公开(公告)号：US20090123517A1

公开(公告)日：2009-05-14

申请号：US12109677

申请日：2008-04-25

Applicant: Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhai ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

Inventor： Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhai ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

IPC: A61F2/82 ,  A61L27/00

CPC classification number: A61F2/91 ,  A61F2/3094 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.

Abstract translation: 一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。 储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。 覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。 用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂 当植入医疗器械时可能释放。 或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

公开(公告)号：US08703168B2

公开(公告)日：2014-04-22

申请号：US12109677

申请日：2008-04-25

Applicant: Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhal ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

Inventor： Aiden Flanagan ,  Robert Herrmann ,  Ken Merdan ,  Michael Kuehling ,  Barry O'Brien ,  Rajesh Radhakishnan ,  Torsten Scheuermann ,  Scott Schewe ,  Anurag Singhal ,  Young-Ho Song ,  Mary Joe Timm ,  Jan Weber ,  Yixin Xu

IPC: A61F2/00

CPC classification number: A61F2/91 ,  A61F2/3094 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.

Abstract translation: 一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。 储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。 覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。 用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂 当植入医疗器械时可能释放。 或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

公开(公告)号：US20110118826A1

公开(公告)日：2011-05-19

申请号：US13014394

申请日：2011-01-26

Applicant: Rajesh Radhakrishnan ,  Chandru Chandrasekaran ,  Scott R. Schewe ,  Ken Merdan

Inventor： Rajesh Radhakrishnan ,  Chandru Chandrasekaran ,  Scott R. Schewe ,  Ken Merdan

IPC: A61F2/82

CPC classification number: A61L31/08

Abstract: An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.

Abstract translation: 内假体包括限定流动通道的多个支柱。 至少一个支柱包括（a）包含生物腐蚀性材料并且具有厚度的主体和（b）覆盖在身体上的涂层。 涂层包括多个区域，当内生假体植入生理环境时，允许生理流体接触下面身体的多个对应区域。 多个区域的尺寸和布置使得当内部假体植入生理环境中时，身体的接触区域在厚度方向上基本上穿过身体侵蚀，同时涂层保留在身体上。

公开(公告)号：US08920490B2

公开(公告)日：2014-12-30

申请号：US13106449

申请日：2011-05-12

Applicant: Rajesh Radhakrishnan ,  Liliana Atanasoska ,  Scott R. Schewe ,  Ken Merdan

Inventor： Rajesh Radhakrishnan ,  Liliana Atanasoska ,  Scott R. Schewe ,  Ken Merdan

IPC: A61F2/82 ,  A61F2/91

CPC classification number: A61F2/91 ,  A61F2250/0068

Abstract: A medical device is provided with a porous region including a reservoir zone including a polymer and a protective zone between adjacent tissue and the reservoir zone that restricts the tissue from direct contact with the polymer.

Abstract translation: 医疗装置设置有多孔区域，该多孔区域包括储存器区域，该储存器区域包括聚合物和相邻组织与储存区域之间的保护区域，其限制组织与聚合物的直接接触。

公开(公告)号：US20080082162A1

公开(公告)日：2008-04-03

申请号：US11855516

申请日：2007-09-14

Applicant: Dennis Boismier ,  Timothy Girton ,  Steven Larsen ,  Matt Shedlov ,  Ken Merdan ,  Barry O`Brien

Inventor： Dennis Boismier ,  Timothy Girton ,  Steven Larsen ,  Matt Shedlov ,  Ken Merdan ,  Barry O`Brien

IPC: A61F2/82

CPC classification number: A61F2/06 ,  A61F2/91 ,  A61F2002/30032 ,  A61F2002/30051 ,  A61F2002/30062 ,  A61F2002/3011 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0002 ,  A61F2250/003 ,  A61F2250/0054 ,  A61L31/022 ,  A61L31/08 ,  A61L31/148

Abstract: A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.

Abstract translation: 生物腐蚀性内用假体侵蚀到可以提供例如改善的机械性能或降解特性的期望几何形状。

公开(公告)号：US08057534B2

公开(公告)日：2011-11-15

申请号：US11855516

申请日：2007-09-14

Applicant: Dennis A. Boismier ,  Timothy S. Girton ,  Steven R. Larsen ,  Matt Shedlov ,  Ken Merdan ,  Barry O'Brien

Inventor： Dennis A. Boismier ,  Timothy S. Girton ,  Steven R. Larsen ,  Matt Shedlov ,  Ken Merdan ,  Barry O'Brien

IPC: A61F2/06

CPC classification number: A61F2/06 ,  A61F2/91 ,  A61F2002/30032 ,  A61F2002/30051 ,  A61F2002/30062 ,  A61F2002/3011 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0002 ,  A61F2250/003 ,  A61F2250/0054 ,  A61L31/022 ,  A61L31/08 ,  A61L31/148

Abstract: A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.

Abstract translation: 生物腐蚀性内用假体侵蚀到可以提供例如改善的机械性能或降解特性的期望几何形状。

公开(公告)号：US07985252B2

公开(公告)日：2011-07-26

申请号：US12182768

申请日：2008-07-30

Applicant: Rajesh Radhakrishnan ,  Chandru Chandrasekaran ,  Scott R. Schewe ,  Ken Merdan

Inventor： Rajesh Radhakrishnan ,  Chandru Chandrasekaran ,  Scott R. Schewe ,  Ken Merdan

IPC: A61F2/24

CPC classification number: A61L31/08

Abstract: An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.

Abstract translation: 内假体包括限定流动通道的多个支柱。 至少一个支柱包括（a）包含生物腐蚀性材料并且具有厚度的主体和（b）覆盖在身体上的涂层。 涂层包括多个区域，当内生假体植入生理环境时，允许生理流体接触下面身体的多个对应区域。 多个区域的尺寸和布置使得当内部假体植入生理环境中时，身体的接触区域在厚度方向上基本上穿过身体侵蚀，同时涂层保留在身体上。

公开(公告)号：US20120053674A1

公开(公告)日：2012-03-01

申请号：US13291769

申请日：2011-11-08

Applicant: Dennis A. Boismier ,  Timothy S. Girton ,  Steven R. Larsen ,  Matt Shedlov ,  Ken Merdan ,  Barry O'Brien

Inventor： Dennis A. Boismier ,  Timothy S. Girton ,  Steven R. Larsen ,  Matt Shedlov ,  Ken Merdan ,  Barry O'Brien

IPC: A61F2/82

CPC classification number: A61F2/06 ,  A61F2/91 ,  A61F2002/30032 ,  A61F2002/30051 ,  A61F2002/30062 ,  A61F2002/3011 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0002 ,  A61F2250/003 ,  A61F2250/0054 ,  A61L31/022 ,  A61L31/08 ,  A61L31/148

Abstract: A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.

Abstract translation: 生物腐蚀性内用假体侵蚀到可以提供例如改善的机械性能或降解特性的期望几何形状。

公开(公告)号：US20100030326A1

公开(公告)日：2010-02-04

申请号：US12182768

申请日：2008-07-30

Applicant: Rajesh Radhakrishnan ,  Chandru Chandrasekaran ,  Scott R. Schewe ,  Ken Merdan

Inventor： Rajesh Radhakrishnan ,  Chandru Chandrasekaran ,  Scott R. Schewe ,  Ken Merdan

IPC: A61F2/82

CPC classification number: A61L31/08

Abstract: An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.

Abstract translation: 内假体包括限定流动通道的多个支柱。 至少一个支柱包括（a）包含生物腐蚀性材料并且具有厚度的主体和（b）覆盖在身体上的涂层。 涂层包括多个区域，当内生假体植入生理环境时，允许生理流体接触下面身体的多个对应区域。 多个区域的尺寸和布置使得当内部假体植入生理环境中时，身体的接触区域在厚度方向上基本上穿过身体侵蚀，同时涂层保留在身体上。

公开(公告)号：US20070075060A1

公开(公告)日：2007-04-05

申请号：US11240148

申请日：2005-09-30

Applicant: Matthew Shedlov ,  Ken Merdan

Inventor： Matthew Shedlov ,  Ken Merdan

IPC: B23K26/38

CPC classification number: B23K26/08

Abstract: A method of manufacturing a medical device from a workpiece is provided. The method begins by generating a pulsed beam of radiation from a radiation source. The pulsed radiation beam is characterized by a prescribed pulse frequency. The pulsed radiation beam is directed onto the workpiece and the workpiece is moved relative to the radiation source so that a prescribed pattern is cut in the workpiece by the pulsed radiation beam. The prescribed pulse frequency is adjusted based on a change in a parameter pertaining to the relative motion of the workpiece.

Abstract translation: 提供了一种从工件制造医疗装置的方法。 该方法开始于从辐射源产生脉冲的辐射束。 脉冲辐射束的特征在于规定的脉冲频率。 脉冲辐射束被引导到工件上，并且工件相对于辐射源移动，使得通过脉冲辐射束在工件中切割规定的图案。 基于与工件的相对运动有关的参数的变化来调整规定的脉冲频率。