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1.发明申请公开(公告)号：US20120189647A1
公开(公告)日：2012-07-26
申请号：US13399208
申请日：2012-02-17
IPC分类号： A61K39/12 , A61P31/12 , C12N15/63 , C07K14/005 , C12N15/31
摘要： Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed.
摘要翻译： 在跨膜亚基（TM）的免疫抑制结构域（ISU）中具有突变的突变病毒ENV蛋白相对于野生型ENV蛋白具有降低的免疫抑制活性。 还公开了包括编码蛋白质的蛋白质和核酸的药物组合物。
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公开(公告)号：US20080220008A1
公开(公告)日：2008-09-11
申请号：US11660449
申请日：2005-08-17
CPC分类号： A61K39/21 , A61K38/162 , A61K2300/00 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/15022 , C12N2740/16322 , G01N2333/163
摘要： Described is the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of the protein.
摘要翻译： 描述了在HIV或SIV辅助蛋白的免疫抑制结构域中使用至少一个氨基酸的突变来调节蛋白质的免疫抑制性质。
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3.发明申请公开(公告)号：US20080008683A1
公开(公告)日：2008-01-10
申请号：US11547399
申请日：2005-03-30
摘要： The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence: X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on the immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
摘要翻译： 本发明涉及具有7至20个氨基酸残基的序列的多肽，其能够调节其表达的宿主（免疫抑制调节序列）的病毒蛋白或其片段的免疫抑制性质（免疫抑制调节序列） 它代替病毒蛋白或片段的同源序列，所述多肽包括最小以下共有氨基酸序列：X 1 Y Y Y Y 其中，选择X 1和X 2，其中X 1，X 2，X 2，X 2， 以影响免疫抑制性质，Y 9至Y 12代表可变氨基酸残基。
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公开(公告)号：US08795685B2
公开(公告)日：2014-08-05
申请号：US11660449
申请日：2005-08-17
CPC分类号： A61K39/21 , A61K38/162 , A61K2300/00 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/15022 , C12N2740/16322 , G01N2333/163
摘要： Described is the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of the protein.
摘要翻译： 描述了在HIV或SIV辅助蛋白的免疫抑制结构域中使用至少一个氨基酸的突变来调节蛋白质的免疫抑制性质。
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5.发明授权Mutated env sequence involved in the modulation of the immunosuppressive effect of viral proteins 有权突变的env序列涉及病毒蛋白的免疫抑制作用的调节公开(公告)号：US08597657B2
公开(公告)日：2013-12-03
申请号：US13399208
申请日：2012-02-17
摘要： Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed.
摘要翻译： 在跨膜亚基（TM）的免疫抑制结构域（ISU）中具有突变的突变病毒ENV蛋白相对于野生型ENV蛋白具有降低的免疫抑制活性。 还公开了包括编码蛋白质的蛋白质和核酸的药物组合物。
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6.发明授权公开(公告)号：US08178657B2
公开(公告)日：2012-05-15
申请号：US11547399
申请日：2005-03-30
摘要： The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence: X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on the immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
摘要翻译： 本发明涉及具有7至20个氨基酸残基的序列的多肽，其能够调节其表达的宿主（免疫抑制调节序列）的病毒蛋白或其片段的免疫抑制性质（免疫抑制调节序列） 其替代病毒蛋白或片段的同源序列，包括最小以下共有氨基酸序列的多肽：X1Y9Y10Y11CY12X2其中X1和X2被选择以影响免疫抑制性质，Y9至Y12表示可变氨基酸残基。
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7.发明授权Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene 有权重组猫白血病病毒疫苗含有优化的猫白血病病毒包膜基因公开(公告)号：US08980280B2
公开(公告)日：2015-03-17
申请号：US13365018
申请日：2012-02-02
申请人： Herve Poulet , Thierry Heidmann
发明人： Herve Poulet , Thierry Heidmann
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2710/24043 , C12N2740/13034 , C12N2740/13071
摘要： The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
摘要翻译： 本发明提供载体，其含有并表达体内或体外FeLV抗原，其在动物或人体内针对FeLV引起免疫应答，包含所述载体和/或FeLV多肽的组合物，针对FeLV的疫苗接种方法以及用于其的试剂盒 方法和组成。
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8.发明申请RECOMBINANT FELINE LEUKEMIA VIRUS VACCINE CONTAINING OPTIMIZED FELINE LEUKEMIA VIRUS ENVELOPE GENE 有权含有优化的FELINE LEUKEMIA VIRUS ENVELOPE GENE的重组FELINE LEUKEMIA VIREINE VACCINE公开(公告)号：US20120183569A1
公开(公告)日：2012-07-19
申请号：US13365018
申请日：2012-02-02
申请人： Hervé Poulet , Thierry Heidmann
发明人： Hervé Poulet , Thierry Heidmann
IPC分类号： A61K39/21 , C12N15/48 , C12N15/63 , A61P31/14 , C12N1/19 , C12N5/10 , A61P37/04 , C07K14/15 , C12N1/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2710/24043 , C12N2740/13034 , C12N2740/13071
摘要： The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
摘要翻译： 本发明提供载体，其含有并表达体内或体外FeLV抗原，其在动物或人体内针对FeLV引起免疫应答，包含所述载体和/或FeLV多肽的组合物，针对FeLV的疫苗接种方法以及用于其的试剂盒 方法和组成。
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9.发明申请RECOMBINANT FELINE LEUKEMIA VIRUS VACCINE CONTAINING OPTIMIZED FELINE LEUKEMIA VIRUS ENVELOPE GENE 有权含有优化的FELINE LEUKEMIA VIRUS ENVELOPE GENE的重组FELINE LEUKEMIA VIREINE VACCINE公开(公告)号：US20130022632A1
公开(公告)日：2013-01-24
申请号：US13364993
申请日：2012-02-02
申请人： Hervé Poulet , Thierry Heidmann
发明人： Hervé Poulet , Thierry Heidmann
IPC分类号： A61K31/711 , A61P31/14 , C12N15/85 , A61K39/21
CPC分类号： C07K14/005 , A61K31/04 , A61K38/162 , A61K39/12 , A61K39/21 , A61K39/275 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , A61K2300/00 , C07K14/15 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2710/24044 , C12N2740/13022 , C12N2740/13034 , C12N2800/22
摘要： The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
摘要翻译： 本发明提供载体，其含有并表达体内或体外FeLV抗原，其在动物或人体内针对FeLV引起免疫应答，包含所述载体和/或FeLV多肽的组合物，针对FeLV的疫苗接种方法以及用于其的试剂盒 方法和组成。
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10.发明授权Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene 有权重组猫白血病病毒疫苗含有优化的猫白血病病毒包膜基因公开(公告)号：US08895027B2
公开(公告)日：2014-11-25
申请号：US13364993
申请日：2012-02-02
申请人： Hervé Poulet , Thierry Heidmann
发明人： Hervé Poulet , Thierry Heidmann
IPC分类号： A61K39/21 , C12N15/00 , C07H21/04 , C07K14/00 , A61K39/12 , A61K39/275 , C07K14/15 , A61K31/04 , A61K38/16 , C07K14/005 , C12N15/86 , A61K39/00
CPC分类号： C07K14/005 , A61K31/04 , A61K38/162 , A61K39/12 , A61K39/21 , A61K39/275 , A61K2039/5256 , A61K2039/53 , A61K2039/70 , A61K2300/00 , C07K14/15 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2710/24044 , C12N2740/13022 , C12N2740/13034 , C12N2800/22
摘要： The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.
摘要翻译： 本发明提供载体，其含有并表达体内或体外FeLV抗原，其在动物或人体内针对FeLV引起免疫应答，包含所述载体和/或FeLV多肽的组合物，针对FeLV的疫苗接种方法以及用于其的试剂盒 方法和组成。
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