BIOREACTOR, CELL CULTURE METHOD, AND SUBSTANCE PRODUCTION METHOD
    1.
    发明申请
    BIOREACTOR, CELL CULTURE METHOD, AND SUBSTANCE PRODUCTION METHOD 审中-公开
    生物反应器,细胞培养方法和物质生产方法

    公开(公告)号:US20090081723A1

    公开(公告)日:2009-03-26

    申请号:US12190162

    申请日:2008-08-12

    IPC分类号: C12P1/00 C12M1/06 C12N5/06

    摘要: The present invention achieves a smaller difference between a dissolved oxygen concentration in an upper part of a culture tank and a dissolved oxygen concentration in a lower part of the culture tank. The present invention comprises: a culture tank; a sparger means arranged in a lower part of the culture tank; and multiple impellers being arranged in multiple stages in a vertical direction of the culture tank and having a larger mass transfer capacity coefficient KLa per unit number of revolutions in an upper stage than in a lower stage.

    摘要翻译: 本发明实现了培养槽上部的溶解氧浓度与培养罐下部的溶解氧浓度之间的较小的差异。 本发明包括:培养罐; 设置在培养罐下部的分布器装置; 并且多个叶轮在培养槽的垂直方向上以多个阶段布置,并且在上段中具有比在下段中更大的每单位转数的传质能力系数KLa。

    Fuel assembly for fast reactors
    2.
    发明授权
    Fuel assembly for fast reactors 失效
    用于快堆的燃料组件

    公开(公告)号:US4654193A

    公开(公告)日:1987-03-31

    申请号:US603824

    申请日:1984-04-25

    摘要: This invention relates to a fuel assembly for fast reactors and aims to reduce stresses induced in fuel pins by interaction between a wrapper tube and a bundle of fuel elements each of which consists of the fuel pin and a wire spacer wound around the fuel pin. The fuel elements consists of two kinds of fuel elements, one of them consists of conventional fuel pins and wire spacers and the other fuel pins of smaller diameter than the conventional fuel pins and wire spacers of larger diameter than the conventional wire spacers whereby the fuel assembly is provided with larger space therein.

    摘要翻译: 本发明涉及一种用于快堆的燃料组件,其目的是通过包裹管和一束燃料元件之间的相互作用来减少燃料销引起的应力,每个燃料元件由燃料销和缠绕在燃料销的线间隔件构成。 燃料元件由两种燃料元件组成,其中之一由传统的燃料销和电线隔离件组成,另一个燃料销包括比常规电线间隔件更大直径的常规燃料销和电线隔板的直径小的燃料销,由此燃料组件 在其中具有较大的空间。

    Operation controller of culture tank
    3.
    发明申请
    Operation controller of culture tank 审中-公开
    培养罐操作控制器

    公开(公告)号:US20070207538A1

    公开(公告)日:2007-09-06

    申请号:US11526595

    申请日:2006-09-26

    申请人: Ken Amano

    发明人: Ken Amano

    IPC分类号: C12M3/00 G06F19/00

    CPC分类号: C12M41/48

    摘要: Provided is an operation controller of a culture tank which can more precisely control the internal state of the culture tank by specifying a relatively small number of internal state variables, thus constructing a mathematical model which describes intracellular conditions by using these internal state variables, and thereby incorporating observable external variables thereto. The operation controller includes: a culture tank in which a culture medium for culturing animal cells or microorganism is enclosed, a measuring device for measuring concentrations of nutrient components, concentrations of products, and the number density of cells in the culture medium; a supply device for replenishing the nutrient components and oxygen into the culture medium; and an arithmetic processing unit in which the measured values from the measuring device are inputted, and which thus controls the supply device. The arithmetic processing unit solves an equation derived from a circuit network of intracellular reaction rates stored in a storage device by using temporal rates of change of the concentrations of the nutrient components, of the concentrations of the products, and of the number density of the cells as input data, and thus calculates a desired intracellular reaction rate. Accordingly, the arithmetic processing unit controls the supply device based on the results of the calculation, whereby the arithmetic processing unit controls the concentrations of the components contained in the culture medium.

    摘要翻译: 提供了一种培养罐的操作控制器,其可以通过指定相对较少数量的内部状态变量来更精确地控制培养箱的内部状态,从而构建通过使用这些内部状态变量来描述细胞内条件的数学模型,从而 结合可观察的外部变量。 操作控制器包括:培养罐,其中封入有用于培养动物细胞或微生物的培养基,测量培养基中营养成分浓度,产物浓度和细胞数密度的测量装置; 供应装置,用于将营养成分和氧气补充到培养基中; 以及运算处理单元,其中来自测量装置的测量值被输入,从而控制供给装置。 算术处理单元通过使用营养成分浓度,产物浓度的时间变化率和细胞数密度的时间变化率来求解存储在存储装置中的电池网络中的细胞内反应速率的方程式 作为输入数据,从而计算所需的细胞内反应速率。 因此,算术处理单元基于计算结果来控制供给装置,由此算术处理单元控制培养基中所含的成分的浓度。

    Fast breeder reactor
    4.
    发明授权
    Fast breeder reactor 失效
    快速增殖反应堆

    公开(公告)号:US4732729A

    公开(公告)日:1988-03-22

    申请号:US703904

    申请日:1985-02-21

    摘要: In the fast breeder reactor according to this invention, a medium-pressure plenum and a high-pressure plenum are disposed, in the mentioned order from above in a reactor core. Sodium is filled in the medium- and high-pressure plenums. The pressure in the medium-pressure plenum is lower than that in the high-pressure plenum. The lower ends of the entrance nozzles of a multiplicity of fuel assemblies loaded in the reactor core are supported by a supporting plate which forms a boundary between the medium- and high-pressure plenums. The entrance nozzles of control rod guide pipes disposed among the multiplicity of fuel assemblies are also supported by said supporting plate. The sodium in the medium-pressure plenum is supplied into each control rod guide pipe through a first opening provided in the lateral surface of the entrance nozzle of each control rod guide pipe. The sodium in the high-pressure plenum is supplied into each fuel assembly from the lower end of the entrance nozzle of each fuel assembly through a second opening provided piercing through the supporting plate. The sodium in the high-pressure plenum is supplied to the medium-pressure plenum through a pressure-reducing orifice.

    摘要翻译: 在根据本发明的快速增殖反应器中,按上述顺序在反应堆堆芯中设置中压增压室和高压增压室。 钠被填充在中高压气室中。 中压增压室的压力低于高压集气室的压力。 装载在反应堆堆芯中的多个燃料组件的入口喷嘴的下端由形成中压和高压集气室之间的边界的支撑板支撑。 设置在多个燃料组件中的控制杆引导管的入口喷嘴也由所述支撑板支撑。 通过设置在每个控制杆导管的入口喷嘴的侧表面上的第一开口将中压压力室中的钠供给到每个控制棒导管中。 高压增压室中的钠从每个燃料组件的入口喷嘴的下端通过穿过支撑板的第二开口供应到每个燃料组件中。 高压增压室中的钠通过减压孔供给中压增压室。

    Control device for fermenter
    6.
    发明授权
    Control device for fermenter 有权
    发酵罐控制装置

    公开(公告)号:US07771988B2

    公开(公告)日:2010-08-10

    申请号:US11355954

    申请日:2006-02-17

    申请人: Ken Amano

    发明人: Ken Amano

    IPC分类号: C12M1/34

    CPC分类号: C12M41/48

    摘要: The control device according to the present invention includes an input device for entering measured data from a measurement unit, which measures nutrient components, the concentrations of oxygen, carbon dioxide, and biomass in a culture medium; a processor for calculating nutrient components uptake rate, oxygen uptake rate and carbon dioxide exhaust rate per unit amount of biomass from the measured data entered in the aforementioned input device, as well as volumetric mass transfer coefficient kLa from turbulent energy k and a turbulent energy dissipation rate e, both of which are calculated by a transport equation, as well as a diffusion coefficient D, followed by calculating the concentrations of the nutrient components, dissolved oxygen and dissolved carbon dioxide in any area in the fermenter; and a display for displaying concentration distribution of the nutrient components, dissolved oxygen, and dissolved carbon dioxide in the fermenter.

    摘要翻译: 根据本发明的控制装置包括用于输入来自测量单元的测量数据的输入装置,其测量营养成分,培养基中的氧气,二氧化碳和生物量的浓度; 用于根据从上述输入装置输入的测量数据计算每单位量生物量的营养成分摄取速率,吸氧速率和二氧化碳排放率的处理器,以及来自湍流能量k的体积传质系数kLa和湍流能量耗散 速率e,它们都通过运输方程计算,以及扩散系数D,然后计算发酵罐中任何区域中的营养成分,溶解氧和溶解的二氧化碳的浓度; 以及显示器,用于显示发酵罐中的营养成分,溶解氧和溶解的二氧化碳的浓度分布。

    Control device for fermenter
    7.
    发明申请
    Control device for fermenter 有权
    发酵罐控制装置

    公开(公告)号:US20060216818A1

    公开(公告)日:2006-09-28

    申请号:US11355954

    申请日:2006-02-17

    申请人: Ken Amano

    发明人: Ken Amano

    IPC分类号: C12M1/34

    CPC分类号: C12M41/48

    摘要: The present invention allows biomass and/or biomass-produced components to be obtained at high yields by executing numeric simulation of flow to reasonably identify the running conditions suitable for a fermenter. The control device according to the present invention comprises an input means for entering measured data from a measurement means, which measures nutrient components, the concentrations of oxygen, carbon dioxide, and biomass in a culture medium; a computation means for calculating nutrient components uptake rate, oxygen uptake rate and carbon dioxide exhaust rate per unit amount of biomass from the measured data entered at the aforementioned input means, as well as volumetric mass transfer coefficient kLa from turbulent energy k and a turbulent energy dissipation rate e, both of which are calculated by a transport equation, as well as a diffusion coefficient D, followed by calculating the concentrations of the nutrient components, dissolved oxygen, and dissolved carbon dioxide in any area in the fermenter using an algorithm to numerically integrate a differential equation describing variations in medium components over time from the calculated nutrient components uptake rate, the calculated oxygen uptake rate, the calculated carbon dioxide exhaust rate, and the calculated volumetric mass transfer coefficient kLa; and a display means for displaying concentration distributions of the nutrient components, dissolved oxygen, and dissolved carbon dioxide in the fermenter based on the concentrations of the nutrient components, dissolved oxygen, and carbon dioxide in any area of the fermenter calculated at aforementioned computation means.

    摘要翻译: 本发明允许通过执行流动的数值模拟以高产率获得生物质和/或生物质产生的组分,以合理地识别适用于发酵罐的运行条件。 根据本发明的控制装置包括输入装置,用于输入来自测量装置的测量数据,该测量装置测量培养基中的营养成分,氧气,二氧化碳和生物质的浓度; 计算装置,用于根据从上述输入装置输入的测量数据计算营养成分摄取率,吸氧速率和每单位量生物量的二氧化碳排放率,以及来自湍流k的体积传质系数kLa和湍流能 耗散率e,它们都是通过运输方程式计算的,以及扩散系数D,然后使用数值算法计算发酵罐任何区域中营养成分,溶解氧和溶解二氧化碳的浓度 从计算的营养成分摄取速率,计算的氧气摄取速率,计算出的二氧化碳排出速率和计算的体积传质系数kLa中积分描述介质成分随时间变化的微分方程; 以及显示装置,用于基于在上述计算装置计算的发酵罐的任何区域中的营养成分,溶解氧和二氧化碳的浓度,显示发酵罐中的营养成分,溶解氧和溶解的二氧化碳的浓度分布。

    PRODUCTION METHOD FOR BIOFUEL
    9.
    发明申请
    PRODUCTION METHOD FOR BIOFUEL 有权
    生物制品生产方法

    公开(公告)号:US20130071889A1

    公开(公告)日:2013-03-21

    申请号:US13699780

    申请日:2011-05-25

    IPC分类号: C12P7/64

    摘要: The present invention provides a production method for biofuel based on a technology to convert carbon-dioxide as a carbon source through photosynthesis by photosynthetic microorganisms to biomass and produce biofuel of the biomass. The production method for biofuel of the present invention comprises a culturing process (S1) of culturing in a culture solution photosynthetic microorganisms which store oils, fats and carbohydrates in cells of the photosynthetic microorganisms, an oil and fat conversion process (S2) of converting the carbohydrates stored in the cells of the photosynthetic microorganisms cultured in the culture apparatus to oils and fats, an extraction process (S3) of extracting the oils and fats out of the cells of the photosynthetic microorganisms, and a reforming process (S4) to reform the extracted oils and fats.

    摘要翻译: 本发明提供了一种生物燃料的生产方法,其基于通过光合微生物通过光合作用将碳二
    氧化碳转化为生物质并生产生物燃料的技术。 本发明的生物燃料的制造方法包括在光合微生物的细胞中储存油,脂肪和碳水化合物的培养液中培养光合微生物的培养方法(S1),将光合微生物的细胞中的油脂转化方法(S2) 储存在培养装置中培养的光合微生物的细胞中的碳水化合物用于油和脂肪,从光合微生物的细胞中提取油和脂肪的提取方法(S3)和重整方法(S4) 提取油脂。