-
公开(公告)号：US08124104B2
公开(公告)日：2012-02-28
申请号：US12383420
申请日：2009-03-24
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
-
2.发明申请PHARMACEUTICAL COMPOSITIONS, COMPRISING A COMBINATION OF SELECT CARRIERS, VITAMINS, TANNINS AND FLAVONOIDS AS ANTIGEN-SPECIFIC IMMUNO-MODULATORS 审中-公开药物组合物，包含选择载体，维生素，鞣剂和氟虫酯作为抗原特异性免疫调节剂的组合公开(公告)号：US20130028961A1
公开(公告)日：2013-01-31
申请号：US13531433
申请日：2012-06-22
申请人： Michael Vajdy , Shore Padrah
发明人： Michael Vajdy , Shore Padrah
IPC分类号： A61K39/39 , A61K31/07 , A61K31/59 , A61P37/02 , A61K9/127 , A61P37/04 , A61P37/06 , A61K31/355 , A61K31/353
CPC分类号： A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/577 , C12N2740/16034 , C12N2760/16134
摘要： The present invention provides adjuvant compositions that are capable of modulating the immune response in a subject, including enhancing or suppressing the immune response. These adjuvant compositions may also be used to enhance or suppress the immunogenicity of antigens by enhancing or suppressing antigen-presentation activity, enhancing or suppressing innate immune responses through activation or suppression of, e.g., natural killer cells, and/or direct activation of subsets of B and/or T cells. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions. In certain embodiments, the compositions comprise combinations of the following: a pharmaceutically acceptable carrier, a flavonoid, a tannin and a vitamin. The compositions may further comprise an antigen.
摘要翻译： 本发明提供能够调节受试者的免疫应答的佐剂组合物，包括增强或抑制免疫应答。 这些佐剂组合物还可用于通过增强或抑制抗原呈递活性来增强或抑制抗原的免疫原性，通过激活或抑制例如天然杀伤细胞增强或抑制先天免疫应答，和/或直接激活 B和/或T细胞。 还提供了制备佐剂组合物的方法以及使用佐剂组合物的方法。 在某些实施方案中，组合物包含以下组合：药学上可接受的载体，类黄酮，单宁和维生素。 组合物还可以包含抗原。
-
公开(公告)号：US20120114693A1
公开(公告)日：2012-05-10
申请号：US13349326
申请日：2012-01-12
IPC分类号： A61K39/21 , A61P37/04 , A61K39/12 , A61K39/193 , A61K39/00 , A61K39/235
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/24143 , C12N2740/16134 , C12N2740/16234 , C12N2770/36143
摘要： Mucosal delivery of antigens using, for example, a replication-defective gene delivery vehicle, particularly replication-defective alphavirus vectors and particles, is described. Also described are compositions comprising a mucosal adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing mucosal, local, and/or systemic immune responses following mucosal immunization regimes.
摘要翻译： 描述了使用例如复制缺陷基因递送载体，特别是复制缺陷型甲病毒载体和颗粒的粘膜递送抗原。 还描述了包含粘膜佐剂和一种或多种源自HIV的抗原的组合物。 还提供了这些基因递送载体在粘膜免疫方案后诱导粘膜，局部和/或全身免疫应答的用途。
-
公开(公告)号：US20110014219A1
公开(公告)日：2011-01-20
申请号：US12383425
申请日：2009-03-24
IPC分类号： A61K39/12 , C07H21/04 , A61K39/295 , A61P31/14 , C12N1/19 , C12N5/10 , A61K31/7088
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
-
公开(公告)号：US20110223197A1
公开(公告)日：2011-09-15
申请号：US12083906
申请日：2006-10-17
申请人： Michael Vajdy
发明人： Michael Vajdy
IPC分类号： A61K39/12 , A61K39/02 , A61K39/00 , A61K39/145 , A61K39/155 , A61K39/29 , A61K39/21 , A61K39/245 , A61P37/04
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/5555 , A61K2039/55566 , A61K2039/57 , C12N2740/16134 , C12N2770/36143 , C12N2770/36171 , A61K2300/00
摘要： Mucosal and systemic administration of compositions comprising alphavirus replicon particles to induce immune responses in a subject is described.
摘要翻译： 描述了包含甲病毒复制子颗粒以在受试者中诱导免疫应答的组合物的粘膜和全身施用。
-
公开(公告)号：US20110104192A1
公开(公告)日：2011-05-05
申请号：US12965344
申请日：2010-12-10
IPC分类号： A61K39/125 , C12P21/02 , C07K14/08 , A61P31/14 , A61P37/04
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
-
公开(公告)号：US20100158943A1
公开(公告)日：2010-06-24
申请号：US12092225
申请日：2006-11-06
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： Patients receive a mucosal influenza vaccine and then receive a parenteral influenza vaccine, in that order, typically during different visits to a vaccination center.
摘要翻译： 患者接受粘膜流感疫苗，然后依次接受肠胃外流感疫苗，通常在不同访问疫苗接种中心期间。
-
公开(公告)号：US20070207526A1
公开(公告)日：2007-09-06
申请号：US11603913
申请日：2006-11-22
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。
-
公开(公告)号：US10561720B2
公开(公告)日：2020-02-18
申请号：US13531433
申请日：2012-06-22
申请人： Michael Vajdy , Shore Padrah
发明人： Michael Vajdy , Shore Padrah
摘要： The present invention provides adjuvant compositions that are capable of modulating the immune response in a subject, including enhancing or suppressing the immune response. These adjuvant compositions may also be used to enhance or suppress the immunogenicity of antigens by enhancing or suppressing antigen-presentation activity, enhancing or suppressing innate immune responses through activation or suppression of, e.g., natural killer cells, and/or direct activation of subsets of B and/or T cells. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions. In certain embodiments, the compositions comprise combinations of the following: a pharmaceutically acceptable carrier, a flavonoid, a tannin and a vitamin. The compositions may further comprise an antigen.
-
公开(公告)号：US08425922B2
公开(公告)日：2013-04-23
申请号：US12651975
申请日：2010-01-04
申请人： Michael Vajdy , Shore Padrah
发明人： Michael Vajdy , Shore Padrah
IPC分类号： A61K36/31 , A61K47/44 , A61K39/00 , A61K31/07 , A61K31/353
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/541 , A61K2039/543 , A61K2039/55511 , A61K2039/55588 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2740/16334 , C12N2760/16034 , C12N2760/16134 , C12N2760/16151
摘要： This disclosure provides adjuvant compositions that are capable of modulating the immune response in a subject. These adjuvant compositions may also be used enhance the immunogenicity of antigens. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions.
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.024 秒)
