-
公开(公告)号：US11464563B2
公开(公告)日：2022-10-11
申请号：US16983408
申请日：2020-08-03
发明人： Brian Kelly , Micheál Moriarty
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology, for example, is directed to a catheter apparatus including an elongated shaft defined by a braid embedded within a polymer. The braid can include one or more thermocouple assemblies intertwined with a braiding element. The thermocouple assemblies can be coupled to one or more electrodes at a distal portion of the shaft.
-
公开(公告)号：US20220296891A1
公开(公告)日：2022-09-22
申请号：US17717958
申请日：2022-04-11
发明人： Ayala Hezi-Yamit , Rudy A. Beasley , Susan Thornton Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
摘要： Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.
-
公开(公告)号：US20220241020A1
公开(公告)日：2022-08-04
申请号：US17727073
申请日：2022-04-22
发明人： Douglas Hettrick , Julie Trudel
IPC分类号： A61B34/10 , A61B5/02 , A61B5/0215 , A61B5/022 , A61B5/026 , A61B5/0538 , A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00 , A61B8/06 , A61B8/08 , A61B18/02 , A61B18/14 , A61N1/05 , A61N1/36
摘要： Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics. Digital data regarding three-dimensional imaging of a target blood vessel and corresponding hemodynamic data are inputs to generating a computational fluid dynamics (CFD) model. The CFD model enables identification of one or more regions of the vessel suitable for neuromodulation therapy and/or identifying one or more regions of the vessel to avoid during such therapy. A system of the present technology can include a neuromodulation catheter, a computing device that can generate and analyze the CFD model, and a user interface for displaying the vessel with indicia for target regions and/or avoidance regions.
-
公开(公告)号：US11376398B2
公开(公告)日：2022-07-05
申请号：US17503866
申请日：2021-10-18
发明人： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC分类号： A61M25/00 , A61B18/14 , A61B17/32 , A61N1/05 , A61N1/06 , A61B18/00 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00
摘要： A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
-
公开(公告)号：US11350992B2
公开(公告)日：2022-06-07
申请号：US16944499
申请日：2020-07-31
发明人： Garrett Pilcher , Robert Melder
IPC分类号： A61B18/14 , A61N7/02 , A61N1/00 , A61N1/36 , A61B5/00 , A61N1/05 , A61N7/00 , A61B18/00 , A61B90/00 , A61B18/02 , A61B18/18 , A61B18/24
摘要： Methods for treating a human patient diagnosed with cancer with therapeutic neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological processes associated with the progression of cancer. One aspect of the present technology is directed to methods that attenuate neural traffic along target sympathetic nerves innervating tissue proximate a primary malignant tumor. Other aspects are directed to methods that at least partially inhibit sympathetic neural activity in a renal nerve of a patient diagnosed with cancer or who has a high risk of developing cancer. Targeted sympathetic nerve activity can be attenuated to improve a measurable physiological parameter corresponding to the progression of cancer in the patient. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.
-
公开(公告)号：US20220096153A1
公开(公告)日：2022-03-31
申请号：US17494648
申请日：2021-10-05
发明人： Martin Rothman , Paul Coates
摘要： Devices, systems, and methods for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.
-
公开(公告)号：US20210386469A1
公开(公告)日：2021-12-16
申请号：US17461449
申请日：2021-08-30
发明人： Robert J. Melder
摘要： Devices, agents, and associated methods for selective modulation of renal nerves by localized delivery of neural ablative substances are disclosed herein. One aspect of the present technology is directed to a method for delivering a neuromodulatory agent (e.g., capsaicin) via a catheter to a kidney of the patient. The neuromodulatory agent selectively neuromodulates afferent renal nerves in a patient compared efferent renal nerves of the patient. The method can also include removing the catheter from the patient after delivering the neuromodulatory agent to conclude the procedure.
-
公开(公告)号：US11147948B2
公开(公告)日：2021-10-19
申请号：US16221220
申请日：2018-12-14
发明人： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC分类号： A61M25/00 , A61B18/14 , A61N1/05 , A61N1/06 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00 , A61B17/32 , A61B18/00
摘要： A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
-
公开(公告)号：US20210267661A1
公开(公告)日：2021-09-02
申请号：US17324889
申请日：2021-05-19
摘要： Methods for treating anxiety disorders and for reducing a risk associated with developing an anxiety disorder in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with anxiety disorders as well as an increased risk of developing an anxiety disorder. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to an anxiety disorder status in the patient. Other aspects are directed to reducing a likelihood of developing an anxiety disorder in patients presenting one or more anxiety disorder risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's anxiety disorder status or risk of developing an anxiety disorder. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g., electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal sympathetic nerve.
-
公开(公告)号：US20210259760A1
公开(公告)日：2021-08-26
申请号：US17314894
申请日：2021-05-07
发明人： Sowmya Ballakur , Robert J. Beetel , Paul Friedrichs , David Herzfeld , Andrew Wu , Denise Zarins , Mark S. Leung
摘要： The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.
-
-
-
-
-
-
-
-
-
搜索结果
429 条记录 (耗时 0.078 秒)