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1.发明申请APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 审中-公开在微流感分析系统中捕获基于珠粒的试剂的装置和方法公开(公告)号：US20110048945A1
公开(公告)日：2011-03-03
申请号：US12852370
申请日：2010-08-06
IPC分类号： G01N27/447
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译： 公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。 还公开了一种处理微流体分析系统内的样品的方法，包括： 提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。 本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。 该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。
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2.发明申请APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 有权在微流感分析系统中捕获基于珠粒的试剂的装置和方法公开(公告)号：US20100326826A1
公开(公告)日：2010-12-30
申请号：US12831949
申请日：2010-07-07
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译： 公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。 还公开了一种处理微流体分析系统内的样品的方法，包括： 提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。 本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。 该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。
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3.发明申请APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 审中-公开在微流感分析系统中捕获基于珠粒的试剂的装置和方法公开(公告)号：US20080237146A1
公开(公告)日：2008-10-02
申请号：US11955902
申请日：2007-12-13
IPC分类号： B01J8/00
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising: providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译： 公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。 还公开了一种处理微流体分析系统内的样品的方法，包括：提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。 本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。 该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。
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4.发明授权Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权在微流体分析系统中捕获珠基试剂的装置和方法公开(公告)号：US07312611B1
公开(公告)日：2007-12-25
申请号：US10148425
申请日：2000-11-27
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. In accordance with the present invention, there is provided a method of concentrating an analyte within a microfluidic analysis system, comprising the steps of: a) providing a main channel having a trapping zone suitable for trapping packing material; b) providing a slurry of a reagent treated packing material prepared in a solution having a predetermined composition of a solvent; c) inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone so as to load said trapping zone and form a packed bed of said packing material; d) and flowing a sample containing analytes through said packed bed, said reagent acting to concentrate at least some of said analytes within said trapping zone. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译： 本发明提供一种片上填充反应器床设计，其允许以小型化水平有效地交换诸如珠粒的包装材料。 根据本发明，提供了一种将分析物浓缩在微流体分析系统内的方法，包括以下步骤：a）提供具有适于捕获包装材料的捕集区的主通道; b）提供在具有预定组成的溶剂的溶液中制备的试剂处理的填充材料的浆料; c）通过连接到所述捕集区的流动通道引导所述包装材料流入所述捕集区域，以便装载所述捕集区并形成所述包装材料的填充床; d）并使含有分析物的样品流过所述填充床，所述试剂用于将所述分析物中的至少一些浓缩至所述捕集区内。 本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。 该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。
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5.发明授权Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权在微流体分析系统中捕获珠基试剂的装置和方法公开(公告)号：US08034628B2
公开(公告)日：2011-10-11
申请号：US12831949
申请日：2010-07-07
CPC分类号： B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , G01N1/40 , G01N1/405 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译： 公开了片上堆叠反应器床设计，其允许在小型化水平上有效地交换包装材料，例如珠粒。 还公开了一种处理微流体分析系统内的样品的方法，包括： 提供具有捕获区的主通道; 提供试剂处理的包装材料的浆料; 通过连接到所述捕集区的流动通道将所述包装材料流入所述捕集区，以加载所述捕集区并形成所述包装材料的填充床; 并将含有分析物的样品流经所述填充床，所述试剂处理样品。 本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。 该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。
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6.发明授权Apparatus and method for trapping bead based reagents within microfluidic analysis systems 有权在微流体分析系统中捕获珠基试剂的装置和方法公开(公告)号：US06432290B1
公开(公告)日：2002-08-13
申请号：US09450272
申请日：1999-11-26
IPC分类号： G01N2726
CPC分类号： G01N30/56 , B01L3/0241 , B01L3/5027 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/0487 , G01N27/44704 , G01N27/44791 , G01N30/6095 , G01N2030/009 , G01N2030/285 , G01N2030/565
摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译： 本发明提供一种片上填充反应器床设计，其允许以小型化水平有效地交换诸如珠粒的包装材料。 本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。 该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。
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