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公开(公告)号：US09791459B2
公开(公告)日：2017-10-17
申请号：US13318797
申请日：2010-05-04
申请人： Matthias Keller , Hans-Peter Deigner , David Enot , Matthias Kohl , Ronnaug Solberg , Ola Didrik Saugstad , Therese Koal
发明人： Matthias Keller , Hans-Peter Deigner , David Enot , Matthias Kohl , Ronnaug Solberg , Ola Didrik Saugstad , Therese Koal
CPC分类号： G01N33/6893 , G01N2800/12 , G06F19/24 , Y02A90/26
摘要： A method for in vitro diagnosing asphyxia and disorders related thereto, a method of in vitro estimating duration of hypoxia in a patient subjected to asphyxia, and a method for in vitro monitoring of normoxic, hypoxic and hyperoxic conditions and/or normobaric and hyperbaric oxygen therapy, includes quantitatively detecting in a biological sample of a patient a plurality of asphyxia specific endogenous compounds which are selected from the group consisting of biogenic amines; carnitine-derived compounds; amino acids; bile acids; carboxylic acids; eicosanoids; lipids; precursors of cholesterol, cholesterol metabolites; prostanoids; and sugars.
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公开(公告)号：US20120136581A1
公开(公告)日：2012-05-31
申请号：US13318797
申请日：2010-05-04
申请人： Matthias Keller , Hans-Peter Deigner , David Enot , Matthias Kohl , Ronnaug Solberg , Olga Didrik Saugstad , Therese Koal
发明人： Matthias Keller , Hans-Peter Deigner , David Enot , Matthias Kohl , Ronnaug Solberg , Olga Didrik Saugstad , Therese Koal
IPC分类号： G06F19/00
CPC分类号： G01N33/6893 , G01N2800/12 , G06F19/24 , Y02A90/26
摘要： A method for in vitro diagnosing asphyxia and disorders related thereto, a method of in vitro estimating duration of hypoxia in a patient subjected to asphyxia, and a method for in vitro monitoring of normoxic, hypoxic and hyperoxic conditions and/or normobaric and hyperbaric oxygen therapy, includes quantitatively detecting in a biological sample of a patient a plurality of asphyxia specific endogenous compounds which are selected from the group consisting of biogenic amines; carnitine-derived compounds; amino acids; bile acids; carboxylic acids; eicosanoids; lipids; precursors of cholesterol, cholesterol metabolites; prostanoids; and sugars.
摘要翻译： 用于体外诊断与其相关的窒息和障碍的方法，体外估计患有窒息的患者的缺氧持续时间的方法和用于体外监测正常氧，缺氧和高氧条件和/或正常和高压氧治疗的方法 包括定量检测患者的生物样品中多种选自生物胺的窒息特异性内源性化合物; 肉碱衍生化合物; 氨基酸; 胆汁酸 羧酸; 类花生酸 脂质 胆固醇前体，胆固醇代谢物; 前列腺素 和糖。
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3.发明申请Method For Normalization in Metabolomics Analysis Methods with Endogenous Reference Metabolites. 审中-公开用内源性参考代谢物代谢组学分析方法进行正常化的方法。公开(公告)号：US20120208282A1
公开(公告)日：2012-08-16
申请号：US13381860
申请日：2010-06-23
申请人： Hans-Peter Deigner , Matthias Kohl , Matthias Keller , Therese Koal , David Enot
发明人： Hans-Peter Deigner , Matthias Kohl , Matthias Keller , Therese Koal , David Enot
IPC分类号： G01N27/62 , G01R33/465
CPC分类号： G16B40/00 , G01N2800/60 , Y10T436/163333 , Y10T436/201666
摘要： The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da.
摘要翻译： 本发明涉及内源性参考代谢物的使用以及对应于哺乳动物受试者的生物样品中所选靶标代谢物的量和/或浓度的强度数据的归一化方法，其中所述强度数据通过代谢组学分析法 与一种或多种内源性参考代谢物，包括在所述生物样品中进行所述选择的目标代谢物的至少一种体外代谢组学分析方法，同时在同一样品中进行一种或多种内源性参考代谢物的定量分析 或其衍生物，其中所述内源性参考代谢物是生物样品中以基本恒定水平存在于受试者中的这样的化合物; 并且其中所述内源性参考代谢物或其衍生物具有小于1500Da的分子量。
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公开(公告)号：US20120115138A1
公开(公告)日：2012-05-10
申请号：US13263429
申请日：2010-03-31
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G16B20/00 , G16B25/00 , G16B40/00 , G16B50/00
摘要： The present invention relates to a method and kit for in vitro diagnosing a complex disease such as cancer, in particular, acute myeloid leukemia (AML), colon cancer, kidney cancer, prostate cancer; transient ischemic attack (TIA), ischemia, in particular stroke, hypoxia, hypoxic-ischemic encephalopathy, perinatal brain damage, hypoxic-ischemic encephalopathy of neotatals asphyxia; demyelinating disease, in particular, white-matter disease, periventricular leukoencephalopathy, multiple sclerosis, Alzheimer and Parkinson's disease; in a biological sample. For the diagnosis, use is made of measuring at least two different species of biomolecules and classifying the results by means of suitable classifier algorithms and other statistical procedures. With the present invention, a significant improvement of the reliability of e.g. expression profiles alone, are achieved. In other words, in a defined collective, an up to 100% accurate positive diagnosis could be achieved, which renders the method of the present invention superior over the prior art.
摘要翻译： 本发明涉及用于体外诊断复杂疾病如癌症，特别是急性骨髓性白血病（AML），结肠癌，肾癌，前列腺癌的方法和试剂盒; 短暂性脑缺血发作（TIA），缺血，特别是中风，缺氧，缺氧缺血性脑病，围产期脑损伤，缺氧缺血性脑病的新生儿窒息; 脱髓鞘疾病，特别是白质病，脑室周围脑白质病，多发性硬化，阿尔茨海默病和帕金森病; 在生物样品中。 对于诊断，使用测量至少两种不同种类的生物分子，并通过适当的分类器算法和其他统计程序对结果进行分类。 通过本发明，可以显着提高可靠性。 单独表达谱。 换句话说，在定义的集体中，可以实现高达100％的准确的阳性诊断，这使得本发明的方法优于现有技术。
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5.发明申请Method for Predicting the likelihood of an Onset of an Inflammation Associated Organ Failure 审中-公开预测炎症相关器官衰竭发生的可能性的方法公开(公告)号：US20120202240A1
公开(公告)日：2012-08-09
申请号：US13387572
申请日：2010-07-23
申请人： Hans-Peter Deigner , Matthias Kohl , David Enot , Theresa Koal , Matthias Keller
发明人： Hans-Peter Deigner , Matthias Kohl , David Enot , Theresa Koal , Matthias Keller
CPC分类号： G01N33/6893 , G01N2800/26 , G16B5/00 , G16B40/00 , Y10T436/173845
摘要： The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing it with a quantitative reference metabolomics profile of a plurality of endogenous organ failure predictive target metabolites in order to predict whether the subject is likely or unlikely to develop an organ failure. Furthermore, the invention relates to the usefulness of endogenous organ failure predictive target metabolites in such a method.
摘要翻译： 本发明涉及用于通过受试者的定量代谢组学谱来预测来自哺乳动物受试者的体外生物样品的炎症相关器官功能衰竭发作的可能性的可靠和统计学上显着的方法，所述定量代谢组学特征包括多种内源性代谢物， 并将其与多种内源性器官衰竭预测目标代谢物的定量参考代谢组学谱进行比较，以便预测受试者是否可能或不可能发生器官功能衰竭。 此外，本发明涉及在这种方法中内源性器官衰竭预测目标代谢物的有用性。
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6.发明申请Method and Use of Metabolites for the Diagnosis of Inflammatory Brain Injury in Preterm Born Infants 审中-公开代谢产物诊断早产儿炎症性脑损伤的方法与用途公开(公告)号：US20140297195A1
公开(公告)日：2014-10-02
申请号：US14000931
申请日：2012-02-22
IPC分类号： G06F19/10 , G01N33/483
CPC分类号： G16B99/00 , G01N33/483 , G01N33/6896 , G01N2800/38
摘要： The present invention relates to novel biomarkers for predicting the likelihood of inflammation-related brain injury in preterm born infants, using a plurality of endogenous target metabolites selected from the group consisting of acyl carnitins, diacylphosphatidylcholines, acyl-alkylphosphatidylchoines, lysophosphatidylcholines and amino acids.
摘要翻译： 本发明涉及使用选自酰基肉毒碱，二酰基磷脂酰胆碱，酰基 - 烷基磷脂酰胆碱，溶血磷脂酰胆碱和氨基酸的多种内源性目标代谢物来预测早产儿婴幼儿发炎相关脑损伤的可能性的新型生物标志物。
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7.发明授权Method and device for measuring radio interference levels with frequency tracking 有权用频率跟踪测量无线电干扰电平的方法和装置公开(公告)号：US07801489B2
公开(公告)日：2010-09-21
申请号：US10595569
申请日：2004-10-11
申请人： Matthias Keller
发明人： Matthias Keller
IPC分类号： H04B17/00
CPC分类号： G01R29/0871 , H04B17/345
摘要： A method for measuring radio interference levels in a specific frequency range. Said method consists in adjusting the frequency range by means of a pre-measurement; respectively detecting, for each measuring frequency one measuring level of the signal which is to be measured; comparing the measured measuring level to the threshold value, characterized in that when the threshold value of the measuring level is exceeded, the measured level is compared to the respective measuring frequency as a radio interference level; and measuring, in a post-measurement phase, each characterized radio interference level in a more precise manner and in relation to the runtime performance thereof. The average frequency of the measuring frequency range of post-measurement, which is repeated in an alternating cyclic manner in relation to the post-measurement, is tracked in relation to the average frequency of the variable radio interference level which was recently determined in previous pre-measurement, for each characterized radio interference level
摘要翻译： 一种在特定频率范围内测量无线电干扰电平的方法。 所述方法包括通过预测量调节频率范围; 分别检测每个测量频率要测量的信号的一个测量电平; 将测量的测量水平与阈值进行比较，其特征在于，当超过测量水平的阈值时，将所测量的水平作为无线电干扰水平与相应的测量频率进行比较; 并且在后测量阶段以更精确的方式并且关于其运行时性能来测量每个表征的无线电干扰水平。 相对于最近在先前预先确定的可变无线电干扰电平的平均频率来跟踪后测量的测量频率范围的平均频率，其以相对于后测量的交替循环方式重复。 测量，对于每个特征的无线电干扰水平
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8.发明授权Method of producing a II-VI semiconductor component containing selenium and/or sulrfur 失效制备含有硒和/或磺胺的II-VI半导体组分的方法公开(公告)号：US06399473B1
公开(公告)日：2002-06-04
申请号：US09480758
申请日：2000-01-10
申请人： Frank Fischer , Matthias Keller , Thomas Litz , Gottfried Landwehr , Hans-Jürgen Lugauer , Andreas Waag , Markus Keim
发明人： Frank Fischer , Matthias Keller , Thomas Litz , Gottfried Landwehr , Hans-Jürgen Lugauer , Andreas Waag , Markus Keim
IPC分类号： H01L2128
CPC分类号： H01L21/02395 , H01L21/02439 , H01L21/0248 , H01L21/02485 , H01L21/02505 , H01L21/02557 , H01L21/0256 , H01L21/02631 , H01S5/327
摘要： A II-VI semiconductor component is produced with an active layer sequence having at least one II-VI semiconductor layer containing Se and/or S on a substrate. First, an Se-free II-VI interlayer based on BeTe is grown epitaxially on the substrate in an essentially Se-free and S-free first epitaxy chamber. The active layer sequence is then grown epitaxially on the Se-free II-VI semiconductor layer.
摘要翻译： 制备具有在衬底上具有含有Se和/或S的至少一个II-VI半导体层的有源层序列的II-VI半导体元件。 首先，在基本上不含Se的无S的第一外延室中，在衬底上外延生长基于BeTe的无Se的II-VI中间层。 然后在无Se的II-VI半导体层上外延生长活性层序列。
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公开(公告)号：US20150338715A1
公开(公告)日：2015-11-26
申请号：US14414080
申请日：2012-07-09
申请人： Eike Schaefer , Rainer Vogt , Michael Brankl , Michael Zeiner , Matthias Keller , Werner Schubert , Stefan Warmuth , Thomas Kloiber , Doris Blume , Jan Herrmann
发明人： Eike Schaefer , Rainer Vogt , Michael Brankl , Michael Zeiner , Matthias Keller , Werner Schubert , Stefan Warmuth , Thomas Kloiber , Doris Blume , Jan Herrmann
CPC分类号： G02F1/163 , A47F3/043 , A47F3/0434 , A47F11/06 , F21V33/00 , F25D1/00 , F25D23/028 , F25D2400/18 , F25D2400/36 , G02F1/13 , G02F1/1334 , G02F1/133615 , G02F1/15 , G02F2201/44 , H01L51/5281
摘要： A display device (1, 1′, 1″, 1″′, 1IV, 1V) comprises at least one transparent or translucent display layer (5, 5′, 5″), and at least one modifiable layer comprised of a film or foil layer, configured and adapted to have a degree of transparency modified depending on an input signal applied thereto and placed at least partly in front and/or behind said display layer. A door or cover plate (17, 17′, 17″) may comprise a display device (1, 1′, 1″, 1″′, 1IV, 1V) as disclosed herein. Furthermore, a cooler (21, 21′) may comprise a display device (1, 1′, 1″, 1″′, 1IV, 1V) and/or a door or cover plate (17, 17′, 17″) as disclosed herein.
摘要翻译： 显示装置（1,1'，1“，1”'，1IV，1V）包括至少一个透明或半透明显示层（5,5'，5“），以及至少一个可修饰层， 箔层，被配置和适于具有根据施加到其上的输入信号而改变的透明度，并至少部分地放置在所述显示层的前面和/或后面。 门或盖板（17,17'，17“）可以包括如本文所公开的显示装置（1,1'，1”，1“'，1IV，1V）。 此外，冷却器（21,21'）可以包括显示装置（1,1'，1“，1”'，1IV，1V）和/或门或盖板（17,17'，17“），如 这里公开。
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公开(公告)号：US11826896B2
公开(公告)日：2023-11-28
申请号：US17550645
申请日：2021-12-14
申请人： Matthias Keller
发明人： Matthias Keller
摘要： A support rack and method of manufacture thereof are provided for retaining a power hand tool or a battery pack on a wall surface. The support rack when configured for storing a power hand tool includes a mounting panel for connection to the wall surface, a support panel that extends from the mounting panel, and at least one projecting structure that extends upwardly from the support panel. The projecting structure is customized in shape and size to releasably engage in a close frictional fit with at least one corresponding interface element (aperture or slot) provided on the power hand tool. The support rack is integrally formed as a unitary piece from a plastic material and thus includes no metallic or conductive components configured to provide power or electrical charging to the power hand tool (or battery pack), thereby providing a reliable physical support for same.
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