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    Autologous somatic cells from peripheral blood and uses thereof
    1.
    发明申请
    Autologous somatic cells from peripheral blood and uses thereof 审中-公开
    来自外周血的自体体细胞及其用途

    公开(公告)号：US20090311323A1

    公开(公告)日：2009-12-17

    申请号：US11919527

    申请日：2006-04-28

    申请人： Joaquin Cortiella ,  Joan E. Nichols ,  Jean A. Niles ,  Eric Lee ,  Donald Prough

    发明人： Joaquin Cortiella ,  Joan E. Nichols ,  Jean A. Niles ,  Eric Lee ,  Donald Prough

    IPC分类号： A61K35/12 ,  C12N5/08 ,  A61K38/20 ,  A61K9/14

    CPC分类号： C12N5/0623 ,  C12N2502/08 ,  C12N2506/11

    摘要： The present invention is directed to developing treatment for spinal cord injury, traumatic brain injury and neural disease using autologous somatic stem cells isolated from peripheral blood. The method identified in the present invention will generate functional neural cells/tissues in order to replace the diseased or damaged neural cells/tissues. In doing so, the cells will not only reverse the motor as well as cognitive dysfunction but will also stabilize the injury site, reduce inflammation and scaring, and halt progressive loss of functional tissue. Further, this method also holds a great promise since it is non-invasive, autologous and can be used acutely.

    摘要翻译： 本发明涉及使用从外周血分离的自体体细胞干细胞来开发脊髓损伤，创伤性脑损伤和神经疾病的治疗。 在本发明中鉴定的方法将产生功能性神经细胞/组织，以便替代患病或受损的神经细胞/组织。 在这样做时，细胞不仅会逆转运动以及认知功能障碍，而且还会稳定受伤部位，减少炎症和惊吓，并停止功能组织的进行性损失。 此外，这种方法也是非常有希望的，因为它是非侵入性的，自体的，可以被急性使用。

    Cell culture well-plates having inverted colloidal crystal scaffolds
    3.
    发明申请
    Cell culture well-plates having inverted colloidal crystal scaffolds 审中-公开
    具有反胶体晶体支架的细胞培养孔板

    公开(公告)号：US20090041825A1

    公开(公告)日：2009-02-12

    申请号：US12228419

    申请日：2008-08-12

    申请人： Nicholas A. Kotov ,  Joaquin Cortiella ,  Joan E. Nichols

    发明人： Nicholas A. Kotov ,  Joaquin Cortiella ,  Joan E. Nichols

    IPC分类号： A61K35/28 ,  A61F2/02 ,  C12N5/02 ,  A61P43/00 ,  C12Q1/02

    CPC分类号： C12M21/08 ,  C12M23/12 ,  C12M25/14 ,  C12N5/0647 ,  C12N5/0669 ,  C12N5/067 ,  C12N5/0697 ,  C12N2502/1171 ,  C12N2502/1394 ,  C12N2503/04 ,  C12N2531/00 ,  C12N2533/30 ,  C12N2533/40 ,  G01N33/5014 ,  G01N33/5088

    摘要： An artificial bone marrow construct comprising a substrate having at least one well; a three dimensional biocompatible polymer matrix comprising a transparent polymer network containing microspherical voids, wherein the microspherical voids are each connected to at least one other void through inter-connecting pores; at least one LBL coating on a surface of at least one of the polymer network, voids and pores, a population of bone marrow cells comprising stem cells and stromal cells; and at least one bioactive agent. An artificial immune network comprising a polymer matrix with a population of immune cells comprising B-cells and T-cells is disclosed. Methods for testing the toxicity of drugs and other agents against bone marrow cells and methods for making universal blood using the artificial bone marrow constructs are also disclosed.

    摘要翻译： 一种人造骨髓构建体，其包含具有至少一个孔的底物; 三维生物相容性聚合物基质，其包含含有微球空隙的透明聚合物网络，其中所述微球形空隙各自通过相互连接的孔连接至至少一个其它空隙; 在聚合物网络，空隙和孔中的至少一个的表面上的至少一个LBL涂层，包含干细胞和基质细胞的骨髓细胞群; 和至少一种生物活性剂。 公开了包含具有包含B细胞和T细胞的免疫细胞群的聚合物基质的人造免疫网络。 还公开了用于测试药物和其它试剂对骨髓细胞的毒性的方法和使用人造骨髓构建体制备普通血液的方法。

    Ex vivo human lung/immune system model using tissue engineering for studying microbial pathogens with lung tropism
    5.
    发明申请
    Ex vivo human lung/immune system model using tissue engineering for studying microbial pathogens with lung tropism 审中-公开
    离体人肺/免疫系统模型使用组织工程研究微生物病原体与肺向性

    公开(公告)号：US20090227025A1

    公开(公告)日：2009-09-10

    申请号：US11352924

    申请日：2006-02-13

    申请人： Joan E. Nichols ,  Joaquin Cortiella ,  Ronald P. Mlcak ,  Jean A. Niles

    发明人： Joan E. Nichols ,  Joaquin Cortiella ,  Ronald P. Mlcak ,  Jean A. Niles

    IPC分类号： C12N5/02 ,  C12Q1/02 ,  C12N5/08

    CPC分类号： A61K9/0073 ,  A61K35/42 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0689 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2533/40

    摘要： A method for studying scaffold-based tissue engineering approaches in combination with the use of progenitor or stem cells to generate new lung tissue in an in vitro system. The engineered tissue system of this invention is used to monitor lung and immune system exposure of pathogen and/or toxins. The method involves growing engineered lung/immune tissue from progenitor cells in a bioreactor and then exposing the engineered lung/immune tissue to a pathogen and/or toxin. Once exposed, response of the engineered tissue is monitored to determine the effects of exposure to the immune component of the tissue and to lung component of the tissue. This invention also involves development of mixed engineered tissues including a first fully functional engineered tissue such as lung tissue and a second fully functional engineered tissued such as immune tissue from a single animal donor. The mixed systems can include more than two engineered tissues.

    摘要翻译： 一种用于研究基于支架的组织工程方法与使用祖细胞或干细胞在体外系统中产生新的肺组织的方法。 本发明的工程组织系统用于监测病原体和/或毒素的肺和免疫系统暴露。 该方法包括在生物反应器中从祖细胞生长工程化的肺/免疫组织，然后将工程化的肺/免疫组织暴露于病原体和/或毒素。 一旦暴露，监测工程组织的反应以确定暴露于组织的免疫组分和组织的肺组分的影响。 本发明还涉及混合工程组织的开发，包括第一完全功能工程化组织，例如肺组织和第二完全功能工程组织，例如来自单个动物供体的免疫组织。 混合系统可以包括两个以上的工程组织。