公开(公告)号：US20050228188A1

公开(公告)日：2005-10-13

申请号：US10511829

申请日：2003-04-28

Applicant: Motoo Sumida ,  Masahiro Nakao ,  Namino Tomimori ,  Koshi Namikawa ,  Harukazu Fukami

Inventor： Motoo Sumida ,  Masahiro Nakao ,  Namino Tomimori ,  Koshi Namikawa ,  Harukazu Fukami

IPC: A23L1/29 ,  A23L1/30 ,  A61K8/37 ,  A61Q1/06 ,  C07C403/24 ,  C12P7/62 ,  C12P7/64 ,  C12P23/00 ,  C07C57/26

CPC classification number: C07C403/24 ,  A23L33/10 ,  A23L33/115 ,  A61K8/37 ,  A61Q1/06 ,  C12P7/62 ,  C12P7/6436 ,  C12P7/6454 ,  C12P23/00

Abstract: The present invention provides an astaxanthin medium-chain fatty acid ester, which is expected to be applied in the fields of food, cosmetics and pharmaceuticals, and has higher digestibility and tissue penetration than long chain fatty acid ester form astaxanthins. When the synthesis of an astaxanthin medium-chain fatty acid ester is attempted using the catalytic action of lipase by conventional methods, ester cannot be formed. However, according to the present invention, a composition comprising an astaxanthin medium-chain fatty acid monoester and/or diester is produced by adding a certain amount of water into a reaction system and reacting an astaxanthin or a long chain fatty acid ester thereof with a medium-chain fatty acid, a triglyceride thereof or a suitable ester. Moreover, these monoesters and/or diesters are isolated, as necessary. The present invention further provides food or cosmetics comprising the composition of the present invention.

Abstract translation: 本发明提供了一种预期用于食品，化妆品和药物领域的虾青素中链脂肪酸酯，并且比长链脂肪酸酯形式的虾青素具有更高的消化率和组织穿透性。 当通过常规方法尝试使用脂肪酶的催化作用来合成虾青素中链脂肪酸酯时，不能形成酯。 然而，根据本发明，通过向反应体系中加入一定量的水并使虾青素或其长链脂肪酸酯与一种虾青素或其长链脂肪酸酯反应而制备包含虾青素中链脂肪酸单酯和/或二酯的组合物 中链脂肪酸，其甘油三酯或合适的酯。 此外，根据需要分离这些单酯和/或二酯。 本发明还提供包含本发明组合物的食品或化妆品。

公开(公告)号：US20050004092A1

公开(公告)日：2005-01-06

申请号：US10831694

申请日：2004-04-26

Applicant: Masaji Ishiguro ,  Takashi Nakatsuka ,  Rie Tanaka ,  Koshi Namikawa ,  Shinsuke Matsuki

Inventor： Masaji Ishiguro ,  Takashi Nakatsuka ,  Rie Tanaka ,  Koshi Namikawa ,  Shinsuke Matsuki

IPC: C07D499/74 ,  C07D499/88 ,  A61K31/43

CPC classification number: C07D499/88 ,  Y02P20/55

Abstract: A penem derivative represented by the following formula (I): wherein R1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted alkenylthio group, a substituted or unsubstituted aralkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted heterocyclic thio group, a substituted or unsubstituted acylthio group, a mercapto group or a hydrogen atom, and R2 represents a hydrogen atom or a carboxyl-protecting group; or a pharmacologically acceptable salt thereof. The compound (I) exhibits strong antibacterial activities, and especially, shows strong activities against MRSA. It is therefore useful not only as a general antibacterial agent but also as an antibacterial agent for MRSA against which no general antibacterial agents are recognized to be-effective.

Abstract translation: 由下式（I）表示的pen嗪衍生物：其中R1表示取代或未取代的烷基，取代或未取代的烯基，取代或未取代的芳烷基，取代或未取代的芳基，取代或未取代的烷硫基， 取代或未取代的链烯硫基，取代或未取代的芳烷硫基，取代或未取代的芳硫基，取代或未取代的杂环基，取代或未取代的杂环硫基，取代或未取代的酰硫基，巯基或氢原子 R 2表示氢原子或羧基保护基; 或其药理学上可接受的盐。 化合物（I）表现出强烈的抗菌活性，特别是对MRSA具有较强的活性。 因此，不仅可以作为一般的抗菌剂，而且作为MRSA的抗菌剂也是有用的，其中没有一般的抗菌剂被认为是有效的。

公开(公告)号：US07556829B2

公开(公告)日：2009-07-07

申请号：US10592426

申请日：2005-03-11

Applicant: Mitsuru Maeda ,  Harukazu Fukami ,  Koshi Namikawa

Inventor： Mitsuru Maeda ,  Harukazu Fukami ,  Koshi Namikawa

IPC: A61K36/00

CPC classification number: C09B61/00 ,  A01N43/16 ,  A01N65/18 ,  A23L3/44 ,  A23L5/43 ,  A61K8/498 ,  A61K8/97 ,  A61K36/47 ,  A61K2800/43 ,  A61Q1/02

Abstract: An object of the present invention is to provide a Mallotus philippinensis extract containing readily water soluble rottlerin. A further object of the present invention is to improve convenience at production steps in a method for producing such an extract, by avoiding the staining of filters and/or pipes during extraction and filtration to reduce washing costs, or by facilitating the introduction of freeze drying and so on. When a dye extract is extracted with water and alcohol from a Mallotus philippinensis plant body, the addition of a base component drastically improves the water solubility of the Mallotus philippinensis extract. This improves extraction rates of rottlerin, facilitates washing in the production and the pulverization of the extract, and also improves the water solubility of the obtained extract.

Abstract translation: 本发明的一个目的是提供一种含有易溶于水溶性罗丹亭的马洛替尼（Mallotus philippinensis）提取物。 本发明的另一个目的是通过避免在提取和过滤期间过滤器和/或管道的污染以降低洗涤成本，或者通过促进冷冻干燥的引入来提高生产这种提取物的方法的生产步骤的便利性 等等。 当从Mallotus philippinensis植物体中用水和酒精提取染料提取物时，添加碱性成分可显着提高Mal蛇提取物的水溶性。 这提高了转铁蛋白的提取率，促进了生产中的洗涤和提取物的粉碎，并且还提高了所得提取物的水溶性。

公开(公告)号：US20070207219A1

公开(公告)日：2007-09-06

申请号：US10592426

申请日：2005-03-11

Applicant: Mitsuru Maeda ,  Harukazu Fukami ,  Koshi Namikawa

Inventor： Mitsuru Maeda ,  Harukazu Fukami ,  Koshi Namikawa

IPC: A61K36/185

CPC classification number: C09B61/00 ,  A01N43/16 ,  A01N65/18 ,  A23L3/44 ,  A23L5/43 ,  A61K8/498 ,  A61K8/97 ,  A61K36/47 ,  A61K2800/43 ,  A61Q1/02

Abstract: An object of the present invention is to provide a Mallotus philippinensis extract containing readily water soluble rottlerin. A further object of the present invention is to improve convenience at production steps in a method for producing such an extract, by avoiding the staining of filters and/or pipes during extraction and filtration to reduce washing costs, or by facilitating the introduction of freeze drying and so on. When a dye extract is extracted with water and alcohol from a Mallotus philippinensis plant body, the addition of a base component drastically improves the water solubility of the Mallotus philippinensis extract. This improves extraction rates of rottlerin, facilitates washing in the production and the pulverization of the extract, and also improves the water solubility of the obtained extract.

Abstract translation: 本发明的一个目的是提供一种含有易溶于水溶性罗丹亭的马洛替尼（Mallotus philippinensis）提取物。 本发明的另一个目的是通过避免在提取和过滤期间过滤器和/或管道的污染以降低洗涤成本，或者通过促进冷冻干燥的引入来提高生产这种提取物的方法的生产步骤的便利性 等等。 当从Mallotus philippinensis植物体中用水和酒精提取染料提取物时，添加碱性成分可显着提高Mal蛇提取物的水溶性。 这提高了转铁蛋白的提取率，促进了生产中的洗涤和提取物的粉碎，并且还提高了所得提取物的水溶性。

公开(公告)号：US20080058409A1

公开(公告)日：2008-03-06

申请号：US11795959

申请日：2006-01-25

Applicant: Harukazu Fukami ,  Masahiro Nakao ,  Koshi Namikawa ,  Mitsuru Maeda

Inventor： Harukazu Fukami ,  Masahiro Nakao ,  Koshi Namikawa ,  Mitsuru Maeda

IPC: A61K31/352 ,  A61P31/04 ,  C07D311/04 ,  C12P17/06

CPC classification number: C12P17/06 ,  A01N43/16 ,  A23L3/3472 ,  A23L3/3517 ,  A61K8/498 ,  A61Q17/005 ,  C07D311/62

Abstract: The present invention provides substances having sufficiently antibacterial activity against heat-resistant spore-forming bacteria that they can be used to improve the shelf life of beverages and processed foods, as well as to control the growth of microorganisms in cosmetics. The present invention provides a catechin ester in which at least one of the hydroxyl groups of a catechin is esterified with a medium-chain fatty acid. This medium-chain fatty acid ester of a catechin, which may be used either alone or as a composition, shows a strong growth suppressing effect on heat-resistant spore-forming bacteria and, if added to foods or beverages, can prevent them from rotting or deterioration and, if added to cosmetics, can prevent their rotting or deterioration.

Abstract translation: 本发明提供对耐热孢子形成细菌具有足够抗菌活性的物质，它们可用于改善饮料和加工食品的保质期，以及控制化妆品中微生物的生长。 本发明提供一种儿茶素酯，其中儿茶素的至少一个羟基与中链脂肪酸酯化。 可以单独或作为组合物使用的儿茶素的该中链脂肪酸酯对耐热孢子形成细菌具有强烈的生长抑制作用，如果添加到食品或饮料中，可以防止它们的腐烂 或变质，如果添加到化妆品中，可以防止其腐烂或变质。