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公开(公告)号:US08865731B2
公开(公告)日:2014-10-21
申请号:US12994923
申请日:2009-05-29
申请人: Jun Ouchi , Shunji Kunori , Yozo Kojima , Katsumi Shinoda , Katsutoshi Sasaki , Shiro Shirakura
发明人: Jun Ouchi , Shunji Kunori , Yozo Kojima , Katsumi Shinoda , Katsutoshi Sasaki , Shiro Shirakura
IPC分类号: A01N43/90 , A61K31/522 , A61K31/52 , A01N43/64 , A61K31/41 , A01N43/78 , A61K31/425 , A01N43/54 , A61K31/517 , A61K31/519 , C07D471/04 , C07D471/22 , C07D487/04 , C07D473/00 , C07D273/00 , C07D239/02 , C07D249/16 , C07D403/00 , A61K31/4439 , C07D473/34 , C07D473/06 , C07D487/14 , C07D417/04 , C07D417/14 , A61K31/506 , A61K45/06 , A61K31/343 , A61K31/427 , A61K31/485
CPC分类号: C07D417/14 , A61K31/343 , A61K31/427 , A61K31/4439 , A61K31/485 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/522 , A61K45/06 , C07D417/04 , C07D473/06 , C07D473/34 , C07D487/04 , C07D487/14 , A61K2300/00
摘要: Provided are: an agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), which comprises a compound having adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.
摘要翻译: 提供:包含具有腺苷A 2A受体拮抗作用的化合物或其药学上可接受的盐作为活性成分的阿片类止痛剂(阿片样物质)的不良作用的药剂。 用于抑制阿片样镇痛药(阿片样物质)的不良作用的药剂,其中阿片类镇痛药(阿片样物质)的不良作用是镇痛耐受性或便秘性; 用于抑制阿片样镇痛药(阿片样物质)的不良作用的药剂,其中阿片类镇痛药(阿片样物质)的不良作用是止痛耐受性; 等等。
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公开(公告)号:US07709234B2
公开(公告)日:2010-05-04
申请号:US11276029
申请日:2006-02-10
申请人: Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
发明人: Katsutoshi Sasaki , Kazumi Miura , Nobuo Hanai , Tatsunari Nishi
CPC分类号: C12N9/1051
摘要: The invention provides a novel species of α-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the α-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The α-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
摘要翻译: 本发明提供由动物细胞克隆的基因表达的α-1,3-岩藻糖基转移酶的新型,编码α-1,3-岩藻糖基转移酶的cDNA,检测或抑制α-1,3-岩藻糖基转移酶的产生的方法, 涉及使用cDNA的1,3-岩藻糖基转移酶,含有DNA作为插入片段的重组载体,携带重组载体的细胞及其生产方法。 本发明的α-1,3-岩藻糖基转移酶可用于生产具有有用生理活性的碳水化合物链,例如唾液酸基路易斯x及其修饰。
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公开(公告)号:US20080158511A1
公开(公告)日:2008-07-03
申请号:US11859275
申请日:2007-09-21
IPC分类号: G03B21/28
CPC分类号: G03B21/28 , G02B27/283 , G03B33/12
摘要: Provided is an image projecting apparatus, including: a polarization separator having a polarization separation surface which transmits or reflects illumination light and reflection light reflected from a reflective image display unit according to polarization directions of the illumination light and the reflection light; and a polarization direction rotating member, disposed between the polarization separator and the reflective image display unit, which rotates a polarization direction of light passing twice through the polarization direction rotating member by 90° about an optical axis of the polarization separator. The polarization separator and the polarization direction rotating member are disposed such that an axis bisecting an angle between a principal ray of the illumination light passing from the polarization separation surface to the reflective image display unit and a principal ray of the reflection light reflected from the reflective image display unit is approximately consistent with the optical axis of the polarization separator.
摘要翻译: 提供一种图像投影装置,包括:偏振分离器,具有偏振分离面,其根据照明光和反射光的偏振方向透射或反射照明光和从反射图像显示单元反射的反射光; 偏振方向旋转部件,配置在偏振光分离器和反射图像显示部之间,使偏振方向旋转部件的光的偏振方向相对于偏振光分离器的光轴旋转了90°。 偏振分离器和偏振方向旋转部件被设置成使从偏振分离面通过的照明光的主光线与反射图像显示部之间的角度平分的轴和从反射镜反射的反射光的主光线 图像显示单元与偏振分离器的光轴大致一致。
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公开(公告)号:US20070037178A1
公开(公告)日:2007-02-15
申请号:US11332785
申请日:2006-01-17
申请人: Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
发明人: Katsutoshi Sasaki , Kazumi Miura , Satoshi Saeki , Misako Suzuki , Kazuya Kishimoto , Hirofumi Kunitomo , Tatsunari Nishi , Masuo Obinata
IPC分类号: C12Q1/68 , A01K67/027 , C12P21/06 , C12N5/06
CPC分类号: C12Q1/6897
摘要: In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or evaluating a substance capable of acting on the cells using the cell line, (4) a method of screening or isolating a useful gene or useful peptide using the cell line and (5) a highly-sensitive and simple assay system for GPCR ligand used in the above expression cloning system.
摘要翻译: 根据本发明,提供了(1)衍生自哺乳动物的下丘脑和朗格汉斯胰岛的各种细胞系,(2)使用细胞系作为宿主的活性肽的生产方法和活性肽前体基因的表达克隆系统 (3)使用细胞系筛选或评价能够作用于细胞的物质的方法,(4)使用细胞系筛选或分离有用基因或有用肽的方法,和(5)高度敏感的 和用于上述表达克隆系统的GPCR配体的简单测定系统。
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公开(公告)号:US06849808B2
公开(公告)日:2005-02-01
申请号:US10209307
申请日:2002-07-29
申请人: Takayuki Enomoto , Takayuki Morikawa , Katsutoshi Sasaki , Hiroyuki Yamazaki , Takashi Takeshita , Hiroshi Matsunaga
发明人: Takayuki Enomoto , Takayuki Morikawa , Katsutoshi Sasaki , Hiroyuki Yamazaki , Takashi Takeshita , Hiroshi Matsunaga
IPC分类号: G01G19/52 , B60N2/00 , B60R21/01 , B60R21/015 , G01G19/414 , B60R21/32
CPC分类号: B60N2/7094 , B60N2/002 , B60R21/01516 , G01G19/4142
摘要: The present invention provides a weight sensor device for detecting a weight of an occupant seated on a seat having a seat frame and a cushion. The device has a sensing wire displaced downward in the seat frame as the cushion is deformed due to the weight of the occupant when the occupant is seated on the seat and a variable resistor for converting a displacement of the sensing wire into an electric signal indicative of the weight of the occupant.
摘要翻译: 本发明提供了一种重量传感器装置,用于检测坐在具有座椅框架和坐垫的座椅上的乘员的重量。 当乘员坐在座椅上时,由于乘员的重量而使坐垫变形,并且将可变电阻器用于将感测线的位移转换为指示 乘客的重量。
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公开(公告)号:US5494790A
公开(公告)日:1996-02-27
申请号:US309985
申请日:1994-09-20
申请人: Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人: Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
CPC分类号: C12N9/1081
摘要: There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译: 提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶,编码α2-> 3唾液酸转移酶的cDNA,通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法 所述cDNA是含有所述cDNA的重组载体,含有所述载体的细胞及其制备方法。
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公开(公告)号:US5079812A
公开(公告)日:1992-01-14
申请号:US594932
申请日:1990-10-10
申请人: Katsutoshi Sasaki , Kenji Hamada
发明人: Katsutoshi Sasaki , Kenji Hamada
CPC分类号: D01D7/00 , B65H54/86 , B65H57/003 , B65H63/003 , B65H2701/31
摘要: A tow feeding apparatus which requires no continuous observation, shortens the reset time when tow is wound around pinch rolls for feeding into a case, and operates safely, includes guide rolls for leading a tow to a winding roll or pinch rolls, a winding roll apparatus provided between the guide rolls and pinch rolls at a normal position for winding up a tow around a winding roll when wrapping trouble occurs at the pinch rolls. A pinch roll apparatus for feeding the tow from the guide rolls through the winding roll apparatus into a case, and a transport device for transporting the winding roll apparatus from the normal position to a reset position behind the pinch roll apparatus when wrapping trouble occurs. A cutter shears the tow along the tow route before the pinch roll apparatus. An exchanger for substituting the pinch roll apparatus with another set of pinch rolls, and a detector for detecting wrapping of a tow around the pinch rolls are further included. A controller receives a signal from said detector to actuate the cutter and the driving motor for driving the winding roll, stops the pinch roll apparatus, drives the exchanger, actuates the transport device for moving the winding roll apparatus from the normal position to the reset position, starts the pinch roll apparatus at the same time as the winding roll apparatus is stopped, and returns the winding roll to the normal position.
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8.
公开(公告)号:US4197156A
公开(公告)日:1980-04-08
申请号:US868362
申请日:1978-01-10
CPC分类号: B29C67/04 , B01D17/045 , B01D29/111 , B01D29/216 , B01D29/237 , B01D39/163 , B01D2201/182 , B01D2239/0216 , B01D2239/0407 , B01D2239/0478 , B01D2239/0613 , B01D2239/064 , B01D2239/065 , B01D2239/0668 , B01D2239/0681 , B01D2239/0695 , B01D2239/10
摘要: A method for producing a hollow-cylindrically shaped fibrous article stabilized by hot adhesion and an apparatus suitable to produce the same are provided. Said method comprises passing a web of gathered fiber layer carried on a conveyer belt through a heating zone, heating said web in such a way that a lower-melting component of composite fiber contained in the lower part of said web contacting the conveyer belt is not in the molten state and a lower-melting component contained in the upper part of said web is in the molten state, while separating said web from the conveyer belt, winding up said web on a take-up rod or tube in such a way that the upper surface thereof occupies the inner side of the winding, while heating the web further, cooling the wound up article and drawing out the take-up rod or tube from the shaped product.The production method of the present invention is simple and does not require complicated apparatus and the resultant product is useful for filtration.
摘要翻译: 提供一种用于制造通过热粘合而稳定的中空圆柱形纤维制品的方法和适于制造其的装置。 所述方法包括将承载在输送带上的聚集的纤维层的纤维网通过加热区,加热所述纤维网,使得包含在所述纤维网的下部的复合纤维的较低熔点成分与传送带接触不接近 在熔融状态下,并且包含在所述幅材的上部中的较低熔点成分处于熔融状态,同时将所述幅材与输送带分离,将所述幅材卷绕在卷取杆或管上,使得 其上表面占据绕组的内侧,同时进一步加热幅材,冷却卷绕物品并从成形产品中拉出卷取杆或管。 本发明的制造方法简单,不需要复杂的装置,所得产物可用于过滤。
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公开(公告)号:US08435763B2
公开(公告)日:2013-05-07
申请号:US10940026
申请日:2004-09-14
申请人: Satoshi Koizumi , Katsutoshi Sasaki , Tetsuo Endo , Kazuhiko Tabata , Akio Ozaki
发明人: Satoshi Koizumi , Katsutoshi Sasaki , Tetsuo Endo , Kazuhiko Tabata , Akio Ozaki
CPC分类号: C12P19/30
摘要: This invention relates to a process for producing a sugar nucleotide, in which a) a culture broth of a microorganism capable of producing NTP from a nucleotide precursor, or a treated product of the culture broth, and b) a culture broth of a microorganism capable of producing a sugar nucleotide from a sugar and NTP, or a treated product of the culture broth, are used as enzyme sources; a process for producing a complex carbohydrate, in which the above-described a) and b) and c) a culture broth of a microorganism, an animal cell or an insect cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth, are used as enzyme sources; a process for producing a complex carbohydrate, in which a culture broth of a microorganism, an animal cell or an insect cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth, is as an enzyme source; and a process for producing N-acetylglucosamine-1-phosphate, in which a culture broth of a microorganism having strong galactokinase activity, or a treated product of the culture broth, is used as the enzyme source.
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公开(公告)号:US07972815B2
公开(公告)日:2011-07-05
申请号:US12019793
申请日:2008-01-25
申请人: Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susume Sekine
发明人: Katsutoshi Sasaki , Norihiko Shiraishi , Ayumi Natsume , Yoji Yamada , Satoshi Nakagawa , Susume Sekine
CPC分类号: C12N9/1051 , A61K38/00 , C07K2319/02 , C12N9/1085
摘要: The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyl transferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.
摘要翻译: 本发明提供了具有“1,3-N-乙酰氨基葡糖基转移酶活性”的新型多肽; 一种生产该多肽的方法; 编码多肽的DNA; 插入DNA的重组载体; 包含重组载体的转化体; 使用该多肽制备糖链或复合碳水化合物的方法; 使用该转化体生产糖链或复合碳水化合物的方法; 识别多肽的抗体; 用于筛选改变编码多肽的基因表达的物质的方法; 以及筛选改变多肽活性的物质的方法。
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