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公开(公告)号：US08057041B2
公开(公告)日：2011-11-15
申请号：US12374772
申请日：2007-07-23
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. The positioning system (122) comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (410; 910); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.
摘要翻译： 本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。 手持式测量仪器（112）包括测量系统（120）和定位系统（122）。 测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于 推测眼液中分析物的浓度。 定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位 坐标。 定位系统（122）包括以下系统中的至少一个：具有至少一个照相机（410; 910）的相机系统，特别是单目或双目相机系统。 图像识别系统; 三角测量系统; 传播时间测量系统，特别是对于1或2维或3维传播时间测量，特别是使用至少一个激光和/或至少一个相位混合检测器（PMD）; 用于至少一个信号的1，2或3维强度测量系统; 2或3维磁阻测量系统。
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公开(公告)号：USD584975S1
公开(公告)日：2009-01-20
申请号：US29294537
申请日：2008-01-16
申请人： Klaus Haberstroh
设计人： Klaus Haberstroh
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公开(公告)号：US20080169577A1
公开(公告)日：2008-07-17
申请号：US11791252
申请日：2005-09-15
CPC分类号： B29D11/00134 , B29C35/0888 , B29C2035/0827 , B29D11/00442 , B29L2011/0016
摘要： In a process for the production of mouldings, e.g. contact lenses, a starting material which contains a photoinitiator with a spectral absorption (AC) in a given wavelength range is exposed to a predefined amount of light of a wavelength from this given wavelength range. Polymerisation and/or crosslinking of the starting material is thereby initiated, and in this way a demouldable moulding is formed The intensity of light is measured, to which end a broadband photoreceiver (511) is used, in front of which receiver a filter (510) is arranged, the transmission (TC1, TC2, TC3; TC4) of which is designed such that the light passing through the filter (510) and impinging on the photoreceiver (511) corresponds in its intensity to the light absorbed by the photoinitiator based on its spectral absorption (AC) at the wavelength from the given wavelength range.
摘要翻译： 在制造模制品的方法中，例如， 隐形眼镜包含在给定波长范围内具有光谱吸收（AC）的光引发剂的起始材料暴露于从该给定波长范围的预定量的波长的光。 由此开始原料的聚合和/或交联，并且以这种方式形成可脱模的模制物。测量光的强度，使用宽带光接收器（511）向该光强度的前面，在该接收器的前面设置滤光器（510 ），透射（TC 1，TC 2，TC 3; TC 4）被设计成使得通过滤光器（510）并且照射在光接收器（511）上的光的强度对应于吸收的光 通过光引发剂基于其在给定波长范围的波长处的光谱吸收（AC）。
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公开(公告)号：US20060155179A1
公开(公告)日：2006-07-13
申请号：US10545220
申请日：2004-02-13
申请人： Achim Muller , Roland Schmieder , Klaus Haberstroh
发明人： Achim Muller , Roland Schmieder , Klaus Haberstroh
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/6821
摘要： The present invention relates to a hand-held fluorescence photometer and method for measuring an analyte level, preferably a blood glucose level, from an ocular fluid. The photometer is based on a dual beams measuring system and it is capable of defining the correct positioning for the measurement. Only when the apparatus is correctly positioned the actual analyte measurement automatically takes place.
摘要翻译： 本发明涉及用于从眼液测量分析物水平，优选血糖水平的手持荧光光度计和方法。 光度计基于双光束测量系统，它能够定义测量的正确定位。 只有当设备正确定位时，才会自动进行实际的分析物测量。
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公开(公告)号：US08563326B2
公开(公告)日：2013-10-22
申请号：US12933832
申请日：2009-03-31
申请人： Klaus Haberstroh , Konrad Faulstich
发明人： Klaus Haberstroh , Konrad Faulstich
IPC分类号： G01N33/53
CPC分类号： G01N21/03 , B01L3/50857 , B01L3/5088 , B01L2200/142 , B01L2300/04 , B01L2300/0822 , B01L2300/0861 , B01L2300/161 , G01N21/25 , G01N21/278 , G01N21/64 , G01N21/76 , G01N35/00029 , G01N2021/0325 , G01N2021/0346 , G01N2021/035 , G02B21/34
摘要： A sample holder, such as a microscope slide, is provided in the form of a card-shaped substrate or plate, preferably for use in an analytical reader. The sample holder comprises at least one hole, preferably a plurality of holes, for receiving a sample to be analyzed. The at least one hole extends completely through the substrate and is sized such that the sample is held within the at least one hole by means of the surface tension of the sample against the force of gravity. Optionally the substrate comprises a first upper substrate and a second lower substrate that together embed a porous membrane. As a further option the sample holder comprises a first cover attached to the top side of the first upper substrate and/or a second cover attached to the bottom side of the second lower substrate. Moreover a method for using such a sample holder in an analytical reader is provided, comprising the steps of: filling the at least one hole of the sample holder with a sample and reagent mixture; inserting the sample holder in the analytical reader; and analyzing the sample and reagent mixture in the at least one hole of the sample holder with the analytical reader.
摘要翻译： 样品架（例如显微镜载玻片）以卡形基板或板的形式提供，优选用于分析读取器。 样品架包括用于接收待分析样品的至少一个孔，优选多个孔。 所述至少一个孔完全延伸穿过基底，并且其尺寸设计成使得样品通过样品的表面张力抵抗重力而保持在至少一个孔内。 可选地，基底包括一起嵌入多孔膜的第一上基底和第二下基底。 作为另一选择，样品架包括附接到第一上基板的顶侧的第一盖和/或附接到第二下基板的底侧的第二盖。 此外，提供了一种在分析读取器中使用这种样品保持器的方法，包括以下步骤：用样品和试剂混合物填充样品架的至少一个孔; 将样品架插入分析读数器; 并用分析读取器分析样品架的至少一个孔中的样品和试剂混合物。
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6.发明授权公开(公告)号：US06878947B2
公开(公告)日：2005-04-12
申请号：US10666559
申请日：2003-09-22
申请人： Klaus Haberstroh
发明人： Klaus Haberstroh
CPC分类号： A61B5/1455 , A61B5/0002 , A61B5/14532 , A61B5/1495 , A61B2560/0456 , G01J3/02 , G01J3/0202 , G01J3/0237 , G01J3/0256 , G01J3/0272 , G01J3/0283 , G01J3/36 , G01J3/4406
摘要： A device for the simultaneous detection of radiation of different wavelength, comprising a number of base modules arranged one on top of the other, an optical module and an electronic module. One device each for reflecting and/or deflecting radiation of a determined wavelength-range is provided in the base modules. The light-detecting elements are associated with one of the devices each. The invention also relates to a base module, a charging unit, a method for adjusting the device and to the use of the device.
摘要翻译： 一种用于同时检测不同波长的辐射的装置，包括一个在另一个顶部上布置的多个基本模块，光学模块和电子模块。 在基本模块中设置有用于反射和/或偏转所确定的波长范围的辐射的一个装置。 光检测元件与每个装置中的一个相关联。 本发明还涉及基本模块，充电单元，用于调节装置的方法和装置的使用。
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公开(公告)号：US20110067489A1
公开(公告)日：2011-03-24
申请号：US12933832
申请日：2009-03-31
申请人： Klaus Haberstroh , Konrad Faulstic
发明人： Klaus Haberstroh , Konrad Faulstic
CPC分类号： G01N21/03 , B01L3/50857 , B01L3/5088 , B01L2200/142 , B01L2300/04 , B01L2300/0822 , B01L2300/0861 , B01L2300/161 , G01N21/25 , G01N21/278 , G01N21/64 , G01N21/76 , G01N35/00029 , G01N2021/0325 , G01N2021/0346 , G01N2021/035 , G02B21/34
摘要： A sample holder, such as a microscope slide, is provided in the form of a card-shaped substrate or plate, preferably for use in an analytical reader. The sample holder comprises at least one hole, preferably a plurality of holes, for receiving a sample to be analyzed. The at least one hole extends completely through the substrate and is sized such that the sample is held within the at least one hole by means of the surface tension of the sample against the force of gravity. Optionally the substrate comprises a first upper substrate and a second lower substrate that together embed a porous membrane. As a further option the sample holder comprises a first cover attached to the top side of the first upper substrate and/or a second cover attached to the bottom side of the second lower substrate. Moreover a method for using such a sample holder in an analytical reader is provided, comprising the steps of: filling the at least one hole of the sample holder with a sample and reagent mixture; inserting the sample holder in the analytical reader; and analyzing the sample and reagent mixture in the at least one hole of the sample holder with the analytical reader.
摘要翻译： 样品架（例如显微镜载玻片）以卡形基板或板的形式提供，优选用于分析读取器。 样品架包括用于接收待分析样品的至少一个孔，优选多个孔。 所述至少一个孔完全延伸穿过基底，并且其尺寸设计成使得样品通过样品的表面张力抵抗重力而保持在至少一个孔内。 可选地，基底包括一起嵌入多孔膜的第一上基底和第二下基底。 作为另一选择，样品架包括附接到第一上基板的顶侧的第一盖和/或附接到第二下基板的底侧的第二盖。 此外，提供了一种在分析读取器中使用这种样品保持器的方法，包括以下步骤：用样品和试剂混合物填充样品架的至少一个孔; 将样品架插入分析读数器; 并用分析读取器分析样品架的至少一个孔中的样品和试剂混合物。
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公开(公告)号：US20100063371A1
公开(公告)日：2010-03-11
申请号：US12374866
申请日：2007-07-23
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.
摘要翻译： 本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。 手持式测量仪器（112）包括测量系统（120）和定位系统（122）。 测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于 推测眼液中分析物的浓度。 定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位 坐标。 此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据 使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。
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公开(公告)号：US08704158B2
公开(公告)日：2014-04-22
申请号：US12937009
申请日：2009-04-17
申请人： Klaus Haberstroh , Konrad Faulstich
发明人： Klaus Haberstroh , Konrad Faulstich
CPC分类号： G01N21/278 , B01L3/50857 , B01L3/5088 , B01L2200/148 , B01L2300/0822 , B01L2300/0829 , G01K11/14 , G01N1/28 , G01N21/6452 , G01N2001/2893 , G01N2015/1018 , G01T1/362 , Y10T436/10
摘要： The invention concerns fluorescence standards, and in particular fluorescence standards for calibrating optical detectors. According to the invention, a fluorescent mineral or mixtures of minerals are employed for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral or a synthetically produced mineral. Preferred fluorescent minerals for use as fluorescence standards are corundum, fluorite, turquoise, amber, zircon, zoisite, iolite or cordierite, spinel, topaz, calcium fluorite, sphalerite or zincblende, calcite or calcspar, apatite, scheelite or calcium tungstate, willemite, feldspars, sodalite, a uranium mineral, a mineral containing Al3+, and in particular ruby and sapphire.
摘要翻译： 本发明涉及荧光标准，特别是用于校准光学检测器的荧光标准。 根据本发明，荧光矿物或矿物质的混合物用作荧光标准。 荧光矿物可以是天然存在的矿物质或合成产生的矿物质。 用作荧光标准的优选的荧光矿物是刚玉，萤石，绿松石，琥珀，锆石，堇青石，石英或堇青石，尖晶石，黄玉，萤石，闪锌矿或闪锌矿，方解石或钙质，磷灰石，白钨矿或钨酸钙，硅锌矿，长石 ，钠盐，铀矿物质，含有Al3 +的矿物，特别是红宝石和蓝宝石。
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公开(公告)号：US08452363B2
公开(公告)日：2013-05-28
申请号：US12374866
申请日：2007-07-23
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223
摘要： The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.
摘要翻译： 本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。 手持式测量仪器（112）包括测量系统（120）和定位系统（122）。 测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于 推断眼液中分析物的浓度。 定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位 坐标。 此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据 使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。
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