公开(公告)号：US4859602A

公开(公告)日：1989-08-22

申请号：US774140

申请日：1985-09-09

Applicant: Gerd Zimmermann ,  Josef Maier ,  Manfred Gloger

Inventor： Gerd Zimmermann ,  Josef Maier ,  Manfred Gloger

IPC: C07F9/30 ,  C07F9/38 ,  C07F9/40 ,  C07F9/6553 ,  C12N9/84 ,  C12N11/00 ,  C12P13/00 ,  C12P41/00 ,  C12R1/19

CPC classification number: C12P41/007 ,  C07F9/301 ,  C07F9/3808 ,  C12N11/00 ,  C12N9/84 ,  C12P13/001

Abstract: The present invention provides a process for the preparation of the stereoisomers of 1-aminoalkylphosphonic acids and of 1-aminoalkylphosphinic acids by enzymatic resolution of their racemic N-acyl derivatives and subsequent deacylation, wherein the enzymatic resolution is carried out with penicillin G amidase.

Abstract translation: 本发明提供了通过酶拆分其外消旋N-酰基衍生物和随后的脱酰基来制备1-氨基烷基膦酸和1-氨基烷基次膦酸的立体异构体的方法，其中酶拆分用青霉素G酰胺酶进行。

公开(公告)号：US4857462A

公开(公告)日：1989-08-15

申请号：US924140

申请日：1986-10-27

Applicant: Josef Maier ,  Manfred Gloger ,  Detlef V. Hoerschelmann ,  Jan Strejcek ,  Sebastian Heimerl

Inventor： Josef Maier ,  Manfred Gloger ,  Detlef V. Hoerschelmann ,  Jan Strejcek ,  Sebastian Heimerl

IPC: C07C27/02 ,  C07C51/09 ,  C12N9/18 ,  C12P7/40 ,  C12P7/52 ,  C12P41/00 ,  C12R1/66

CPC classification number: C12P41/005 ,  C07C51/09 ,  C12N9/18 ,  C12P7/40

Abstract: A process for obtaining D-2-(6-methoxy-2-naphthyl)-propionic acid from a mixture of D- and L-2-(6-methoxy-2-naphthyl)-propionic acid lower alkyl esters is provided by asymmetric hydrolysis of the L-ester with a microbial enzyme, separation of the 2-(6-methoxy-2-naphthyl)-propionic acid from the D-2-(6-methoxy-2-naphthyl)-propionic acid lower alkyl ester and saponification of the latter, wherein the saponification is carried out enzymatically with esterase from hog liver or from Pleurotus ostreatus.

Abstract translation: 由D-和L- -2-（6-甲氧基-2-萘基） - 丙酸低级烷基酯的混合物获得D-2-（6-甲氧基-2-萘基） - 丙酸的方法由不对称 用微生物酶水解L-酯，从D-2-（6-甲氧基-2-萘基） - 丙酸低级烷基酯分离2-（6-甲氧基-2-萘基） - 丙酸，和 后者的皂化，其中皂化通过来自猪肝或来自侧耳菇的酯酶进行酶促进行。

公开(公告)号：US4950609A

公开(公告)日：1990-08-21

申请号：US844691

申请日：1986-03-27

Applicant: Wilhelm Tischer ,  Manfred Gloger ,  Josef Heinle

Inventor： Wilhelm Tischer ,  Manfred Gloger ,  Josef Heinle

IPC: C12N9/00 ,  C12N9/06 ,  C12N9/96 ,  C12N11/10 ,  C12Q1/26

CPC classification number: C12Q1/26 ,  C12N11/10 ,  C12N9/96 ,  Y10S435/81

Abstract: The present invention provides a stabilized sarcosine oxidase preparation which contains creatineamidinohydrolase covalently bound to a water-soluble polysaccharide.

Abstract translation: 本发明提供了含有与水溶性多糖共价结合的肌酸酰氨基水解酶的稳定肌氨酸氧化酶制剂。

公开(公告)号：US4474887A

公开(公告)日：1984-10-02

申请号：US409277

申请日：1982-08-18

Applicant: Josef Maier ,  Manfred Gloger ,  Brigitte Drager

Inventor： Josef Maier ,  Manfred Gloger ,  Brigitte Drager

IPC: G01N33/68 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N2800/044 ,  Y10T436/104165

Abstract: The present invention provides a process for the determination of the .beta.-lipoprotein fraction (LDL) in body fluids, especially in serum or plasma, wherein the LDL fraction is selectively precipitated from the sample by the addition of a polyvinyl sulphate with monovalent cations and then determined.The present invention also provides a reagent for the determination of the .beta.-lipoprotein fraction (LDL) in body fluids, especially in serum or plasma, wherein it contains polyvinyl sulphate.

Abstract translation: 本发明提供了一种测定体液中特别是血清或血浆中的β-脂蛋白分数（LDL）的方法，其中通过加入具有一价阳离子的聚乙烯硫酸盐从样品中选择性沉淀LDL级分，然后 决心。 本发明还提供用于测定体液中特别是血清或血浆中的β-脂蛋白分数（LDL）的试剂，其中它含有聚乙烯硫酸盐。

公开(公告)号：US4569917A

公开(公告)日：1986-02-11

申请号：US240720

申请日：1981-03-05

Applicant: Josef Maier ,  Manfred Gloger ,  Brigitte Draeger

Inventor： Josef Maier ,  Manfred Gloger ,  Brigitte Draeger

IPC: G01N33/68 ,  C12Q1/68 ,  G01N33/92

CPC classification number: C12Q1/68 ,  G01N33/92 ,  G01N2800/044 ,  Y10T436/255

Abstract: Method of direct determination of beta-lipoproteins in a blood sample containing pre-beta-lipoprotein, (VLDL) alpha-lipoprotein (HDL), and beta-lipoprotein (LDL), comprising mixing the blood plasma or serum of the blood sample with a solid, water-insoluble anion exchanger operable to retain the pre-beta-lipoprotein (VLDL) and the alpha-lipoprotein (HDL) to remove them from solution, separating the blood plasma or serum from the anion exchanger and thereafter determining the amount of beta-lipoprotein (LDL) remaining in solution.

Abstract translation: 含有前β-脂蛋白（VLDL）α-脂蛋白（HDL）和β-脂蛋白（LDL）的血液样品中直接测定β-脂蛋白的方法，包括将血液样品的血浆或血清与 固体，不溶于水的阴离子交换剂，其可操作地保留前β-脂蛋白（VLDL）和α-脂蛋白（HDL）以从溶液中除去它们，将血浆或血清与阴离子交换剂分离，然后测定β - 脂蛋白（LDL）残留在溶液中。

公开(公告)号：US4460683A

公开(公告)日：1984-07-17

申请号：US394562

申请日：1982-07-02

Applicant: Manfred Gloger ,  Josef Heinle ,  Helmut Schlumberger

Inventor： Manfred Gloger ,  Josef Heinle ,  Helmut Schlumberger

IPC: C12N9/00 ,  C12N9/06 ,  C12N11/08 ,  C12N11/10 ,  C12Q1/26 ,  C12Q1/62 ,  C12N11/02 ,  C12N11/06

CPC classification number: C12N11/10 ,  C12N11/08 ,  C12Q1/62

Abstract: The present invention provides liver uricase, wherein it is covalently bond to a water-soluble polysaccharide, polyacid anhydride, polyvinylpyrrolidone or acid anhydride as carrier substance and is still soluble at pH values below 6.The present invention also provides a process for the preparation of this liver uricase.

Abstract translation: 本发明提供肝尿酸酶，其中其与水溶性多糖，多酸酐，聚乙烯吡咯烷酮或酸酐共价键合作为载体物质，并且在pH值低于6时仍然是可溶的。本发明还提供了制备 这种肝尿酸酶。