公开(公告)号：US08027148B2

公开(公告)日：2011-09-27

申请号：US12710381

申请日：2010-02-23

申请人： Robert C. West ,  Lingzhi Zhang

发明人： Robert C. West ,  Lingzhi Zhang

IPC分类号： H01G9/00 ,  H01G9/02

CPC分类号： H01G11/62 ,  C07F7/081 ,  C07F7/0838 ,  H01G9/038 ,  Y02E60/13 ,  Y02T10/7022

摘要： Disclosed are electrochemical double-layer capacitors having an electrode with a substrate and an electrolyte/quaternary ammonium salt capable of penetrating the substrate. Such salts have a moiety of the following formula: In one form all of the R groups are methyl. These electrodes appear particularly suitable for use at high voltages in applications such as electric and hybrid electric vehicles.

摘要翻译： 公开了具有能够穿透基板的具有基板的电极和能够渗透基板的电解质/季铵盐的电化学双层电容器。 这样的盐具有下式的部分：在一种形式中，所有的R基团都是甲基。 这些电极特别适用于诸如电动和混合电动车辆的应用中的高电压。

公开(公告)号：US07846664B2

公开(公告)日：2010-12-07

申请号：US12096628

申请日：2006-12-07

申请人： Paul A. Insel ,  Lingzhi Zhang ,  Fiona Murray ,  Joan R. Kanter ,  Thomas Kipps ,  Laura Rassenti

发明人： Paul A. Insel ,  Lingzhi Zhang ,  Fiona Murray ,  Joan R. Kanter ,  Thomas Kipps ,  Laura Rassenti

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided.

摘要翻译： 本发明通过确定与CLL特别是PDE7B和/或PDE3B相关的环核苷酸磷酸二酯酶（PDE）的同种型的表达水平，以及PDE7B的mRNA表达比例与PDE7B的mRNA表达的比例，提供了用于诊断慢性淋巴细胞性白血病（CLL）的诊断方法和试剂盒 PDE3B。 本发明提供了CLL淋巴细胞相对于正常淋巴细胞均匀表达高水平的PDE7B和低水平的PDE3B。 还提供了一种治疗方法和用于CLL的药物组合物，其包含一种或多种能够调节与CLL相关的PDE的同种型的表达或活性水平和/或逆转PDE7B / PDE3B mRNA表达水平的比例的治疗剂。

公开(公告)号：US20090088583A1

公开(公告)日：2009-04-02

申请号：US11865089

申请日：2007-10-01

申请人： Robert C. West ,  Lingzhi Zhang

发明人： Robert C. West ,  Lingzhi Zhang

IPC分类号： C07F7/10

CPC分类号： H01G11/62 ,  C07F7/081 ,  C07F7/0838 ,  H01G9/038 ,  Y02E60/13 ,  Y02T10/7022

摘要： Disclosed are electrolytes that are organosilicon amine-based, and supercapacitors which incorporate them. These electrolytes are quaternary ammonium salts with an organosilicon moiety. They appear particularly suitable for use at high voltages in applications such as electric and hybrid electric vehicles.

摘要翻译： 公开了基于有机硅胺的电解质和包含它们的超级电容器。 这些电解质是具有有机硅部分的季铵盐。 它们特别适用于诸如电动和混合电动车辆的应用中的高电压。

公开(公告)号：US20150303511A1

公开(公告)日：2015-10-22

申请号：US14648859

申请日：2013-09-04

申请人： Lingzhi ZHANG ,  Tianqiao YONG ,  GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCES

发明人： Lingzhi Zhang ,  Tianqiao Yong

IPC分类号： H01M10/0525 ,  C07C311/00 ,  C07F7/18 ,  C07F5/02 ,  H01G11/62 ,  C07C215/40 ,  C07C213/06 ,  C07C253/30 ,  H01M10/0567 ,  H01G11/04 ,  C07C217/08 ,  C07C255/16

CPC分类号： H01M10/0525 ,  C07C213/06 ,  C07C215/40 ,  C07C217/08 ,  C07C253/30 ,  C07C255/16 ,  C07C311/00 ,  C07C311/48 ,  C07F5/022 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/188 ,  H01G11/04 ,  H01G11/62 ,  H01G11/64 ,  H01M10/0567 ,  H01M10/0569 ,  H01M2300/0025 ,  Y02E60/13

摘要： The present invention discloses a process for preparing a functionalized choline chloride ionic liquid as defined in formula (I), and thereof use in an electrochemical energy storage device, as an electrolyte solution or an additive for a lithium ion battery and a supercapacitor. The ionic liquid electrolyte material has better biocompatibility, flame retardance, high ionic conductivity, low viscosity, and wide electrochemical window. wherein R1 is selected from the group consisting of: (CH2═CH—(CH2)n)—, CN(CH2)n—, or R23Si—; R2 is selected from CH3—(CH2)m—, n is an integer selected from 1 to 3, m is an integer selected from 0 to 2; or one of R2 is (CH3)3Si—O—. Anion A in Formula I is selected from the group consisting of: Cl−, Br−, I−, BF4−, NO3−, SO42−, CF3COO−, CF3SO3−, (CF3SO2)2N−, PF6−, BF2C2O4−, or B(C2O4)2−.

摘要翻译： 本发明公开了一种制备式（I）中定义的官能化氯化胆碱离子液体的方法，其用于电化学能量存储装置中，作为电解质溶液或锂离子电池和超级电容器的添加剂。 离子液体电解质材料具有更好的生物相容性，阻燃性，高离子电导率，低粘度和广泛的电化学窗口。 其中R 1选自：（CH 2 = CH - （CH 2）n） - ，CN（CH 2）n - 或R 23 Si-; R2选自CH 3 - （CH 2）m - ，n是选自1至3的整数，m是选自0至2的整数; 或者R 2中的一个为（CH 3）3 Si-O-。 式I中的阴离子A选自：Cl-，Br-，I-，BF 4 - ，NO 3 - ，SO 4 2-，CF 3 COO-，CF 3 SO 3 - ，（CF 3 SO 2）2 N - ，PF 6 - ，BF 2 C 2 O 4 - 或 B（C2O4）2-。

公开(公告)号：US08968602B2

公开(公告)日：2015-03-03

申请号：US12441706

申请日：2007-10-02

申请人： Kai Su ,  Nurxat Nuraje ,  Lingzhi Zhang ,  Hiroshi Matsui ,  Nan Loh Yang

发明人： Kai Su ,  Nurxat Nuraje ,  Lingzhi Zhang ,  Hiroshi Matsui ,  Nan Loh Yang

IPC分类号： H01B1/00 ,  H01M4/88 ,  H01L51/00 ,  H01B1/12 ,  H01L51/05

CPC分类号： H01L51/0037 ,  H01B1/124 ,  H01L51/0575 ,  H01L51/0591

摘要： The present invention is directed to crystalline organic polymer nanoparticles comprising a conductive organic polymer; wherein the crystalline organic polymer nanoparticles have a size of from 10 nm to 200 nm and exhibits two current-voltage states: (1) a high resistance current-voltage state, and (2) a low resistance current-voltage state, wherein when a first positive threshold voltage (Vth1) or higher positive voltage, or a second negative threshold voltage (Vth2) or higher negative voltage is applied to the nanoparticle, the nanoparticle exhibits the low-resistance current-voltage state, and when a voltage less positive than the first positive threshold voltage or a voltage less negative than the second negative threshold voltage is applied to the nanoparticle, the nanoparticle exhibits the high-resistance current-voltage state. The present invention is also directed methods of manufacturing the nanoparticles using novel interfacial oxidative polymerization techniques.

摘要翻译： 本发明涉及包含导电有机聚合物的结晶有机聚合物纳米颗粒; 其中所述结晶有机聚合物纳米颗粒具有10nm至200nm的尺寸，并且具有两种电流 - 电压状态：（1）高电阻电流 - 电压状态，和（2）低电阻电流 - 电压状态，其中当 第一正阈值电压（Vth1）或更高的正电压或第二负阈值电压（Vth2）或更高的负电压施加到纳米颗粒，纳米颗粒呈现低电阻电流 - 电压状态，并且当电压小于 将第一正阈值电压或比第二负阈值电压小的电压施加到纳米颗粒，纳米颗粒呈现高电阻电流 - 电压状态。 本发明还涉及使用新的界面氧化聚合技术制造纳米颗粒的方法。

公开(公告)号：US08114590B2

公开(公告)日：2012-02-14

申请号：US12960955

申请日：2010-12-06

申请人： Paul A. Insel ,  Lingzhi Zhang ,  Fionna Murray ,  Joan R. Kanter ,  Thomas Kipps ,  Laura Rassenti

发明人： Paul A. Insel ,  Lingzhi Zhang ,  Fionna Murray ,  Joan R. Kanter ,  Thomas Kipps ,  Laura Rassenti

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL, particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided.

摘要翻译： 本发明通过测定与CLL，特别是PDE7B和/或PDE3B相关的环状核苷酸磷酸二酯酶（PDEs）的同种型的表达水平以及PDE7B的mRNA表达的比例来提供用于诊断慢性淋巴细胞性白血病（CLL）的诊断方法和试剂盒 到PDE3B。 本发明提供了CLL淋巴细胞相对于正常淋巴细胞均匀表达高水平的PDE7B和低水平的PDE3B。 还提供了一种治疗方法和用于CLL的药物组合物，其包含一种或多种能够调节与CLL相关的PDE的同种型的表达或活性水平和/或逆转PDE7B / PDE3B mRNA表达水平的比例的治疗剂。

公开(公告)号：US07947251B2

公开(公告)日：2011-05-24

申请号：US11917509

申请日：2006-06-15

申请人： Umit S. Ozkan ,  Xueqin Wang ,  Lingzhi Zhang ,  Sittichai Natesakhawat

发明人： Umit S. Ozkan ,  Xueqin Wang ,  Lingzhi Zhang ,  Sittichai Natesakhawat

IPC分类号： C01B3/12 ,  B01J23/00 ,  B01J21/00 ,  B01J20/00

CPC分类号： C01B3/16 ,  B01J23/002 ,  B01J23/745 ,  B01J31/2234 ,  B01J35/002 ,  B01J37/033 ,  B01J37/036 ,  B01J2231/70 ,  B01J2523/00 ,  B01J2531/842 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/066 ,  C01B2203/1041 ,  C01B2203/1047 ,  C01B2203/1076 ,  Y02P20/52 ,  B01J2523/17 ,  B01J2523/31 ,  B01J2523/842

摘要： Fe—Al—Cu catalysts have numerous industrial applications, for example, as catalysts in a water gas shift reactor. A method of producing a Fe—Al—Cu catalyst comprises the steps of providing an organic iron precursor, dissolving the organic iron precursor in a solvent solution, adding an aqueous solution comprising aluminum nitrate and copper nitrate to the organic iron pre-cursor-solvent solution, precipitating a gel comprising Fe—Al—Cu by adding a base, and drying the gel to form the Fe—Al—Cu catalyst.

摘要翻译： Fe-Al-Cu催化剂具有许多工业应用，例如作为水煤气变换反应器中的催化剂。 制备Fe-Al-Cu催化剂的方法包括提供有机铁前体，将有机铁前体溶解在溶剂溶液中，向有机铁前体溶剂中加入包含硝酸铝和硝酸铜的水溶液 溶液，通过加入碱沉淀包含Fe-Al-Cu的凝胶，并干燥凝胶以形成Fe-Al-Cu催化剂。

公开(公告)号：US20090314998A1

公开(公告)日：2009-12-24

申请号：US12441706

申请日：2007-10-02

申请人： Kai Su ,  Nurxat Nuraje ,  Lingzhi Zhang ,  Hiroshi Matsui ,  Nan Loh Yang

发明人： Kai Su ,  Nurxat Nuraje ,  Lingzhi Zhang ,  Hiroshi Matsui ,  Nan Loh Yang

IPC分类号： H01B1/12

CPC分类号： H01L51/0037 ,  H01B1/124 ,  H01L51/0575 ,  H01L51/0591

摘要： The present invention is directed to crystalline organic polymer nanoparticles comprising a conductive organic polymer; wherein the crystalline organic polymer nanoparticles have a size of from 10 nm to 200 nm and exhibits two current-voltage states: (1) a high resistance current-voltage state, and (2) a low resistance current-voltage state, wherein when a first positive threshold voltage (Vth1) or higher positive voltage, or a second negative threshold voltage (Vth2) or higher negative voltage is applied to the nanoparticle, the nanoparticle exhibits the low-resistance current-voltage state, and when a voltage less positive than the first positive threshold voltage or a voltage less negative than the second negative threshold voltage is applied to the nanoparticle, the nanoparticle exhibits the high-resistance current-voltage state. The present invention is also directed methods of manufacturing the nanoparticles using novel interfacial oxidative polymerization techniques.

摘要翻译： 本发明涉及包含导电有机聚合物的结晶有机聚合物纳米颗粒; 其中所述结晶有机聚合物纳米颗粒具有10nm至200nm的尺寸，并且具有两种电流 - 电压状态：（1）高电阻电流 - 电压状态，和（2）低电阻电流 - 电压状态，其中当 第一正阈值电压（Vth1）或更高的正电压或第二负阈值电压（Vth2）或更高的负电压施加到纳米颗粒，纳米颗粒呈现低电阻电流 - 电压状态，并且当电压小于 将第一正阈值电压或比第二负阈值电压小的电压施加到纳米颗粒，纳米颗粒呈现高电阻电流 - 电压状态。 本发明还涉及使用新的界面氧化聚合技术制造纳米颗粒的方法。

公开(公告)号：US09728806B2

公开(公告)日：2017-08-08

申请号：US14648859

申请日：2013-09-04

申请人： GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCES ,  Lingzhi Zhang ,  Tianqiao Yong

发明人： Lingzhi Zhang ,  Tianqiao Yong

IPC分类号： C07C253/30 ,  C07F7/18 ,  H01M10/0525 ,  C07C213/06 ,  C07C215/40 ,  C07C217/08 ,  H01G11/62 ,  H01M10/0567 ,  C07C255/16 ,  C07C311/00 ,  C07F5/02 ,  C07C311/48 ,  C07F7/10 ,  H01G11/64 ,  H01G11/04 ,  H01M10/0569

CPC分类号： H01M10/0525 ,  C07C213/06 ,  C07C215/40 ,  C07C217/08 ,  C07C253/30 ,  C07C255/16 ,  C07C311/00 ,  C07C311/48 ,  C07F5/022 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/188 ,  H01G11/04 ,  H01G11/62 ,  H01G11/64 ,  H01M10/0567 ,  H01M10/0569 ,  H01M2300/0025 ,  Y02E60/13

摘要： The present invention discloses a process for preparing a functionalized choline chloride ionic liquid as defined in formula (I), and thereof use in an electrochemical energy storage device, as an electrolyte solution or an additive for a lithium ion battery and a supercapacitor. The ionic liquid electrolyte material has better biocompatibility, flame retardance, high ionic conductivity, low viscosity, and wide electrochemical window. wherein R1 is selected from the group consisting of: (CH2═CH—(CH2)n)—, CN(CH2)n—, or R23Si—; R2 is selected from CH3—(CH2)m—, n is an integer selected from 1 to 3, m is an integer selected from 0 to 2; or one of R2 is (CH3)3Si—O—. Anion A in Formula I is selected from the group consisting of: Cl−, Br−, I−, BF4−, NO3−, SO42−, CF3COO−, CF3SO3−, (CF3SO2)2N−, PF6−, BF2C2O4−, or B(C2O4)2−.

公开(公告)号：US20130084490A1

公开(公告)日：2013-04-04

申请号：US13702576

申请日：2011-03-10

申请人： Lingzhi Zhang ,  Hao Luo ,  Xinyue Zhao

发明人： Lingzhi Zhang ,  Hao Luo ,  Xinyue Zhao

IPC分类号： C07F7/18 ,  H01M10/056 ,  C07F7/10

CPC分类号： C07F7/1804 ,  C07F7/081 ,  C07F7/0838 ,  C07F7/10 ,  H01G11/62 ,  H01M10/0525 ,  H01M10/056 ,  H01M10/0565 ,  H01M10/0567 ,  Y02E60/122 ,  Y02E60/13

摘要： The invention provides an organosilicon amine electrolyte material containing a polyether chain, which has a wide range of applications, as well as an application of the electrolyte material in a lithium ion battery. The chemical structure thereof is as shown in Formula 1, wherein R1 and R2 are selected from the same or different C1-C10 alkyls; A is a polyether chain segment having the structure of (CH2)nO[(CH2)mO]x(CH2)y, where n and m are integers from 0 to 10, and x is an integer from 1 to 10; R3, R4 and R5 are selected from the same or the different C1-C10 alkyls or alkoxyl groups, or are equivalent to ANR1R2 or —O—SiR6R7R8 in structure; wherein R6, R7 and R8 are C1-C10 alkyls.

摘要翻译： 本发明提供一种含有聚醚链的有机硅胺电解质材料，其具有广泛的应用范围，以及在锂离子电池中应用电解质材料。 其化学结构如式1所示，其中R 1和R 2选自相同或不同的C 1 -C 10烷基; A是具有（CH 2）n O [（CH 2）m O] x（CH 2）y结构的聚醚链段，其中n和m是0至10的整数，x是1至10的整数; R3，R4和R5选自相同或不同的C1-C10烷基或烷氧基，或相当于结构中的ANR1R2或-O-SiR6R7R8; 其中R6，R7和R8是C1-C10烷基。