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    Method for preparing engineered tissue
    1.
    发明申请
    Method for preparing engineered tissue 失效
    制备工程组织的方法

    公开(公告)号：US20060128010A1

    公开(公告)日：2006-06-15

    申请号：US10522010

    申请日：2002-07-16

    申请人： Lucie Germain ,  Francois Auger ,  Francois Bergeron ,  Charles Roberge

    发明人： Lucie Germain ,  Francois Auger ,  Francois Bergeron ,  Charles Roberge

    IPC分类号： C12N5/08 ,  C12N5/06

    CPC分类号： C12N5/0062

    摘要： A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is applied in direction normal to the surface of the tissue. A multi-layer tissue produced by the method decribed above can also possess at least two different types of sheets and/or consist essentially of between two and twelve sheets of living tissue. The method can also be used to prepare a planar tissue that can further be incorporated in a multi-layer tissue construct. The methods and tissues described herein are useful for the preparation of engineered tissues.

    摘要翻译： 一种通过向生物体组织堆叠施加压缩力来制备人或动物组织的方法，从而导致相邻层彼此熔合或粘附。 力沿垂直于组织表面的方向施加。 通过上述方法生产的多层组织也可以具有至少两种不同类型的片材和/或基本上由两片和12片生物组织组成。 该方法也可用于制备可以进一步掺入多层组织结构中的平面组织。 本文所述的方法和组织可用于制备工程组织。

    Method for preparing tissue constructs
    2.
    发明申请
    Method for preparing tissue constructs 审中-公开
    制备组织结构的方法

    公开(公告)号：US20050170501A1

    公开(公告)日：2005-08-04

    申请号：US10511433

    申请日：2003-04-24

    申请人： Francois Auger ,  Francois Bergeron ,  Lucie Germain

    发明人： Francois Auger ,  Francois Bergeron ,  Lucie Germain

    IPC分类号： C12N5/071 ,  C12N5/08

    CPC分类号： C12N5/0691 ,  C12N5/0697 ,  C12N2502/1323 ,  C12N2502/28

    摘要： The present invention relates to a method of assembling a single living tissue sheet formed of different cell populations. According to this invention at least two cell populations composing at least two living tissue sheets can be assembled into a single continuous tissue construct. The cells of this construct can also be autologous or heterologous depending on the needs and the type of implant to be transferred in a recipient patient.

    摘要翻译： 本发明涉及组装由不同细胞群形成的单个活组织片的方法。 根据本发明，构成至少两个活组织片的至少两个细胞群可以组装成单个连续的组织构建体。 这种构建体的细胞也可以是自体的或异源的，这取决于在受体患者中要转移的植入物的需要和类型。

    Method and apparatus for inducing controlled mechanical constraints in a tissue construct
    3.
    发明申请
    Method and apparatus for inducing controlled mechanical constraints in a tissue construct 失效
    用于在组织构建体中诱导受控机械约束的方法和装置

    公开(公告)号：US20050019897A1

    公开(公告)日：2005-01-27

    申请号：US10866708

    申请日：2004-06-15

    申请人： Francois Bergeron ,  Lucie Germain ,  Francois Auger

    发明人： Francois Bergeron ,  Lucie Germain ,  Francois Auger

    IPC分类号： C12M3/00

    CPC分类号： C12M35/04 ,  C12M23/48

    摘要： A method and a device (10) for reorganizing the fibers of a matrix in a living tissue sheet (S) by inducing controlled mechanical constraints in the living tissue (S) sheet thus causing the fibers of the matrix to be aligned parallel to the strain orientation. The sheet (S) is held in a stretched state until the fibers set in place.

    摘要翻译： 一种方法和装置（10），用于通过在活组织（S）片中引起受控的机械约束来重新组织活组织片（S）中的基质的纤维，从而使基质的纤维平行于菌株 方向。 片材（S）保持在拉伸状态，直到纤维固定就位。

    Method for preparing tissue constructs
    4.
    发明申请
    Method for preparing tissue constructs 审中-公开
    制备组织结构的方法

    公开(公告)号：US20070111307A1

    公开(公告)日：2007-05-17

    申请号：US11603865

    申请日：2006-11-24

    申请人： Francois Auger ,  Francois Bergeron ,  Lucie Germain

    发明人： Francois Auger ,  Francois Bergeron ,  Lucie Germain

    IPC分类号： C12N5/08 ,  C12N5/06

    CPC分类号： C12N5/0691 ,  C12N5/0697 ,  C12N2502/1323 ,  C12N2502/28

    摘要： The present invention relates to a method of assembling a single living tissue sheet formed of different cell populations. According to this invention at least two cell populations composing at least two living tissue sheets can be assembled into a single continuous tissue construct The cells of this construct can also be autologous or heterologous depending on the needs and the type of implant to be transferred in a recipient patient.

    摘要翻译： 本发明涉及组装由不同细胞群形成的单个活组织片的方法。 根据本发明，构成至少两个活组织片的至少两个细胞群可以组装成单个连续组织构建体。该构建体的细胞也可以是自体的或异源的，这取决于待转移的植入物的需要和类型 受试者。

    Method of isolating cells from umbilical cord
    7.
    发明申请
    Method of isolating cells from umbilical cord 审中-公开
    从脐带分离细胞的方法

    公开(公告)号：US20060199263A1

    公开(公告)日：2006-09-07

    申请号：US11314153

    申请日：2005-12-21

    申请人： Francois Auger ,  Lucie Germain ,  Murielle Remy-Zolghadri ,  Cindy Hayward

    发明人： Francois Auger ,  Lucie Germain ,  Murielle Remy-Zolghadri ,  Cindy Hayward

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0605 ,  C12N5/0629 ,  C12N5/0652 ,  C12N5/069 ,  C12N5/0691 ,  C12N2509/00

    摘要： The present invention relates a method for isolating four cell types from a single umbilical cord as pure cultures. These cell lines (epithelial cells, fibroblasts, smooth muscle cells and endothelial cells) can be characterised and utilised in experimental models and for therapeutic purposes. Particularly, the umbilical cells isolated herein are used to form a tissue replacement or engineered living composition. Also, the isolated umbilical cells of the invention may have the potential of progenitor cells.

    摘要翻译： 本发明涉及一种从单一脐带中分离四种细胞类型的纯化方法。 这些细胞系（上皮细胞，成纤维细胞，平滑肌细胞和内皮细胞）可用于实验模型和治疗目的。 特别地，本文分离的脐带细胞用于形成组织替代或工程生物组合物。 此外，本发明的分离的脐带细胞可能具有祖细胞的潜力。

    Method for preparing engineered tissue
    8.
    发明授权
    Method for preparing engineered tissue 失效
    制备工程组织的方法

    公开(公告)号：US07521231B2

    公开(公告)日：2009-04-21

    申请号：US10522010

    申请日：2003-07-16

    申请人： Lucie Germain ,  François Auger ,  François Bergeron ,  Charles Roberge

    发明人： Lucie Germain ,  François Auger ,  François Bergeron ,  Charles Roberge

    IPC分类号： C12N5/06 ,  C12N5/08

    CPC分类号： C12N5/0062

    摘要： A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is applied in direction normal to the surface of the tissue. A multi-layer tissue produced by the method described above can also possess at least two different types of sheets and/or consist essentially of between two and twelve sheets of living tissue. The method can also be used to prepare a planar tissue that can further be incorporated in a multi-layer tissue construct. The methods and tissues described herein are useful for the preparation of engineered tissues.

    摘要翻译： 一种通过向生物体组织堆叠施加压缩力来制备人或动物组织的方法，从而导致相邻层彼此熔合或粘附。 力沿垂直于组织表面的方向施加。 通过上述方法生产的多层织物还可以具有至少两种不同类型的片材和/或基本上由两片和12片生物组织组成。 该方法也可用于制备可以进一步掺入多层组织结构中的平面组织。 本文所述的方法和组织可用于制备工程组织。

    Chimeric sheets of epithelial cells
    9.
    发明授权
    Chimeric sheets of epithelial cells 失效
    嵌合片上皮细胞

    公开(公告)号：US5610007A

    公开(公告)日：1997-03-11

    申请号：US7318

    申请日：1993-01-21

    申请人： Fran.cedilla.ois A. Auger ,  Mahmoud Rouabhia ,  Louis Lafleur ,  Lucie Germain

    发明人： Fran.cedilla.ois A. Auger ,  Mahmoud Rouabhia ,  Louis Lafleur ,  Lucie Germain

    IPC分类号： A61K35/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/60 ,  C12N5/071 ,  C12N5/06 ,  A61F2/10

    CPC分类号： A61L27/3813 ,  A61L27/60 ,  C12N5/0629 ,  A61K35/12 ,  C12N2500/16 ,  C12N2501/11 ,  Y10S623/915

    摘要： A process for culturing and generating a chimeric cell culture, in particular chimeric epithelium, is disclosed. The chimeric epithelium can be used to treat skin trauma such as burn victims. Autologous epithelial grafts have been used on burn patients although this requires that the patient's cells are cultured and expanded in vitro which generally takes four to five weeks. The chimeric epithelium of the present invention is composed of cells that are both autologous and allogeneic to the host. Therefore, the allogeneic cells can be maintained in a cell bank and co-cultured with autologous host cells when needed. This significantly reduces the time required (by up to 50%) for autologous cell expansion and culture prior to grafting. Furthermore, it has been demonstrated that the allogeneic cells are passively eliminated from the graft without rejection of the total graft.

    摘要翻译： 公开了一种培养和产生嵌合细胞培养物，特别是嵌合上皮的方法。 嵌合上皮可用于治疗皮肤损伤，如烧伤受害者。 自体上皮移植物已经用于烧伤患者，尽管这要求患者的细胞在体外培养和扩增，通常需要四至五周。 本发明的嵌合上皮由对宿主自体和同种异体的细胞组成。 因此，当需要时，同种异体细胞可以保持在细胞库中并与自体宿主细胞共培养。 这显着减少了移植前自体细胞扩增和培养所需的时间（高达50％）。 此外，已经证明，同种异体细胞被从移植物被动消除而不排斥总移植物。