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公开(公告)号：US20050025677A1
公开(公告)日：2005-02-03
申请号：US10494725
申请日：2002-10-21
申请人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
发明人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/0081 , B01L9/527 , B01L2200/028
摘要： The invention related to a microreactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said microreactor in carrying out a chemical reaction. According to said invention, (a) said mircoreactor system (11) is of modular design, (b) a processing unit (10) is made up of processing modules which are connected to each other by frictional engagement and (c) the fluid connections in said processing unit (10) can be obtained by the frictional connection of said processing modules.
摘要翻译： 本发明涉及用于连续合成的微反应器系统，其提供用于所述合成的限定的反应室和条件，以及所述微反应器在进行化学反应中的用途。 根据所述发明，（a）所述微电机系统（11）具有模块化设计，（b）处理单元（10）由处理模块组成，所述处理模块通过摩擦接合彼此连接，（c）流体连接 在所述处理单元（10）中可以通过所述处理模块的摩擦连接获得。
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公开(公告)号：US06537506B1
公开(公告)日：2003-03-25
申请号：US09496999
申请日：2000-02-03
申请人： Thomas Schwalbe , Klaus Golbig , Michael Hohmann , Petra Georg , Andreas Oberbeck , Bernd Dittmann , Jiri Stastna , Sebastian Oberbeck
发明人： Thomas Schwalbe , Klaus Golbig , Michael Hohmann , Petra Georg , Andreas Oberbeck , Bernd Dittmann , Jiri Stastna , Sebastian Oberbeck
IPC分类号： B01J1900
CPC分类号： B01F13/0066 , B01F5/0604 , B01F13/0059 , B01F13/0064 , B01F13/0093 , B01F13/0094 , B01F13/1013 , B01F13/1022 , B01F15/06 , B01J19/0093 , B01J19/249 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , B01J2219/00961 , B01J2219/2453 , B01J2219/2456 , B01J2219/246 , B01J2219/2462 , B01J2219/2464 , B01J2219/247 , B01J2219/2485 , B01J2219/2486 , B01J2219/2487 , B01J2219/2488 , B01J2219/249 , B01J2219/2493 , B01J2219/2495 , B01J2219/2496 , B01J2219/2497 , F28D9/0093 , F28F2260/02
摘要： A stacked plate chemical reactor in which simple plates, each incorporating no surface features other that an opening, are stacked together. When openings in adjacent plates are properly aligned, a fluid pathway is defined between inlet ports for each chemical reactant and an outlet port for a chemical product. In one embodiment of the invention, sixteen simple plates are stacked to provide a reactor incorporating three heat transfer fluid pathways, two reactant fluid pathways, one product fluid pathway, multiple mixing chambers, multiple reaction chambers, two reactant pretreatment heat exchangers, two reaction chamber heat exchangers, and multiple temperature sensor pathways. Precise dimensional control of the reactant fluid pathway height enables stacked laminar flow paths for the reactants to be achieved, allowing efficient and rapid diffusion mixing to occur. Because the simple plates incorporate no features other than openings, fabrication of such plates is easily achieved. Different reactor designs, having additional reactant pathways, more or fewer heat transfer fluid pathways, more or fewer heat exchangers, more or fewer mixing chambers, more of fewer reaction chambers, and more or fewer sensor pathways can readily be achieved by adding or removing plates from the stack, and or by changing the pattern and number of openings in the simple plates that are used. The simple plates can be field in the stack during use of the chemical reactor using pressure exerted on opposite outer simple plates of the stack, or can be permanently joined. A preferred material for the fabrication of the plates is stainless steel, although other materials such as glass, plastic, and other metals can alternatively be used, which are compatible with the selected reactants and the desired product.
摘要翻译： 堆叠板式化学反应器，其中每个不具有开口的表面特征的简单板堆叠在一起。 当相邻板中的开口正确对准时，在每个化学反应物的入口和用于化学产品的出口之间限定流体通道。 在本发明的一个实施方案中，堆叠十六个简单的板以提供一个结合有三个传热流体路径，两个反应物流体路径，一个产物流体路径，多个混合室，多个反应室，两个反应物预处理热交换器，两个反应室 热交换器和多个温度传感器通路。 反应物流体通道高度的精确尺寸控制能够实现用于反应物的堆叠层流路径，从而允许发生高效和快速的扩散混合。 由于简单的板不包含开口以外的特征，所以容易实现这种板的制造。 不同的反应器设计，具有额外的反应物途径，更多或更少的传热流体途径，更多或更少的热交换器，更多或更少的混合室，更多的更少的反应室和更多或更少的传感器通路可以容易地通过添加或去除板 并且或通过改变所使用的简单板中的开口的图案和数量。 在使用化学反应器的过程中，简单的板可以使用施加在堆叠的相对的外部简单板上的压力，或者可以永久地连接在堆叠中。 用于制造板的优选材料是不锈钢，尽管可以替代地使用其它材料如玻璃，塑料和其它金属，其与选择的反应物和所需产物相容。
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公开(公告)号：US07468165B2
公开(公告)日：2008-12-23
申请号：US10494725
申请日：2002-10-21
申请人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
发明人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/0081 , B01L9/527 , B01L2200/028
摘要： The invention related to a microreactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said microreactor in carrying out a chemical reaction. According to said invention, (a) said mircoreactor system (11) is of modular design, (b) a processing unit (10) is made up of processing modules which are connected to each other by frictional engagement and (c) the fluid connections in said processing unit (10) can be obtained by the frictional connection of said processing modules.
摘要翻译： 本发明涉及用于连续合成的微反应器系统，其提供用于所述合成的限定的反应室和条件，以及所述微反应器在进行化学反应中的用途。 根据所述发明，（a）所述微电机系统（11）具有模块化设计，（b）处理单元（10）由处理模块组成，所述处理模块通过摩擦接合彼此连接，（c）流体连接 在所述处理单元（10）中可以通过所述处理模块的摩擦连接获得。
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公开(公告)号：US07247276B2
公开(公告)日：2007-07-24
申请号：US10343275
申请日：2001-07-25
申请人： Harald Schuppich , Klaus Golbig , Bernd Dittmann
发明人： Harald Schuppich , Klaus Golbig , Bernd Dittmann
CPC分类号： F28F3/048 , B01J19/0093 , B01J2219/00783 , B01J2219/00835 , B01J2219/00873 , B01J2219/00952 , B01J2219/00959 , B01J2219/00961 , B01J2219/00966 , B81B1/00 , F28D3/00 , F28F2260/02
摘要： Described herein is a microreactor for carrying out chemical reactions between a reaction partner in liquid form and a reaction partner in gaseous form, if necessary in the presence of a solid catalyst, whereby the chemical process guidance takes place in spaces that are formed by two or more essentially coplanar plates or layers, with at least one of these plates or layers being a fluid guidance plate (1) that is structured and/or arranged in such a way that the fluid reaction partner flows in at least one essentially uninterrupted capillary thread along the surface of this plate or layer only due to the influence of gravity and/or capillary forces and thereby comes into contact and reacts with the gaseous reaction partner.
摘要翻译： 本文描述的是一种微反应器，用于在固体催化剂存在的情况下，如果需要，在液体形式的反应对象和气态反应对象之间进行化学反应，由此化学过程引导在由两个或 更基本上共面的板或层，其中这些板或层中的至少一个是流体引导板（1），其被构造和/或布置成使得流体反应对象沿着至少一个基本上不间断的毛细管线流动 该板或层的表面仅仅是由于重力和/或毛细管力的影响，从而与气体反应配合物接触并反应。
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公开(公告)号：US06436720B1
公开(公告)日：2002-08-20
申请号：US09662678
申请日：2000-09-15
IPC分类号： G01N110
CPC分类号： B01J19/2415 , B01J19/0093 , B01J2219/00835 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00891 , B01J2219/00934 , B01J2219/0095 , B01J2219/00952 , B01J2219/00984 , Y10T137/0318 , Y10T137/86187 , Y10T137/86196 , Y10T436/2575
摘要： A variable residence time chamber module that provides an additional residence time for a reaction of mixed reactants to reach completion. The module includes a thermally insulated housing in which are disposed a plurality of residence time chambers. A rotary inlet valve and rotary outlet valve select among the plurality of chambers, coupling them respectively to an inlet port through which the mixed but incompletely reacted reactants are supplied and an outlet port through which a desired product of the reaction is withdrawn. A heat transfer media is preferably used to control the temperature of the residence time chambers, so that an optimal reaction temperature is provided. The mixed reactants pass through the inlet valve into a selected one of the plurality of residence time chambers. Once the selected residence time chamber is full, the inlet valve is actuated to supply the mixed reactants to a successive residence time chamber. After the reactants in a filled residence time chamber have completely reacted to form the desired product, the outlet valve is actuated to withdraw the desired product. Because a plurality of different residence time chambers are provided, it is possible for the module to be used with a chemical processing system that produces different products in sequence. Each of the residence time chambers can be filled with a different mixture of reactants. It is then preferable that the valves and empty residence time chambers be flushed with solvent to ensure that no cross-reactions and no contamination occurs among different reactants/products.
摘要翻译： 可变停留时间室模块，为混合反应物的反应达到完成提供额外的停留时间。 该模块包括隔热壳体，其中设置有多个停留时间室。 在多个室中选择旋转入口阀和旋转出口阀，将它们分别连接到供应混合但不完全反应的反应物的入口和出口，通过该出口排出反应的期望产物。 优选使用传热介质来控制停留时间室的温度，从而提供最佳的反应温度。 混合的反应物通过入口阀进入多个停留时间室中的选定的一个。 一旦选定的停留时间室满了，启动入口阀，将混合的反应物供应到连续的停留时间室。 在填充的停留时间室中的反应物已经完全反应以形成所需产物之后，启动出口阀以抽出所需的产物。 由于提供了多个不同的停留时间室，所以可以将模块与依次产生不同产品的化学处理系统一起使用。 每个停留时间室可以填充不同的反应物混合物。 然后优选的是用溶剂冲洗阀和空的停留时间室，以确保不同反应物/产物之间不发生交叉反应和不发生污染。
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公开(公告)号：US07413714B1
公开(公告)日：2008-08-19
申请号：US09617068
申请日：2000-07-16
申请人： Thomas Schwalbe , Klaus Golbig , Michael Hohmann , Andreas Oberbeck , Shahriyar Taghavi-Moghadam
发明人： Thomas Schwalbe , Klaus Golbig , Michael Hohmann , Andreas Oberbeck , Shahriyar Taghavi-Moghadam
IPC分类号： B01J19/24
CPC分类号： C07C233/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00337 , B01J2219/00389 , B01J2219/00495 , B01J2219/0059 , B01J2219/00686 , B01J2219/00689 , B01J2219/00704 , B01J2219/0072 , C40B40/04 , C40B50/08 , C40B60/14 , Y10T436/115831 , Y10T436/12
摘要： An automated sequential reaction system that can be used to either sequentially produce a plurality of different products each requiring a single reaction, or to produce a desired product that requires a series of sequential reactions. A system controller controls an automated reactant supply, a solvent supply, a reaction module, a detector, and a product collector. Prior to initiating any reaction, the system is flushed with solvent and a heat exchanger supplies the reaction module with a temperature-conditioned fluid to maintain the reaction module at a desired temperature. For single reactions, a plurality of reactants are injected into a chemical reactor included in the reaction module. As fluid exits the chemical reactor, the detector determines if the fluid is a desired chemical product or solvent, and routes the fluid to the appropriate receptacle. Once a predetermined volume of a desired product is obtained, the system is flushed with solvent, and a different set of reactants are injected into the chemical reactor to produce the next desired product. The process is repeated until a substance library of the desired products is obtained. For products requiring sequential reaction steps, either a plurality of reactors are employed, or an intermediate product produced by a previous reaction is reintroduced into the reaction module with an appropriate reactant to complete the next sequential reaction.
摘要翻译： 一种自动化顺序反应系统，其可用于顺序地产生多个不同的产物，每个产物需要单次反应，或产生需要一系列顺序反应的所需产物。 系统控制器控制自动反应物供应源，溶剂供应源，反应模块，检测器和产品收集器。 在开始任何反应之前，系统用溶剂冲洗，热交换器向反应模块提供温度调节的流体，以将反应模块保持在所需温度。 对于单次反应，将多个反应物注入包含在反应模块中的化学反应器中。 当流体离开化学反应器时，检测器确定流体是否是期望的化学产品或溶剂，并将流体引导到适当的容器。 一旦获得了预定体积的所需产物，则用溶剂冲洗该系统，并将不同组的反应物注入化学反应器以产生下一个所需产物。 重复该过程，直到获得所需产物的物质文库。 对于需要顺序反应步骤的产物，使用多个反应器，或者通过先前反应产生的中间产物用适当的反应物引入反应模块中以完成下一个顺序反应。
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公开(公告)号：US07241423B2
公开(公告)日：2007-07-10
申请号：US09991377
申请日：2001-11-15
申请人： Klaus Golbig , Volker Autze , Peter Born , Christian Drescher
发明人： Klaus Golbig , Volker Autze , Peter Born , Christian Drescher
IPC分类号： B01J19/00
CPC分类号： B01F5/0604 , B01F13/0059 , B01F13/0064 , B01F13/0066 , B01F13/0093 , B01F13/0094 , B01F13/1013 , B01F13/1022 , B01F15/06 , B01J19/0093 , B01J19/248 , B01J19/249 , B01J2219/00783 , B01J2219/00804 , B01J2219/00835 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00961 , B01J2219/00995 , B01J2219/00997 , B01J2219/2453 , B01J2219/2456 , B01J2219/246 , B01J2219/2462 , B01J2219/2464 , B01J2219/247 , B01J2219/2485 , B01J2219/2486 , B01J2219/2487 , B01J2219/2488 , B01J2219/249 , B01J2219/2493 , B01J2219/2495 , B01J2219/2496 , B01J2219/2497 , F28D9/0093 , F28F2210/02 , F28F2260/02
摘要： A stacked plate chemical reactor in which simple plates are stacked together to form the reactor. When openings in adjacent plates are properly aligned, fluid pathways and processing volumes are defined for chemical reactants, heat transfer medium, and a product. In one embodiment of the invention, an n-fold internal array is achieved by providing a first group of simple plates defining a reaction unit that includes bypass fluid channels and reaction fluid channels for each reactant, such that a portion of each reactant is directed to subsequent groups of simple plates defining additional reaction units. A chemical reactor with variable output is obtained in a preferred embodiment by reversibly joining reactor stacks comprising irreversibly joined reaction units, these reaction units consisting of a plurality of simple plates. Other embodiments employ at least one of an array of parallel fluid channels having different widths, bifurcated fluid distribution channels to achieve a substantially even flow equipartition for fluids with varying viscosities flowing within the fluid channels of each reaction unit.
摘要翻译： 堆叠板式化学反应器，其中简单的板堆叠在一起以形成反应器。 当相邻板中的开口正确对准时，为化学反应物，传热介质和产品定义流体路径和加工体积。 在本发明的一个实施例中，通过提供限定反应单元的第一组简单板来实现n折内部阵列，所述反应单元包括每个反应物的旁路流体通道和反应流体通道，使得每个反应物的一部分被引导到 随后的简单板组定义了额外的反应单元。 通过可逆地连接包括不可逆连接的反应单元的反应堆，在优选的实施方案中获得具有可变输出的化学反应器，这些反应单元由多个简单的板组成。 其他实施例采用具有不同宽度的平行流体通道的阵列中的至少一个，分叉的流体分配通道，以实现在每个反应单元的流体通道内流动的具有变化的粘度的流体的基本均匀的流量均分。
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公开(公告)号：US07056477B1
公开(公告)日：2006-06-06
申请号：US09578224
申请日：2000-05-24
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00867 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0095 , B01J2219/00984 , B01J2219/0099
摘要： A modular chemical production system that preferably includes a microreactor for producing a product by reacting two or more reactants. Modularization enables components such as controllers, pumps, valves, microreactors, and processing modules to be added or removed from the system as required to produce a desired product. A minimum system includes a control module and a reaction module, which has a mixing volume and a reaction volume. Various pumping modules and residence time modules may also be included in the system. Modules can be changed if malfunctioning, or for producing a different product, or to change a quantity of the chemical produced. The control module preferably accesses a database in which data define parameters for a plurality of different reactions that are optimized for the production of different chemical products. The user selects the product desired and the amount of the product, provides the reactants, solvents, and heat transfer media supplies, and the control module operates the system to automatically produce the product until the desired amount is obtained. The reaction module preferably includes a microreactor, which can be replaced with a microreactor of a different configuration to produce a different product. Connections between modules are designed to enable quick connection and disconnection of modules, and fluid lines are self sealing to prevent leakage of fluids when changing modules.
摘要翻译： 模块化化学生产系统，其优选包括用于通过使两种或更多种反应物反应来生产产物的微反应器。 模块化使控制器，泵，阀，微反应器和处理模块等组件可根据需要从系统中添加或移除，以产生所需产品。 最小系统包括具有混合体积和反应体积的控制模块和反应模块。 系统中还可以包括各种泵送模块和停留时间模块。 如果发生故障或生产不同的产品，或者改变生产的化学品的数量，可以改变模块。 控制模块优选地访问数据库，其中数据定义为针对不同化学产品的生产而优化的多个不同反应的参数。 用户选择所需的产品和产品的量，提供反应物，溶剂和传热介质供应，并且控制模块操作系统以自动生产产品，直到获得所需的量。 反应模块优选地包括微反应器，其可以用不同构型的微反应器代替以产生不同的产物。 模块之间的连接被设计成能够快速连接和断开模块，并且流体管线是自密封的，以防止在更换模块时泄漏流体。
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