Microfluidic device and method of manufacturing the same
    2.
    发明申请
    Microfluidic device and method of manufacturing the same 失效
    微流体装置及其制造方法

    公开(公告)号:US20060257627A1

    公开(公告)日:2006-11-16

    申请号:US11414711

    申请日:2006-04-28

    IPC分类号: B05D3/00 B29C71/04 B32B3/00

    摘要: Provided is a method of manufacturing a microfludic device in which coating film patterns made of a coupling agent are formed in microchannels. The method includes: forming the coating film patterns made of the coupling agent on a Si substrate; selectively oxidizing coupling agent-free regions of the Si substrate having thereon the coating film patterns made of the coupling agent using an oxidizing agent with an oxidation potential from 1 to 2 V; and adhering a PDMS (polydimethylsiloxane) microchannel structure to the selectively oxidized Si substrate to form the microchannels.

    摘要翻译: 本发明提供一种微流控装置的制造方法,其中,在微通道中形成由偶联剂形成的涂膜图案。 该方法包括:在Si衬底上形成由偶联剂制成的涂膜图案; 使用氧化电位为1〜2V的氧化剂选择性地氧化其上具有由偶联剂形成的涂膜图案的Si基板的无偶联剂区域; 并将PDMS(聚二甲基硅氧烷)微通道结构粘附到选择性氧化的Si衬底上以形成微通道。

    Method of electrically detecting biomolecule
    3.
    发明申请
    Method of electrically detecting biomolecule 失效
    电气检测生物分子的方法

    公开(公告)号:US20060246478A1

    公开(公告)日:2006-11-02

    申请号:US11345790

    申请日:2006-02-02

    IPC分类号: C12Q1/68 G01N33/53 C12M1/34

    CPC分类号: G01N33/54306

    摘要: Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.

    摘要翻译: 提供了一种使用bioFET感测生物分子的方法,该方法包括:在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针,以及具有与探针不完全结合的硫醇基(-SH)的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。

    Sensing switch and detecting method using the same
    5.
    发明授权
    Sensing switch and detecting method using the same 失效
    感应开关及使用其的检测方法

    公开(公告)号:US07510865B2

    公开(公告)日:2009-03-31

    申请号:US11347185

    申请日:2006-02-03

    IPC分类号: C12M1/34

    CPC分类号: G01N33/54373

    摘要: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译: 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括:基板; 底物上的支撑物; 感测板,其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时,引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极,并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注,不需要使用分析装置的荧光或电检测信号的信号处理,并且可以通过确认电流是否流过开关直接解码信号。

    Ion exchangeable mixture and method of producing the same

    公开(公告)号:US20060284138A1

    公开(公告)日:2006-12-21

    申请号:US11453116

    申请日:2006-06-14

    IPC分类号: C01B31/16

    摘要: An ion exchangeable mixture containing a polymeric compound consisting of an ion exchange resin, an acrylamide mixture containing at least one bisacrylamide and at least one acrylamide, and a copolymer obtained by reacting the polymeric compound with the acrylamide mixture, and a method of producing the same are provided. The ion exchangeable membrane produced by using the ion exchangeable mixture has significantly smaller electric resistance than conventional ion exchangeable membranes, and has excellent selective permeability because the ion exchangeable membrane is electrically charged. The ion exchangeable membrane can be produced under very mild production conditions, and thus can be produced very easily. Furthermore, the ion exchangeable membrane can be also formed into film during a crosslinking reaction in a solvent of water, and thus is advantageous in that the ion exchangeable membrane can be freely produced into desired sizes, shapes and forms.

    Ion exchangeable mixture and method of producing the same
    8.
    发明授权
    Ion exchangeable mixture and method of producing the same 有权
    可离子交换混合物及其制备方法

    公开(公告)号:US08519014B2

    公开(公告)日:2013-08-27

    申请号:US13605503

    申请日:2012-09-06

    IPC分类号: B01J49/00 C08J5/20 C01B31/16

    摘要: An ion exchangeable mixture containing a polymeric compound consisting of an ion exchange resin, an acrylamide mixture containing at least one bisacrylamide and at least one acrylamide, and a copolymer obtained by reacting the polymeric compound with the acrylamide mixture, and a method of producing the same are provided. The ion exchangeable membrane produced by using the ion exchangeable mixture has significantly smaller electric resistance than conventional ion exchangeable membranes, and has excellent selective permeability because the ion exchangeable membrane is electrically charged. The ion exchangeable membrane can be produced under very mild production conditions, and thus can be produced very easily. Furthermore, the ion exchangeable membrane can be also formed into film during a crosslinking reaction in a solvent of water, and thus is advantageous in that the ion exchangeable membrane can be freely produced into desired sizes, shapes and forms.

    摘要翻译: 含有由离子交换树脂,含有至少一种双丙烯酰胺和至少一种丙烯酰胺的丙烯酰胺混合物组成的聚合物的离子交换性混合物和通过使聚合物与丙烯酰胺混合物反应得到的共聚物及其制造方法 被提供。 通过使用离子交换性混合物制造的离子交换膜的电阻比常规的离子交换膜的电阻小得多,并且由于可离子交换膜带电而具有优异的选择性渗透性。 离子交换膜可以在非常温和的生产条件下生产,因此可以非常容易地生产。 此外,在水的溶剂中的交联反应期间,也可以将离子交换膜形成为膜,因此有利的是可离子交换膜可以自由地制成所需的尺寸,形状和形状。

    SENSING SWITCH AND DETECTING METHOD USING THE SAME
    9.
    发明申请
    SENSING SWITCH AND DETECTING METHOD USING THE SAME 有权
    感应开关及其检测方法

    公开(公告)号:US20100329931A1

    公开(公告)日:2010-12-30

    申请号:US12833095

    申请日:2010-07-09

    IPC分类号: G01N27/00

    CPC分类号: G01N33/54373

    摘要: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译: 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括:基板; 底物上的支撑物; 感测板,其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时,引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极,并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注,不需要使用分析装置的荧光或电检测信号的信号处理,并且可以通过确认电流是否流过开关直接解码信号。

    SENSING SWITCH AND DETECTING METHOD USING THE SAME
    10.
    发明申请
    SENSING SWITCH AND DETECTING METHOD USING THE SAME 有权
    感应开关及其检测方法

    公开(公告)号:US20090170211A1

    公开(公告)日:2009-07-02

    申请号:US12272183

    申请日:2008-11-17

    IPC分类号: G01N27/00

    CPC分类号: G01N33/54373

    摘要: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译: 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括:基板; 底物上的支撑物; 感测板,其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时,引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极,并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注,不需要使用分析装置的荧光或电检测信号的信号处理,并且可以通过确认电流是否流过开关直接解码信号。