公开(公告)号：US20170146381A1

公开(公告)日：2017-05-25

申请号：US15343865

申请日：2016-11-04

申请人： The University of North Carolina at Chapel Hill

发明人： Stephen Eckel ,  Christopher Roberts ,  Chase Dubois ,  Jorge Martínez-Blat ,  John C. Pamplin

IPC分类号： G01F11/02 ,  A61J1/20 ,  A61M5/315

CPC分类号： G01F11/027 ,  A61J1/2096 ,  A61M5/1782 ,  A61M5/31533 ,  A61M5/31535 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2005/31508 ,  A61M2205/3306 ,  A61M2205/3317 ,  A61M2205/3375 ,  A61M2205/3396 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/70 ,  G01F11/029 ,  G06F19/00 ,  G06F19/3468

摘要： Devices, systems, and methods for volumetrically measuring syringe fluid are disclosed. In one aspect, a device for volumetrically measuring syringe fluid includes a reference plate, a flange adapter base attached at a first end of the reference plate for receiving a flange of a syringe, a plunger adapter disposed adjacent to a housing for receiving a plunger of the syringe, the plunger adapter being configured to slidingly move along a length of the reference plate, a displacement sensor disposed in the housing and configured to measure a displacement of the plunger adapter in relation to the flange adapter base as the plunger adapter is slid along the length of the reference plate, and a displacement conversion mechanism disposed in the housing and configured to convert the displacement measurement of the plunger adapter to a volumetric measurement in order to determine a volume of fluid the syringe has drawn in.

公开(公告)号：US09592345B2

公开(公告)日：2017-03-14

申请号：US14413631

申请日：2013-07-10

申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH

发明人： Thomas Nagel ,  Rene Richter ,  Robert Witt ,  Richard Guenther ,  Johannes Vogel

IPC分类号： A61M5/315 ,  G01S15/36 ,  G01S15/88 ,  A61M5/168

CPC分类号： A61M5/315 ,  A61M5/1684 ,  A61M5/31568 ,  A61M2205/3306 ,  A61M2205/3375 ,  A61M2205/3389 ,  G01F11/029 ,  G01F17/00 ,  G01F22/00 ,  G01S15/36 ,  G01S15/88

摘要： The invention relates to an arrangement for determining a position (x) of a stopper relative to a container in a drug delivery device, comprising an acoustic source configured to emit an acoustic signal and an acoustic sensor configured to detect an acoustic signal, a processing unit for controlling the acoustic source and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper. Furthermore, the invention relates to a method for determining a position (x) of a stopper relative to a container in a drug delivery device, the method comprising the steps of emitting an acoustic signal from an acoustic source, detecting an acoustic signal caused by the emitted acoustic signal by means of an acoustic sensor, and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper by means of a processing unit.

摘要翻译： 本发明涉及一种用于确定止动器相对于药物输送装置中的容器的位置（x）的装置，包括构造成发出声信号的声源和被配置为检测声信号的声传感器，处理单元 用于控制声源并处理检测到的声信号以确定与止动器的位置（x）相关的声信号的特性。 此外，本发明涉及一种用于在药物输送装置中确定塞子相对于容器的位置（x）的方法，该方法包括以下步骤：从声源发射声信号，检测由声源引起的声信号 通过声学传感器发射声信号，并且通过处理单元处理所检测的声信号以确定与阻挡物的位置（x）相关的声信号的特性。

公开(公告)号：US09539596B2

公开(公告)日：2017-01-10

申请号：US14383366

申请日：2013-03-07

申请人： MUSASHI ENGINEERING, INC.

发明人： Kazumasa Ikushima

IPC分类号： B05B3/00 ,  F04B39/00 ,  B65D83/00 ,  B05B9/04 ,  B05C11/10 ,  G01F11/02 ,  B05B3/18 ,  F04B9/10 ,  F04B7/00 ,  F04B13/02 ,  F04B35/04 ,  B05C5/02

CPC分类号： B05B9/0409 ,  B05B3/18 ,  B05C5/0212 ,  B05C5/0225 ,  B05C5/0229 ,  B05C11/1002 ,  B05C11/1047 ,  B65D83/0022 ,  F04B7/0023 ,  F04B9/10 ,  F04B13/02 ,  F04B35/04 ,  G01F11/021 ,  G01F11/029

摘要： A liquid dispensing apparatus (1) includes a liquid contact member (2) that has measuring bores (11, 11). A first piston (3) slides in the first measuring bore (11) and a second piston (3) sliding in the second measuring bore (11). A supply channel (5) communicates with a storage unit (17). An ejection channel (6) communicates with a nozzle (18). A switching valve (4) is disposed in a space in the liquid contact member (2), and that has a first position and a second position. A valve driving mechanism (8) operates the switching valve (4). A piston driving mechanism (9) operates an arm (19) connected to the first and second pistons. The first and second measuring bores are arranged to oppose to each other on both sides of the switching valve (4), and the supply channel (5) and the ejection channel (6) are arranged adjacent to the switching valve.

摘要翻译： 液体分配装置（1）包括具有测量孔（11,11）的液体接触构件（2）。 第一活塞（3）在第一测量孔（11）中滑动，而第二活塞（3）在第二测量孔（11）中滑动。 供应通道（5）与存储单元（17）通信。 喷射通道（6）与喷嘴（18）连通。 切换阀（4）设置在液体接触构件（2）的空间中，并且具有第一位置和第二位置。 阀驱动机构（8）操作切换阀（4）。 活塞驱动机构（9）操作连接到第一和第二活塞的臂（19）。 第一测量孔和第二测量孔布置成在切换阀（4）的两侧彼此相对，并且供应通道（5）和喷射通道（6）被布置成与切换阀相邻。

公开(公告)号：US09517487B2

公开(公告)日：2016-12-13

申请号：US14228642

申请日：2014-03-28

申请人： Nordson Corporation

发明人： David J. Dunlap ,  Laurence B. Saidman ,  Edward C. Taylor

IPC分类号： B05C5/02 ,  B05C11/10 ,  G01F11/02

CPC分类号： B05C5/0291 ,  B05C5/0225 ,  B05C11/1034 ,  G01F11/021 ,  G01F11/029

摘要： A dispenser for applying small amounts of liquid to a substrate. The dispenser includes a dispenser body, an actuator in the dispenser body, and a dispensing element including a dispensing element body removably coupled to the dispenser body. A valve stem is mounted for reciprocating movement within the dispensing element body. Additional aspects include a deformable valve seat, a deformable and resilient valve stem tip and a method of applying liquid in discrete amounts to a substrate.

摘要翻译： 用于将少量液体施加到基底的分配器。 分配器包括分配器主体，分配器主体中的致动器以及包括可拆卸地联接到分配器本体的分配元件本体的分配元件。 安装阀杆用于在分配元件主体内往复运动。 另外的方面包括可变形阀座，可变形和弹性的阀杆尖端以及将液体以离散的量施加到基底的方法。

公开(公告)号：US20160273951A1

公开(公告)日：2016-09-22

申请号：US14392332

申请日：2014-04-01

申请人： SEYONIC S.A.

发明人： Bart van der Schoot ,  Yari Luchessa ,  Marc Boillat

IPC分类号： G01F11/02 ,  G01N1/14

CPC分类号： G01F11/029 ,  B01L3/021 ,  B01L2200/0684 ,  B01L2200/143 ,  G01F25/0092 ,  G01N1/14 ,  G01N35/1016 ,  G01N2035/1018

摘要： A method for controlling pipetting operations done by a pipetting device having a system for measuring the flow rate of the liquid suctioned or dispensed and electronics to communicate with a computer. The method is based on detection of flow rate variations and the moments at which those variations occur. The method includes obtaining a curve of liquid flow rate by the pipette as a function of time, computing the first deviation of the curve, identifying and recording the maximum and minimum values of the first deviation and the moments at which the maximum and minimum values occur, comparing the maximum and minimum values and the moments at which the maximum and minimum values occur with predetermined references for the values and the moments at which they occur, and based on the result of the comparison, providing a validation or error message.

摘要翻译： 一种用于控制由移液装置完成的移液操作的方法，所述移液装置具有用于测量被抽吸或分配的液体的流速的系统和电子装置与计算机通信的系统。 该方法基于流量变化的检测和发生这些变化的时刻。 该方法包括通过移液管获得作为时间的函数的液体流速曲线，计算曲线的第一偏差，识别和记录第一偏差的最大值和最小值以及出现最大值和最小值的力矩 比较最大值和最小值以及发生最大值和最小值的时刻与其发生的值和时刻的预定参考值，并且基于比较结果，提供验证或错误消息。

公开(公告)号：US20150174330A1

公开(公告)日：2015-06-25

申请号：US14413631

申请日：2013-07-10

申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH

发明人： Thomas Nagel ,  Rene Richter ,  Robert Witt ,  Richard Guenther ,  Johannes Vogel

IPC分类号： A61M5/315 ,  G01S15/88 ,  G01S15/36

CPC分类号： A61M5/315 ,  A61M5/1684 ,  A61M5/31568 ,  A61M2205/3306 ,  A61M2205/3375 ,  A61M2205/3389 ,  G01F11/029 ,  G01F17/00 ,  G01F22/00 ,  G01S15/36 ,  G01S15/88

摘要： The invention relates to an arrangement for determining a position (x) of a stopper relative to a container in a drug delivery device, comprising an acoustic source configured to emit an acoustic signal and an acoustic sensor configured to detect an acoustic signal, a processing unit for controlling the acoustic source and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper. Furthermore, the invention relates to a method for determining a position (x) of a stopper relative to a container in a drug delivery device, the method comprising the steps of emitting an acoustic signal from an acoustic source, detecting an acoustic signal caused by the emitted acoustic signal by means of an acoustic sensor, and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper by means of a processing unit.

摘要翻译： 本发明涉及一种用于确定止动器相对于药物输送装置中的容器的位置（x）的装置，包括构造成发出声信号的声源和被配置为检测声信号的声传感器，处理单元 用于控制声源并处理检测到的声信号以确定与止动器的位置（x）相关的声信号的特性。 此外，本发明涉及一种用于在药物输送装置中确定塞子相对于容器的位置（x）的方法，该方法包括以下步骤：从声源发射声信号，检测由声源引起的声信号 通过声学传感器发射声信号，并且通过处理单元处理所检测的声信号以确定与阻挡物的位置（x）相关的声信号的特性。

公开(公告)号：US08915405B2

公开(公告)日：2014-12-23

申请号：US13319412

申请日：2010-05-04

申请人： Luca Sassatelli ,  Claudio Trebbi

发明人： Luca Sassatelli ,  Claudio Trebbi

IPC分类号： B65D88/54 ,  B67D7/58 ,  B67D7/84 ,  B65B43/42 ,  G01F11/02 ,  B65B1/36 ,  G01F11/00 ,  B65B3/32 ,  B65B3/30 ,  B65B3/00 ,  B65B59/04

CPC分类号： G01F11/029 ,  B65B1/363 ,  B65B3/003 ,  B65B3/305 ,  B65B3/32 ,  B65B59/04 ,  G01F11/006 ,  G01F11/02

摘要： A dosing apparatus includes a dosing unit provided with a casing for supporting or containing a dosing device and a support device that are associated in particular with a filling machine, for supporting and locking the dosing unit in a mounting configuration. The apparatus further includes a coupling device associated with a casing and slidingly insertable into or disconnectable from a guide of the support device along a first direction. The support device further includes a fixing device for reversibly locking the coupling device to the guide in the mounting configuration.

摘要翻译： 定量给料装置包括一个计量单元，该计量单元设置有用于支撑或容纳定量装置的壳体，以及特别是与填充机相关联的支撑装置，用于将配量单元支撑并锁定在安装构型中。 该装置还包括与壳体相关联的联接装置，并且可沿着第一方向滑动地插入支撑装置的引导件或与支撑装置的导向件分离。 支撑装置还包括用于在安装配置中将联接装置可逆地锁定到引导件的固定装置。

公开(公告)号：US20140252025A1

公开(公告)日：2014-09-11

申请号：US14238866

申请日：2012-08-15

申请人： Henkel AG & Co. KGaA

发明人： Christoph Schmid ,  Thoma Daum

IPC分类号： B67D7/22 ,  B67D7/70

CPC分类号： B65D83/0005 ,  B05C11/1002 ,  B05C17/00553 ,  B05C17/0103 ,  G01F11/023 ,  G01F11/029 ,  G01F22/00

摘要： A discharging system (100, 200, 300, 400, 500) for discharging liquid to pasty compounds (107, 207, 30, 507) out of cavities (106, 206, 306, 506) of at least two containers (105, 205, 305, 405, 405′, 505), comprising a delivery end (109, 209, 309, 409, 509) at which the compounds (107, 207, 307, 507) are discharged; a receiving unit (101, 201, 301, 401, 401′, 501) for at least two containers (105, 205, 305, 405, 405′, 505) comprising the cavities (106, 206, 306, 506) filled with the compounds (107, 207, 307, 507) to be discharged; for each container, a respective advancing rod (103, 203, 303, 403, 403′, 503) with a pusher element (104, 204, 304, 504) provided on that side of the advancing rod (103, 203, 303, 403, 403′, 503) facing toward the delivery end (109, 209, 309, 409, 509); for each container, a respective advancing device for advancing the advancing rod (103, 203, 303, 403, 403′, 503), with the pusher element (104, 204, 304, 504), toward the delivery end (109, 209, 309, 409, 509) in order to discharge the compounds; for each container, a respective means for determining the volume of respectively discharged compound (107, 207, 307, 507).

摘要翻译： 用于将液体从糊状化合物（107,207,307,507）排出至少两个容器（105,205）的空腔（106,206,306,506）的排放系统（100,200,300,400,500） ，305,405,305,507），其包括放出所述化合物（107,207,307,507）的输送端（109,209,309,409,509）。 用于至少两个容器（105,205,305,405,405'，505）的接收单元（101,201,301,401,401'，501）包括填充有所述空腔（106,206,306,506）的空腔 待排出的化合物（107,207,307,507）; 对于每个容器，具有设置在前进杆（103,203,303,503）的该侧上的推动元件（104,204,304,504）的相应的前进杆（103,203,303,403,403'，503） 403,409,409,509）;面向传送端（109,209,309,409,509）; 对于每个容器，用于使推进元件（104,204,304,504）前进的前进杆（103,203,303,403,403'，503）朝向输送端（109,29 ，309,409,509）以排出化合物; 对于每个容器，分别确定分别排出的化合物（107,207,307,507）的体积的装置。

公开(公告)号：US08572834B2

公开(公告)日：2013-11-05

申请号：US13195525

申请日：2011-08-01

申请人： J. Michael Cude

发明人： J. Michael Cude

IPC分类号： B21D39/00 ,  A61M25/16

CPC分类号： A61M5/14546 ,  A61M5/007 ,  A61M5/14566 ,  G01F11/029 ,  Y10T29/49826 ,  Y10T29/49947 ,  Y10T29/49948

摘要： A syringe adapter assembly 10 for permitting a front loadable power injector 100 having a pressure jacket 106 with an open front end to attach syringes 70 that do not require pressure jackets for their intended purpose. The syringe adapter assembly comprises a main adapter body 12 having a central bore 28 therethrough, a lifting ring 60 secured within the main adapter body 12, a connector plate 50 for attaching the main adapter body to the door injector, and a drive ram extender 30 that attaches to the drive ram. Additionally, the ram extender 30 may have a ram tip cone 40 attached at its forward end. The connector plate 50 is inserted into a recess 112 in the rear side of the door, and attaches to the main adapter body 12 located on the front side of the door. The invention additionally or alternatively comprises both a syringe lock 120 that locks an installed syringe relative to the injector to prevent unwanted movement of the syringe, and a method of locking syringe relative to an injector.

摘要翻译： 一种注射器适配器组件10，用于允许具有开口前端的压力护套106的前部可装载动力注射器100，以连接不需要压力夹套用于其预期目的的注射器70。 注射器适配器组件包括具有穿过其中的中心孔28的主适配器主体12，固定在主适配器主体12内的提升环60，用于将主适配器主体附接到门喷射器的连接板50和驱动柱塞延伸器30 它附着在驱动柱上。 另外，压头延伸器30可以具有连接在其前端的活塞尖端锥体40。 连接板50插入到门的后侧的凹部112中，并且附接到位于门前侧的主适配器主体12。 本发明另外或可选地包括注射器锁120，其相对于注射器锁定已安装的注射器，以防止注射器的不期望的移动，以及相对于注射器锁定注射器的方法。

公开(公告)号：US08534505B2

公开(公告)日：2013-09-17

申请号：US12550730

申请日：2009-08-31

申请人： Mario Romanin ,  Brian Burkley ,  Les Varga ,  Chuck Ganzer ,  Jeff Owen

发明人： Mario Romanin ,  Brian Burkley ,  Les Varga ,  Chuck Ganzer ,  Jeff Owen

IPC分类号： G01F11/04

CPC分类号： B05C11/1002 ,  B05C5/0225 ,  B05C5/0229 ,  G01F11/021 ,  G01F11/029 ,  G01F11/04

摘要： Methods and apparatus for dispensing liquid material provide the option to dispense precise and repeatable quantities or volume of material over a wide range of viscosities. In one embodiment, a metering chamber is provided that can be filled and emptied at the same time so as to eliminate time delays between dispensing operations. The material may be under pressure and that pressure is used to fill and empty a metering chamber. In another embodiment, a control device is provided with a metering chamber wherein the control device operates to switch pressurized fluid between two passages to the metering chamber. In a more specific embodiment, the control device may be, for example, a valve, and more specifically in one embodiment a pneumatically actuated spool valve.

摘要翻译： 用于分配液体材料的方法和设备提供了在宽范围的粘度下分配精确和可重复的量或体积的材料的选择。 在一个实施例中，提供了可以同时填充和排空的计量室，以便消除分配操作之间的时间延迟。 材料可能处于压力下，并且使用该压力来填充和清空计量室。 在另一个实施例中，控制装置设置有计量室，其中控制装置操作以将加压流体在两个通道之间切换到计量室。 在更具体的实施例中，控制装置可以是例如阀，并且更具体地，在一个实施例中是气动致动的滑阀。