公开(公告)号：US07812005B2

公开(公告)日：2010-10-12

申请号：US10557860

申请日：2004-05-19

申请人： Umberto Cornelli ,  Luigi De Ambrosi ,  Stanley Lorens ,  Jawed Fareed ,  John Lee ,  Israel Hanin ,  Ronald Mervis

发明人： Umberto Cornelli ,  Luigi De Ambrosi ,  Stanley Lorens ,  Jawed Fareed ,  John Lee ,  Israel Hanin ,  Ronald Mervis

IPC分类号： A61K31/726 ,  A61K31/715 ,  A61K31/727 ,  A61K31/737

CPC分类号： A61K31/715

摘要： The present invention relates to the use of glycosaminoglycan fractions having an average molecular weight of 2400 (±200) D for the preparation of pharmaceutical compositions suitable for the treatment of emotional dysfunctions, especially depressive disorders, anxiety disorders, anxiety neurosis, agitation, confusion.

摘要翻译： 本发明涉及平均分子量为2400（±200）D的糖胺聚糖级分用于制备适于治疗情绪功能障碍，特别是抑郁障碍，焦虑症，焦虑神经症，激动，混乱的药物组合物的用途。

公开(公告)号：US06979680B1

公开(公告)日：2005-12-27

申请号：US10048542

申请日：2000-05-12

申请人： Umberto Cornelli ,  Luigi De Ambrosi ,  Israel Hanin ,  Jawed Fareed ,  John Lee ,  Stanley Lorens ,  Ronald F. Mervis

发明人： Umberto Cornelli ,  Luigi De Ambrosi ,  Israel Hanin ,  Jawed Fareed ,  John Lee ,  Stanley Lorens ,  Ronald F. Mervis

IPC分类号： A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  A61P25/28 ,  C08B37/00 ,  A01N43/04

CPC分类号： A61K31/726 ,  A61K31/727 ,  C08B37/0078

摘要： The present invention relates to the use of glycosaminoglycans having an average/molecular weight of 2,400 D for the preparation of pharmaceutical compositions suitable for the treatment of senile dementia, in particular for the treatment of Alzheimer's disease or SDAT (Senile Dementia Alzheimer's Type) and of the cerebral neurological lesions from ictus and from traumas.

摘要翻译： 本发明涉及平均/分子量为2,400D的糖胺聚糖用于制备适于治疗老年性痴呆的药物组合物，特别是用于治疗阿尔茨海默氏病或​​SDAT（老年痴呆症阿尔茨海默氏症）和 来自ictus和创伤的脑神经病变。

公开(公告)号：US20110288047A1

公开(公告)日：2011-11-24

申请号：US13129030

申请日：2009-09-29

申请人： Luigi De Ambrosi

发明人： Luigi De Ambrosi

IPC分类号： A61K31/727 ,  C08B37/10 ,  A61Q19/02 ,  A61Q19/08 ,  A61P29/00

CPC分类号： A61K8/73 ,  A61K31/726 ,  A61K31/727 ,  A61K2800/522 ,  A61K2800/75 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to cosmetological and dermatological compositions comprising heparan sulfate. The invention further discloses a process for the purification of heparan sulfate for dermatological and cosmetological applications, which process comprises the following steps: solubilization of heparan sulfate in water, adsorption on an anion exchange resin, desorption from the resin by using conditions which result in selective desorption of hepar an sulfate. The cosmetological and dermatological compositions according to the invention show, inter alia, anti-age, lenitive, and whitening effect.

摘要翻译： 本发明涉及包含硫酸乙酰肝素的美容和皮肤病学组合物。 本发明还公开了一种用于皮肤病学和美容应用的硫酸乙酰肝素的纯化方法，该方法包括以下步骤：将硫酸乙酰肝素溶解于水中，在阴离子交换树脂上吸附，通过使用导致选择性的条件从树脂中解吸 肝素硫酸盐解吸。 根据本发明的美容和皮肤病学组合物尤其表现出抗衰老，延缓和美白效果。

公开(公告)号：US07939512B2

公开(公告)日：2011-05-10

申请号：US11279699

申请日：2006-04-13

申请人： Luigi De Ambrosi ,  Sergio Gonella ,  Donata Bensi ,  Giangiacomo Torri ,  Antonella Bisio ,  Elena Vismara

发明人： Luigi De Ambrosi ,  Sergio Gonella ,  Donata Bensi ,  Giangiacomo Torri ,  Antonella Bisio ,  Elena Vismara

IPC分类号： A61K31/727 ,  C08B37/10

CPC分类号： C08B37/0078

摘要： The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.

摘要翻译： 本发明涉及用于肝素物理解聚的多步骤方法，其中肝素进行至少两次γ射线照射，并且其中在两个照射步骤之间进行解聚的肝素进行分离步骤，并且仅将解聚的肝素的一部分 从第一次照射得到的第二照射工序。 还涉及通过本发明的方法获得的肝素衍生的寡糖级分。

公开(公告)号：US5116963A

公开(公告)日：1992-05-26

申请号：US600267

申请日：1990-10-23

申请人： Rinaldo Del Bono ,  Luigi De Ambrosi ,  Gianni Ferrari ,  Pier L. Rugarli ,  Pier G. Pagella

发明人： Rinaldo Del Bono ,  Luigi De Ambrosi ,  Gianni Ferrari ,  Pier L. Rugarli ,  Pier G. Pagella

IPC分类号： C08B37/00 ,  A61K20060101 ,  A61K31/715 ,  A61K35/00 ,  A61P7/02 ,  C08B20060101 ,  C08B37/08 ,  C08B37/10 ,  C08L20060101 ,  C12P19/00 ,  C12P19/04 ,  C12P19/26 ,  C12P19/44

CPC分类号： C08B37/0069

摘要： A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in micropolysaccharides (MPS), by: a) stabilizing the fresh organs by freezing them either as such or in the form of powder, b) micronizing the material containing the MPS with an aqueous CaCl.sub.2 solution, c) digesting the homogenate comprising the raw material and the CaCl.sub.2 with proteolytic enzyme at alkaline pH and at low temperature, d) acidifying, heating and filtering the lysate, e) treating the filtrate with quaternary ammonium salts able to undergo complexing with and thus precipitate either the DS alone or all the MPS selectively, f) recovering and purifying the DS either directly from the ammonium salt complex containing it or from the complex obtained from the mixture of ammonium salt complexes of all the MPS by fractional solubilization with acetone.

公开(公告)号：US07321034B2

公开(公告)日：2008-01-22

申请号：US10518980

申请日：2003-06-18

申请人： Luigi De Ambrosi ,  Nicola Iannaccone ,  Sergio Gonella ,  Elena Vismara ,  Solitario Nesti ,  Giangiaocomo Torri

发明人： Luigi De Ambrosi ,  Nicola Iannaccone ,  Sergio Gonella ,  Elena Vismara ,  Solitario Nesti ,  Giangiaocomo Torri

IPC分类号： C08B37/10

CPC分类号： C08B37/0063 ,  C08B37/0075 ,  C08B37/0078

摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

摘要翻译： 本发明涉及通过使用电子束辐射特征的糖胺聚糖解聚方法，任选地在选自醚，醇，醛，酰胺和甲酸的有机化合物存在下进行。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中并通过凝胶渗透分馏以获得所需的分子量。

公开(公告)号：US4216293A

公开(公告)日：1980-08-05

申请号：US916536

申请日：1978-06-19

申请人： Gianfranco Fedeli ,  Luigi De Ambrosi

发明人： Gianfranco Fedeli ,  Luigi De Ambrosi

IPC分类号： C12N9/99 ,  A61K35/12 ,  A61K35/42 ,  A61K38/55 ,  C07K14/81 ,  C08B37/00 ,  C08B37/10 ,  C12N9/48 ,  C07G7/00

CPC分类号： C08B37/0066 ,  C07K14/8117

摘要： Protease inhibitor is extracted from fresh or frozen organs of slaughtered animals by an enzymolysis operation which excludes any possibility of interference by azymic autolysis, the enzymolysis being stopped after a time not exceeding 4 hours, whereafter a lysate aqueous solution is obtained by filtration and a quaternary ammonium base is added to the lysate solution to precipitate insolubles, the filtrate being the fraction which contains the expected protease inhibitor.

摘要翻译： 通过酶解操作从屠宰动物的新鲜或冷冻器官中提取蛋白酶抑制剂，其排除任何可能的干扰自由酶的可能性，在不超过4小时的时间后停止酶解，然后通过过滤获得裂解物水溶液， 将铵碱加入裂解液中以沉淀不溶物，滤液为含有预期蛋白酶抑制剂的级分。

公开(公告)号：US07605242B2

公开(公告)日：2009-10-20

申请号：US10555897

申请日：2004-05-06

申请人： Luigi De Ambrosi ,  Donata Bensi ,  Elena Vismara

发明人： Luigi De Ambrosi ,  Donata Bensi ,  Elena Vismara

IPC分类号： C08B37/00 ,  C08B37/10

CPC分类号： C08B37/0063 ,  C08B37/0069 ,  C08B37/0078

摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

摘要翻译： 本发明涉及以使用UVC辐射为特征的糖胺聚糖解聚方法。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中并通过凝胶渗透分馏以获得所需的分子量。

公开(公告)号：US4987222A

公开(公告)日：1991-01-22

申请号：US120953

申请日：1987-11-16

申请人： Luigi De Ambrosi ,  Walter Recchia ,  Gianni Ferrari

发明人： Luigi De Ambrosi ,  Walter Recchia ,  Gianni Ferrari

IPC分类号： B01J19/08 ,  C08B37/00 ,  C08B37/04 ,  C08B37/08 ,  C08B37/10

CPC分类号： B01J19/082 ,  C08B37/0063 ,  C08B37/0078

摘要： A process for the controlled preparation of low molecular weight glucosaminoglycans by treating conventional high molecular weight glucosaminoglycans in the solid state or in solution form with a rectilinear gamma ray beam at doses within the range of 2.5 to 20 Mrad supplied by successive irradiation stages with cooling intervals between one irradiation stage and the next in the dynamic phase.The mixture obtained is subjected to fractionation, purification, neutralization and lyophilization. The glucosaminoglycans obtained have a molecular weight of between 1000 and 35,000 daltons and are used for the preparation of pharmaceutical compositions possessing antithrombotic, fibinolytic, antiatherogenic and heparin cofactor II activation activity.

摘要翻译： 通过用连续照射阶段提供的剂量在2.5至20Mrad范围内的剂量处理固体状态或溶液形式的常规高分子量葡糖胺聚糖与冷却间隔来控制制备低分子量葡糖胺聚糖的方法 在一个辐射阶段和下一个在动态阶段之间。 将得到的混合物进行分馏，纯化，中和和冻干。 获得的葡糖胺聚糖具有1000至35,000道尔顿之间的分子量，并且用于制备具有抗血栓形成，纤维蛋白溶解，抗动脉粥样化和肝素辅因子II活化活性的药物组合物。

公开(公告)号：US4746730A

公开(公告)日：1988-05-24

申请号：US74862

申请日：1987-07-17

申请人： Luigi De Ambrosi ,  Piergiuseppe Pagella

发明人： Luigi De Ambrosi ,  Piergiuseppe Pagella

IPC分类号： C07K1/113 ,  A61K38/00 ,  A61K38/16 ,  A61K38/42 ,  A61P7/06 ,  C07K14/00 ,  C07K14/805 ,  C07K13/00 ,  A61K37/14

CPC分类号： C07K14/805 ,  A61K38/00

摘要： Bio-available iron-protein derivatives having an iron content of from 2% to 20% by weight and a nitrogen content of from 12% to 16% by weight obtained by reacting acetylated globin with an iron compound selected from the group consisting of ferric chloride, iron fructate and iron saccharate, and pharmaceutical compositions for treating and preventing iron deficiency in animals and humans.

摘要翻译： 通过使乙酰化球蛋白与选自三氯化铁的铁化合物反应获得的铁含量为2重量％〜20重量％，氮含量为12〜16重量％的生物有效的铁蛋白衍生物 铁果酸铁和糖精酸铁，以及用于治疗和预防动物和人类铁缺乏症的药物组合物。