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公开(公告)号：US11764031B2
公开(公告)日：2023-09-19
申请号：US17425420
申请日：2020-01-30
CPC分类号： H01J37/222 , H01J37/28 , H01J2237/2802
摘要： The present invention concerns a method and a system for imaging at least a part of a specimen by means of two microscopy imaging methods, where a surface (11) of the specimen (10) is imaged by means of a first microscopy imaging method, where a replica (25) of the surface (11) to be imaged by means of the first microscopy imaging method is produced and this replica (25) is simultaneously imaged by means of a second microscopy imaging method, where the images produced by means of the first and the second microscopy imaging methods are overlaid at the correct scale.
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公开(公告)号：US20230120051A1
公开(公告)日：2023-04-20
申请号：US18045179
申请日：2022-10-10
发明人： Heinz Plank , Tim Laugks , Ulrike Laugks , Roland Thuenauer
IPC分类号： G01N1/42
摘要： A sample holder for holding a sample carrier carrying a sample includes a sample carrier fixing element. The sample carrier fixing element includes a first section configured, when in a first position, to fix the sample carrier to the sample holder, and, when in a second position, to release the sample carrier or to provide access to an area where the sample carrier is to be located. The sample carrier fixing element also includes a second section different from the first section, the second section being operable such that upon operation of the second section the first section switches from the first position into the second position or from the second position into the first position.
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公开(公告)号：US20230045321A1
公开(公告)日：2023-02-09
申请号：US17873266
申请日：2022-07-26
发明人： Reinhard LIHL
摘要： A system (100) for loading a sample into and/or manipulating a sample in a sample transfer device (180) at cryogenic temperatures, comprising the sample transfer device (180) being configured to receive a sample through a receiving opening (182) of the sample transfer device (180) and configured to transfer the sample to a processing or analysing unit, and a dry box (110) having an interface opening (112) and being configured to be coupled to the sample transfer device (180) such that the interface opening (112) of the dry box (110) is located opposite the receiving opening (182) of the sample transfer device (180).
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公开(公告)号：US20220074834A1
公开(公告)日：2022-03-10
申请号：US17460383
申请日：2021-08-30
发明人： Rainer WOGRITSCH , Paul WURZINGER
摘要： The present disclosure relates to a device (10) for preparing a microscopic sample (1) for a high-pressure freezing process in which the sample (1) is provided using an arrangement comprising a middle plate (33) of a high-pressure freezing cartridge (30) and an incubation chamber (100, 200), the middle plate (33) being attached to the incubation chamber (100, 200) and being detachable from the incubation chamber (100, 200) by effecting a relative movement between the middle plate (33) and the incubation chamber (100, 200), and the sample (1) being provided on an enclosing element (37) which is fitted into an opening (36) of the middle plate (33), wherein the device (10) comprises an engagement structure (11, 21) adapted to engage with the middle plate (33) and to restrict a movement of the middle plate (33) while the incubation chamber (100, 200) is moved, such as to effect said relative movement between the middle plate (33) and the incubation chamber (100, 200) and to thereby detach the middle plate (33) from the incubation chamber (100, 200). Also, an incubation chamber (100, 200), a middle plate (33) of a high-pressure freezing cartridge (30), an arrangement comprising these components, and a corresponding method are part of the present disclosure.
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公开(公告)号：US10520398B2
公开(公告)日：2019-12-31
申请号：US14991631
申请日：2016-01-08
发明人： Reinhard Lihl , Michael Zimmermann
摘要： A microtome system has a cryomicrotome with a sectioning device in which is provided a preparation holder and a knife edge that are guided past one another inside a working space during a sectioning operation, in order to produce thin sections of a preparation retained in the preparation holder. A micromanipulator is operable outside the working space. With the micromanipulator, a tool for retention of a specimen support is positioned proximate the knife edge during a sectioning operation in order to receive the sections that are produced, preferably for substantially stationary retention of the specimen support.
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公开(公告)号：US20160030941A1
公开(公告)日：2016-02-04
申请号：US14804942
申请日：2015-07-21
发明人： Reinhard LIHL , Leander GAECHTER , John BRIGGS , Martin SCHORB
IPC分类号： B01L9/00
CPC分类号： B01L9/00 , B01L7/50 , B01L9/50 , B01L2200/025 , B01L2200/087 , B01L2200/185 , B01L2300/041 , B01L2300/0609
摘要： In a manipulation container (1) for cryomicroscopy, having at least one holder (9) for a sample carrier mount (7) and at least one manipulation opening (2) for manipulating sample carriers or sample carrier mounts (7), the holder (9) for a sample carrier mount (7) is movable into a displacement path (11), passing completely through the manipulation container (1), of a displacement apparatus (3) for the sample carrier mount (7).
摘要翻译： 在用于冷冻显微镜的操作容器（1）中，具有至少一个用于样品载体安装件（7）的保持器（9）和用于操纵样品载体或样品载体安装件（7）的至少一个操纵开口（2） 用于样品载体安装件（7）的移动装置（7）可移动到位移路径（11）中，完全穿过操作容器（1），用于样品载体安装件（7）的位移设备（3）。
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公开(公告)号：US20130319328A1
公开(公告)日：2013-12-05
申请号：US13906444
申请日：2013-05-31
发明人： Paul WURZINGER , Anton LANG
IPC分类号： H01J37/26
CPC分类号： H01J37/261 , C23C14/24 , C23C14/54
摘要： An apparatus (100, 200) for coating specimens comprises a vacuum chamber (105, 205); at least one source, associated with the vacuum chamber, of a coating material; at least one sample holder (120) for positioning at least one sample within the vacuum chamber; an electronic control system; an operating console (103, 203) for inputting instructions for the electronic control system; and a housing (101, 201) surrounding at least the vacuum chamber and the electronic control system. The housing has a width (b, b″) that substantially corresponds to the width (b′) of the vacuum chamber. The vacuum chamber comprises a door (106, 206) on a front side of the chamber. The operating console is located in or in front of a base region (102, 202) of the housing. The at least one source is installable on an upper side of the vacuum chamber.
摘要翻译： 用于涂覆试样的装置（100,200）包括真空室（105,205）; 与真空室相关联的至少一个源，涂覆材料; 用于将至少一个样品定位在所述真空室内的至少一个样品保持器（120） 电子控制系统; 操作台（103,203），用于输入电子控制系统的指令; 以及至少包围真空室和电子控制系统的壳体（101,201）。 壳体具有基本上对应于真空室的宽度（b'）的宽度（b，b“）。 真空室包括位于室前侧的门（106,206）。 操作控制台位于壳体的基部区域（102,202）中或前面。 该至少一个源可安装在真空室的上侧。
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8.发明申请公开(公告)号：US20130227970A1
公开(公告)日：2013-09-05
申请号：US13778720
申请日：2013-02-27
发明人： Reinhard LIHL , Rainer WOGRITSCH , Heinz PLANK
IPC分类号： G01N1/42
CPC分类号： G01N1/42 , B29C45/0053 , B29C2045/0075 , B29K2083/005 , G01Q30/10 , G02B7/007 , G21K7/00
摘要： In a device (1) for rapid pressure-freezing an aqueous sample (3), such as a biological specimen, a pressurized cooling medium can be fed into a high-pressure chamber (11) into which a sample holder (30) containing a sample (3) is inserted and which is sealed with a pressure-tight seal, to the location of the sample holder (30) held therein. The high-pressure chamber (11) comprises a viewing window structure (2) with a pressure-tight window (20), through which light can be directed from the outside onto the sample (3) located in the sample holder (30). The window (20) can comprise a transparent window element made of a high-pressure-resistant material, wherein the window element (20) is held by a pressure- and temperature-resistant window bearing provided in the high-pressure chamber.
摘要翻译： 在用于快速冷冻含水样品（3）（例如生物样品）的装置（1）中，加压冷却介质可以被供给到高压室（11）中，其中含有 将样品（3）插入并且用耐压密封件密封到保持在其中的样品保持器（30）的位置。 高压室（11）包括具有耐压窗（20）的观察窗结构（2），光可从外部引导到位于样品架（30）中的样品（3）上。 窗口（20）可以包括由耐高压材料制成的透明窗口元件，其中窗口元件（20）由设置在高压室中的耐压耐温窗口轴承保持。
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9.发明公开公开(公告)号：US20240075476A1
公开(公告)日：2024-03-07
申请号：US18460717
申请日：2023-09-05
发明人： Michael ZIMMERMANN
IPC分类号： B01L3/00
CPC分类号： B01L3/5085
摘要： A sample holder for holding a sample carrier for carrying a microscopic sample is provided. The sample holder includes a clamping arrangement with an upper leg and a lower leg. The clamping arrangement is configured to clamp the sample carrier between the upper leg and the lower leg, such that a part of the sample carrier is clamped between respective first ends of the upper leg and the lower leg. The clamping arrangement is also configured to be actuated by an external force such that the respective first ends of the upper and lower leg are separated from each other. The clamping arrangement is also configured to exert a clamping force via the respective first ends of the upper and lower leg to the sample carrier to clamp the sample carrier between the upper and lower leg, when the clamping arrangement is not actuated by the external force.
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10.发明公开公开(公告)号：US20230386779A1
公开(公告)日：2023-11-30
申请号：US18320212
申请日：2023-05-19
发明人： Thomas Pfeifer , Heinz Plank , Miriam Weller , Konrad Winkler , Rainer Wogritsch
IPC分类号： H01J37/20
CPC分类号： H01J37/20 , H01J2237/204 , H01J2237/2007
摘要： A sample holder includes a main component comprising a first surface area, and a retaining mechanism comprising a holding component. The retaining mechanism is configured to retain a sample between the holding component of the retaining mechanism and the first surface area in a closed state of the retaining mechanism. The retaining mechanism is further configured to enter an opened state upon mechanical actuation of the retaining mechanism. The opened state allows insertion and removal of the sample. The retaining mechanism is further configured to revert to the closed state once the mechanical actuation is removed.
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