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11 条记录 (耗时 0.022 秒)

    Method for the preparation of aryl ethers
    1.
    发明申请
    Method for the preparation of aryl ethers 审中-公开
    芳基醚的制备方法

    公开(公告)号：US20050187388A1

    公开(公告)日：2005-08-25

    申请号：US11059895

    申请日：2005-02-17

    申请人： Mateusz Cebula ,  Kevin Henegar

    发明人： Mateusz Cebula ,  Kevin Henegar

    IPC分类号： C07D265/30 ,  C07D265/32

    CPC分类号： C07D265/30

    摘要： The invention provides a method of preparing a compound of formula (I): wherein R, R1, n and m are as defined herein, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供制备式（I）化合物的方法：其中R 1，R 1，n和m如本文所定义，或其药学上可接受的盐。

    Process and intermediates to prepare latanoprost
    6.
    发明申请
    Process and intermediates to prepare latanoprost 审中-公开
    制备拉坦前列素的方法和中间体

    公开(公告)号：US20050038123A1

    公开(公告)日：2005-02-17

    申请号：US10920567

    申请日：2004-08-18

    申请人： Kevin Henegar

    发明人： Kevin Henegar

    IPC分类号： C07C59/54 ,  C07C59/72 ,  C07C405/00 ,  C07D307/935 ,  A61K31/557 ,  A61K31/19

    CPC分类号： C07D307/935 ,  C07C59/54 ,  C07C59/72 ,  C07C405/0016

    摘要： The present invention is a novel intermediate, compound of the formula (VI) and salts thereof. In addition, the invention includes a process for the preparation of a prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1) contacting a the corresponding enone with (−)-chlorodiisopinocampheylborane while maintaining the reaction mixture temperature in the range of from about −50° to about 0° and (2) contacting the reaction mixture of step (1) with a boron complexing agent.

    摘要翻译： 本发明是一种新的中间体式（Ⅵ）化合物及其盐。 另外，本发明包括制备前列腺素中间体化合物（Ⅳ）和（ⅩⅧ）的方法，其包括（1）使相应的烯酮与（ - ） - 氯二异蒎烷yl基硼烷接触，同时保持反应混合物的温度在 约-50°至约0°，和（2）使步骤（1）的反应混合物与硼络合剂接触。

    System and method for configuring computer for operation
    8.
    发明申请
    System and method for configuring computer for operation 有权

    公开(公告)号：US20060041883A1

    公开(公告)日：2006-02-23

    申请号：US10922264

    申请日：2004-08-19

    申请人： Howell Chambers ,  Kevin Henegar ,  David Karner ,  Andrew Mueller

    发明人： Howell Chambers ,  Kevin Henegar ,  David Karner ,  Andrew Mueller

    IPC分类号： G06F9/445

    CPC分类号： G06F9/4411

    摘要： A method for deploying software in a computer system includes providing a deployment maintenance mechanism (DMM) which includes drivers for hardware. A deployment mechanism which includes an image with drivers for hardware and which identifies hardware associated with the computer, along with a native operating system, are also provided. For hardware detected by the deployment mechanism and not having an associated driver in the image, a driver from the DMM is copied into the deployment mechanism using the native operating system. The native operating system is then re-booted to deploy drivers for hardware associated with the computer.

    COMPOUNDS USEFUL IN PREPARING CAMPTOTHECIN DERIVATIVES
    9.
    发明申请
    COMPOUNDS USEFUL IN PREPARING CAMPTOTHECIN DERIVATIVES 审中-公开
    化合物可用于制备CAMPTOTHECIN衍生物

    公开(公告)号：US20050197355A1

    公开(公告)日：2005-09-08

    申请号：US10791198

    申请日：2004-03-02

    申请人： Kevin Henegar

    发明人： Kevin Henegar

    IPC分类号： A61K31/4545 ,  A61K31/4745

    CPC分类号： A61K31/4745 ,  A61K31/4545 ,  A61K2300/00

    摘要： Novel compounds are provided having the formula and salts thereof, where R1 is hydrogen, an alkyl, aralkyl, hydroxymethyl, carboxymethyl, acyloxymethyl or trialkylsilyl group, or a group —CH2NR3R4 where N is a linking nitrogen atom and where (a) R3 and R4 are independently selected from hydrogen and alkyl, alkenyl, hydroxyalkyl and alkoxyalkyl groups; (b) R3 is hydrogen or an alkyl, alkenyl, hydroxyalkyl or alkoxyalkyl group, and R4 is —COR5 where R5 is hydrogen or an alkyl, alkenyl, hydroxyalkyl or alkoxyalkyl group; or (c) R3 and R4 taken together with the linking nitrogen atom form a saturated 3- to 7-member heterocyclic group. These compounds are useful intermediates in a process to prepare camptothecin derivatives including the anti-cancer drug irinotecan.

    摘要翻译： 提供了具有式及其盐的新化合物，其中R 1是氢，烷基，芳烷基，羟甲基，羧甲基，酰氧基甲基或三烷基甲硅烷基或基团-CH 2 其中N为连接氮原子，其中（a）R 3和R 4为H， 独立地选自氢和烷基，烯基，羟基烷基和烷氧基烷基; （b）R 3是氢或烷基，烯基，羟基烷基或烷氧基烷基，R 4是-COR 5，其中R SUP > 5是氢或烷基，烯基，羟基烷基或烷氧基烷基; 或（c）R 3和R 4与连接氮原子一起形成饱和的3-至7-元杂环基。 这些化合物在制备喜树碱衍生物的方法中是有用的中间体，包括抗癌药物伊立替康。