利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.042 秒)

    Medical devices having a coating of inorganic material
    3.
    发明授权
    Medical devices having a coating of inorganic material 有权
    具有无机材料涂层的医疗器械

    公开(公告)号：US08920491B2

    公开(公告)日：2014-12-30

    申请号：US12425791

    申请日：2009-04-17

    申请人： Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    发明人： Aiden Flanagan ,  John Kilcooley ,  Tim O'Connor ,  Barry O'Brien ,  Dominique Seidel ,  Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber

    IPC分类号： A61F2/06 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

    CPC分类号： A61L29/10 ,  A61L29/16 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/61

    摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.

    摘要翻译： 在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。 在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中 可膨胀材料是暴露于含水环境时膨胀的材料。 在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。 在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中， 阻挡层具有多个不连续性。 还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

    Medical devices having metal coatings for controlled drug release
    5.
    发明授权
    Medical devices having metal coatings for controlled drug release 有权
    具有用于受控药物释放的金属涂层的医疗装置

    公开(公告)号：US08361139B2

    公开(公告)日：2013-01-29

    申请号：US12498829

    申请日：2009-07-07

    申请人： Aiden Flanagan ,  Barry O'Brien ,  Torsten Scheuermann

    发明人： Aiden Flanagan ,  Barry O'Brien ,  Torsten Scheuermann

    IPC分类号： A61F2/06 ,  A61F2/00

    CPC分类号： A61L31/088 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/624

    摘要： Medical devices having a plurality of nanoparticles disposed over a surface of the medical device. The nanoparticles have a core comprising a therapeutic agent and a shell surrounding the core, wherein the shell comprises a metal. A barrier layer is disposed over the nanoparticles. The barrier layer is water-permeable and comprises a metal that may be different from the metal used in the nanoparticle shells. In certain embodiments, the metal in the barrier layer undergoes galvanic corrosion. Also disclosed are medical device having a reservoir containing a therapeutic agent, with nanoparticles and a barrier layer being disposed over the reservoir; and medical devices having multiple barrier layers and multiple reservoirs containing therapeutic agents.

    摘要翻译： 具有设置在医疗装置的表面上的多个纳米颗粒的医疗装置。 纳米颗粒具有包含治疗剂的核心和围绕核心的壳体，其中壳体包含金属。 阻挡层设置在纳米粒子上。 阻挡层是透水性的并且包含可以与纳米颗粒壳中使用的金属不同的金属。 在某些实施例中，阻挡层中的金属经历电偶腐蚀。 还公开了具有包含治疗剂的储存器的医疗装置，其中纳米颗粒和阻挡层设置在储存器上方; 以及具有多个阻隔层的医疗装置和含有治疗剂的多个储存器。

    MEDICAL DEVICES HAVING METAL COATINGS FOR CONTROLLED DRUG RELEASE
    6.
    发明申请
    MEDICAL DEVICES HAVING METAL COATINGS FOR CONTROLLED DRUG RELEASE 有权
    具有用于控制药物释放的金属涂层的医疗装置

    公开(公告)号：US20100015206A1

    公开(公告)日：2010-01-21

    申请号：US12498829

    申请日：2009-07-07

    申请人： Aiden FLANAGAN ,  Barry O'Brien ,  Torsten SCHEUERMANN

    发明人： Aiden FLANAGAN ,  Barry O'Brien ,  Torsten SCHEUERMANN

    IPC分类号： A61F2/82

    CPC分类号： A61L31/088 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/624

    摘要： Medical devices having a plurality of nanoparticles disposed over a surface of the medical device. The nanoparticles have a core comprising a therapeutic agent and a shell surrounding the core, wherein the shell comprises a metal. A barrier layer is disposed over the nanoparticles. The barrier layer is water-permeable and comprises a metal that may be different from the metal used in the nanoparticle shells. In certain embodiments, the metal in the barrier layer undergoes galvanic corrosion. Also disclosed are medical device having a reservoir containing a therapeutic agent, with nanoparticles and a barrier layer being disposed over the reservoir; and medical devices having multiple barrier layers and multiple reservoirs containing therapeutic agents.

    摘要翻译： 具有设置在医疗装置的表面上的多个纳米颗粒的医疗装置。 纳米颗粒具有包含治疗剂的核心和围绕核心的壳体，其中壳体包含金属。 阻挡层设置在纳米颗粒上。 阻挡层是透水性的并且包含可以与纳米颗粒壳中使用的金属不同的金属。 在某些实施例中，阻挡层中的金属经历电偶腐蚀。 还公开了具有包含治疗剂的储存器的医疗装置，其中纳米颗粒和阻挡层设置在储存器上方; 以及具有多个阻隔层的医疗装置和含有治疗剂的多个储存器。

    Endoprostheses having porous claddings prepared using metal hydrides
    7.
    发明授权
    Endoprostheses having porous claddings prepared using metal hydrides 失效
    具有使用金属氢化物制备的多孔包层的内用假体

    公开(公告)号：US07883736B2

    公开(公告)日：2011-02-08

    申请号：US11851127

    申请日：2007-09-06

    申请人： Aiden Flanagan ,  Barry O'Brien

    发明人： Aiden Flanagan ,  Barry O'Brien

    IPC分类号： A61L33/00

    CPC分类号： A61F2/82 ,  A61L31/082 ,  A61L31/088 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/416 ,  B05D3/06

    摘要： A process for making an endoprosthesis comprising: (a) applying a powder that includes a metal hydride to a surface of a metal endoprosthesis, or precursor tubing thereof; and (b) exposing the powder to a heat source to melt the powder and liberate hydrogen gas, thereby forming a porous coating on the surface of the endoprosthesis, or precursor tubing thereof.

    摘要翻译： 一种制造内用假体的方法，包括：（a）将包含金属氢化物的粉末施加到金属内用假体的表面或其前体管; 和（b）将粉末暴露于热源以熔化粉末并释放氢气，从而在内用假体或其前体管的表面上形成多孔涂层。

    Stent with protective pads or bulges
    8.
    发明申请
    Stent with protective pads or bulges 审中-公开
    支架与保护垫或凸起

    公开(公告)号：US20050230039A1

    公开(公告)日：2005-10-20

    申请号：US10828021

    申请日：2004-04-19

    申请人： Michael Austin ,  Aiden Flanagan ,  Barry O'Brien

    发明人： Michael Austin ,  Aiden Flanagan ,  Barry O'Brien

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  B23K26/40 ,  B32B31/00

    CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2220/0058 ,  A61F2250/0036 ,  A61F2250/0039 ,  B23K26/40 ,  B23K2103/05 ,  B23K2103/172 ,  B23K2103/42 ,  B23K2103/50

    摘要： A stent having at least one strut comprising at least one pad or bulge is disclosed. The pads or bulges are of a height that are preferably slightly greater than the thickness of a coating that can be disposed on the strut. The coating is not disposed on the pads. When the stent is placed within a delivery member such as a sheath or a catheter, the pads or bulges contact the inner surface of the delivery member, preventing the coating from contacting the inner surface. Damage to the coating that may be caused by friction with or adhesion to the delivery member is thus prevented. Methods for forming such a stent are also discussed.

    摘要翻译： 公开了具有至少一个包括至少一个垫或凸起的支柱的支架。 垫或凸起的高度优选略大于可以设置在支柱上的涂层的厚度。 涂层没有设置在焊盘上。 当支架放置在诸如护套或导管的递送构件中时，垫或凸起接触输送构件的内表面，防止涂层接触内表面。 因此防止了可能由与传送构件的摩擦或粘附引起的涂层的损伤。 还讨论了形成这种支架的方法。