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公开(公告)号：US20080220008A1
公开(公告)日：2008-09-11
申请号：US11660449
申请日：2005-08-17
CPC分类号： A61K39/21 , A61K38/162 , A61K2300/00 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/15022 , C12N2740/16322 , G01N2333/163
摘要： Described is the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of the protein.
摘要翻译： 描述了在HIV或SIV辅助蛋白的免疫抑制结构域中使用至少一个氨基酸的突变来调节蛋白质的免疫抑制性质。
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2.发明申请公开(公告)号：US20080008683A1
公开(公告)日：2008-01-10
申请号：US11547399
申请日：2005-03-30
摘要： The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence: X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on the immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
摘要翻译： 本发明涉及具有7至20个氨基酸残基的序列的多肽，其能够调节其表达的宿主（免疫抑制调节序列）的病毒蛋白或其片段的免疫抑制性质（免疫抑制调节序列） 它代替病毒蛋白或片段的同源序列，所述多肽包括最小以下共有氨基酸序列：X 1 Y Y Y Y 其中，选择X 1和X 2，其中X 1，X 2，X 2，X 2， 以影响免疫抑制性质，Y 9至Y 12代表可变氨基酸残基。
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公开(公告)号：US07700303B2
公开(公告)日：2010-04-20
申请号：US11839894
申请日：2007-08-16
CPC分类号： G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/566
摘要： The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.
摘要翻译： 本发明涉及生物传感器，获得它们的方法及其在直接免疫荧光中检测，测定或定位诸如异种群体中的抗原或半抗原的配体的用途。 生物传感器包括（i）属于本质上蛋白质的受体的至少一个片段，其能够经由活性位点结合配体，其中位于活性位点附近的片段的至少一个氨基酸残基是天然的 以Cys残基的形式存在，或被Cys残基取代，和（ii）与Cys残基偶联的荧光团。
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4.发明申请公开(公告)号：US20120189647A1
公开(公告)日：2012-07-26
申请号：US13399208
申请日：2012-02-17
IPC分类号： A61K39/12 , A61P31/12 , C12N15/63 , C07K14/005 , C12N15/31
摘要： Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed.
摘要翻译： 在跨膜亚基（TM）的免疫抑制结构域（ISU）中具有突变的突变病毒ENV蛋白相对于野生型ENV蛋白具有降低的免疫抑制活性。 还公开了包括编码蛋白质的蛋白质和核酸的药物组合物。
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公开(公告)号：US07271249B2
公开(公告)日：2007-09-18
申请号：US10204431
申请日：2001-03-01
CPC分类号： G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/566
摘要： The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of said active site is naturally present in the form of a cystein Cys residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.
摘要翻译： 本发明涉及生物传感器，获得它们的方法及其在直接免疫荧光中检测，测定或定位异构群体中的配体如抗原或半抗原的用途。 生物传感器包括（i）属于本质上蛋白质的受体的至少一个片段，其能够经由活性位点结合配体，其中位于所述活性位点附近的片段的至少一个氨基酸残基是天然的 以半胱氨酸Cys残基的形式存在，或被Cys残基取代，和（ii）与Cys残基偶联的荧光团。
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6.发明授权公开(公告)号：US08178657B2
公开(公告)日：2012-05-15
申请号：US11547399
申请日：2005-03-30
摘要： The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence: X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on the immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
摘要翻译： 本发明涉及具有7至20个氨基酸残基的序列的多肽，其能够调节其表达的宿主（免疫抑制调节序列）的病毒蛋白或其片段的免疫抑制性质（免疫抑制调节序列） 其替代病毒蛋白或片段的同源序列，包括最小以下共有氨基酸序列的多肽：X1Y9Y10Y11CY12X2其中X1和X2被选择以影响免疫抑制性质，Y9至Y12表示可变氨基酸残基。
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公开(公告)号：US20100159480A1
公开(公告)日：2010-06-24
申请号：US12693013
申请日：2010-01-25
IPC分类号： G01N33/573 , G01N33/566
CPC分类号： G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/566
摘要： The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.
摘要翻译： 本发明涉及生物传感器，获得它们的方法及其在直接免疫荧光中检测，测定或定位诸如异种群体中的抗原或半抗原的配体的用途。 生物传感器包括（i）属于本质上蛋白质的受体的至少一个片段，其能够经由活性位点结合配体，其中位于活性位点附近的片段的至少一个氨基酸残基是天然的 以Cys残基的形式存在，或被Cys残基取代，和（ii）与Cys残基偶联的荧光团。
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公开(公告)号：US08795685B2
公开(公告)日：2014-08-05
申请号：US11660449
申请日：2005-08-17
CPC分类号： A61K39/21 , A61K38/162 , A61K2300/00 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/15022 , C12N2740/16322 , G01N2333/163
摘要： Described is the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of the protein.
摘要翻译： 描述了在HIV或SIV辅助蛋白的免疫抑制结构域中使用至少一个氨基酸的突变来调节蛋白质的免疫抑制性质。
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9.发明授权Mutated env sequence involved in the modulation of the immunosuppressive effect of viral proteins 有权突变的env序列涉及病毒蛋白的免疫抑制作用的调节公开(公告)号：US08597657B2
公开(公告)日：2013-12-03
申请号：US13399208
申请日：2012-02-17
摘要： Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed.
摘要翻译： 在跨膜亚基（TM）的免疫抑制结构域（ISU）中具有突变的突变病毒ENV蛋白相对于野生型ENV蛋白具有降低的免疫抑制活性。 还公开了包括编码蛋白质的蛋白质和核酸的药物组合物。
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公开(公告)号：US20090017454A1
公开(公告)日：2009-01-15
申请号：US11839894
申请日：2007-08-16
IPC分类号： C12Q1/68 , G01N33/566 , C12Q1/02 , C12N15/00 , C40B50/14
CPC分类号： G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/566
摘要： The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.
摘要翻译： 本发明涉及生物传感器，获得它们的方法及其在直接免疫荧光中检测，测定或定位诸如异种群体中的抗原或半抗原的配体的用途。 生物传感器包括（i）属于本质上蛋白质的受体的至少一个片段，其能够经由活性位点结合配体，其中位于活性位点附近的片段的至少一个氨基酸残基是天然的 以Cys残基的形式存在，或被Cys残基取代，和（ii）与Cys残基偶联的荧光团。
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