利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.051 秒)

    T cell peptides of the CRX JII allergen
    1.
    发明授权
    T cell peptides of the CRX JII allergen 失效
    CRX JII变应原的T细胞肽

    公开(公告)号：US6090386A

    公开(公告)日：2000-07-18

    申请号：US467023

    申请日：1995-06-06

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K39/00 ,  C07K14/415 ,  C07K14/725 ,  A61K38/10 ,  A61K39/36 ,  C07K7/08

    CPC分类号： C07K14/415 ,  A61K39/00

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Allergenic proteins and peptides from Japanese cedar pollen
    2.
    发明授权
    Allergenic proteins and peptides from Japanese cedar pollen 有权
    来自日本雪松花粉的过敏蛋白和肽

    公开(公告)号：US08540999B2

    公开(公告)日：2013-09-24

    申请号：US10931260

    申请日：2004-08-30

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-Chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-Chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Allergenic proteins and peptides from Japanese cedar pollen
    3.
    发明授权
    Allergenic proteins and peptides from Japanese cedar pollen 失效

    公开(公告)号：US06982326B1

    公开(公告)日：2006-01-03

    申请号：US09240203

    申请日：1999-01-29

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： C07H21/04

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    Allergenic proteins and peptides from Japanese cedar pollen
    7.
    发明申请
    Allergenic proteins and peptides from Japanese cedar pollen 有权
    来自日本雪松花粉的过敏蛋白和肽

    公开(公告)号：US20050152927A1

    公开(公告)日：2005-07-14

    申请号：US10931260

    申请日：2004-08-30

    申请人： Irwin Griffith ,  Joanne Pollock ,  Julian Bond ,  Richard Garman ,  Mei-Chang Kuo ,  Stephen Powers ,  Mark Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin Griffith ,  Joanne Pollock ,  Julian Bond ,  Richard Garman ,  Mei-Chang Kuo ,  Stephen Powers ,  Mark Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/415 ,  C07K16/16 ,  A61K39/35

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Cache line allocation method and system
    9.
    发明授权
    Cache line allocation method and system 有权
    缓存线分配方法和系统

    公开(公告)号：US08994740B2

    公开(公告)日：2015-03-31

    申请号：US13448255

    申请日：2012-04-16

    申请人： Bingxu Gao ,  Xian Chen

    发明人： Bingxu Gao ,  Xian Chen

    IPC分类号： G06F12/00 ,  G06F12/02 ,  G06F13/00 ,  G06F13/28 ,  G09G5/36 ,  G06F9/38 ,  G06F12/08 ,  G06F12/12 ,  G06T1/60 ,  G06T1/00

    CPC分类号： G06F9/38 ,  G06F12/0875 ,  G06F12/0886 ,  G06F12/0897 ,  G06F12/126 ,  G06F2212/1016 ,  G06F2212/452 ,  G06T1/00 ,  G06T1/60

    摘要： A cache line allocation method, wherein the cache is coupled to a graphic processing unit and the cache comprising a plurality of cache lines, each cache line stores one of a plurality of instructions the method comprising the steps of: putting the plurality of instructions in whole cache lines; locking the whole cache lines if an instruction size is less than a cache size; locking a first number of cache lines when the instruction size is larger than the cache size and a difference between the instruction size and the cache size is less than or equal to a threshold; and locking a second number of cache lines when the instruction size is larger than the cache size and a difference between the instruction size and the cache size is large than the threshold; wherein the first number is greater than the second number.

    摘要翻译： 一种高速缓存行分配方法，其中所述高速缓存耦合到图形处理单元，并且所述高速缓存包括多个高速缓存行，每个高速缓存线存储多个指令中的一个，所述方法包括以下步骤：将所述多个指令整体放置 缓存线 如果指令大小小于缓存大小，则锁定整个高速缓存行; 当指令大小大于高速缓存大小并且指令大小与高速缓存大小之间的差小于或等于阈值时，锁定第一数量的高速缓存行; 并且当指令大小大于高速缓存大小并且指令大小与高速缓存大小之间的差大于阈值时，锁定第二数量的高速缓存行; 其中所述第一数量大于所述第二数量。

    Method of Preparing Silver-Based Oxide Electrical Contact Materials with Fiber-like Arrangement
    10.
    发明申请
    Method of Preparing Silver-Based Oxide Electrical Contact Materials with Fiber-like Arrangement 有权
    制备具有纤维状排列的银基氧化物电接触材料的方法

    公开(公告)号：US20130266468A1

    公开(公告)日：2013-10-10

    申请号：US13578253

    申请日：2011-04-11

    申请人： Lesheng Chen ,  Xian Chen ,  Gengxin Qi ,  Chengfa Mu

    发明人： Lesheng Chen ,  Xian Chen ,  Gengxin Qi ,  Chengfa Mu

    IPC分类号： H01B1/02 ,  B22F3/20 ,  B22F3/24

    CPC分类号： H01B1/02 ,  B22F3/04 ,  B22F3/10 ,  B22F3/14 ,  B22F3/20 ,  B22F3/24 ,  C22C1/1078 ,  C22C1/1084 ,  C22C5/06 ,  H01H1/0237 ,  H01H1/02372 ,  H01H1/02374 ,  H01H1/02376

    摘要： A method of preparing silver-based oxide electrical contact materials with fiber-like arrangement, includes the following steps of: (1) uniformly mixing the silver-metal alloy powders and graphite powders and then ball-milling; (2) internally oxidizing the ball-milled powders; (3) sieving; (4) placing the sieved powders and the matrix powders into the powder mixer for mixing; (5) cold-isostatically pressing; (6) sintering; (7) hot-pressing; and (8) hot-extruding, thereby obtaining the silver-based oxide electrical contact material with fiber-like arrangement. The method of the present invention can obtain the silver-based oxide electrical contact material having neat fiber-like arrangement with no specific requirement on processing deformation, plasticity and ductility of the reinforcing phase. The production process in this method is simple and is easy to operate. Besides, there is no particular requirement on the equipment. The method greatly improves the performance of contact materials in aspects of resistance to welding and arc erosion, conductivity, and processing performance

    摘要翻译： 制备具有纤维状布置的银基氧化物电接触材料的方法包括以下步骤：（1）均匀混合银 - 金属合金粉末和石墨粉末，然后进行球磨; （2）对球磨粉末进行内部氧化; （3）筛选; （4）将筛分的粉末和基质粉末放入粉末混合器中进行混合; （5）冷等静压; （6）烧结; （7）热压; 和（8）热挤压，从而获得具有纤维状布置的银基氧化物电接触材料。 本发明的方法可以获得具有纯纤维状布置的银基氧化物电接触材料，而对增强相的加工变形，可塑性和延展性没有特别要求。 该方法的生产工艺简单易操作。 此外，对设备没有特别的要求。 该方法在抵抗焊接和电弧腐蚀，导电性和加工性能方面大大提高了接触材料的性能