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公开(公告)号：US20160178487A1
公开(公告)日：2016-06-23
申请号：US14953313
申请日：2015-11-28
发明人： Reinhard LIHL , Michael ZIMMERMANN
CPC分类号： G01N1/286 , G01N1/42 , G01N2001/2873
摘要： A freeze fracture machine (100) comprises a vacuum chamber (110); a sample receptacle (160) for receiving a sample to be processed and a knife receptacle (150) for receiving a knife (110) for processing of the sample arranged in the vacuum chamber (155); a transfer lock (130) on the vacuum chamber (110) through which a sample and a knife (155) are introducible into the vacuum chamber (155) and positionable in the vacuum chamber (110) by means of a positioning apparatus (135); the sample and the sample receptacle (160) being positionable with respect to one another such that the sample is mountable on the sample receptacle (160) by means of the positioning apparatus (135); and the knife (155) and the knife receptacle (150) being positionable with respect to one another such that the knife (155) is mountable on the knife receptacle (150) by means of the positioning apparatus (135).
摘要翻译： 冷冻断裂机（100）包括真空室（110）; 用于接收待处理样品的样品容器（160）和用于接收用于处理设置在真空室（155）中的样品的刀具的刀容器）。 真空室（110）上的传送锁（130），样品和刀（155）通过该传送锁（130）被引入真空室155并且可通过定位装置135定位在真空室110中， ; 样品和样品容器（160）可相对于彼此定位，使得样品可通过定位装置（135）安装在样品容器（160）上; 并且所述刀（155）和所述刀座（150）能够相对于彼此定位，使得所述刀（155）可通过所述定位装置（135）安装在所述刀座上。
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2.发明申请公开(公告)号：US20180290144A1
公开(公告)日：2018-10-11
申请号：US15943763
申请日：2018-04-03
摘要： The invention relates to a holding apparatus (100) for sample carriers (200) for use in cryomicroscopy, encompassing: a body having at least one sample carrier receptacle that comprises at least one sample carrier support surface against which at least one sample carrier (200) is abuttable; at least one first sample carrier holding means (121); and at least one second sample carrier holding means (131) that is configured to impinge upon the sample carrier (200) with force against the first sample carrier holding means (121); and to an arrangement having a manipulation container and such a holding apparatus (100), and to methods for introducing and withdrawing a sample carrier (200).
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公开(公告)号：US20170213694A1
公开(公告)日：2017-07-27
申请号：US15329716
申请日：2015-07-15
发明人： Reinhard LIHL , Leander GAECHTER
CPC分类号： H01J37/20 , G01N1/06 , G01N1/32 , G01N1/42 , G02B21/00 , H01J37/18 , H01J37/26 , H01J2237/16 , H01J2237/20221 , H01J2237/262
摘要： A loading station (100, 200) for translocating a frozen sample for electron microscopy, encompassing a chamber (104, 204), open toward the top, that is fillable at least partly with a coolant, the chamber (104, 204) comprising in its side wall at least two ports (101a, 102a, 103a) each for different sample transfer devices (101, 102, 103), the ports (101a, 102a, 103a) permitting introduction of a frozen sample into the chamber (104, 204) via a selected sample transfer device and withdrawal of a frozen sample from the chamber via a respective different sample transfer device; and wherein a receptacle (108, 208) for at least two differently configured sample holders (109, 110) is arranged in the chamber (104, 204), the at least two sample holders (109, 110) being detachably fastenable to at least one of the sample transfer devices (101) for introduction of the frozen sample into the chamber (104, 204) and for withdrawal of the frozen sample from the chamber (104, 204).
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公开(公告)号：US20230045321A1
公开(公告)日：2023-02-09
申请号：US17873266
申请日：2022-07-26
发明人： Reinhard LIHL
摘要： A system (100) for loading a sample into and/or manipulating a sample in a sample transfer device (180) at cryogenic temperatures, comprising the sample transfer device (180) being configured to receive a sample through a receiving opening (182) of the sample transfer device (180) and configured to transfer the sample to a processing or analysing unit, and a dry box (110) having an interface opening (112) and being configured to be coupled to the sample transfer device (180) such that the interface opening (112) of the dry box (110) is located opposite the receiving opening (182) of the sample transfer device (180).
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公开(公告)号：US20160030941A1
公开(公告)日：2016-02-04
申请号：US14804942
申请日：2015-07-21
发明人： Reinhard LIHL , Leander GAECHTER , John BRIGGS , Martin SCHORB
IPC分类号： B01L9/00
CPC分类号： B01L9/00 , B01L7/50 , B01L9/50 , B01L2200/025 , B01L2200/087 , B01L2200/185 , B01L2300/041 , B01L2300/0609
摘要： In a manipulation container (1) for cryomicroscopy, having at least one holder (9) for a sample carrier mount (7) and at least one manipulation opening (2) for manipulating sample carriers or sample carrier mounts (7), the holder (9) for a sample carrier mount (7) is movable into a displacement path (11), passing completely through the manipulation container (1), of a displacement apparatus (3) for the sample carrier mount (7).
摘要翻译： 在用于冷冻显微镜的操作容器（1）中，具有至少一个用于样品载体安装件（7）的保持器（9）和用于操纵样品载体或样品载体安装件（7）的至少一个操纵开口（2） 用于样品载体安装件（7）的移动装置（7）可移动到位移路径（11）中，完全穿过操作容器（1），用于样品载体安装件（7）的位移设备（3）。
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6.发明申请公开(公告)号：US20130227970A1
公开(公告)日：2013-09-05
申请号：US13778720
申请日：2013-02-27
发明人： Reinhard LIHL , Rainer WOGRITSCH , Heinz PLANK
IPC分类号： G01N1/42
CPC分类号： G01N1/42 , B29C45/0053 , B29C2045/0075 , B29K2083/005 , G01Q30/10 , G02B7/007 , G21K7/00
摘要： In a device (1) for rapid pressure-freezing an aqueous sample (3), such as a biological specimen, a pressurized cooling medium can be fed into a high-pressure chamber (11) into which a sample holder (30) containing a sample (3) is inserted and which is sealed with a pressure-tight seal, to the location of the sample holder (30) held therein. The high-pressure chamber (11) comprises a viewing window structure (2) with a pressure-tight window (20), through which light can be directed from the outside onto the sample (3) located in the sample holder (30). The window (20) can comprise a transparent window element made of a high-pressure-resistant material, wherein the window element (20) is held by a pressure- and temperature-resistant window bearing provided in the high-pressure chamber.
摘要翻译： 在用于快速冷冻含水样品（3）（例如生物样品）的装置（1）中，加压冷却介质可以被供给到高压室（11）中，其中含有 将样品（3）插入并且用耐压密封件密封到保持在其中的样品保持器（30）的位置。 高压室（11）包括具有耐压窗（20）的观察窗结构（2），光可从外部引导到位于样品架（30）中的样品（3）上。 窗口（20）可以包括由耐高压材料制成的透明窗口元件，其中窗口元件（20）由设置在高压室中的耐压耐温窗口轴承保持。
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公开(公告)号：US20170227752A1
公开(公告)日：2017-08-10
申请号：US15329704
申请日：2015-07-15
发明人： Reinhard LIHL , John BRIGGS , Martin SCHORB , Leander GAECHTER
摘要： In a light microscope (1) for cryomicroscopy, encompassing at least an objective (2) and a sample stage (3) having a cutout (7) for a coolable holder (8) for a sample carrier mount, the cutout (7) being covered by a cover (6), the sample stage (3) is displaceable in two horizontal directions (4). The cover (6) rests floatingly on the sample stage (3), and the objective (2) passes through a cutout (12), corresponding to the objective (2), in the cover (6). The method for cooling a holder (8) for a sample carrier mount in a light microscope (1) for cryomicroscopes, by means of a flow of liquid nitrogen through a cooling conduit (15), open at at least one end, in the holder (8), is notable for the fact that the quantity of liquid nitrogen is dimensioned so that all of the nitrogen is present in gaseous form at at least one open end (16) of the cooling conduit (15).
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8.发明申请公开(公告)号：US20130133342A1
公开(公告)日：2013-05-30
申请号：US13666776
申请日：2012-11-01
发明人： Reinhard LIHL , Robert RANNER
摘要： For cooled processing of a sample, a system for cooling the sample includes a holding device (22) for receiving the sample in a sample holder (20), as well as a cooling chamber (12) that surrounds the position (P) of the sample mounted on the holding device. Provided in the cooling chamber (12) is a window through which a tool receptacle (16) for receiving a tool (W) for processing the sample projects into the cooling chamber (12). The holding device (22) is coolable to a settable temperature by means of a fluid coolant, and ensures cooling of the sample. For this, a coolant, e.g. liquid nitrogen, flows through a coolant conduit of the holding device (22), which conduit is furnished with the coolant at the input end (31) and opens at the output end (41) into the cooling chamber (12), which in this fashion is filled with coolant gas.
摘要翻译： 对于样品的冷却处理，用于冷却样品的系统包括用于将样品接收在样品保持器（20）中的保持装置（22）以及围绕所述样品保持器的位置（P）的冷却室（12） 样品安装在保持装置上。 在冷却室（12）中设置有用于接收用于处理样品的工具（W）投入冷却室（12）的工具容器（16）的窗口。 保持装置（22）通过流体冷却剂可冷却至可设定的温度，并且确保样品的冷却。 为此，例如冷却剂。 液氮流过保持装置（22）的冷却剂导管，该导管在输入端（31）处配备有冷却剂，并在输出端（41）处打开进入冷却室（12），在该冷却室 时尚充满冷却剂气体。
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