公开(公告)号：US09791459B2

公开(公告)日：2017-10-17

申请号：US13318797

申请日：2010-05-04

申请人： Matthias Keller ,  Hans-Peter Deigner ,  David Enot ,  Matthias Kohl ,  Ronnaug Solberg ,  Ola Didrik Saugstad ,  Therese Koal

发明人： Matthias Keller ,  Hans-Peter Deigner ,  David Enot ,  Matthias Kohl ,  Ronnaug Solberg ,  Ola Didrik Saugstad ,  Therese Koal

IPC分类号： G01N33/48 ,  G01N33/68 ,  G06F19/24

CPC分类号： G01N33/6893 ,  G01N2800/12 ,  G06F19/24 ,  Y02A90/26

摘要： A method for in vitro diagnosing asphyxia and disorders related thereto, a method of in vitro estimating duration of hypoxia in a patient subjected to asphyxia, and a method for in vitro monitoring of normoxic, hypoxic and hyperoxic conditions and/or normobaric and hyperbaric oxygen therapy, includes quantitatively detecting in a biological sample of a patient a plurality of asphyxia specific endogenous compounds which are selected from the group consisting of biogenic amines; carnitine-derived compounds; amino acids; bile acids; carboxylic acids; eicosanoids; lipids; precursors of cholesterol, cholesterol metabolites; prostanoids; and sugars.

公开(公告)号：US08362123B2

公开(公告)日：2013-01-29

申请号：US13240237

申请日：2011-09-22

申请人： Matthias Kohl ,  Manfred Proebster ,  Sandra Foncillas

发明人： Matthias Kohl ,  Manfred Proebster ,  Sandra Foncillas

IPC分类号： C09J177/00 ,  C09J133/08 ,  C09J167/00

CPC分类号： C08G65/336 ,  C08F230/08 ,  C08L67/00 ,  C08L77/00 ,  C08L2666/02 ,  C09J171/02 ,  Y10T428/283 ,  Y10T428/2887 ,  Y10T428/31612 ,  Y10T428/31663

摘要： A one-component moisture-curing adhesive containing at least one flowable polyoxyalkylene or polyacrylate prepolymer with at least one hydrolyzable silane group, at least one inert additive solid at room temperature selected from hydrocarbon resins, polyesters or polyamides with a softening point of 40 to 150° C., together with auxiliary substances and additives.

摘要翻译： 含有至少一种具有至少一种可水解硅烷基团的可流动的聚氧化烯或聚丙烯酸酯预聚物的单组分湿固化粘合剂，室温下至少一种惰性添加剂固体，其选自烃树脂，聚酯或软化点为40至150的聚酰胺 °C，以及辅助物质和添加剂。

公开(公告)号：US20120329942A1

公开(公告)日：2012-12-27

申请号：US13558507

申请日：2012-07-26

申请人： Matthias Kohl ,  Andreas Bolte ,  Nick Spielkamp ,  Manfred Pröbster ,  Deniz Yilmazoglu

发明人： Matthias Kohl ,  Andreas Bolte ,  Nick Spielkamp ,  Manfred Pröbster ,  Deniz Yilmazoglu

IPC分类号： C08G77/04 ,  C09D183/04 ,  C08L83/04

CPC分类号： C08L71/02 ,  C08G65/336 ,  C08L83/04

摘要： The invention relates to curable compositions comprising a) at least one organic polymer selected from polyethers and polyacrylic acid esters, wherein the organic polymer has at least one defined, cross-linkable end group having at least one C1-C8-alkoxy- or C1-C8-acyloxy radical, b) at least one poly(dialkylsiloxane) having at least one defined, cross-linkable end group having at least one vinyl radical and likewise at least one C1-C8-alkoxy- or C1-C8-acyloxy radical and c) at least one flame-retarding additive selected from red phosphorus, organic phosphor compounds, ammonia polyphosphate, metal hydroxides, expandable graphite, zinc borate and melamine salts, to the use of such compositions as adhesive, sealing or coating material, in particular for providing a substrate having a flame-retardant, elastic coating, to a coating thus obtained and to the use of at least one poly(dialkylsiloxane) b) to improve the fire properties of a curable composition comprising at least one organic polymer a).

摘要翻译： 本发明涉及包含a）至少一种选自聚醚和聚丙烯酸酯的有机聚合物的可固化组合物，其中有机聚合物具有至少一个具有至少一个具有至少一个C 1 -C 8 - 烷氧基 - 或C 1 -C 8 - C8-酰氧基，b）至少一种具有至少一个具有至少一个乙烯基和同样至少一个C 1 -C 8 - 烷氧基 - 或C 1 -C 8 - 酰氧基的至少一个限定的可交联端基的聚（二烷基硅氧烷），和 c）至少一种选自红磷，有机磷光体化合物，多磷酸铵，金属氢氧化物，可膨胀石墨，硼酸锌和三聚氰胺盐的阻燃添加剂，用于粘合剂，密封或涂料的这种组合物，特别是用于 向由此获得的涂层提供具有阻燃弹性涂层的基材，以及使用至少一种聚（二烷基硅氧烷）b）来改善包含至少一种有机溶剂的可固化组合物的耐火性能 lymer a）。

公开(公告)号：US20120277559A1

公开(公告)日：2012-11-01

申请号：US13514376

申请日：2010-12-08

申请人： Matthias Kohl-Bareis ,  Branislav Ebert ,  Jens P. Dreier ,  Christoph Leithner ,  Ute Lindauer ,  Georg Royl

发明人： Matthias Kohl-Bareis ,  Branislav Ebert ,  Jens P. Dreier ,  Christoph Leithner ,  Ute Lindauer ,  Georg Royl

IPC分类号： A61B5/0265 ,  A61B6/00 ,  A61B5/1455

CPC分类号： A61B5/0261

摘要： Apparatus for measuring blood parameters such as chromophore, for example haemoglobin, concentration and blood flow detects light scattered from tissue surface (20) with a multispectral detector (24) that is sensitive to light across a range of different wavelengths. Algorithms are described that demonstrate extraction of chromophore information from scattered light occupying two, red and green or blue, or three bands of the visible spectrum. Simultaneous extraction of blood flow information from scattered laser light occupying either the same or a distinct spectral band is also described.

摘要翻译： 用于测量血液参数的装置，例如发色团，例如血红蛋白，浓度和血液流量，利用对不同波长范围的光敏感的多光谱检测器（24）检测从组织表面（20）散射的光。 描述了算法，其演示了从占据两个红色和绿色或蓝色或三个可见光谱带的散射光中提取发色团信息。 还描述了从占据相同或不同光谱带的分散激光中同时提取血流信息。

公开(公告)号：US08101681B2

公开(公告)日：2012-01-24

申请号：US12483521

申请日：2009-06-12

申请人： Matthias Kohl ,  Manfred Pröbster

发明人： Matthias Kohl ,  Manfred Pröbster

IPC分类号： C08L83/00

CPC分类号： C08G65/336 ,  C08L23/26 ,  C08L51/06 ,  C08L2666/06 ,  C09D171/02 ,  C09J171/02

摘要： Monocomponent water-hardening adhesive/sealant compositions comprising mixtures of at least one silane-functional polyoxyalkylene prepolymer and at least one silane-functional polyolefin are described. These compositions may optionally comprise other nonpolar plasticizers, as well as catalysts, fillers, and adhesives. Such adhesive/sealant compositions exhibit outstanding adhesion to plastic substrates and to painted surfaces, whereby the adhesion is maintained even after storage in wet conditions.

摘要翻译： 描述了包含至少一种硅烷官能聚氧化烯预聚物和至少一种硅烷官能聚烯烃的混合物的单组分水硬化粘合剂/密封剂组合物。 这些组合物可任选地包含其它非极性增塑剂，以及催化剂，填料和粘合剂。 这种粘合剂/密封剂组合物对塑料基材和涂漆表面表现出优异的粘合性，由此即使在潮湿条件下储存之后仍保持粘合。

公开(公告)号：US20070088110A1

公开(公告)日：2007-04-19

申请号：US11593189

申请日：2006-11-03

申请人： Matthias Kohl ,  Roland Reichenbach-Klinke ,  Patrick Steigerwald ,  Gisbert Kern ,  Manfred Proebster

发明人： Matthias Kohl ,  Roland Reichenbach-Klinke ,  Patrick Steigerwald ,  Gisbert Kern ,  Manfred Proebster

IPC分类号： B60C1/00 ,  C08K5/24

CPC分类号： C08G18/10 ,  C08G2190/00 ,  C09J201/10 ,  C08G18/289 ,  C08G18/307

摘要： A two part adhesive/sealant composition is provided, wherein component A contains at least one silane-terminated prepolymer, at least one silane crosslinking catalyst, and at least one low molecular weight organofunctional silane and component B contains at least one silane-terminated prepolymer, water and at least one water-dissolving and/or water-adsorbing agent such as an organic or inorganic thickener. Such compositions are exceptionally insensitive to mixing and dosing errors in use and are useful for forming elastic bonds between substrates.

摘要翻译： 提供两部分粘合剂/密封剂组合物，其中组分A包含至少一种硅烷封端的预聚物，至少一种硅烷交联催化剂和至少一种低分子量有机官能硅烷，组分B含有至少一种硅烷封端的预聚物， 水和至少一种水溶性和/或水吸附剂如有机或无机增稠剂。 这种组合物对使用中的混合和给料误差特别不敏感，并且可用于在基材之间形成弹性粘合。

公开(公告)号：US20120208282A1

公开(公告)日：2012-08-16

申请号：US13381860

申请日：2010-06-23

申请人： Hans-Peter Deigner ,  Matthias Kohl ,  Matthias Keller ,  Therese Koal ,  David Enot

发明人： Hans-Peter Deigner ,  Matthias Kohl ,  Matthias Keller ,  Therese Koal ,  David Enot

IPC分类号： G01N27/62 ,  G01R33/465

CPC分类号： G16B40/00 ,  G01N2800/60 ,  Y10T436/163333 ,  Y10T436/201666

摘要： The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da.

摘要翻译： 本发明涉及内源性参考代谢物的使用以及对应于哺乳动物受试者的生物样品中所选靶标代谢物的量和/或浓度的强度数据的归一化方法，其中所述强度数据通过代谢组学分析法 与一种或多种内源性参考代谢物，包括在所述生物样品中进行所述选择的目标代谢物的至少一种体外代谢组学分析方法，同时在同一样品中进行一种或多种内源性参考代谢物的定量分析 或其衍生物，其中所述内源性参考代谢物是生物样品中以基本恒定水平存在于受试者中的这样的化合物; 并且其中所述内源性参考代谢物或其衍生物具有小于1500Da的分子量。

公开(公告)号：US20120202240A1

公开(公告)日：2012-08-09

申请号：US13387572

申请日：2010-07-23

申请人： Hans-Peter Deigner ,  Matthias Kohl ,  David Enot ,  Theresa Koal ,  Matthias Keller

发明人： Hans-Peter Deigner ,  Matthias Kohl ,  David Enot ,  Theresa Koal ,  Matthias Keller

IPC分类号： G01N27/62 ,  G01R33/48 ,  G06F19/00 ,  H01J49/26 ,  G01N27/72

CPC分类号： G01N33/6893 ,  G01N2800/26 ,  G16B5/00 ,  G16B40/00 ,  Y10T436/173845

摘要： The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.

摘要翻译： 本发明涉及用于通过受试者的定量代谢组学谱来预测来自哺乳动物受试者的体外生物样品的炎症相关器官功能衰竭发作的可能性的可靠和统计学上显着的方法，所述定量代谢组学特征包括多种内源性代谢物， 并将其与多种内源性器官衰竭预测目标代谢物的定量参考代谢组学谱进行比较，以便预测受试者是否可能或不可能发生器官功能衰竭。 此外，本发明涉及在这种方法中内源性器官衰竭预测目标代谢物的有用性。

公开(公告)号：US07259209B2

公开(公告)日：2007-08-21

申请号：US10240144

申请日：2001-03-20

申请人： Stefan Grimm ,  Manfred Proebster ,  Matthias Kohl ,  Andreas Ferencz

发明人： Stefan Grimm ,  Manfred Proebster ,  Matthias Kohl ,  Andreas Ferencz

IPC分类号： C08L43/00 ,  C08L9/00 ,  C08L47/00 ,  C08L23/04 ,  C08L23/10 ,  C08L25/02

CPC分类号： C09J123/22 ,  C08J3/124 ,  C08L23/22 ,  C08L23/26 ,  C08L51/04 ,  C08L2312/00 ,  C08L2666/04 ,  C08L2666/24 ,  C09J123/26

摘要： A mixture of at least two thermoplastic particles having reactive grups which when melted and mixed react to form a high molecular weight polymer. The blend of particles when molten is particularly useful in forming double insulating glass or plastic panels.

摘要翻译： 具有反应性聚合物的至少两种热塑性颗粒的混合物在熔融和混合时反应以形成高分子量聚合物。 当熔融时颗粒的混合物特别适用于形成双层绝缘玻璃或塑料板。

公开(公告)号：US5825488A

公开(公告)日：1998-10-20

申请号：US745204

申请日：1996-11-08

申请人： Matthias Kohl ,  Mark Cope ,  Matthias Essenpreis ,  Dirk Boecker

发明人： Matthias Kohl ,  Mark Cope ,  Matthias Essenpreis ,  Dirk Boecker

IPC分类号： G01N33/483 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/49 ,  G01N33/543 ,  G01N21/47

CPC分类号： G01N21/49

摘要： A method and an apparatus for determining analytical data concerning the inside of a scattering matrix, in particular of a biological sample. In a detection step detection measurements are carried out in which light is irradiated into the matrix as primary light at an irradiation site (12) through an interface bounding the scattering matrix (6) and light emerging out of the scattering matrix through the interface is detected as secondary light at a detection site (13) at a predetermined measuring distance from the irradiation site, in order to determine as a measurement variable a measurable physical property of the light which varies due to the interaction of the light with the scattering matrix, which measurement variable is a measure of the analytical data to be determined. In an evaluation step the analytical data are determined on the basis of the measurement variable measured in the detection step. In order that such a matrix analysis may be carried out with relatively simple measuring means, at least two detection measurements are carried out in the detection step with different reflection conditions at the interface (5) between the irradiation site (12) and the detection site (13), in each of which the measurement value of the measurement variable is determined.

摘要翻译： 一种用于确定关于散射矩阵，特别是生物样品的内部的分析数据的方法和装置。 在检测步骤中，进行检测测量，其中在辐射位置（12）处通过界定散射矩阵（6）的界面将光照射到基质中作为初级光，并且检测出通过界面从散射矩阵出射的光 作为在距离照射部位预定测量距离处的检测部位（13）处的二次光，以便将由于光与散射矩阵的相互作用而变化的光的可测量的物理性质确定为测量变量，其中 测量变量是要确定的分析数据的度量。 在评估步骤中，基于在检测步骤中测量的测量变量来确定分析数据。 为了可以用相对简单的测量装置进行这种矩阵分析，在具有不同反射条件的检测步骤中，在照射部位（12）和检测部位（5）之间的界面（5）处进行至少两次检测测量 （13），其中每个测量变量的测量值被确定。