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公开(公告)号：US06902721B1
公开(公告)日：2005-06-07
申请号：US09421545
申请日：1999-10-20
IPC分类号： A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , A61K7/16
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性或蛋白酶体蛋白生成并促进骨形成的化合物，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺陷，转移性骨病， 溶骨性骨病，后整形手术，假体后关节外科手术和牙后植入术，在此是可取的。
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公开(公告)号：US08652505B2
公开(公告)日：2014-02-18
申请号：US12717666
申请日：2010-03-04
摘要： A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.
摘要翻译： 一种用于药物递送的医用植入物，其包括分散在其中的药物的内层，其中包含药物的内层，然后外层可以以可控的方式调节药物的释放。 外层可以粘附和/或穿透下面的层并且提供保护性涂层以及改善的机械强度以及水合和变得透水并允许药物释放的能力。
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3.发明申请BMP-2 Upregulating Compounds For Healing Bone Tissue And Screening Methods For Selecting Such Compounds 审中-公开BMP-2上调化合物用于愈合骨组织和筛选方法用于选择这些化合物公开(公告)号：US20120316111A1
公开(公告)日：2012-12-13
申请号：US13156089
申请日：2011-06-08
申请人： Jorge G. ROSSINI
发明人： Jorge G. ROSSINI
IPC分类号： A61K38/18 , A61K31/473 , A61K31/4745 , A61K31/472 , A61P35/04 , A61K38/19 , A61K38/30 , A61P19/10 , A61P19/08 , A61K31/517 , A61K38/29
CPC分类号： A61K31/473 , A61K31/472 , A61K31/4745 , A61K31/517 , A61K38/18 , A61K38/22 , A61K2300/00
摘要： The present disclosure relates to a method to stimulate endogenous BMP-2 up-regulation in a subject which method comprises administering to a subject an effective amount of one or more of the following compounds prazosin, quinacrine, emetine, apomorphine, and debrisoquine, whereby endogenous BMP-2 up-regulation is stimulated in said subject. The endogenous BMP-2 up-regulation may enhance bone formation and/or cartilage formation.
摘要翻译： 本公开内容涉及一种刺激受试者内源性BMP-2上调的方法，该方法包括向受试者施用有效量的一种或多种以下化合物哌唑嗪，奎那克，伊马替丁，阿扑吗啡，和无效喹诺酮，其中内源性 在所述受试者中刺激BMP-2上调。 内源性BMP-2上调可增强骨形成和/或软骨形成。
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公开(公告)号：US20110217351A1
公开(公告)日：2011-09-08
申请号：US12717666
申请日：2010-03-04
摘要： A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.
摘要翻译： 一种用于药物递送的医用植入物，其包括分散在其中的药物的内层，其中包含药物的内层，然后外层可以以可控的方式调节药物的释放。 外层可以粘附和/或穿透下面的层并且提供保护性涂层以及改善的机械强度以及水合和变得透水并允许药物释放的能力。
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公开(公告)号：US06958220B2
公开(公告)日：2005-10-25
申请号：US10050425
申请日：2002-01-15
IPC分类号： A61K45/00 , A61K31/00 , A61K31/351 , A61K31/40 , A61K31/4015 , A61K31/522 , A61K31/566 , A61K31/663 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/27 , A61K45/06 , A61P1/02 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , C12Q1/37
CPC分类号： A61K45/06 , A61K8/64 , A61K31/00 , A61K31/165 , A61K31/166 , A61K31/27 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/66 , A61K38/05 , A61K38/06 , A61K2800/91 , A61Q7/00 , G01N33/6872 , G01N2500/00 , Y10S514/88 , A61K2300/00
摘要： This inventions relates to compounds that inhibit the activity of the proteasome and both promotes hair growth and stimulates the production of hair follicles. The compounds provided herein are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性并且促进毛发生长并刺激毛囊生成的化合物。 因此，本文提供的化合物可用于在需要的受试者中刺激包括毛发密度的毛发生长。
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