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1.发明授权公开(公告)号：US07931592B2
公开(公告)日：2011-04-26
申请号：US11090156
申请日：2005-03-28
IPC分类号： A61B5/00
CPC分类号： A61B5/150007 , A61B5/0059 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/6833 , A61B2562/12 , A61M5/1723
摘要： The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
摘要翻译： 本发明涉及一种用于透皮采样的系统和方法，包括：至少一个采样器，用于从受试者皮肤透皮获取和转移至少一种分析物; 至少一个用于识别和定量所述至少一种分析物的检测器系统; 以及至少一个逻辑模块，用于（i）从所述至少一个检测器接收和存储输入数据，（ii）将输入数据与从对象获得的其他数据相关联，（iii）显示输出信息，（iv） 信息到另一系统，以及（v）控制所述至少一个取样器和至少一个检测器的操作。
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公开(公告)号：US5986291A
公开(公告)日：1999-11-16
申请号：US135003
申请日：1993-10-12
IPC分类号： H01L29/778 , H01L31/0328 , H01L31/0336 , H01L31/072 , H01L31/109
CPC分类号： H01L29/7786
摘要： The channel region of the FET device has a first portion adjacent the source which has a higher bandgap energy or a higher electron affinity than a remaining portion of the channel. A quasi-electric field in the channel near the source is intensified and as a result, accelerates charge carriers in the channel and increases switching speed. An infrared controlled FET device is also disclosed in which a low bandgap channel layer has a large bandgap layer deposited on it to result in a conduction band discontinuity at the junction between the large bandgap semiconductor layer and the low bandgap channel layer and a two-dimensional electron gas (2DEG) channel in the low bandgap channel layer so that photons reaching the 2DEG eject charges and allow conduction through the channel layer.
摘要翻译： FET器件的沟道区域具有与源极相邻的第一部分，其具有比沟道的剩余部分更高的带隙能量或更高的电子亲和力。 源极附近的通道中的准电场增强，结果加速了通道中的电荷载流子并提高了开关速度。 还公开了一种红外控制FET器件，其中低带隙沟道层在其上沉积有大的带隙层，导致在大带隙半导体层和低带隙沟道层之间的接合处的导带不连续性，以及二维 电子气体（2DEG）通道，使得到达2DEG的光子弹出电荷并允许通过沟道层的导电。
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公开(公告)号：US5080503A
公开(公告)日：1992-01-14
申请号：US593262
申请日：1990-10-01
IPC分类号： G02B6/124
CPC分类号： G02B6/124
摘要： The present disclosure describes an optical waveguide device and a method for making such device. The device comprises a substrate; a waveguide embedded in the substrate, the waveguide having a refractive index higher than the refractive index of the substrate; and first and second optical mirrors placed respectively in two different positions along the waveguide. The method comprises steps of (a) cleaning a substrate by means of a cleaning agent; (b) embedding a waveguide in the substrate; and (c) placing first and second optical mirrors respectively at two different positions in the substrate, the steps (b) and (c) being performed in such a manner that the mirrors being positioned along the waveguide.
摘要翻译： 本公开描述了一种光波导器件及其制造方法。 该装置包括基板; 嵌入在所述衬底中的波导，所述波导具有高于所述衬底的折射率的折射率; 以及沿着波导分别放置在两个不同位置的第一和第二光学镜。 该方法包括以下步骤：（a）借助于清洁剂清洗基底; （b）在衬底中嵌入波导; 和（c）将第一和第二光学镜分别放置在衬底中的两个不同位置，步骤（b）和（c）以使得反射镜沿着波导定位的方式进行。
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公开(公告)号：US20130123595A1
公开(公告)日：2013-05-16
申请号：US13609838
申请日：2012-09-11
IPC分类号： A61B5/157 , A61B5/1491 , A61B5/1477
CPC分类号： A61B5/150022 , A61B5/0022 , A61B5/14532 , A61B5/1486 , A61B5/150076 , A61B5/150122 , A61B5/150358 , A61B5/150412 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150946 , A61B5/150984 , A61B5/15134 , A61B5/157 , A61B2562/0295
摘要： Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.
摘要翻译： 提供透皮取样和分析装置，方法和系统非侵入性地和经皮地获得来自受试者的生物样品，并确定获得的生物样品的分析物水平。 透皮取样和分析装置，方法和系统可能导致皮肤细胞的破坏，从而产生毛细管样通道，生物样品可以从该细胞流动到经皮采样和分析装置。 透皮采样和分析装置，方法和系统可以将储存器中的生物样品收集并将生物样品运送到感测室。 感测室可以包含至少两个感测电极，其被涂覆有与被输送的生物样品反应的生物反应性元件。 感测室可以被配置为减轻气泡的形成，这可能阻碍生物样品在整个感测室上的输送和分布。
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公开(公告)号：US20120150004A1
公开(公告)日：2012-06-14
申请号：US13294368
申请日：2011-11-11
IPC分类号： A61B5/157
CPC分类号： A61B5/150022 , A61B5/0022 , A61B5/14532 , A61B5/1486 , A61B5/150076 , A61B5/150122 , A61B5/150358 , A61B5/150412 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150946 , A61B5/150984 , A61B5/15134 , A61B5/157 , A61B2562/0295
摘要： Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.
摘要翻译： 提供透皮取样和分析装置，方法和系统非侵入性地和经皮地获得来自受试者的生物样品，并确定获得的生物样品的分析物水平。 透皮取样和分析装置，方法和系统可能导致皮肤细胞的破坏，从而产生毛细管样通道，生物样品可以从该细胞流动到透皮取样和分析装置。 透皮采样和分析装置，方法和系统可以将生物样品收集在储存器中，其中生物样品可以与生物反应性元件发生化学反应。 传感器可以将产生的电子（离子）转换成测量的电信号。 可以测量转换的信号，并且可以基于测量的信号来确定分析物的水平。
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公开(公告)号：US06270651B1
公开(公告)日：2001-08-07
申请号：US09498211
申请日：2000-02-04
申请人： Abetif Essalik , John F. Currie
发明人： Abetif Essalik , John F. Currie
IPC分类号： G01N27407
CPC分类号： G01N27/4073
摘要： The present invention is an electrolyte composition in bulk, thick film and sputtered thin film form forming with different metal sensing and reference electrodes a highly stable gas component concentration sensor.
摘要翻译： 本发明是一种体积大，厚膜和溅射薄膜形式的电解质组合物，其形成有不同的金属感测和参比电极，它是高度稳定的气体组分浓度传感器。
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公开(公告)号：US5267325A
公开(公告)日：1993-11-30
申请号：US755722
申请日：1991-09-06
CPC分类号： G06K9/32 , G06K2209/01
摘要： Characters are located in a character recognition system by providing images in response to scanning characters, and then smearing black pixels in an image in up and down and left and right directions for detecting corners which are used to produce candidate character frames. These candidate character frames are scored based on how well they correspond to character size and expected location to determine which character frames are to be submitted for character recognition.
摘要翻译： 字符位于字符识别系统中，通过提供响应于扫描字符的图像，然后在上下左右方向上涂抹图像中的黑色像素，以检测用于产生候选字符帧的角部。 这些候选字符帧基于它们对应于字符大小和预期位置的程度进行评分，以确定哪些字符帧将被提交用于字符识别。
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8.发明申请公开(公告)号：US20120010487A1
公开(公告)日：2012-01-12
申请号：US13085775
申请日：2011-04-13
IPC分类号： A61B5/145
CPC分类号： A61B5/150007 , A61B5/0059 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/6833 , A61B2562/12 , A61M5/1723
摘要： The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
摘要翻译： 本发明涉及一种用于透皮采样的系统和方法，包括：至少一个采样器，用于从受试者皮肤透皮获取和转移至少一种分析物; 至少一个用于识别和定量所述至少一种分析物的检测器系统; 以及至少一个逻辑模块，用于（i）从所述至少一个检测器接收和存储输入数据，（ii）将输入数据与从对象获得的其他数据相关联，（iii）显示输出信息，（iv） 信息到另一系统，以及（v）控制所述至少一个取样器和至少一个检测器的操作。
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公开(公告)号：US09877673B2
公开(公告)日：2018-01-30
申请号：US13294368
申请日：2011-11-11
CPC分类号： A61B5/150022 , A61B5/0022 , A61B5/14532 , A61B5/1486 , A61B5/150076 , A61B5/150122 , A61B5/150358 , A61B5/150412 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150946 , A61B5/150984 , A61B5/15134 , A61B5/157 , A61B2562/0295
摘要： Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.
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公开(公告)号：US09451913B2
公开(公告)日：2016-09-27
申请号：US13609838
申请日：2012-09-11
CPC分类号： A61B5/150022 , A61B5/0022 , A61B5/14532 , A61B5/1486 , A61B5/150076 , A61B5/150122 , A61B5/150358 , A61B5/150412 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150946 , A61B5/150984 , A61B5/15134 , A61B5/157 , A61B2562/0295
摘要： Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.
摘要翻译： 提供透皮取样和分析装置，方法和系统非侵入性地和经皮地获得来自受试者的生物样品，并确定获得的生物样品的分析物水平。 透皮取样和分析装置，方法和系统可能导致皮肤细胞的破坏，从而产生毛细管样通道，生物样品可以从该细胞流动到经皮采样和分析装置。 透皮采样和分析装置，方法和系统可以将储存器中的生物样品收集并将生物样品运送到感测室。 感测室可以包含至少两个感测电极，其被涂覆有与被输送的生物样品反应的生物反应性元件。 感测室可以被配置为减轻气泡的形成，这可能阻碍生物样品在整个感测室上的输送和分布。
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