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    Sustained release capsules
    2.
    发明授权
    Sustained release capsules 有权
    缓释胶囊

    公开(公告)号：US09555225B2

    公开(公告)日：2017-01-31

    申请号：US14274282

    申请日：2014-05-09

    申请人： Merial Limited

    发明人： Robert William Lachlan Holmes

    IPC分类号： A61M31/00 ,  A61D7/00 ,  A61K9/00 ,  A61K9/48 ,  A61J3/07

    CPC分类号： A61M31/002 ,  A61D7/00 ,  A61J3/07 ,  A61K9/0068 ,  A61K9/4808 ,  A61K9/4816

    摘要： The invention relates to an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral. The capsule can have a dissolvable overcap molded from plasticized starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule. A piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen. After insertion of the capsule in the animal the overcap (if present) dissolves and separates from the capsule to release the dump dose of medicament. The sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present).

    摘要翻译： 本发明涉及一种能够将第一药物的持续释放剂量递送至动物的肿瘤内缓释胶囊，以及第二种药物或矿物质的倾倒剂量和第三种药物的出口剂量中的任一种或两种 药物或矿物质。 胶囊可以具有由可塑化淀粉模制的可溶性顶帽，从而能够将倾倒剂量的药剂保持在胶囊的顶盖和一端之间。 胶囊体内的活塞可以被修改以使其能够容纳在其中空内部中的出口剂量的药物，其与胶囊末端的孔对齐，这使得药物能够释放到瘤胃。 在将胶囊插入动物中之后，顶盖（如果存在）溶解并与胶囊分离以释放药物的吐出剂量。 然后通过有孔端分配缓释药物，然后释放出口剂量的药物（如果存在）。