knowing the geometry of the probe tip, the vacuum can be converted to a sample weight and volume, based on sample densities. Non-ideal conditions, such as foam on the surface of the fluid or a clot in the fluid, result in a sample volume much lighter in the case if foam, or much greater, in the case of a clot, than anticipated. The method also determines the elapsed time of the aspiration. Foamy samples result in aspiration times shorter than normal. Clotted samples result in aspiration times longer than normal.
摘要翻译： 验证样品体积的方法通过检测样品中泡沫或凝块的存在来量化吸入的液体体积并验证样品均匀性。 抽吸后，使用压力传感器来测量在探针尖端中压住流体柱所需的真空度。 通过了解探针尖端的几何形状，可以根据样品密度将真空转化为样品重量和体积。 非理想条件，例如流体表面上的泡沫或流体中的凝块，导致在泡沫的情况下样品体积更轻，或者在凝血块的情况下比预期的要大得多。 该方法还确定吸气的经过时间。 泡沫样品导致吸气时间比正常时间短。 凝结的样品导致吸入时间比正常时间长。
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公开(公告)号：US6121049A
公开(公告)日：2000-09-19
申请号：US329918
申请日：1999-06-10
CPC分类号： G01N35/1016 , G01N2035/1018 , G01N2035/1032 , Y10T436/115831 , Y10T436/119163 , Y10T436/2575
摘要： A method of verifying sample volume quantifies the fluid volume aspirated and verifies sample uniformity by detecting the presence of foam or clots in the sample. After aspiration, a pressure sensor is used to measure the vacuum needed to hold up the column of fluid in the probe tip. By knowing the geometry of the probe tip, the vacuum can be converted to a sample weight and volume, based on sample densities. Non-ideal conditions, such as foam on the surface of the fluid or a clot in the fluid, result in a sample volume much lighter, in the case of foam, or much greater, in the case of a clot, than anticipated. The method also determines the elapsed time of the aspiration. Foamy samples result in aspiration times shorter than normal. Clotted samples result in aspiration times longer than normal. Additionally, a determination can be made as to whether an error condition occurred. The error condition could be the occurrence of the sample fluid container becoming substantially empty of sample fluid during aspiration or the sample probe no longer being in contact with the fluid due to the probe not following a declining fluid level as the fluid is aspirated.
摘要翻译： 验证样品体积的方法通过检测样品中泡沫或凝块的存在来量化吸入的液体体积并验证样品均匀性。 抽吸后，使用压力传感器来测量在探针尖端中压住流体柱所需的真空度。 通过了解探针尖端的几何形状，可以根据样品密度将真空转化为样品重量和体积。 不理想的条件，例如流体表面上的泡沫或流体中的凝块，导致样品体积在泡沫的情况下更轻，或者在凝血块的情况下比预期的要大得多。 该方法还确定吸气的经过时间。 泡沫样品导致吸气时间比正常时间短。 凝结的样品导致吸入时间比正常时间长。 此外，可以确定是否发生错误状况。 误差条件可能是在抽吸期间样品流体容器变得基本上没有样品流体的情况，或者由于当吸入流体时探针不跟随流体水平下降，样品探针不再与流体接触。
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公开(公告)号：US5750881A
公开(公告)日：1998-05-12
申请号：US501806
申请日：1995-07-13
IPC分类号： G01F13/00 , G01F11/02 , G01F23/14 , G01N1/00 , G01N1/38 , G01N35/10 , G01M3/02 , B01L3/02 , G01N1/14
CPC分类号： G01N35/1009 , G01F11/021 , G01F11/029 , G01F23/14 , G01M3/26 , G01N1/38 , G01N2035/1025
摘要： A method and apparatus for aspirating and dispensing a sample fluid. The apparatus includes an air source having an output port coupled to a first port of a flow through pressure transducer. A second port of the flow through pressure transducer is coupled to a first port of a sample probe. The flow through pressure transducer provides transducer signals to a detector circuit. In response to the transducer signals provided thereto, the detector detects the occurrence or non-occurrence of a plurality of different events.
摘要翻译： 用于抽吸和分配样品流体的方法和装置。 该装置包括具有连接到流过压力传感器的第一端口的输出端口的空气源。 流过压力传感器的第二端口耦合到样品探针的第一端口。 通过压力传感器的流量将检测器信号提供给检测器电路。 响应于提供给其的换能器信号，检测器检测多个不同事件的发生或不发生。
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公开(公告)号：US6158269A
公开(公告)日：2000-12-12
申请号：US204912
申请日：1998-12-03
CPC分类号： G01N35/1009 , G01F11/021 , G01F11/029 , G01N1/38 , G01N2035/1025
摘要： A method and apparatus for aspirating and dispensing a sample fluid. The apparatus includes a dilutor having a port coupled to a first port of a flow through pressure transducer and to a bleed valve. A second port of the flow through pressure transducer is coupled to a first port of a sample probe. The flow through pressure transducer provides transducer signals to a detector circuit. In response to the transducer signals provided thereto, the detector detects the occurrence or non-occurrence of a plurality of different events. The dilutor is operational to aspirate and dispense fluids such as air or liquid samples in order to provide accurate aspiration and dispensation of a sample fluid. The method includes the steps of first aspirating a predetermined amount of air with the dilutor, dispensing air while moving the sample probe towards the fluid sample, measuring the pressure in the probe and using this pressure value as a baseline, monitoring the pressure and detecting when the pressure changes, which is indicative of the probe entering the fluid sample, bleeding the pressure into the atmosphere while returning the dilutor to its home position, aspirating a predetermined amount of fluid to remove dilutor backlash, waiting a predetermined amount of time to finish bleeding the system, then aspirating the fluid sample with the dilutor. With such a method and apparatus, accurate aspirations/dispensations are provided, especially when small volumes are required.
摘要翻译： 用于抽吸和分配样品流体的方法和装置。 该装置包括具有连接到流过压力传感器的第一端口和排放阀的端口的稀释器。 流过压力传感器的第二端口耦合到样品探针的第一端口。 通过压力传感器的流量将检测器信号提供给检测器电路。 响应于提供给其的换能器信号，检测器检测多个不同事件的发生或不发生。 稀释剂可用于抽吸和分配诸如空气或液体样品的流体，以便提供样品流体的准确抽吸和分配。 该方法包括以下步骤：首先用稀释器抽吸预定量的空气，在将样品探针移向流体样品时分配空气，测量探针中的压力并使用该压力值作为基线，监测压力和检测何时 指示进入流体样品的探针的压力变化将压力排出到大气中，同时将稀释器返回到其原始位置，吸出预定量的流体以除去稀释剂间隙，等待预定量的时间以完成出血 系统，然后用稀释剂吸出流体样品。 利用这种方法和装置，提供准确的愿望/分配，特别是当需要小体积时。
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