-
1.发明申请公开(公告)号：US20200179524A1
公开(公告)日：2020-06-11
申请号：US16608781
申请日：2018-04-25
发明人： Dmitry Genkin
摘要： The present invention demonstrates that erythropoietin (EPO)-receptor (EPOR) is a malignant myeloma biomarker of sensitivity to EPO treatment and, itself a target for myeloma treatment. A low EPOR level in a myeloma cells of the subject indicates non-response to EPO treatment. Patients having high EPOR level in myeloma cells can be effectively treated with EPO, in particular an EPO derivatized with polysialic acid.
-
公开(公告)号：US10406150B2
公开(公告)日：2019-09-10
申请号：US15476617
申请日：2017-03-31
发明人： Dmitry Genkin , Kirill Surkov
IPC分类号： A61K31/473 , A61K31/135 , A61K31/138 , A61K31/40 , A61K31/565 , A61K31/57 , A61K31/58
摘要： The invention provides a method for treatment of primary progesterone receptor-negative (PR−) endometrial cancer comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a progesterone receptor (PR) agonist. The invention further provides a method for treatment of a primary estrogen receptor-negative (ER−) breast cancer, comprising administering (i) cridanimod or a salt or an ester thereof and (ii) a selective estrogen receptor modulator (SERM) or a selective estrogen receptor down-regulator (SERD). Also provided are compositions related to the above methods.
-
公开(公告)号：US09790288B2
公开(公告)日：2017-10-17
申请号：US14924637
申请日：2015-10-27
发明人： Sanjay Jain , Ioannis Papaioannou , Peter Laing
IPC分类号： B01D15/34 , B01D15/36 , C08B37/00 , C07K14/61 , C07K1/18 , A61K47/48 , B01D24/02 , B01D15/42
CPC分类号： C08B37/0006 , A61K47/61 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/424 , B01D15/426 , C07K1/18 , C07K14/61 , C08B37/0003
摘要： Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd
-
公开(公告)号：US09579393B2
公开(公告)日：2017-02-28
申请号：US15001135
申请日：2016-01-19
IPC分类号： A61K38/00 , A61K38/18 , A61K47/48 , A61K47/46 , C07K14/535 , C07K14/52 , C07K14/505 , C07K14/575 , A61K38/46 , A61K38/19
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
-
公开(公告)号：US20160159936A1
公开(公告)日：2016-06-09
申请号：US14924637
申请日：2015-10-27
发明人： Sanjay Jain , Ioannis Papaioannou , Peter Laing
CPC分类号： C08B37/0006 , A61K47/61 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/424 , B01D15/426 , C07K1/18 , C07K14/61 , C08B37/0003
摘要： Polydisperse and charged polysaccharides are fractionated into low polydispersity fractions (preferably having pd
-
公开(公告)号：US20160095930A1
公开(公告)日：2016-04-07
申请号：US14689627
申请日：2015-04-17
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
-
公开(公告)号：US09234020B2
公开(公告)日：2016-01-12
申请号：US14561991
申请日：2014-12-05
IPC分类号： A61K38/18 , A61K38/00 , C07K14/505 , A61K47/48 , C07K14/535 , C07K14/52 , C07K14/575 , A61K38/46
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
-
公开(公告)号：US20150307633A1
公开(公告)日：2015-10-29
申请号：US14791468
申请日：2015-07-05
发明人： Dale Howard Hreczuk-Hirst , Sanjay Jain , Peter Laing , Gregory Gregoriadis , Ioannis Papaioannou
CPC分类号： C08B37/0006 , A61K31/715 , A61K47/61 , A61K47/68 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K14/001 , C07K17/10 , C08B37/00 , C12N9/96
摘要： A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.
摘要翻译： 将多唾液酸化合物与异双功能试剂反应以引入用于位点特异性缀合的侧链官能团，例如巯基，例如药物，药物递送系统，蛋白质或肽中半胱氨酸单元的侧链。 官能团是例如N-马来酰亚胺基团。
-
公开(公告)号：US20150252090A1
公开(公告)日：2015-09-10
申请号：US14720700
申请日：2015-05-22
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis
IPC分类号： C07K14/535 , A61K47/48 , A61K38/19
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
摘要翻译： 本发明涉及作为GCSF的多糖衍生物或GCSF样蛋白质的化合物，其中多糖是阴离子的并且包含2至200个糖单元。 本发明还涉及包含新化合物的药物组合物和制备新化合物的方法。
-
公开(公告)号：US09102699B2
公开(公告)日：2015-08-11
申请号：US14251596
申请日：2014-04-12
发明人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
CPC分类号： C07H15/26 , A61K38/27 , A61K47/61 , C07H1/00 , C08B37/00 , C08B37/0006 , Y02A50/473
摘要： An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids.
摘要翻译： 唾液酸单元的胺或酰肼衍生物，例如 在多糖中与双功能试剂反应，其功能中的至少一个是N-羟基琥珀酰亚胺的酯，以形成酰胺或酰肼产物。 该产品具有有用的功能，其允许其结合，例如结合蛋白质，药物，药物递送系统等。 该方法特别适用于衍生聚唾液酸唾液酸端基引入的胺基。
-
-
-
-
-
-
-
-
-
搜索结果
77 条记录 (耗时 0.034 秒)