公开(公告)号：US09236235B2

公开(公告)日：2016-01-12

申请号：US12277198

申请日：2008-11-24

申请人： Felician Muntean ,  Urs Steiner

发明人： Felician Muntean ,  Urs Steiner

IPC分类号： H01J49/06

CPC分类号： H01J49/063

摘要： An ion guide includes a plurality of curved electrodes and an ion deflecting device. The electrodes are arranged in parallel with each other and with a central curved axis, the curved central axis being co-extensive with an arc of a circular section having a radius of curvature, each electrode being radially spaced from the curved central axis, wherein the plurality of electrodes define a curved ion guide region arranged about the curved central axis and between opposing pairs of the electrodes. The ion deflecting device may include a device for applying a DC electric field to two or more of the electrodes in a radial direction. The ion deflecting device may include a pair of curved, parallel ion deflecting electrodes, which are in addition to curved electrodes utilized for applying an RF ion guiding field.

摘要翻译： 离子导向器包括多个弯曲电极和离子偏转装置。 电极彼此平行并具有中心的弯曲轴线，弯曲的中心轴与具有曲率半径的圆形截面的弧共同延伸，每个电极与弯曲的中心轴径向间隔开，其中， 多个电极限定围绕弯曲的中心轴线布置并且在相对的电极对之间布置的弯曲离子引导区域。 离子偏转装置可以包括用于沿径向向两个或更多个电极施加DC电场的装置。 离子偏转装置可以包括一对弯曲的平行离子偏转电极，这些电极除了用于施加RF离子引导场的弯曲电极之外。

公开(公告)号：US08772709B2

公开(公告)日：2014-07-08

申请号：US13550061

申请日：2012-07-16

申请人： Roy P Moeller ,  Rohan Thakur ,  Felician Muntean ,  Maurizio A Splendore ,  Stephen Zanon

发明人： Roy P Moeller ,  Rohan Thakur ,  Felician Muntean ,  Maurizio A Splendore ,  Stephen Zanon

IPC分类号： H01J49/26 ,  H01J49/10 ,  H01J49/16

CPC分类号： H01J49/10 ,  H01J49/165 ,  H01J49/167

摘要： An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source.

摘要翻译： 用于电喷雾离子源的组件包括毛细管，用于引导通常含有目标分析物的液体流，所述分析物将被电喷雾到电离室中，第一管至少部分地封装毛细管，使得第一 在毛细管附近产生用于引导第一可加热气体的导管，以及具有内部抽真空空间并位于毛细管外周的中空构件，使得来自第一可加热气体的热传递从毛细管附近流到液体中 毛细管受阻。 该组件提供了一种简单且精益/紧凑的方法来防止电喷雾离子源的毛细管中的液体过度传热。

公开(公告)号：US20090045330A1

公开(公告)日：2009-02-19

申请号：US11893308

申请日：2007-08-15

申请人： Mingda Wang ,  Charles A. Fancher ,  Felician Muntean ,  Urs Steiner

发明人： Mingda Wang ,  Charles A. Fancher ,  Felician Muntean ,  Urs Steiner

IPC分类号： H01J49/26

CPC分类号： H01J49/0477 ,  H01J49/0404 ,  H01J49/044

摘要： Sample material ionized in a sample receiving chamber is flowed into a sample conduit. Drying gas may also flow into the sample conduit and may be heated. The pressure and length of the sample conduit may be provided according to the product 50 or greater Torr-cm. The sample conduit may include a turn. The sample conduit may lead to an ion extraction chamber at which a sampling orifice may lead to a mass spectrometer. The diameter of the sample conduit may be larger than the diameter of the sampling orifice. An electrical field may be applied in the ion extraction chamber to slow incoming ions. A voltage jump may be applied to the sample conduit.

摘要翻译： 在样品接收室中离子化的样品材料流入样品导管。 干燥气体也可以流入样品管道并且可以被加热。 样品导管的压力和长度可以根据产品50或更大的Torr-cm提供。 样品管道可以包括转弯。 样品导管可导致离子提取室，采样孔可以在该离子提取室处导致质谱仪。 样品导管的直径可以大于采样孔的直径。 可以在离子提取室中施加电场以减慢入射离子。 电压跳变可以施加到样品导管。

公开(公告)号：US20130256523A1

公开(公告)日：2013-10-03

申请号：US13418743

申请日：2012-03-13

申请人： Urs Steiner ,  Felician Muntean ,  Bert D. Egley

发明人： Urs Steiner ,  Felician Muntean ,  Bert D. Egley

IPC分类号： G01N30/72 ,  H01J49/26

CPC分类号： H01J49/0422 ,  G01N30/7206 ,  H01J49/04

摘要： A transfer line for conveying the column effluent from a gas chromatograph to an ion source of a mass spectrometer has a transfer line body and a mechanism for moving the transfer line body either towards or away from the mass spectrometer. A gas seal between the housing of the mass spectrometer and the transfer line body prevents vacuum leak when the transfer line body is moved. In one embodiment, the transfer line body outer periphery is threaded and a hand wheel engages the transfer line body threads via complementary threads in order to move the body. When the transfer line is moved towards the mass spectrometer, the body presses an ion source, which is not rigidly fixed to the housing of the mass spectrometer, into a recess seat of the housing, and aligns the ion source in an operating position.

摘要翻译： 用于将柱流出物从气相色谱仪输送到质谱仪的离子源的输送管线具有输送管线主体和用于使输送管线体朝向或远离质谱仪移动的机构。 质量分析仪的壳体与传输线体之间的气体密封防止输送线主体移动时的真空泄漏。 在一个实施例中，输送线主体外周是带螺纹的，并且手轮通过互补螺纹与传输线主体线接合，以便移动主体。 当传送线向质谱仪移动时，身体将没有刚性地固定到质谱仪的壳体上的离子源按压到壳体的凹座中，并将离子源对准在操作位置。

公开(公告)号：US08084750B2

公开(公告)日：2011-12-27

申请号：US12474161

申请日：2009-05-28

申请人： Felician Muntean

发明人： Felician Muntean

IPC分类号： H01J3/14

CPC分类号： H01J49/421 ,  H01J49/063

摘要： An ion guide includes a plurality of curved electrodes and an ion deflecting device. The electrodes are arranged about and radially spaced from a central curved axis, and circumscribe a curved ion guide region from an ion entrance to an ion exit. The ion deflecting device may include a device for applying a DC electric field to one or more electrodes in a radial direction. The magnitude of the DC electric field, and thus the ion deflecting force, varies along the curved axis. The ion guide may for example operate as a collision cell or like instrument.

摘要翻译： 离子导向器包括多个弯曲电极和离子偏转装置。 电极围绕中心弯曲的轴线并且沿径向隔开设置，并且从离子入口到离子出口限定弯曲的离子引导区域。 离子偏转装置可以包括用于沿径向向一个或多个电极施加DC电场的装置。 DC电场的大小，从而离子偏转力沿曲线轴线变化。 离子导向器例如可以作为碰撞室或类似仪器工作。

公开(公告)号：US08525106B2

公开(公告)日：2013-09-03

申请号：US13103415

申请日：2011-05-09

申请人： Felician Muntean

发明人： Felician Muntean

IPC分类号： H01J49/10 ,  H01J49/42

CPC分类号： H01J49/062 ,  H01J49/0481

摘要： A method and apparatus for transmitting ions in a mass spectrometer from an ion source to a mass analyzer extracts analyte ions from the ion source in such a manner that the number of extracted analyte ions is maximized. The ions are then transmitted through an ion guide to the mass analyzer. The ion guide is filled with an interaction gas and its operating parameters are adjusted so that, as the ions pass through the ion guide, the analyte ion energy distribution width is narrowed and the analyte ions are collimated within the ion guide to improve the resolution and sensitivity of the mass analyzer.

摘要翻译： 用于将质谱仪中的离子从离子源传输到质量分析器的方法和装置以使提取的分析物离子的数量最大化的方式从离子源中提取分析物离子。 然后离子通过离子导向器传输到质量分析器。 离子导向器填充有相互作用气体，并且其操作参数被调节，使得当离子通过离子导向器时，分析物离子能量分布宽度变窄，并且分析物离子在离子导向器内准直以提高分辨率， 质量分析仪的灵敏度。

公开(公告)号：US20130015348A1

公开(公告)日：2013-01-17

申请号：US13370513

申请日：2012-02-10

申请人： Stephen ZANON ,  Roy P. MOELLER ,  Urs STEINER ,  Felician MUNTEAN

发明人： Stephen ZANON ,  Roy P. MOELLER ,  Urs STEINER ,  Felician MUNTEAN

IPC分类号： H01J49/26 ,  H01R43/00

CPC分类号： H01J37/04 ,  H01J49/0468 ,  H01J49/063 ,  H01J49/068 ,  H01J2237/053 ,  H01J2237/057 ,  H01J2237/1516

摘要： An ion optics assembly is formed by four quarter-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a quarter-circular channel with quarter-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. Quarter-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. A heater is provided at the entrance to the ion transfer optics, to prevent accumulation of ions on the poles. A thermal break is provided in the quad, so as to enable maintaining the front of the quad heated and the rest of the quad cooler.

摘要翻译： 离子光学组件由四个四分之一圆形的轮廓元件形成，所有元件都附着在相同的参考板上。 因此，所有四个元件保持与相同的参考板对准。 四个元件形成四分之一圆形四通道四通道。 四极电极接收电势以形成将离子聚焦并保持在通道中心所需的场。 在通道的所有侧面都设有四分之一圆形的绝缘体，以便从质谱仪的内部将通道密封在其长度上。 在离子转移光学器件的入口处设置加热器，以防止离子在极上的积聚。 在四边形中提供热断裂，以便能够保持四边形的前部被加热并且四分之一冷却器的其余部分。

公开(公告)号：US20130015344A1

公开(公告)日：2013-01-17

申请号：US13285168

申请日：2011-10-31

申请人： Felician MUNTEAN

发明人： Felician MUNTEAN

IPC分类号： H01J49/26

CPC分类号： H01J49/0036 ,  H01J49/4215

摘要： In a quadrupole mass spectrometer, which measures ion currents of a single mass with substantially constant RF and DC voltages during a measuring period and measures ions of different masses by varying the RF and DC voltages, a statistical evaluation is performed during data acquisition by a determination of the distribution of the measured and digitized noise values around an average noise level in the mass spectrometer output signal. The determined noise levels are subtracted from the signal output values separately for each measurement period.

摘要翻译： 在四极质谱仪中，其在测量期间测量具有基本上恒定的RF和DC电压的单个质量的离子电流，并且通过改变RF和DC电压来测量不同质量的离子，通过测定在数据采集期间执行统计评估 测量和数字化噪声值分布在质谱仪输出信号的平均噪声电平附近。 对于每个测量周期，分别从信号输出值中减去确定的噪声电平。

公开(公告)号：US08759758B2

公开(公告)日：2014-06-24

申请号：US13418743

申请日：2012-03-13

申请人： Urs Steiner ,  Felician Muntean ,  Bert D. Egley

发明人： Urs Steiner ,  Felician Muntean ,  Bert D. Egley

IPC分类号： H01J49/04 ,  G01N30/72

CPC分类号： H01J49/0422 ,  G01N30/7206 ,  H01J49/04

摘要： A transfer line for conveying the column effluent from a gas chromatograph to an ion source of a mass spectrometer has a transfer line body and a mechanism for moving the transfer line body either towards or away from the mass spectrometer. A gas seal between the housing of the mass spectrometer and the transfer line body prevents vacuum leak when the transfer line body is moved. In one embodiment, the transfer line body outer periphery is threaded and a hand wheel engages the transfer line body threads via complementary threads in order to move the body. When the transfer line is moved towards the mass spectrometer, the body presses an ion source, which is not rigidly fixed to the housing of the mass spectrometer, into a recess seat of the housing, and aligns the ion source in an operating position.

摘要翻译： 用于将柱流出物从气相色谱仪输送到质谱仪的离子源的输送管线具有输送管线主体和用于使输送管线体朝向或远离质谱仪移动的机构。 质量分析仪的壳体与传输线体之间的气体密封防止输送线主体移动时的真空泄漏。 在一个实施例中，输送线主体外周是带螺纹的，并且手轮通过互补螺纹与传输线主体线接合，以便移动主体。 当传送线向质谱仪移动时，身体将没有刚性地固定到质谱仪的壳体上的离子源按压到壳体的凹座中，并将离子源对准在操作位置。

公开(公告)号：US08680462B2

公开(公告)日：2014-03-25

申请号：US13370513

申请日：2012-02-10

申请人： Stephen Zanon ,  Roy P Moeller ,  Urs Steiner ,  Felician Muntean

发明人： Stephen Zanon ,  Roy P Moeller ,  Urs Steiner ,  Felician Muntean

IPC分类号： H01J49/06

CPC分类号： H01J37/04 ,  H01J49/0468 ,  H01J49/063 ,  H01J49/068 ,  H01J2237/053 ,  H01J2237/057 ,  H01J2237/1516

摘要： An ion optics assembly is formed by four quarter-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a quarter-circular channel with quarter-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. Quarter-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. A heater is provided at the entrance to the ion transfer optics, to prevent accumulation of ions on the poles. A thermal break is provided in the quad, so as to enable maintaining the front of the quad heated and the rest of the quad cooler.

摘要翻译： 离子光学组件由四个四分之一圆形的轮廓元件形成，所有元件都附着在相同的参考板上。 因此，所有四个元件保持与相同的参考板对准。 四个元件形成四分之一圆形四通道四通道。 四极电极接收电势以形成将离子聚焦并保持在通道中心所需的场。 在通道的所有侧面都设有四分之一圆形的绝缘体，以便从质谱仪的内部将通道密封在其长度上。 在离子转移光学器件的入口处设置加热器，以防止离子在极上的积聚。 在四边形中提供热断裂，以便能够保持四边形的前部被加热并且四分之一冷却器的其余部分。