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    PURINE DERIVATIVES AS IMMUNOMODULATORS
    4.
    发明申请
    PURINE DERIVATIVES AS IMMUNOMODULATORS 审中-公开
    作为免疫调节剂的嘌呤衍生物

    公开(公告)号：US20100120799A1

    公开(公告)日：2010-05-13

    申请号：US12527820

    申请日：2008-02-15

    申请人： Linos Lazarides ,  Stephen Allan Smith ,  Richard Stocker ,  Colin Jack Theobald

    发明人： Linos Lazarides ,  Stephen Allan Smith ,  Richard Stocker ,  Colin Jack Theobald

    IPC分类号： A61K31/522 ,  C07D473/18 ,  A61P35/00 ,  A61P29/00 ,  A61P11/06

    CPC分类号： C07D473/18 ,  C07D473/16

    摘要： Compounds of formula (I): wherein R1 is C1-8alkylamino, C1-8alkoxy, C3-7cycloalkylC1-6alkylamino, C3-7cycloalkylC1-6alkoxy, C1-3alkoxyC2-3alkoxy, or Hetb-C1-3alkoxy; Hetb is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen atom; R2 is —(CH2)n-Het; n is an integer having a value of 1 to 4; Het is a 5- or 6-membered saturated aliphatic heterocycle containing one oxygen heteroatom, which heterocycle may be substituted by one or two C1-4alkyl groups, and salts and solvates thereof, are inducers of human interferon and may be useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.

    摘要翻译： 式（I）化合物：其中R 1是C 1-8烷基氨基，C 1-8烷氧基，C 3-7环烷基C 1-6烷基氨基，C 3-7环烷基C 1-6烷氧基，C 1-3烷氧基C 2-3烷氧基或Hetb-C 1-3烷氧基; Hetb是含有一个氧原子的5或6元饱和脂肪族杂环; R2是 - （CH2）n-Het; n为1〜4的整数， Het是含有一个氧杂原子的5-或6-元饱和脂族杂环，该杂环可以被一个或两个C 1-4烷基取代，其盐和溶剂化物是人类干扰素的诱导剂，可用于治疗 各种疾病，特别是传染病，癌症，过敏性疾病和其他炎性病症，例如过敏性鼻炎和哮喘，以及疫苗佐剂。

    Adenine derivatives
    5.
    发明授权
    Adenine derivatives 有权
    腺嘌呤衍生物

    公开(公告)号：US08563717B2

    公开(公告)日：2013-10-22

    申请号：US13058465

    申请日：2009-08-07

    申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

    发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

    IPC分类号： A61K31/522 ,  A61P29/02 ,  A61P37/08 ,  C07D473/16

    CPC分类号： C07D473/16 ,  A61K31/522 ,  C07D473/18

    摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基或C 1-6烷氧基; R2是具有以下结构的基团：n是具有1至6的整数; Het是含有一个氮原子的6元饱和杂环，其中Het与杂环的任何碳原子连接至 - （CH 2）n - 部分; R3是氢，C1-8烷基或C3-7环烷基C0-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。