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    Methods for embolizing blood vessels
    4.
    发明授权
    Methods for embolizing blood vessels 失效
    栓塞栓塞方法

    公开(公告)号：US6017977A

    公开(公告)日：2000-01-25

    申请号：US868931

    申请日：1997-06-04

    申请人： Scott Evans ,  John Perl, II ,  Richard Greff

    发明人： Scott Evans ,  John Perl, II ,  Richard Greff

    IPC分类号： A61B17/12 ,  A61K49/04 ,  A61L24/00 ,  A61L24/02 ,  A61L24/04 ,  A61L31/02 ,  C08L29/04 ,  A61K31/765 ,  C08K5/41

    CPC分类号： A61L24/0015 ,  A61L24/001 ,  A61L24/02 ,  A61L24/04 ,  A61L31/02 ,  A61L2300/418 ,  A61L2300/44 ,  A61L2430/36

    摘要： Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer and a biocompatible solvent.The biocompatible solvent is miscible or soluble in blood and also solubilizes the polymer during delivery. The biocompatible polymer is selected to be soluble in the biocompatible solvent but insoluble in blood. Upon contact with the blood, the biocompatible solvent dissipates from the embolic composition whereupon the biocompatible polymer precipitates. Precipitation of the polymer in the presence of the non-particulate agent permits the agent to act as a structural lattice for the growing polymer precipitate.In another embodiment, the biocompatible polymer composition can be replaced with a biocompatible prepolymer composition containing a biocompatible prepolymer.

    摘要翻译： 公开了可用于治疗血管损伤的方法，其中将非颗粒剂如金属盘管与包含生物相容性聚合物和生物相容性溶剂的栓塞组合物一起引入血管部位（例如，动脉瘤腔）。 生物相容性溶剂是可混溶的或可溶于血液，并且在递送过程中也溶解聚合物。 选择生物相容性聚合物可溶于生物相容性溶剂，但不溶于血液。 当与血液接触时，生物相容性溶剂从栓塞组合物中消散，因此生物相容性聚合物沉淀。 聚合物在非颗粒剂存在下的析出使得该试剂作为生长聚合物沉淀物的结构晶格。 在另一个实施方案中，生物相容性聚合物组合物可以用含有生物相容性预聚物的生物相容性预聚物组合物代替。

    Catheter system and method for injection of a liquid embolic composition and a solidification agent
    10.
    发明授权
    Catheter system and method for injection of a liquid embolic composition and a solidification agent 失效
    导管系统和注射液体栓塞组合物和凝固剂的方法

    公开(公告)号：US06964657B2

    公开(公告)日：2005-11-15

    申请号：US10361851

    申请日：2003-02-11

    申请人： Andrew H. Cragg ,  Richard J. Greff ,  Robert Pecor ,  John Perl ,  Blair Walker ,  George Wallace

    发明人： Andrew H. Cragg ,  Richard J. Greff ,  Robert Pecor ,  John Perl ,  Blair Walker ,  George Wallace

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61M25/00 ,  A61M37/00 ,  A61M31/00

    CPC分类号： A61B17/12022 ,  A61B17/00491 ,  A61B17/12113 ,  A61B17/12186 ,  A61B90/39 ,  A61B2017/00495 ,  A61B2017/1205 ,  A61M25/00 ,  A61M25/0097 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/0039

    摘要： A catheter according to the present invention includes a multiple lumen catheter for delivery of a liquid embolic composition through a first lumen and delivery of a solidification agent through a second lumen. The catheter allows adjustment of the relative longitudinal position of the two lumens to control the solidification of the embolic composition within a blood vessel. The multiple lumen catheter system is used by inserting the catheter endovascularly into an aneurysm site and injecting a liquid embolic composition through the first lumen while injecting a solidification agent through the second lumen to wash the area of the aneurysm of blood which has become saturated with solvent, while replacing it with a fresh solidification agent. The controlled solidification of the liquid embolic composition by use of the solidification agent allows the aneurysm to be filled precisely and rapidly even when the aneurysm is located such that gravity does not cause the liquid embolic composition to flow into the aneurysm.

    摘要翻译： 根据本发明的导管包括多腔导管，用于通过第一腔输送液体栓塞组合物并且通过第二腔输送凝固剂。 导管允许调整两个腔的相对纵向位置以控制栓塞组合物在血管内的凝固。 通过将血管内导管插入动脉瘤部位并通过第一管腔注射液体栓塞组合物，同时通过第二腔注入凝固剂来洗涤已经变得饱和的血液的动脉瘤的区域，使用多腔导管系统 ，同时用新鲜的固化剂代替。 通过使用凝固剂对液体栓塞组合物的受控凝固允许即使当动脉瘤被定位成使得重力不会使液体栓塞组合物流入动脉瘤时，动脉瘤被精确和快速地填充。