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公开(公告)号：US20240238445A1
公开(公告)日：2024-07-18
申请号：US18552290
申请日：2022-07-08
Applicant: NEURACLE SCIENCE CO., LTD. , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS
Inventor： Jae Young SEONG , Youngjoo BYUN , Hoyun KWAK , Sitaek OH , Min-Hyeok LEE , Yongwoo JEONG , Nui HA , Eun-Ho CHO , Suhyun LEE , Sang-Myeong LEE , Yerim LEE , Eun Bee CHO , Jae Keun LEE , Han-Byul KIM , Soon-gu KWON
IPC: A61K48/00 , A61K31/055 , A61K31/085 , A61K31/136 , A61K31/137 , A61K38/08 , A61K38/10 , A61K38/17 , A61K45/06 , A61K47/64 , A61P25/02 , A61P25/28 , C12N5/0793
CPC classification number: A61K48/005 , A61K31/055 , A61K31/085 , A61K31/136 , A61K31/137 , A61K38/08 , A61K38/10 , A61K38/1709 , A61K45/06 , A61K47/64 , A61P25/02 , A61P25/28 , C12N5/0619
Abstract: The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.
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2.发明公开公开(公告)号：US20240212800A1
公开(公告)日：2024-06-27
申请号：US18544488
申请日：2023-12-19
Applicant: LumanLab Inc. , Korea University Research and Business Foundation , Korea University Research and Business Foundation, Sejong Campus
Inventor： Jae Hyun LIM , Chul Hyun CHO , Seung Pil PACK
CPC classification number: G16H10/20 , A61B5/16 , G16H50/20 , G16H50/30 , A61B2503/06
Abstract: An electronic device and a method to assess a mental health state of an adolescent by using a survey formed based on an artificial intelligence (AI). The method comprises: collecting physical information of a user through a pre-installed application, verifying survey questions regarding a mental health depending on the physical information, and verifying answers to the verified survey questions through the application; forming additional survey questions after having verified the answers and calculating a prediction rate of an appearance of symptoms of a mental illness regarding the additional survey questions by using AI models; verifying a set of survey questions including a plurality of sub-questions depending on the calculated prediction rate; outputting the verified set of survey questions through the application; outputting result data by adjusting the prediction rate; and transmitting the outputted result data.
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公开(公告)号：US20220289657A1
公开(公告)日：2022-09-15
申请号：US17637565
申请日：2020-08-21
Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventor： Youngjoo BYUN , Hee Deung PARK , Sangjin NAM , Sang-Hyun SON , So Young HAM , Han Shin KIM
IPC: C07C49/255 , C07C49/248 , C07C49/235 , A61K31/12 , A61P31/04
Abstract: The present invention relates to a 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof, the compound being capable of inhibiting biofilm formation and production of virulence factors. The 4-gingerol derivative compound according to the present invention has binding affinity to RhlR and corresponding RhlR antagonism activity that are significantly improved, and therefore can effectively inhibit biofilm formation and production of virulence factors. Furthermore, various bacterial infectious diseases caused by biofilms can be fundamentally prevented or treated by using a pharmaceutical composition comprising the 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof as an active ingredient.
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公开(公告)号：US20200283364A1
公开(公告)日：2020-09-10
申请号：US16632592
申请日：2018-07-19
Applicant: Korea University Research and Business Foundation, Sejong Campus , Korea University Research and Business Foundation
Inventor： Youngjoo BYUN , Hee-Deung PARK , Sang-Hyun SON , Eunji CHA , So-Young HAM , Hyunsuk CHOI
IPC: C07C49/255 , C07C49/245 , A61P31/04
Abstract: The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.
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公开(公告)号：US11964935B2
公开(公告)日：2024-04-23
申请号：US16632592
申请日：2018-07-19
Applicant: Korea University Research and Business Foundation, Sejong Campus , Korea University Research and Business Foundation
Inventor： Youngjoo Byun , Hee-Deung Park , Sang-Hyun Son , Eunji Cha , So-Young Ham , Hyunsuk Choi
IPC: C07C49/255 , A61P31/04 , C07C49/245
CPC classification number: C07C49/255 , A61P31/04 , C07C49/245
Abstract: The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.
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Patent Agency Ranking
公开(公告)号：US11298534B2
公开(公告)日：2022-04-12
申请号：US16235498
申请日：2018-12-28
Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , Korea University Research and Business Foundation, Sejong Campus
Inventor： Hoon Jai Chun , Jung Hwa Hong , Dong Geun Sul , Bora Keum , Eun Sun Kim , Hyuk Soon Choi , Seung Han Kim
Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.
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公开(公告)号：US20190321631A1
公开(公告)日：2019-10-24
申请号：US16235498
申请日：2018-12-28
Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventor： Hoon Jai Chun , Jung Hwa Hong , Dong Geun Sul , Bora Keum , Eun Sun Kim , Hyuk Soon Choi , Seung Han Kim
Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.
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公开(公告)号：US20250143061A1
公开(公告)日：2025-05-01
申请号：US18885073
申请日：2024-09-13
Inventor： Hyo Jae YOON , Gyudon KONG
Abstract: Disclosed is a molecular diode using the assignment of electrical properties to inactive organic molecules when a self-assembled monolayer (SAM) thin film including an electrically inactive organic molecule is formed without synthesizing a separate organic molecule having electrical activity. The disadvantage of the instability of a conventional SAM can be overcome, a function can be extended, and electrical properties, such as a rectification characteristic in a non-functional molecule, can be induced even without the design and synthesis of organic molecules for introducing a functional molecule. Accordingly, the embodiments of the present disclosure can be usefully used in various technical fields in which an SAM is used, in particular, wide fields such as electronics, an organic display (OLED), solar cells, sensors, non-uniform catalysts, frictional electricity, cell growth surfaces, and a heat transfer control film.
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公开(公告)号：US20250136820A1
公开(公告)日：2025-05-01
申请号：US18693765
申请日：2023-06-07
Inventor： Heon LEE
Abstract: The present invention relates to a radiative cooling paint consisting of ceramic fine particles as pigments, a polymer resin as a binder, and a solvent. According to the present invention, a substrate is coated with the radiative cooling paint, and then a paint film layer is formed. The paint film layer performs a radiative cooling function by preventing energy inflow from incident sunlight by maximizing reflection of incident sunlight; minimizing absorption of incident sunlight; and maximizing emission of long-wavelength infrared light corresponding to 8 μm to 13 μm and increasing energy discharge through emission of long-wavelength infrared light, and pores with a volume of 3% to 50% are formed inside the paint film layer to enhance reflection of incident sunlight without reducing emission of long-wavelength infrared light.
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公开(公告)号：US20250125742A1
公开(公告)日：2025-04-17
申请号：US18909716
申请日：2024-10-08
Inventor： Hyung-Min LEE , Hyun-Su LEE
Abstract: The present disclosure relates to a resonant regulating rectifier, including an input unit that receives wireless power; and a resonant regulating rectification unit that modulates and rectifies a voltage level of the wireless power based on PWM according to a first demand voltage of a first load and a second demand voltage of a second load to apply a first target voltage to the first load through a first output transistor, and apply a second target voltage to the second load through a second output transistor. This may allow another output to be generated by utilizing a section wasted in a PWM method that modulates a voltage width, thereby reducing wasted energy.
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