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1.发明申请HLA-BINDING PEPTIDE, PRECURSOR THEREOF, AND DNA FRAGMENT AND RECOMBINANT VECTOR CODING FOR SAID HLA-BINDING PEPTIDE 审中-公开HLA-BINDING PEPTIDE，其前体和DNA片段和重组载体编码用于HLA HLA-BINDING PEPTIDE公开(公告)号：US20110087005A1
公开(公告)日：2011-04-14
申请号：US12947624
申请日：2010-11-16
申请人： Tomoya MIYAKAWA , Keiko UDAKA
发明人： Tomoya MIYAKAWA , Keiko UDAKA
IPC分类号： C07K7/06
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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公开(公告)号：US20100322968A1
公开(公告)日：2010-12-23
申请号：US12449377
申请日：2008-02-07
申请人： Keiko Udaka , Masahide Ishibashi
发明人： Keiko Udaka , Masahide Ishibashi
CPC分类号： A61K39/099 , A61K39/0011 , A61K2039/521 , A61K2039/55505 , A61K2039/55594 , C07K14/4747 , C07K14/4748 , Y02A50/386
摘要： The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
摘要翻译： 本发明提供了含有百日咳疫苗作为主要成分的癌抗原肽疫苗和病毒抗原肽的佐剂。 本发明还提供了癌症或病毒感染性疾病的治疗剂，以及含有癌抗原肽或病毒抗原肽和百日咳疫苗的癌症转移或复发或病毒诱导肿瘤发病的预防剂。 可以适当使用的百日咳疫苗是全细胞体百日咳疫苗。 可以以多个剂量安全地施用本发明的药剂。
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3.发明申请METHOD FOR INDUCING CYTOTOXIC T-CELLS, CYTOTOXIC T-CELL INDUCERS, AND PHARMACEUTICAL COMPOSITIONS AND VACCINES EMPLOYING THEM 审中-公开诱导细胞毒性T细胞，细胞毒性T细胞诱导剂和药物组合物的方法及使用它们的疫苗公开(公告)号：US20100255020A1
公开(公告)日：2010-10-07
申请号：US12743733
申请日：2008-11-20
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K39/00 , C12N5/0783 , C07K7/06 , A61K38/08 , A61P35/00
CPC分类号： A61K38/08 , A61K39/0011
摘要： A method for inducing cytotoxic T-cells is provided that includes binding to an HLA molecule on the surface of a cell that is a target of a cytotoxic T-cell, a peptide containing one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1, 2, and 3 and composed of not less than 8 and not more than 11 amino acid residues, or a peptide derived from a precursor thereof.
摘要翻译： 提供了诱导细胞毒性T细胞的方法，其包括与作为细胞毒性T细胞靶标的细胞表面上的HLA分子的结合，含有一种或多种类型的氨基酸序列的肽，所述氨基酸序列选自 SEQ ID NO：1,2和3，并且由不少于8个且不超过11个氨基酸残基组成，或由其前体衍生的肽。
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4.发明申请HLA-BINDING PEPTIDE, PRECURSOR THEREOF, AND DNA FRAGMENT AND RECOMBINANT VECTOR CODING FOR SAID HLA-BINDING PEPTIDE 审中-公开HLA-BINDING PEPTIDE，其前体和DNA片段和重组载体编码用于HLA HLA-BINDING PEPTIDE公开(公告)号：US20090023895A1
公开(公告)日：2009-01-22
申请号：US12278348
申请日：2007-02-06
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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5.发明申请HLA-BINDING PEPTIDES, PRECURSORS THEREOF, DNA FRAGMENTS AND RECOMBINANT VECTORS THAT CODE FOR THOSE PEPTIDE SEQUENCES 审中-公开HLA-BINDING PEPTIDES，其前身，DNA片段和重组载体，用于这些肽序列的代码公开(公告)号：US20150087809A1
公开(公告)日：2015-03-26
申请号：US14563502
申请日：2014-12-08
申请人： Tomoya MIYAKAWA , Keiko UDAKA
发明人： Tomoya MIYAKAWA , Keiko UDAKA
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/005 , C12N2770/24222
摘要： An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 183, and not less than 8 and not more than 11 amino acid residues is provided. Any of the amino acid sequence is predicted to have the binding property to a human HLA-A type molecule by a predicting program using an active learning experiment method as illustrated in FIG. 1.
摘要翻译： 与HLA-A型分子结合的HLA结合肽，所述HLA结合肽包含至少一种选自SEQ ID NO：1至183，不小于8且不小于8的氨基酸序列 提供了11个氨基酸残基。 通过使用如图1所示的主动学习实验方法的预测程序，预测任何氨基酸序列具有与HLA-A型分子的结合特性。 1。
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6.发明申请HLA-BINDING PEPTIDES, PRECURSORS THEREOF, DNA FRAGMENTS AND RECOMBINANT VECTORS THAT CODE FOR THOSE PEPTIDE SEQUENCES 审中-公开HLA-BINDING PEPTIDES，其前身，DNA片段和重组载体，用于这些肽序列的代码公开(公告)号：US20110060124A1
公开(公告)日：2011-03-10
申请号：US12903000
申请日：2010-10-12
申请人： Tomoya MIYAKAWA , Keiko UDAKA
发明人： Tomoya MIYAKAWA , Keiko UDAKA
CPC分类号： C07K14/47 , C07K14/005 , C12N2770/24222
摘要： An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 183, and not less than 8 and not more than 11 amino acid residues is provided. Any of the amino acid sequences is predicted to have the binding property to a human HLA-A type molecule by a predicting program using an active learning experiment method as illustrated in FIG. 1.
摘要翻译： 与HLA-A型分子结合的HLA结合肽，所述HLA结合肽包含至少一种选自SEQ ID NO：1至183，不小于8且不小于8的氨基酸序列 提供了11个氨基酸残基。 通过使用如图1所示的主动学习实验方法的预测程序，预测任何氨基酸序列具有与HLA-A型分子的结合特性。 1。
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公开(公告)号：US09045556B2
公开(公告)日：2015-06-02
申请号：US12449377
申请日：2008-02-07
申请人： Keiko Udaka , Masahide Ishibashi
发明人： Keiko Udaka , Masahide Ishibashi
CPC分类号： A61K39/099 , A61K39/0011 , A61K2039/521 , A61K2039/55505 , A61K2039/55594 , C07K14/4747 , C07K14/4748 , Y02A50/386
摘要： The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
摘要翻译： 本发明提供了含有百日咳疫苗作为主要成分的癌抗原肽疫苗和病毒抗原肽的佐剂。 本发明还提供了癌症或病毒感染性疾病的治疗剂，以及含有癌抗原肽或病毒抗原肽和百日咳疫苗的癌症转移或复发或病毒诱导肿瘤发病的预防剂。 可以适当使用的百日咳疫苗是全细胞体百日咳疫苗。 可以以多个剂量安全地施用本发明的药剂。
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8.发明授权HLA-binding peptide, precursor thereof, and DNA fragment and recombinant vector coding for said HLA-binding peptide 有权HLA结合肽，其前体和编码所述HLA结合肽的DNA片段和重组载体公开(公告)号：US09045531B2
公开(公告)日：2015-06-02
申请号：US12947624
申请日：2010-11-16
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K38/08 , C07K7/06 , C07K14/005 , A61K39/145 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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9.发明申请Hla-Binding Peptide, and Dna Fragment and Recombinant Vector Coding for Said Hla-Binding Peptide 审中-公开Hla结合肽和Dna片段和用于所述Hla结合肽的重组载体编码公开(公告)号：US20080306243A1
公开(公告)日：2008-12-11
申请号：US12065444
申请日：2006-09-07
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
CPC分类号： C07K14/70539 , C07K16/2833
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 30, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括至少一种选自SEQ ID NO：1至30，以及不少于8个且不超过11个氨基的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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10.发明授权HLA-binding peptide, and DNA fragment and recombinant vector coding for said HLA-binding peptide 有权HLA结合肽和编码所述HLA结合肽的DNA片段和重组载体公开(公告)号：US08487076B1
公开(公告)日：2013-07-16
申请号：US11814709
申请日：2005-12-06
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K38/04
CPC分类号： C07K7/06 , A61K38/00 , C07K14/4738
摘要： There is provided an HLA-binding peptide binding to a HLA-A type molecule, the HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 80, and consisting of not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences herein mentioned are the predicted amino acid sequences binding to a human HLA-A type molecule with the prediction program using the certain active learning method.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，HLA结合肽包含至少一种选自SEQ ID NO：1至80的氨基酸序列，并且不少于 超过8个，不超过11个氨基酸残基。 本文提及的所有这些氨基酸序列是使用某些主动学习方法的预测程序与人HLA-A型分子结合的预测氨基酸序列。
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