-
1.发明申请公开(公告)号：US20110244014A1
公开(公告)日：2011-10-06
申请号：US13018038
申请日：2011-01-31
CPC分类号： A61K38/39 , A61K38/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/25 , A61L2300/254 , A61L2300/606 , C08L89/00 , C08L89/06
摘要： Laminin-containing coatings for the surfaces of implantable medical devices are disclosed. The coatings promote the formation of vessels in association with the coated surfaces with minimal fibrotic response.
摘要翻译： 公开了用于可植入医疗装置的表面的含层粘蛋白的涂层。 涂层促进与涂层表面相关联的血管的形成，具有最小的纤维化反应。
-
公开(公告)号：US20080243243A1
公开(公告)日：2008-10-02
申请号：US11824908
申请日：2007-07-03
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61F2/91 , A61L27/34 , A61L31/10 , A61L33/0029 , A61L33/122 , A61L33/128 , A61L2420/08 , C08L89/00 , C08L89/06
摘要： Coatings including adhesion factors for the surfaces of implantable medical articles are disclosed. The coatings are used to improve the function of the device by promoting a pro-healing response following implantation. The coatings can modulate endothelialization of the article surface to reduce the risk of adverse tissue responses that may reduce the functionality of the device.
摘要翻译： 公开了包括可植入医疗制品表面的粘附因子的涂层。 涂层用于通过促进植入后的预愈合反应来改善装置的功能。 涂层可以调节制品表面的内皮化，以减少可能降低装置功能的不利组织反应的风险。
-
公开(公告)号：US07220276B1
公开(公告)日：2007-05-22
申请号：US09519246
申请日：2000-03-06
IPC分类号： A61F2/06
CPC分类号： A61L27/16 , A61L27/56 , A61L31/048 , A61L2430/36 , C08L27/18
摘要： An endovascular graft, having both an expandable stent portion and a stent cover portion positioned, the graft itself and/or a stent cover-portion coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft prevents endoleaking by promoting a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups.
摘要翻译： 一种血管内移植物，其具有定位的可扩张的支架部分和支架覆盖部分，移植物本身和/或涂覆有适于促进初始血栓形成的生物活性剂的支架覆盖部分，优选地是长期纤维组织向内生长。 血管内移植物通过在周边区域促进短期止血作用来防止内分泌。 这种短期效应又可用于促进或允许长期的纤维组织向内生长。 特别是在支架覆盖部分由选自PET和ePTFE的多孔材料制备的情况下，生物活性剂可以包括血栓形成剂，例如在支架盖的至少外表面上以薄的保形涂层的形式共价附着的胶原 。 通过激活光反应性基团形成这种类型的最佳涂层。
-
公开(公告)号：US5744515A
公开(公告)日：1998-04-28
申请号：US729537
申请日：1996-10-11
申请人： David L. Clapper
发明人： David L. Clapper
CPC分类号： A61L27/56 , A61L27/16 , A61L27/18 , A61F2/0077 , A61F2/06 , Y10S623/924
摘要： A porous material with an appropriate surface chemistry that promotes capillary endothelialization is disclosed. The material has a porosity that is sufficient to allow capillary endothelialization and a tenaciously bound adhesion molecule that promotes the ingrowth of endothelial cells into the porosity of the material.
摘要翻译： 公开了具有促进毛细血管内皮化的适当表面化学物质的多孔材料。 该材料具有足以允许毛细血管内皮化的孔隙度和促进内皮细胞向内生长的物质的顽固结合的粘附分子。
-
公开(公告)号：US07094418B2
公开(公告)日：2006-08-22
申请号：US10990582
申请日：2004-11-17
CPC分类号： A61K9/1647 , A61K9/1641 , A61K38/1875 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L27/34 , A61L29/085 , A61L31/148 , Y10S623/92 , Y10S623/921 , Y10S623/923 , Y10S623/926
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.
-
公开(公告)号：US06924370B2
公开(公告)日：2005-08-02
申请号：US10176203
申请日：2002-06-20
IPC分类号： A61K9/16 , A61K35/12 , A61K38/18 , A61L24/00 , A61L27/34 , A61L29/08 , A61L31/14 , C07H1/00 , C08B37/08 , C08G63/91
CPC分类号： A61K9/1647 , A61K9/1641 , A61K38/1875 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L27/34 , A61L29/085 , A61L31/148 , Y10S623/92 , Y10S623/921 , Y10S623/923 , Y10S623/926
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.
-
7.发明授权Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups 有权具有聚合物骨架和潜在反应性部分和生物活性基团的多功能试剂公开(公告)号：US06514734B1
公开(公告)日：2003-02-04
申请号：US09591564
申请日：2000-06-09
IPC分类号： C12N1108
CPC分类号： G01N33/6845 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10 , A61L33/0011 , A61L33/0047 , C08J7/12 , C12N11/08 , C12Q1/56 , C12Q1/6834 , G01N33/54353 , G01N33/54366 , G01N33/68 , G01N33/6854 , G01N2333/78 , G01N2333/8128 , G01N2333/815 , G01N2333/974 , Y10S530/815 , Y10S530/816
摘要： A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
摘要翻译： 提供了具有聚合物主链，一个或多个潜在潜在反应性（优选光反应性）部分和两个或更多个侧悬生物活性基团的多功能试剂。 试剂可以被活化以形成散装材料，或者可以与先前形成的生物材料的表面接触并活化以形成涂层。 悬浮生物活性基团通过促进特定分子或细胞附着到大块材料或涂层表面而起作用。 生物活性基团可以包括蛋白质，肽，碳水化合物，核酸和能够非共价结合分子或细胞的特定和互补部分的其它分子。
-
公开(公告)号：US06410044B1
公开(公告)日：2002-06-25
申请号：US09571525
申请日：2000-05-16
IPC分类号： A61F206
CPC分类号： A61K9/1647 , A61K9/1641 , A61K38/1875 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L27/34 , A61L29/085 , A61L31/148 , Y10S623/92 , Y10S623/921 , Y10S623/923 , Y10S623/926
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.
摘要翻译： 一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。 大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个引发剂基团（例如聚合物 - 侧基引发剂基团）。 当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。 大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。 本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。 在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。
-
9.发明授权Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups 失效具有聚合物主链和光反应性部分和生物活性基团的多功能试剂
公开(公告)号：US6121027A
公开(公告)日：2000-09-19
申请号：US916913
申请日：1997-08-15
IPC分类号： A61L27/00 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10 , A61L33/00 , C08J7/12 , C08L33/26 , C12N11/08 , C12Q1/00 , C12Q1/56 , C12Q1/68 , G01N33/543 , G01N33/68 , G03F7/004 , A61K38/00 , C07K17/08 , G01N33/545
CPC分类号： G01N33/6845 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10 , A61L33/0011 , A61L33/0047 , C08J7/12 , C12N11/08 , C12Q1/56 , C12Q1/6834 , G01N33/54353 , G01N33/54366 , G01N33/68 , G01N33/6854 , G01N2333/78 , G01N2333/8128 , G01N2333/815 , G01N2333/974 , Y10S530/815 , Y10S530/816
摘要： A polybifunctional reagent is provided having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
摘要翻译： 提供了具有聚合物主链，一个或多个侧基光反应性部分和两个或更多个侧链生物活性基团的多功能试剂。 试剂可以被活化以形成散装材料，或者可以与先前形成的生物材料的表面接触并活化以形成涂层。 悬浮生物活性基团通过促进特定分子或细胞附着到大块材料或涂层表面而起作用。 生物活性基团可以包括蛋白质，肽，碳水化合物，核酸和能够非共价结合分子或细胞的特定和互补部分的其它分子。
-
10.发明授权Cell culture support containing a cell adhesion factor and a positively-charged molecule 失效含有细胞粘附因子和带正电荷的分子的细胞培养支持物
公开(公告)号：US5512474A
公开(公告)日：1996-04-30
申请号：US208916
申请日：1994-03-09
申请人： David L. Clapper , Wei-Shou Hu
发明人： David L. Clapper , Wei-Shou Hu
CPC分类号： C12N5/0075 , C12M25/16 , C12N2533/30 , C12N2533/32 , C12N2533/54 , C12N2533/70 , Y10S530/81 , Y10S530/815
摘要： A combination of a cell adhesion factor and a positively-charged molecule are bound to the surface of a cell culture support of a bioreactor to improve cell attachment and stabilize cell growth. The positively charged molecule is preferably polylysine, chitosan, poly(ethyleneimine) or acrylics polymerized from acrylamide or methacrylamide and incorporating positively-charged groups in the form of primary, secondary or tertiary amines, or quaternary salts. The cell adhesion factor is preferably fibronectin, laminin, collagen, vitronectin or tenascin, or fragments or analogs having a cell binding domain thereof. The positively-charged molecule and the cell adhesion factor can be covalently bound to the supporting surface. In another embodiment, the positively-charged molecule and the cell adhesion factor are covalently bound to one another and either the positively-charged molecule or the cell adhesion factor is covalently bound to the supporting surface. Also, the positively-charged molecule or the cell adhesion factor or both cam be provided in the form of a stable coating non-covalently bound around the surface of the support. The cell culture support may be in the form of a microcarrier and can be made of polystyrene or polypropylene
摘要翻译： 细胞粘附因子和带正电荷的分子的组合结合到生物反应器的细胞培养支持物的表面，以改善细胞附着并稳定细胞生长。 带正电荷的分子优选为聚丙烯酰胺，壳聚糖，聚（乙烯亚胺）或丙烯酸酯，由丙烯酰胺或甲基丙烯酰胺聚合并引入伯胺，仲胺或叔胺或季盐形式的带正电荷的基团。 细胞粘附因子优选是纤连蛋白，层粘连蛋白，胶原，玻连蛋白或腱生蛋白，或其具有细胞结合结构域的片段或类似物。 带正电的分子和细胞粘附因子可以共价结合到支持表面。 在另一个实施方案中，带正电荷的分子和细胞粘附因子彼此共价结合，并且带正电荷的分子或细胞粘附因子共价结合到支持表面。 此外，带正电荷的分子或细胞粘附因子或两个凸轮以不是共价结合在支撑体表面上的稳定涂层的形式提供。 细胞培养载体可以是微载体的形式，并且可以由聚苯乙烯或聚丙烯制成
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.034 秒)
