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    AUTONOMIC MODULATION USING PERIPHERAL NERVE FIELD STIMULATION
    1.
    发明申请
    AUTONOMIC MODULATION USING PERIPHERAL NERVE FIELD STIMULATION 有权
    使用外周神经网络自动化调制

    公开(公告)号：US20130138167A1

    公开(公告)日：2013-05-30

    申请号：US13686336

    申请日：2012-11-27

    申请人： Kerry Bradley ,  Rafael Carbunaru ,  Jason J. Hamann

    发明人： Kerry Bradley ,  Rafael Carbunaru ,  Jason J. Hamann

    IPC分类号： A61N1/36 ,  A61N1/39

    CPC分类号： A61N1/36114 ,  A61N1/3605 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/36146 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/37235 ,  A61N1/37282 ,  A61N1/37288 ,  A61N1/3962

    摘要： Some embodiments provide a system, comprising a peripheral nerve field modulation (PNFM) therapy delivery system, PNFM electrodes configured to be implanted subcutaneously, and a controller. The PNFM electrodes are electrically connected to the PNFM therapy system. The PNFM therapy delivery system and the PNFM electrodes are configured to deliver current and/or control the field potentials at one or more peripheral nerve fields. The controller is configured to control the PNFM therapy delivery system to deliver a PNFM therapy to the one or more peripheral nerve fields. The controller includes a scheduler configured to control timing of the PNFM therapy.

    摘要翻译： 一些实施例提供一种包括周边神经域调制（PNFM）治疗递送系统，以及被配置为皮下植入的PNFM电极和控制器的系统。 PNFM电极电连接到PNFM治疗系统。 PNFM治疗递送系统和PNFM电极被配置为在一个或多个周围神经区传递电流和/或控制场电位。 控制器被配置为控制PNFM治疗递送系统将PNFM治疗递送到一个或多个周围神经区域。 控制器包括被配置为控制PNFM治疗的定时的调度器。

    SYSTEMS FOR PATIENT CONTROL OF IMPLANTABLE MEDICAL DEVICE THERAPY
    2.
    发明申请
    SYSTEMS FOR PATIENT CONTROL OF IMPLANTABLE MEDICAL DEVICE THERAPY 有权
    可植入医疗器械治疗患者控制系统

    公开(公告)号：US20110282416A1

    公开(公告)日：2011-11-17

    申请号：US13104635

    申请日：2011-05-10

    申请人： Jason J. Hamann ,  Stephen Ruble ,  Rafael Carbunaru ,  David J. Ternes

    发明人： Jason J. Hamann ,  Stephen Ruble ,  Rafael Carbunaru ,  David J. Ternes

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37247 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36132

    摘要： Various embodiments provide a method performed by an IMD to deliver a therapy to a patient. In some embodiments of the method, the therapy is delivered to the patient, and a trigger that is controlled by the patient is detected by the IMD. The therapy is automatically interrupted in response to the detected trigger, and is automatically restored after a defined period after the detected trigger. In some embodiments of the method, a trigger that is controlled by the patient is detected. The therapy is automatically initiated in response to the detected trigger, and is automatically stopped after a defined period after the detected trigger.

    摘要翻译： 各种实施例提供了由IMD执行以将治疗递送给患者的方法。 在该方法的一些实施例中，将治疗传递给患者，由IMD检测由患者控制的触发。 治疗根据检测到的触发自动中断，并在检测到的触发之后的定义的时间段后自动恢复。 在该方法的一些实施例中，检测由患者控制的触发器。 治疗根据检测到的触发自动启动，并且在检测到的触发之后的确定的时间段后自动停止。

    Systems for patient control of implantable medical device therapy
    3.
    发明授权
    Systems for patient control of implantable medical device therapy 有权
    用于患者控制植入式医疗器械治疗的系统

    公开(公告)号：US09242104B2

    公开(公告)日：2016-01-26

    申请号：US13104635

    申请日：2011-05-10

    申请人： Jason J. Hamann ,  Stephen Ruble ,  Rafael Carbunaru ,  David J. Ternes

    发明人： Jason J. Hamann ,  Stephen Ruble ,  Rafael Carbunaru ,  David J. Ternes

    IPC分类号： A61N1/00 ,  A61N1/372 ,  A61N1/36

    CPC分类号： A61N1/37247 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36132

    摘要： Various embodiments provide a method performed by an IMD to deliver a therapy to a patient. In some embodiments of the method, the therapy is delivered to the patient, and a trigger that is controlled by the patient is detected by the IMD. The therapy is automatically interrupted in response to the detected trigger, and is automatically restored after a defined period after the detected trigger. In some embodiments of the method, a trigger that is controlled by the patient is detected. The therapy is automatically initiated in response to the detected trigger, and is automatically stopped after a defined period after the detected trigger.

    摘要翻译： 各种实施例提供了由IMD执行以将治疗递送给患者的方法。 在该方法的一些实施例中，将治疗传递给患者，由IMD检测由患者控制的触发。 治疗根据检测到的触发自动中断，并在检测到的触发之后的定义的时间段后自动恢复。 在该方法的一些实施例中，检测由患者控制的触发器。 治疗根据检测到的触发自动启动，并且在检测到的触发之后的确定的时间段后自动停止。

    Cavernous nerve stimulation via unidirectional propagation of action potentials
    6.
    发明授权
    Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
    通过动作电位的单向传播进行海绵体神经刺激

    公开(公告)号：US07203548B2

    公开(公告)日：2007-04-10

    申请号：US10176743

    申请日：2002-06-20

    申请人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru ,  Matthew I Haller ,  Tom Xiaohai He ,  Kerry Bradley

    发明人： Todd K Whitehurst ,  James P McGivern ,  Rafael Carbunaru ,  Matthew I Haller ,  Tom Xiaohai He ,  Kerry Bradley

    IPC分类号： A61N1/05 ,  A61N1/18

    CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/37205

    摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.

    摘要翻译： 提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。 能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。 一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

    Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement
    7.
    发明授权
    Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement 有权
    使用脉冲放置避免频率锁定在多通道神经刺激系统中的方法

    公开(公告)号：US08543200B2

    公开(公告)日：2013-09-24

    申请号：US12550237

    申请日：2009-08-28

    申请人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K. L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    发明人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K. L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    IPC分类号： A61N1/00

    CPC分类号： A61N1/08 ,  A61N1/36071 ,  A61N1/36082

    摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.

    摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。

    METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT
    9.
    发明申请
    METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT 有权
    使用脉冲放置在多通道神经元系统中避免频率锁定的方法

    公开(公告)号：US20110054568A1

    公开(公告)日：2011-03-03

    申请号：US12550237

    申请日：2009-08-28

    申请人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K.L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    发明人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K.L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    IPC分类号： A61N1/08 ,  A61N1/36

    CPC分类号： A61N1/08 ,  A61N1/36071 ,  A61N1/36082

    摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.

    摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。