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    BILATERAL RENAL NEUROMODULATION
    1.
    发明申请
    BILATERAL RENAL NEUROMODULATION 有权

    公开(公告)号：US20210330378A1

    公开(公告)日：2021-10-28

    申请号：US17365868

    申请日：2021-07-01

    申请人： Medtronic Ardian Luxembourg S.a.r.l.

    发明人： Denise Zarins ,  Hanson Gifford, III ,  Mark E. Deem ,  Douglas Sutton ,  Howard R. Levin ,  Mark Gelfand

    IPC分类号： A61B18/14 ,  A61N1/05 ,  A61M5/142 ,  A61N1/36 ,  A61N1/32 ,  A61N7/02 ,  A61F7/12 ,  A61N7/00

    摘要： Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

    METHODS AND APPARATUS FOR INTRAVASCULARLY-INDUCED NEUROMODULATION
    3.
    发明申请
    METHODS AND APPARATUS FOR INTRAVASCULARLY-INDUCED NEUROMODULATION 审中-公开

    公开(公告)号：US20190090943A1

    公开(公告)日：2019-03-28

    申请号：US16141042

    申请日：2018-09-25

    申请人： Medtronic Ardian Luxembourg S.a.r.l.

    发明人： Denise Zarins ,  Nicolas Zadno ,  Benjamin J. Clark ,  Erik Thai

    IPC分类号： A61B18/14 ,  A61N1/36 ,  A61B17/12 ,  A61N1/40 ,  A61N1/32 ,  A61M25/10 ,  A61B18/00 ,  A61N1/372 ,  A61M25/01

    CPC分类号： A61B18/1492 ,  A61B17/12136 ,  A61B2018/00083 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00613 ,  A61M25/0108 ,  A61M25/10 ,  A61N1/327 ,  A61N1/36007 ,  A61N1/36121 ,  A61N1/36182 ,  A61N1/37205 ,  A61N1/40

    摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.