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    Luminescent materials that emit light in the visible range or the near infrared range
    1.
    发明授权
    Luminescent materials that emit light in the visible range or the near infrared range 有权
    在可见光范围或近红外范围内发光的发光材料

    公开(公告)号：US07641815B2

    公开(公告)日：2010-01-05

    申请号：US11689381

    申请日：2007-03-21

    Applicant: John Varadarajan ,  Mirna Resan ,  Fanxin Wu ,  William M. Pfenninger ,  Nemanja Vockic ,  John Kenney

    Inventor： John Varadarajan ,  Mirna Resan ,  Fanxin Wu ,  William M. Pfenninger ,  Nemanja Vockic ,  John Kenney

    IPC: C09K11/66 ,  C09K11/61 ,  C09K11/55

    CPC classification number: C09K11/665 ,  C09K11/613 ,  C09K11/616 ,  C09K11/628 ,  C09K11/667 ,  C09K11/668 ,  C09K11/693 ,  C09K11/72 ,  C09K11/7435 ,  C23C14/0694 ,  C23C14/16 ,  C23C14/24 ,  C23C14/30 ,  C23C14/5806

    Abstract: Luminescent materials and the use of such materials in anti-counterfeiting, inventory, photovoltaic, and other applications are described herein. In one embodiment, a luminescent material has the formula: [AaBbXxX′x′X″x″][dopants], wherein A is selected from at least one of elements of Group IA; B is selected from at least one of elements of Group VA, elements of Group IB, elements of Group IIB, elements of Group IIIB, elements of Group IVB, and elements of Group VB; X, X′, and X″ are independently selected from at least one of elements of Group VIIB; the dopants include electron acceptors and electron donors; a is in the range of 1 to 9; b is in the range of 1 to 5; and x, x′, and x″ have a sum in the range of 1 to 9. The luminescent material exhibits photoluminescence having: (a) a quantum efficiency of at least 20 percent; (b) a spectral width no greater than 100 nm at Full Width at Half Maximum; and (c) a peak emission wavelength in the near infrared range.

    Abstract translation: 本文描述了发光材料以及这些材料在防伪，库存，光伏和其它应用中的用途。 在一个实施方案中，发光材料具有下式：[AaBbXxX'x'X'x“] [掺杂剂]，其中A选自组IA中的至少一种元素; B选自VA组的元素，IB组元素，IIB族元素，IIIB族元素，IVB族元素和VB族元素中的至少一种; X，X'和X“独立地选自VIIB族元素中的至少一种; 掺杂剂包括电子受体和电子给体; a在1到9的范围内; b在1〜5的范围内; 并且x，x'和x“具有在1至9范围内的和。发光材料表现出光致发光，其具有：（a）至少20％的量子效率; （b）半宽度全宽下的光谱宽度不大于100nm; 和（c）近红外范围的峰值发射波长。

    Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylethyl-ethanolamine sulphonate esters as intermediates
    2.
    发明授权
    Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylethyl-ethanolamine sulphonate esters as intermediates 失效
    正 - 芳基甲基氮丙啶衍生物，由其获得的1,4,7,10-四氮杂环十二烷衍生物和作为中间体的正 - 芳乙基 - 乙醇胺磺酸酯的制备

    公开(公告)号：US06288224B1

    公开(公告)日：2001-09-11

    申请号：US09546430

    申请日：2000-04-10

    Applicant: Janis Vasilevskis ,  John Varadarajan ,  Martha Garrity ,  Jere Douglas Fellmann ,  Louis Messerle ,  Gandara Amarasinghe

    Inventor： Janis Vasilevskis ,  John Varadarajan ,  Martha Garrity ,  Jere Douglas Fellmann ,  Louis Messerle ,  Gandara Amarasinghe

    IPC: C07D25702

    CPC classification number: C07D203/08 ,  A61K49/0002 ,  A61K49/06 ,  C07C303/44 ,  C07D255/00 ,  C07D257/02 ,  C07D259/00 ,  C07C305/06

    Abstract: Aziridines may be subjeted to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particular is useful as it can be cyclotetramerized and debenzylated to yield cyclen, a key intermediate in chelating agent preparation. The invention provides a particularly attractive route to production of N-benzyl and other N-arylmethyl aziridines of formula (I) where each R1 is independently hydrogen or a group AR and Ar is an optionally substituted phenyl group. The process comprises reacting a purified N-arylmethylethanolamine-sulphonate sulphonate ester with a base. N-aryimethyl-ethanolamine sulphonate ester of the formula R′NHCH2CH2OSO3H, wherein the N-arylmethyl group R′ is an N-(bisarylmethyl) or N-(triarylmethyl) group, as intermediates. In a further aspect, the invention provides compounds of formula (II) where Ar and R1 are as hereinabove defined and at least two differing ArCHR21 moieties are present.

    Abstract translation: 氮杂环丁烷可以被喷射到环烯化反应中以产生用于例如制备用于诊断成像造影剂的螯合剂的多氮杂环烷烃化合物。 特别是N-苄基 - 氮丙啶是有用的，因为它可以进行环化聚合和脱苄基化，以产生螯合剂，螯合剂制备中的关键中间体。 本发明提供了生产式（I）的N-苄基和其它N-芳基甲基氮丙啶的特别有吸引力的途径，其中每个R 1独立地为氢或基团AR，Ar为任选取代的苯基。 该方法包括使纯化的N-芳基甲基乙醇胺 - 磺酸酯磺酸酯与碱反应。 作为中间体，式R'NHCH2CH2OSO3H的N-芳基甲基 - 乙醇胺磺酸酯，其中N-芳基甲基R'是N-（二芳基甲基）或N-（三芳基甲基）基团。 在另一方面，本发明提供式（II）的化合物，其中Ar和R 1如上所定义，并且存在至少两个不同的ArCHR 21部分。

    Chelant moieties linked to an aryl moiety by an interrupted alkylene linker
    3.
    发明授权
    Chelant moieties linked to an aryl moiety by an interrupted alkylene linker 失效
    通过间断的亚烷基接头与芳基部分连接的螯合部分

    公开(公告)号：US5798089A

    公开(公告)日：1998-08-25

    申请号：US727594

    申请日：1997-01-17

    Applicant: John Varadarajan ,  Alan David Watson ,  Arne Berg

    Inventor： John Varadarajan ,  Alan David Watson ,  Arne Berg

    IPC: A61K31/555 ,  A61K49/00 ,  A61K49/06 ,  C07C217/22 ,  C07C237/08 ,  C07C237/12 ,  C07C323/41 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D273/00 ,  C07F5/00 ,  A61K51/04 ,  A61B5/055 ,  C07D225/00

    CPC classification number: A61K49/06 ,  C07C237/08 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D273/00

    Abstract: The invention provides amphiphilic compounds of the formula (I) Ch--(--L--Ar--(--AH).sub.n).sub.m (where Ch is a hydrophilic chelant moiety or a salt or a chelate thereof); each L is an optionally oxo substituted C.sub.2-25 -alkylene linker wherein at least one CH.sub.2 moiety is replaced by a group X.sup.1 (e.g. L may include a chain sequence, an X.sup.1 (CH.sub.2 CH.sub.2 X.sup.1).sub.u (where u is a positive integer) such as X.sup.1 (CH.sub.2 CH.sub.2 X.sup.1).sub.u, CH.sub.2 X.sup.1 CH.sub.2 CH.sub.2 X.sup.1 CH.sub.2 CH.sub.2 X.sup.1, CH.sub.2 X.sup.1 CH.sub.2 CH.sub.2 X.sup.1 CH.sub.2 CH.sub.2 X.sup.1 CH.sub.2 CH.sub.2 X.sup.1, etc.), and wherein L is optionally interrupted by a metabolizable group M but with the provisos that the terminus of L adjacent Ch is CH.sub.2 and that the terminus of L adjacent Ar is X.sup.1 or a CH.sub.2 group adjacent or separated by one CH.sub.2 from a group X.sup.1 (thus, for example the L--Ar linkage may be L.sup.1 --X.sup.1 --Ar, L.sup.1 --CH.sub.2 --Ar, L.sup.1 --X.sup.1 CH.sub.2 --Ar or L.sup.1 --X.sup.1 CH.sub.2 CH.sub.2 --Ar, where L.sup.1 is the residue of L; each Ar is an aryl ring optionally substituted by or having fused thereto a further aryl ring; each AH is a protic acid group, preferably an oxyacid, e.g. a carbon, sulphur or phosphorus oxyacid or a salt thereof; each X.sup.1 is O, S, NR.sup.1 or PR.sup.1, preferably no more than 3 X.sup.1 groups being present in L; each R.sup.1 is hydrogen, alkyl or aryl; and m and n are positive integers, m being for example 1 to 4, especially 1 or 2 and n being for example, 1, 2 or 3) which are especially suited for use in diagnostic imaging of the hepatobiliary system.

    Abstract translation: PCT No.PCT / GB95 / 00833 Sec。 371日期1997年1月17日 102（e）日期1997年1月17日PCT提交1995年4月12日PCT公布。 公开号WO95 / 28392 日期：1995年10月26日本发明提供式（I）Ch - （ - L-Ar - （ - AH）n）m（其中Ch为亲水螯合剂部分或其盐或螯合物）的两亲化合物; 每个L是任选氧代取代的C2-25-亚烷基连接体，其中至少一个CH2部分被基团X1替代（例如L可以包括链序列，X1（CH2CH2X1）u（其中u是正整数），例如 X1（CH2CH2X1）u，CH2X1CH2CH2X1CH2CH2X1，CH2X1CH2CH2X1CH2CH2X1CH2CH2X1等），其中L任选地被可代谢基团M中断，但条件是L相邻的Ch的末端是CH2，并且L相邻的Ar的末端是X1或 CH2基团与X1组相邻或分开一个CH2（因此，例如L-Ar键可以是L1-X1-Ar，L1-CH2-Ar，L1-X1CH2-Ar或L1-X1CH2CH2-Ar，其中L1 是L的残基;每个Ar是任选地被另外的芳环取代或与其稠合的芳基环;每个AH是优质酸基团，优选含氧酸，例如碳，硫或磷氧基酸或其盐;每个 X1是O，S，NR1或PR1，优选不超过3个X1基团存在于L中;每个R 1是氢，烷基或芳基;以及m和 n为正整数，m为例如1至4，特别是1或2，n为例如1,2或3），其特别适用于肝胆系统的诊断成像。

    LUMINESCENT MATERIALS THAT EMIT LIGHT IN THE VISIBLE RANGE OR THE NEAR INFRARED RANGE
    4.
    发明申请
    LUMINESCENT MATERIALS THAT EMIT LIGHT IN THE VISIBLE RANGE OR THE NEAR INFRARED RANGE 有权
    可见光范围内的发光材料或近红外范围的发光材料

    公开(公告)号：US20080014463A1

    公开(公告)日：2008-01-17

    申请号：US11689381

    申请日：2007-03-21

    Applicant: John Varadarajan ,  Mirna Resan ,  Fanxin Wu ,  William Pfenninger ,  Nemanja Vockic ,  John Kenney

    Inventor： John Varadarajan ,  Mirna Resan ,  Fanxin Wu ,  William Pfenninger ,  Nemanja Vockic ,  John Kenney

    IPC: B05D5/12 ,  B32B9/00

    CPC classification number: C09K11/665 ,  C09K11/613 ,  C09K11/616 ,  C09K11/628 ,  C09K11/667 ,  C09K11/668 ,  C09K11/693 ,  C09K11/72 ,  C09K11/7435 ,  C23C14/0694 ,  C23C14/16 ,  C23C14/24 ,  C23C14/30 ,  C23C14/5806

    Abstract: Luminescent materials and the use of such materials in anti-counterfeiting, inventory, photovoltaic, and other applications are described herein. In one embodiment, a luminescent material has the formula: [AaBbXxX′x′X″x″][dopants], wherein A is selected from at least one of elements of Group IA; B is selected from at least one of elements of Group VA, elements of Group IB, elements of Group IIB, elements of Group IIIB, elements of Group IVB, and elements of Group VB; X, X′, and X″ are independently selected from at least one of elements of Group VIIB; the dopants include electron acceptors and electron donors; a is in the range of 1 to 9; b is in the range of 1 to 5; and x, x′, and x″ have a sum in the range of 1 to 9. The luminescent material exhibits photoluminescence having: (a) a quantum efficiency of at least 20 percent; (b) a spectral width no greater than 100 nm at Full Width at Half Maximum; and (c) a peak emission wavelength in the near infrared range.

    Abstract translation: 本文描述了发光材料以及这些材料在防伪，库存，光伏和其它应用中的用途。 在一个实施方案中，发光材料具有以下分子式：[A a] a B b B x X x'x' “掺杂剂”，其中A选自组IA的至少一个元素; B选自VA组的元素，IB组元素，IIB族元素，IIIB族元素，IVB族元素和VB族元素中的至少一种; X，X'和X“独立地选自VIIB族元素中的至少一种; 掺杂剂包括电子受体和电子给体; a在1到9的范围内; b在1〜5的范围内; 并且x，x'和x“具有在1至9范围内的和。发光材料表现出光致发光，其具有：（a）至少20％的量子效率; （b）半宽度全宽下的光谱宽度不大于100nm; 和（c）近红外范围的峰值发射波长。

    Preparation of N-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and N-arylmethyl-ethanol-amine sulphonate esters as intermediates
    5.
    发明授权
    Preparation of N-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and N-arylmethyl-ethanol-amine sulphonate esters as intermediates 失效
    制备N-芳基甲基氮丙啶衍生物，由其得到的1,4,7,10-四氮杂环十二烷衍生物和N-芳基甲基 - 乙醇 - 胺磺酸酯作为中间体

    公开(公告)号：US6048979A

    公开(公告)日：2000-04-11

    申请号：US894790

    申请日：1997-12-02

    Applicant: Janis Vasilevskis ,  John Varadarajan ,  Martha Garrity ,  Jere Douglas Fellmann ,  Louis Messerle ,  Gandara Amarasinghe

    Inventor： Janis Vasilevskis ,  John Varadarajan ,  Martha Garrity ,  Jere Douglas Fellmann ,  Louis Messerle ,  Gandara Amarasinghe

    IPC: A61K49/00 ,  A61K49/06 ,  C07C303/44 ,  C07C305/06 ,  C07D203/08 ,  C07D255/00 ,  C07D257/02 ,  C07D259/00 ,  C07D255/02 ,  C07D203/06 ,  C07D203/14

    CPC classification number: C07D203/08 ,  A61K49/0002 ,  A61K49/06 ,  C07C303/44 ,  C07D255/00 ,  C07D257/02 ,  C07D259/00

    Abstract: Aziridines may be subjected to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particular is useful as it can be cyclotetramerized and debenzylated to yield cyclen, a key intermediate in chelating agent preparation. The invention provides a particularly attractive route to production of N-benzyl and other N-arylmethyl aziridines of formula (I) where each R.sub.1 is independently hydrogen or a group AR and Ar is an optionally substituted phenyl group. The process comprises reacting a purified N-arylmethylethanolaminesulphonate ester with a base. N-arylmethyl-ethanolamine sulphonate ester of the formula R'NHCH.sub.2 CH.sub.2 OSO.sub.3 H, wherein the N-arylmethyl group R' is an N-(bisarylmethyl) or N-(triarylmethyl) group, as intermediates. In a further aspect, the invention provides compounds of formula (II) ##STR1## where Ar and R.sub.1 are as hereinabove defined and at least two differing ArCHR.sub.21 moieties are present.

    Abstract translation: PCT No.PCT / GB96 / 00552 Sec。 371日期1997年12月2日第 102（e）1997年12月2日PCT PCT 1996年3月8日PCT公布。 出版物WO96 / 28420 PCT 日期1996年9月19日可以将齐拉地嗪进行环烯基化反应以产生用于例如制备用于诊断成像造影剂的螯合剂的多氮杂环烷烃化合物。 特别是N-苄基 - 氮丙啶是有用的，因为它可以进行环化聚合和脱苄基化，以产生螯合剂，螯合剂制备中的关键中间体。 本发明提供了生产式（I）的N-苄基和其它N-芳基甲基氮丙啶的特别有吸引力的途径，其中每个R 1独立地为氢或基团AR，Ar为任选取代的苯基。 该方法包括使纯化的N-芳基甲基乙醇胺磺酸酯与碱反应。 作为中间体，式R'NHCH2CH2OSO3H的N-芳基甲基 - 乙醇胺磺酸酯，其中N-芳基甲基R'是N-（二芳基甲基）或N-（三芳基甲基）基团。 在另一方面，本发明提供式（II）的化合物，其中Ar和R 1如上所定义，并且存在至少两个不同的ArCHR 21部分。

    Liposomal agents
    7.
    发明授权
    Liposomal agents 失效
    脂质体

    公开(公告)号：US6045821A

    公开(公告)日：2000-04-04

    申请号：US809729

    申请日：1997-05-29

    Applicant: Martha Garrity ,  John Varadarajan ,  Alan David Watson

    Inventor： Martha Garrity ,  John Varadarajan ,  Alan David Watson

    IPC: A61K9/127 ,  A61K33/00 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K51/00 ,  A61K51/12

    CPC classification number: A61K49/1812 ,  A61K51/1234

    Abstract: The present invention relates to a liposomal agent comprising liposomes having bound to a membrane thereof a chelated diagnostically or therapeutically effective metal ion. The chelating agent binding the metal ion has a macrocyclic chelant moiety with, attached to a single ring atom thereof, a lipophilic membrane associating moiety.

    Abstract translation: PCT No.PCT / GB95 / 02378第 371日期1997年5月29日 102（e）日期1997年5月29日PCT提交1995年10月9日PCT公布。 公开号WO96 / 11023 日本1996年4月18日本发明涉及包含与其膜结合螯合的诊断或治疗有效金属离子的脂质体的脂质体。 结合金属离子的螯合剂具有连接到其单环原子上的亲脂性膜缔合部分的大环螯合剂部分。

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