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公开(公告)号：US20100322968A1
公开(公告)日：2010-12-23
申请号：US12449377
申请日：2008-02-07
申请人： Keiko Udaka , Masahide Ishibashi
发明人： Keiko Udaka , Masahide Ishibashi
CPC分类号： A61K39/099 , A61K39/0011 , A61K2039/521 , A61K2039/55505 , A61K2039/55594 , C07K14/4747 , C07K14/4748 , Y02A50/386
摘要： The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
摘要翻译： 本发明提供了含有百日咳疫苗作为主要成分的癌抗原肽疫苗和病毒抗原肽的佐剂。 本发明还提供了癌症或病毒感染性疾病的治疗剂，以及含有癌抗原肽或病毒抗原肽和百日咳疫苗的癌症转移或复发或病毒诱导肿瘤发病的预防剂。 可以适当使用的百日咳疫苗是全细胞体百日咳疫苗。 可以以多个剂量安全地施用本发明的药剂。
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公开(公告)号：US09045556B2
公开(公告)日：2015-06-02
申请号：US12449377
申请日：2008-02-07
申请人： Keiko Udaka , Masahide Ishibashi
发明人： Keiko Udaka , Masahide Ishibashi
CPC分类号： A61K39/099 , A61K39/0011 , A61K2039/521 , A61K2039/55505 , A61K2039/55594 , C07K14/4747 , C07K14/4748 , Y02A50/386
摘要： The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
摘要翻译： 本发明提供了含有百日咳疫苗作为主要成分的癌抗原肽疫苗和病毒抗原肽的佐剂。 本发明还提供了癌症或病毒感染性疾病的治疗剂，以及含有癌抗原肽或病毒抗原肽和百日咳疫苗的癌症转移或复发或病毒诱导肿瘤发病的预防剂。 可以适当使用的百日咳疫苗是全细胞体百日咳疫苗。 可以以多个剂量安全地施用本发明的药剂。
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3.发明申请METHOD FOR INDUCING CYTOTOXIC T-CELLS, CYTOTOXIC T-CELL INDUCER, AND PHARMACEUTICAL COMPOSITION AND VACCINE EMPLOYING SAME 审中-公开诱导细胞毒T细胞，CYTOTOXIC T细胞诱导剂和药物组合物的方法及其使用的疫苗公开(公告)号：US20110206711A1
公开(公告)日：2011-08-25
申请号：US12279556
申请日：2007-02-16
申请人： Tomoya Miyakawa , Keiko Udaka , Morikazu Onji
发明人： Tomoya Miyakawa , Keiko Udaka , Morikazu Onji
CPC分类号： A61K39/29 , A61K38/162 , A61K39/12 , A61K2039/53 , A61K2039/55594 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234 , G16B20/00 , G16B40/00
摘要： A method for inducing cytotoxic T-cells that includes binding to an HLA molecule on the surface of a cell that is a target of a cytotoxic T-cell a peptide containing one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 13 and consisting of not less than 8 and not more than 11 amino acid residues, or a peptide derived from a precursor thereof.
摘要翻译： 一种诱导细胞毒性T细胞的方法，其包括与作为细胞毒性T细胞靶标的细胞表面上的HLA分子结合，所述肽含有一种或多种类型的氨基酸序列，所述氨基酸序列选自SEQ ID NO： NOS：1至13并且由不少于8个且不超过11个氨基酸残基组成，或由其前体衍生的肽。
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4.发明申请METHOD FOR INDUCING CYTOTOXIC T-CELLS, CYTOTOXIC T-CELL INDUCERS, AND PHARMACEUTICAL COMPOSITIONS AND VACCINES EMPLOYING THEM 审中-公开诱导细胞毒性T细胞，细胞毒性T细胞诱导剂和药物组合物的方法及使用它们的疫苗公开(公告)号：US20100255020A1
公开(公告)日：2010-10-07
申请号：US12743733
申请日：2008-11-20
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K39/00 , C12N5/0783 , C07K7/06 , A61K38/08 , A61P35/00
CPC分类号： A61K38/08 , A61K39/0011
摘要： A method for inducing cytotoxic T-cells is provided that includes binding to an HLA molecule on the surface of a cell that is a target of a cytotoxic T-cell, a peptide containing one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1, 2, and 3 and composed of not less than 8 and not more than 11 amino acid residues, or a peptide derived from a precursor thereof.
摘要翻译： 提供了诱导细胞毒性T细胞的方法，其包括与作为细胞毒性T细胞靶标的细胞表面上的HLA分子的结合，含有一种或多种类型的氨基酸序列的肽，所述氨基酸序列选自 SEQ ID NO：1,2和3，并且由不少于8个且不超过11个氨基酸残基组成，或由其前体衍生的肽。
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5.发明申请HLA-BINDING PEPTIDE, PRECURSOR THEREOF, AND DNA FRAGMENT AND RECOMBINANT VECTOR CODING FOR SAID HLA-BINDING PEPTIDE 审中-公开HLA-BINDING PEPTIDE，其前体和DNA片段和重组载体编码用于HLA HLA-BINDING PEPTIDE公开(公告)号：US20090023895A1
公开(公告)日：2009-01-22
申请号：US12278348
申请日：2007-02-06
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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6.发明授权HLA-binding peptide, precursor thereof, and DNA fragment and recombinant vector coding for said HLA-binding peptide 有权HLA结合肽，其前体和编码所述HLA结合肽的DNA片段和重组载体公开(公告)号：US09045531B2
公开(公告)日：2015-06-02
申请号：US12947624
申请日：2010-11-16
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K38/08 , C07K7/06 , C07K14/005 , A61K39/145 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , A61K38/08 , A61K39/00 , A61K39/12 , A61K39/145 , C07K7/06 , C12N2760/16022 , C12N2760/16034
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括一种或多种选自SEQ ID NO：1至52和不少于8个且不超过11个氨基酸的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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7.发明申请Hla-Binding Peptide, and Dna Fragment and Recombinant Vector Coding for Said Hla-Binding Peptide 审中-公开Hla结合肽和Dna片段和用于所述Hla结合肽的重组载体编码公开(公告)号：US20080306243A1
公开(公告)日：2008-12-11
申请号：US12065444
申请日：2006-09-07
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
CPC分类号： C07K14/70539 , C07K16/2833
摘要： An HLA-binding peptide binding to an HLA-A type molecule is provided that includes at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 30, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，其包括至少一种选自SEQ ID NO：1至30，以及不少于8个且不超过11个氨基的氨基酸序列 酸残留。 所有这些氨基酸序列是使用图1所示的主动学习实验方法的预测程序预测结合人HLA-A分子的氨基酸序列。 1。
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8.发明授权HLA-binding peptide, and DNA fragment and recombinant vector coding for said HLA-binding peptide 有权HLA结合肽和编码所述HLA结合肽的DNA片段和重组载体公开(公告)号：US08487076B1
公开(公告)日：2013-07-16
申请号：US11814709
申请日：2005-12-06
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
IPC分类号： A61K38/04
CPC分类号： C07K7/06 , A61K38/00 , C07K14/4738
摘要： There is provided an HLA-binding peptide binding to a HLA-A type molecule, the HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 80, and consisting of not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences herein mentioned are the predicted amino acid sequences binding to a human HLA-A type molecule with the prediction program using the certain active learning method.
摘要翻译： 提供了与HLA-A型分子结合的HLA结合肽，HLA结合肽包含至少一种选自SEQ ID NO：1至80的氨基酸序列，并且不少于 超过8个，不超过11个氨基酸残基。 本文提及的所有这些氨基酸序列是使用某些主动学习方法的预测程序与人HLA-A型分子结合的预测氨基酸序列。
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9.发明授权HLA-binding peptide, precursor thereof, DNA fragment and recombinant vector encoding the same 有权HLA结合肽，其前体，DNA片段和编码其的重组载体公开(公告)号：US08324345B2
公开(公告)日：2012-12-04
申请号：US12444988
申请日：2007-10-03
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
CPC分类号： C07K14/70539 , A61K38/00 , Y02A50/385
摘要： There is provided an HLA-binding peptide being excellent in binding affinity to an HLA-A type molecule. An HLA-binding peptide capable of binding to an HLA-A type molecule, including one or more amino acid sequences selected from the group consisting of SEQ ID NOs: 1 to 50, and being composed of 8 or more and 11 or less amino acid residues, is provided. All of the amino acid sequences are the amino acid sequences that are predicted to be capable of binding to an HLA-A molecule by using a prediction program utilizing an active learning method shown in FIG. 1.
摘要翻译： 提供了对HLA-A型分子的结合亲和性优异的HLA结合肽。 能够结合HLA-A型分子的HLA结合肽，包括一个或多个选自SEQ ID NO：1至50的氨基酸序列，并且由8个或更多个和11个或更少的氨基酸组成 残留物。 所有氨基酸序列是通过使用利用图1所示的主动学习方法的预测程序预测能够结合HLA-A分子的氨基酸序列。 1。
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10.发明申请HLA-BINDING PEPTIDE, PRECURSOR THEREOF, DNA FRAGMENT AND RECOMBINANT VECTOR ENCODING THE SAME 有权HLA结合肽，其前体，DNA片段和编码其的重组载体公开(公告)号：US20100144025A1
公开(公告)日：2010-06-10
申请号：US12444988
申请日：2007-10-03
申请人： Tomoya Miyakawa , Keiko Udaka
发明人： Tomoya Miyakawa , Keiko Udaka
CPC分类号： C07K14/70539 , A61K38/00 , Y02A50/385
摘要： There is provided an HLA-binding peptide being excellent in binding affinity to an HLA-A type molecule. An HLA-binding peptide capable of binding to an HLA-A type molecule, including one or more amino acid sequences selected from the group consisting of SEQ ID NOs: 1 to 50, and being composed of 8 or more and 11 or less amino acid residues, is provided. All of the amino acid sequences are the amino acid sequences that are predicted to be capable of binding to an HLA-A molecule by using a prediction program utilizing an active learning method shown in FIG. 1.
摘要翻译： 提供了对HLA-A型分子的结合亲和性优异的HLA结合肽。 能够结合HLA-A型分子的HLA结合肽，包括一个或多个选自SEQ ID NO：1至50的氨基酸序列，并且由8个或更多个和11个或更少的氨基酸组成 残留物。 所有氨基酸序列是通过使用利用图1所示的主动学习方法的预测程序预测能够结合HLA-A分子的氨基酸序列。 1。
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