Method of preparing crosslinked collagen microspheres
    9.
    发明申请
    Method of preparing crosslinked collagen microspheres 审中-公开
    制备交联胶原微球的方法

    公开(公告)号:US20060222680A1

    公开(公告)日:2006-10-05

    申请号:US11095802

    申请日:2005-03-31

    IPC分类号: A61F2/00

    CPC分类号: B01J13/14

    摘要: The present invention is drawn to methods of preparing crosslinked collagen microspheres and microparticles, where a solution of soluble collagen in an aqueous acidic medium is combined with an emulsifying agent to form a first mixture of the soluble collagen solution and the emulsifying agent, the first mixture then is combined with a hydrophobic liquid under conditions effective to form water-in-oil emulsion of the hydrophobic liquid and the first mixture, the water-in-oil emulsion then is added to a buffered alcohol solution under conditions effective to form a dispersion of a continuous liquid phase and a dispersed solid phase of collagen fibers reconstituted from the soluble collagen solution, the liquid phase then is removed from the dispersion to provide collagen microspheres, the collagen microspheres then are crosslinked to form crosslinked collagen microspheres, and the crosslinked collagen microspheres then are optionally dried to form crosslinked collagen microparticles.

    摘要翻译: 本发明涉及制备交联胶原微球和微粒的方法,其中可溶性胶原在酸性介质中的溶液与乳化剂结合形成可溶性胶原溶液和乳化剂的第一混合物,第一混合物 然后在有效形成疏水性液体和第一混合物的油包水乳液的条件下与疏水性液体混合,然后在有效形成分散体的条件下将油包水乳液加入缓冲的醇溶液中 从可溶性胶原溶液中重新构成胶原纤维的连续液相和分散固相,然后从分散体中除去液相,提供胶原微球,然后将胶原微球交联形成交联胶原微球,并将交联的胶原微球 然后任选地干燥以形成交联的胶原微粒。