公开(公告)号：US07531165B2

公开(公告)日：2009-05-12

申请号：US10997945

申请日：2004-11-29

申请人： Katsuhisa Inoue ,  Takeshi Kaharu ,  Tohru Katoh

发明人： Katsuhisa Inoue ,  Takeshi Kaharu ,  Tohru Katoh

IPC分类号： A61K8/41

CPC分类号： C07D295/15 ,  A61K8/42 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  C07C237/08

摘要： A hair cosmetic which can impart, to hairs, flexibility, smoothness and oily feeling when the hairs are wetted and smoothness, softness and combing easiness after the hairs are dried are provided, the hair cosmetic comprising an amine represented by the formula (I):Formula (I) (wherein R1 represents a C8-40 alkyl group or alkenyl group or a group represented by the formula R5O-(AO)n—CmH2m—(R5 represents a C8-40 alkyl group or alkenyl group having 8 to 40 carbon atoms, A represents a C2-3 alkylene group, n denotes a number from 0 to 30 in average and m denotes an integer of 2 or 3), R2 represents a C1-5 alkylene group, R3 represents H, a C1-24 alkyl group, alkenyl group or hydroxyalkyl group or a C6-28 aryl group or arylalkyl group, R4 represents H, a C1-5 alkyl group, alkylene group or hydroxyalkyl group or a C6-28 aryl group or arylalkyl group, p denotes an integer from 1 to 3, q and r denote integers from 0 to 2 and p+q+r is equal to 3. Also, the amine (I) can be produced with high selectivity and highly economically by reacting a primary amine with an aminocarboxylic acid to run amidation. An amine represented by the formula (1), its salt or quaternary ammonium salt are also provided: Formula (1)

摘要翻译： 本发明提供一种毛发化妆品，其含有由式（I）表示的胺类的毛发化妆品，其能够赋予毛发润湿后的毛发，柔软性，平滑性，油性感，柔软性，梳理容易性。 式（I）（其中，R 1表示碳原子数为8〜40的烷基或烯基或由式R 5 O-（AO）表示的基团n -C m H 2m - （R 5表示碳原子数为8〜40的碳原子数为8〜40的烷基或烯基） 原子，A表示C2-3亚烷基，n表示平均为0〜30的数，m表示2或3的整数），R2表示C1-5亚烷基，R3表示H，C1-24烷基 基团，烯基或羟基烷基或C 6-28芳基或芳烷基，R 4表示H，C 1-5烷基，亚烷基或羟烷基或C 6-28芳基或芳烷基，p表示 1至3，q和r表示0至2的整数，p + q + r等于3.另外，胺（I）可以高 选择性和高度经济地通过伯胺与氨基羧酸反应进行酰胺化反应。 还提供了由式（1）表示的胺，其盐或季铵盐：式（1）

公开(公告)号：US20050232893A1

公开(公告)日：2005-10-20

申请号：US11098528

申请日：2005-04-05

申请人： Takeshi Kaharu ,  Katsuhisa Inoue

发明人： Takeshi Kaharu ,  Katsuhisa Inoue

IPC分类号： A61K8/00 ,  A61K8/34 ,  A61K8/36 ,  A61K8/365 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  C08L83/04 ,  A61K7/06 ,  A61K7/075 ,  A61K7/08

CPC分类号： A61Q5/02 ,  A61K8/42 ,  A61Q5/12

摘要： The invention relates to a hair cosmetic composition comprising amideamine (I) and aliphatic alcohol (II): wherein R1CO represents aliphatic acid residues among which C20 or more aliphatic acid residues account for 60 wt % or more, preferably 75 wt % or more, C20 aliphatic acid residues account for 3 wt % or more, and C22 aliphatic acid residues account for 50 to 95 wt %, and R2—OH  (II) wherein R2 represents C8 to C30 aliphatic hydrocarbon groups wherein linear aliphatic hydrocarbon groups account for 80 wt % or more to the total aliphatic hydrocarbon groups.

摘要翻译： 本发明涉及包含酰胺胺（I）和脂族醇（II）的毛发化妆品组合物：其中R 1 CO代表脂族酸残基，其中C20或更多脂肪酸残基占60重量％以上 ，优选75重量％以上的C20脂肪酸残基占3重量％以上，C22脂肪酸残基占50〜95重量％，＆lt;＆lt;线内配方说明=“直列式”末端 =“lead”→R 2 -OH（II）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 2 = SUP>表示C8〜C30脂肪族烃基，其中直链脂族烃基占总脂族烃基的80重量％以上。

公开(公告)号：US20050095240A1

公开(公告)日：2005-05-05

申请号：US10718359

申请日：2003-11-20

申请人： Vadivel Ganapathy ,  Katsuhisa Inoue ,  You-Jun Fei

发明人： Vadivel Ganapathy ,  Katsuhisa Inoue ,  You-Jun Fei

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N15/11 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K14/705 ,  A01K67/0336 ,  A01K2217/05 ,  A01K2217/058 ,  A01K2227/703 ,  A01K2267/0362 ,  A01K2267/0393 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/6872

摘要： The present invention provides the identification and characterization of a novel transmembrane transporter, a Na+-coupled citrate transporter (“NaCT”). Isolated polynucleotides encoding the transmembrane transporter, the transmembrane transporter polypeptide itself, antibodies thereto, and methods of use, are provided.

摘要翻译： 本发明提供了一种新型跨膜转运蛋白，一种Na +联合的柠檬酸转运蛋白（“NaCT”）的鉴定和表征。 提供了编码跨膜转运蛋白的分离的多核苷酸，跨膜转运蛋白多肽本身，其抗体及其使用方法。

公开(公告)号：US20050091763A1

公开(公告)日：2005-05-05

申请号：US10997945

申请日：2004-11-29

申请人： Katsuhisa Inoue ,  Takeshi Kaharu ,  Tohru Katoh

发明人： Katsuhisa Inoue ,  Takeshi Kaharu ,  Tohru Katoh

IPC分类号： C07C237/08 ,  C07D295/15 ,  A61K7/13

CPC分类号： C07D295/15 ,  A61K8/42 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  C07C237/08

摘要： A hair cosmetic which can impart, to hairs, flexibility, smoothness and oily feeling when the hairs are wetted and smoothness, softness and combing easiness after the hairs are dried are provided, the hair cosmetic comprising an amine represented by the formula (I): Formula (I) (wherein R1 represents a C8-40 alkyl group or alkenyl group or a group represented by the formula R5O—(AO)n—CmH2m—(R5 represents a C8-40 alkyl group or alkenyl group having 8 to 40 carbon atoms, A represents a C2-3 alkylene group, n denotes a number from 0 to 30 in average and m denotes an integer of 2 or 3), R2 represents a C1-5 alkylene group, R3 represents H, a C1-24 alkyl group, alkenyl group or hydroxyalkyl group or a C6-28 aryl group or arylalkyl group, R4 represents H, a C1-5 alkyl group, alkylene group or hydroxyalkyl group or a C6-28 aryl group or arylalkyl group, p denotes an integer from 1 to 3, q and r denote integers from 0 to 2 and p+q+r is equal to 3. Also, the amine (I) can be produced with high selectivity and biaghly economically by reacting a primary amine with an aminocarboxylic acid to run amidation. An amine represented by the formula (1), its salt or quaternary ammonium salt are also provided: Formula (1)

摘要翻译： 本发明提供一种毛发化妆品，其特征在于，含有由式（I）表示的胺类的毛发化妆品，其能够赋予毛发润湿后的毛发，柔软性，平滑性，油性感，柔软性，梳理容易性。 式（I）（其中R 1表示C 8-20烷基或烯基或由式R 5 O表示的基团） - （AO）N 2 -C（O）H 2 - （R 5）表示C 8 - 40个碳原子数为8〜40的烷基或烯基，A表示C 2-3亚烷基，n表示平均为0〜30的数，m表示 2或3），R 2表示C 1-5亚烷基，R 3表示H，C 1-24 烷基，烯基或羟烷基或C 6-28芳基或芳烷基，R 4表示H，C 1〜 5个烷基，亚烷基或羟烷基或C 1 芳基或芳烷基，p表示1〜3的整数，q和r表示0〜2的整数，p + q + r等于3.另外，胺（I ）可以通过使伯胺与氨基羧酸反应进行酰胺化而以高选择性和经济地生产。 还提供了由式（1）表示的胺，其盐或季铵盐：式（1）

公开(公告)号：US08877702B2

公开(公告)日：2014-11-04

申请号：US13383497

申请日：2010-07-14

申请人： Masato Nomura ,  Katsuhisa Inoue ,  Hisato Fukuda

发明人： Masato Nomura ,  Katsuhisa Inoue ,  Hisato Fukuda

IPC分类号： C11D17/00 ,  C11D1/83 ,  C11D1/29 ,  C11D1/722

CPC分类号： C11D1/8305 ,  C11D1/29 ,  C11D1/722 ,  C11D1/83

摘要： The present invention relates to the detergent composition, containing (a) a nonionic surfactant represented by the formula (1); and (b) a sulfuric acid ester salt represented by the formula (2): R—O-(EO)m—(PO)n-(EO)m′—H  (1) wherein, R represents a hydrocarbon group having 6 to 24 carbon atoms; EO represents an ethyleneoxy group; PO represents a propyleneoxy group; m=0.1 to 25; m′=0 to 24.9; m+m′=0.5 to 25; and n=0.1 to 10; with the proviso that (EO)m, (PO)n, and (EO)m′ are arranged in a block addition mode in this order; R1—O—(PO)x-(EO)y—SO3M  (2) wherein, R1 represents a hydrocarbon group having 6 to 24 carbon atoms; x=0.1 to 10; y=0 to 30; (PO)x and (EO)y are arranged in any order in any addition mode, being a block addition or a random addition, M is a counter ion.

摘要翻译： 本发明涉及含有（a）由式（1）表示的非离子表面活性剂的洗涤剂组合物。 和（b）由式（2）表示的硫酸酯盐：R-O-（EO）m-（PO）n-（EO）m'-H（1）其中，R表示具有6 至24个碳原子; EO表示乙烯氧基; PO表示丙烯氧基; m = 0.1〜25; m'= 0〜24.9; m + m'= 0.5〜25; n = 0.1〜10; 条件是（EO）m，（PO）n和（EO）m'按顺序排列成块加成模式; R1-O-（PO）x-（EO）y-SO3M（2）其中R1表示碳原子数为6〜24的烃基; x = 0.1〜10; y = 0〜30; （PO）x和（EO）y以任何加成模式排列，为嵌段加成或无规加成，M为抗衡离子。

公开(公告)号：US07713341B2

公开(公告)日：2010-05-11

申请号：US12078690

申请日：2008-04-03

申请人： Katsuhisa Inoue ,  Hidehito Ikebata ,  Kazuhiko Kurita ,  Tetsuaki Fukushima ,  Tadayuki Suzuki

发明人： Katsuhisa Inoue ,  Hidehito Ikebata ,  Kazuhiko Kurita ,  Tetsuaki Fukushima ,  Tadayuki Suzuki

IPC分类号： A01N33/12 ,  A01N33/02 ,  B27K3/34 ,  B27K3/50 ,  B27K3/00

CPC分类号： C07C217/08 ,  A01N33/12 ,  A01N33/02 ,  A01N33/04 ,  A01N37/02 ,  A01N2300/00

摘要： The present invention relates to a quaternary ammonium salt composition containing (a) a quaternary ammonium salt represented by the following general formula (1), (b) a specific tertiary amine and (c) an organic acid ester in specific mass ratios which is excellent in hue and storage stability, a process for producing the quaternary ammonium salt composition, and a wood preservative containing the quaternary ammonium salt composition. wherein R1 is an alkyl or alkenyl group; R2 is an alkyl, alkenyl or hydroxyalkyl group; R3 is an alkyl or hydroxyalkyl group; R4 is an alkylene group; n is a number of from 1 to 5; and A is a counter ion derived from sulfonic acid, etc.

摘要翻译： 本发明涉及一种季铵盐组合物，其含有（a）由以下通式（1）表示的季铵盐，（b）特定的叔胺和（c）特定质量比的有机酸酯，其优异 在色调和储存稳定性方面，制备季铵盐组合物的方法和含有季铵盐组合物的木材防腐剂。 其中R1是烷基或烯基; R2是烷基，烯基或羟烷基; R3是烷基或羟烷基; R4是亚烷基; n是从1到5的数字; 而A是衍生自磺酸等的抗衡离子

公开(公告)号：US20050037934A1

公开(公告)日：2005-02-17

申请号：US10948656

申请日：2004-09-24

申请人： Katsuhisa Inoue ,  Takeshi Kaharu ,  Tohru Katoh

发明人： Katsuhisa Inoue ,  Takeshi Kaharu ,  Tohru Katoh

IPC分类号： C07C237/08 ,  C07D295/15 ,  A61K7/075

CPC分类号： C07D295/15 ,  A61K8/42 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  C07C237/08

摘要： A hair cosmetic which can impart, to hairs, flexibility, smoothness and oily feeling when the hairs are wetted and smoothness, softness and combing easiness after the hairs are dried are provided, the hair cosmetic comprising an amine represented by the formula (I): (wherein R1 represents a C8-40 alkyl group or alkenyl group or a group represented by the formula R5O-(AO)n—CmH2m—(R5 represents a C8-40 alkyl group or alkenyl group having 8 to 40 carbon atoms, A represents a C2-3 alkylene group, n denotes a number from 0 to 30 in average and m denotes an integer of 2 or 3), R represents a C1-5 alkylene group, R represents H, a C1-24 alkyl group, alkenyl group or hydroxyalkyl group or a C6-28 aryl group or arylalkyl group, R4 represents H, a C1-5 alkyl group, alkylene group or hydroxyalkyl group or a C6-28 aryl group or arylalkyl group, p denotes an integer from 1 to 3, q and r denote integers from 0 to 2 and p+q+r is equal to 3. Also, the amine (I) can be produced with high selectivity and highly economically by reacting a primary amine with an aminocarboxylic acid to run amidation. An amine represented by the formula (1), its salt or quaternary ammonium salt are also provided:

摘要翻译： 本发明提供一种毛发化妆品，其含有由式（I）表示的胺类的毛发化妆品，其能够赋予毛发润湿后的毛发，柔软性，平滑性，油性感，柔软性，梳理容易性。 （其中R 1表示C8-40烷基或烯基或由式R 5表示的基团O-（AO）n -C m H 2m - （R 5）表示C8-40烷基或烯基 具有8〜40个碳原子的基团，A表示C2-3亚烷基，n表示平均为0〜30的数，m表示2或3的整数），R表示C 1-5亚烷基，R表示H ，C 1-4烷基，烯基或羟烷基或C 6-28芳基或芳烷基，R 4表示H，C 1-5烷基，亚烷基或羟烷基或C 6-28芳基 或芳烷基，p表示1至3的整数，q和r表示0至2的整数，p + q + r等于3.此外，胺（I）可以以高选择性 并且通过使伯胺与氨基羧酸反应以进行酰胺化而高度经济地进行。 还提供了由式（1）表示的胺，其盐或季铵盐：

公开(公告)号：US08476217B2

公开(公告)日：2013-07-02

申请号：US13502859

申请日：2010-10-18

申请人： Masato Nomura ,  Satoru Kijima ,  Katsuhisa Inoue ,  Tetsuaki Fukushima ,  Tomoya Sato

发明人： Masato Nomura ,  Satoru Kijima ,  Katsuhisa Inoue ,  Tetsuaki Fukushima ,  Tomoya Sato

IPC分类号： C11D1/72 ,  C11D1/722 ,  C11D1/825

CPC分类号： C11D1/722

摘要： The present invention provides the nonionic surfactant represented by the formula (1): R—O—(PO)m-(EO)n—H  (1) wherein, R represents a saturated linear-chain hydrocarbon group having 8 to 18 carbon atoms, and n-octyl groups are 20 to 80% by mole of the saturated linear-chain hydrocarbon groups, n-decyl groups are 0 to 10% by mole of the saturated linear-chain hydrocarbon groups, and saturated linear-chain hydrocarbon groups having 12 to 18 carbon atoms are 20 to 80% by mole of the saturated linear-chain hydrocarbon groups; PO represents a propyleneoxy group; EO represents an ethyleneoxy group; m represents an average addition mole number of propyleneoxy groups ranging from 0.1 to 5; n represents an average addition mole number of ethyleneoxy groups ranging from 0.5 to 20; and (PO)m and (EO)n are bonded as blocks in this order.

摘要翻译： 本发明提供由式（1）表示的非离子型表面活性剂：RO-（PO）m-（EO）nH（1）其中，R表示碳原子数8〜18的饱和直链烃基， 辛基的饱和直链烃基为20〜80摩尔％，正癸基为饱和直链烃基的0〜10摩尔％，碳原子数为12〜18的饱和直链烃基 原子为饱和直链烃基的20〜80摩尔％ PO表示丙烯氧基; EO表示乙烯氧基; m表示丙烯氧基的平均加成摩尔数为0.1〜5; n表示0.5〜20的乙烯氧基的平均加成摩尔数; 和（PO）m和（EO）n以该顺序键合。

公开(公告)号：US08197800B2

公开(公告)日：2012-06-12

申请号：US11392621

申请日：2006-03-30

申请人： Katsuhisa Inoue ,  Takeshi Kaharu

发明人： Katsuhisa Inoue ,  Takeshi Kaharu

IPC分类号： A61K8/00 ,  A61Q5/12

CPC分类号： A61Q5/12 ,  A61K8/41 ,  A61K8/416 ,  A61K8/42 ,  A61K8/44

摘要： The present invention relates to a hair treating agent containing (a) an organic acid represented by the formula (1), an organic acid represented by the formula (2) or their salts and (b) a quaternary ammonium salt, a tertiary amine or a salt thereof: wherein R1 and R2 independently represent an alkyl or hydroxyalkyl group having 1 to 5 carbon atoms or —R8—COOH, R3, R4 and R8 independently represent an alkylene group having 1 to 5 carbon atoms, R5 represent an alkyl or hydroxyalkyl group having 1 to 5 carbon atoms or —R9—COOH and R6, R7 and R9 independently represent an alkylene group having 1 to 5 carbon atoms.

摘要翻译： 本发明涉及含有（a）由式（1）表示的有机酸，由式（2）表示的有机酸或其盐和（b）季铵盐，叔胺或 其盐：其中R 1和R 2独立地表示具有1至5个碳原子的烷基或羟烷基或-R 8 -COOH，R 3，R 4和R 8独立地表示具有1至5个碳原子的亚烷基，R 5表示烷基或羟烷基 具有1至5个碳原子的基团或-R 9 -COOH，R 6，R 7和R 9独立地表示具有1至5个碳原子的亚烷基。

公开(公告)号：US20120115769A1

公开(公告)日：2012-05-10

申请号：US13383497

申请日：2010-07-14

申请人： Masato Nomura ,  Katsuhisa Inoue ,  Hisato Fukuda

发明人： Masato Nomura ,  Katsuhisa Inoue ,  Hisato Fukuda

IPC分类号： C11D1/83 ,  C11D3/43

CPC分类号： C11D1/8305 ,  C11D1/29 ,  C11D1/722 ,  C11D1/83

摘要： The present invention relates to the detergent composition, containing (a) a nonionic surfactant represented by the formula (1); and (b) a sulfuric acid ester salt represented by the formula (2): R—O-(EO)m—(PO)n-(EO)m′—H  (1) wherein, R represents a hydrocarbon group having 6 to 24 carbon atoms; EO represents an ethyleneoxy group; PO represents a propyleneoxy group; m=0.1 to 25; m′=0 to 24.9; m+m′=0.5 to 25; and n=0.1 to 10; with the proviso that (EO)m, (PO)n, and (EO)m′ are arranged in a block addition mode in this order; R1—O—(PO)x-(EO)y—SO3M  (2) wherein, R1 represents a hydrocarbon group having 6 to 24 carbon atoms; x=0.1 to 10; y=0 to 30; (PO)x and (EO)y are arranged in any order in any addition mode, being a block addition or a random addition, M is a counter ion.

摘要翻译： 本发明涉及含有（a）由式（1）表示的非离子表面活性剂的洗涤剂组合物。 和（b）由式（2）表示的硫酸酯盐：R-O-（EO）m-（PO）n-（EO）m'-H（1）其中，R表示具有6 至24个碳原子; EO表示乙烯氧基; PO表示丙烯氧基; m = 0.1〜25; m'= 0〜24.9; m + m'= 0.5〜25; n = 0.1〜10; 条件是（EO）m，（PO）n和（EO）m'按顺序排列成块加成模式; R1-O-（PO）x-（EO）y-SO3M（2）其中R1表示碳原子数为6〜24的烃基; x = 0.1〜10; y = 0〜30; （PO）x和（EO）y以任何加成模式排列，为嵌段加成或无规加成，M为抗衡离子。