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公开(公告)号：US20220296891A1
公开(公告)日：2022-09-22
申请号：US17717958
申请日：2022-04-11
发明人： Ayala Hezi-Yamit , Rudy A. Beasley , Susan Thornton Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
摘要： Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.
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公开(公告)号：US09597018B2
公开(公告)日：2017-03-21
申请号：US13791751
申请日：2013-03-08
IPC分类号： A61B5/157 , A61N1/05 , A61B5/00 , A61N1/36 , A61B5/145 , A61B5/15 , A61B10/00 , A61B5/20 , A61B18/14 , A61B18/18 , A61N1/32 , G01N33/68 , A61B18/00
CPC分类号： A61B5/157 , A61B5/1405 , A61B5/14503 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150992 , A61B5/20 , A61B5/201 , A61B5/4035 , A61B5/4836 , A61B5/4848 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/6858 , A61B10/0045 , A61B10/007 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00279 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00875 , A61B2018/0212 , A61N1/05 , A61N1/32 , A61N1/36007 , A61N1/3605 , A61N1/40 , A61N7/02 , G01N33/68 , G01N2800/347
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.
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公开(公告)号：US11338140B2
公开(公告)日：2022-05-24
申请号：US15667901
申请日：2017-08-03
发明人： Ayala Hezi-Yamit , Rudy Beasley , Susan Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
IPC分类号： A61B5/145 , A61B18/14 , A61B5/00 , A61B18/02 , A61N1/36 , A61B18/00 , A61N1/05 , A61B5/20 , A61B5/15 , A61B5/157 , A61B10/00 , A61B18/18 , A61N1/32 , G01N33/68 , A61N1/40 , A61N7/02
摘要： Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers. One aspect includes a comparison of baseline and post-modulation levels of one or more biomarkers in bodily fluid that have each been collected from a human subject at a relevant time, and that may be used to assess the neuromodulation efficacy. The post-neuromodulation levels for the one or more biomarkers may be collected from the human subject within about 5 minutes to about 14 days post-neuromodulation.
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公开(公告)号：US09510777B2
公开(公告)日：2016-12-06
申请号：US13791681
申请日：2013-03-08
发明人： Ayala Hezi-Yamit , Rudy Beasley , Susan Thornton Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
IPC分类号： A61B18/18 , A61N1/32 , A61B5/15 , A61B5/157 , A61N1/36 , A61B5/145 , A61B5/00 , A61N1/05 , A61B10/00 , A61B5/20 , A61B18/14 , A61B18/00 , G01N33/68
CPC分类号： A61B5/157 , A61B5/1405 , A61B5/14503 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150992 , A61B5/20 , A61B5/201 , A61B5/4035 , A61B5/4836 , A61B5/4848 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/6858 , A61B10/0045 , A61B10/007 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00279 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00875 , A61B2018/0212 , A61N1/05 , A61N1/32 , A61N1/36007 , A61N1/3605 , A61N1/40 , A61N7/02 , G01N33/68 , G01N2800/347
摘要： Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on detecting changes in the level or activity of one or more target biomarkers associated with neuromodulation, as well as methods and processes of performing neuromodulation that incorporate monitoring of neuromodulation efficacy based on changes in level or activity of one or more target biomarkers.
摘要翻译： 本文提供了用于监测神经调节功效的方法，装置，组合物和试剂盒，其基于检测与神经调节相关的一种或多种目标生物标志物的水平或活性的变化，以及进行神经调节的方法和过程，其纳入基于神经调节功效的监测 关于一种或多种目标生物标志物的水平或活性的变化。
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5.发明申请Devices and Methods for Photodynamically Modulating Neural Function in a Human 审中-公开用于光动力调制人类神经功能的装置和方法公开(公告)号：US20150133904A1
公开(公告)日：2015-05-14
申请号：US14573291
申请日：2014-12-17
CPC分类号： A61B18/18 , A61B2018/0022 , A61B2018/00434 , A61B2018/00791 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/063 , A61N2005/0651 , A61N2005/0652 , A61N2005/0661 , A61N2005/0666
摘要： Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.
摘要翻译： 用于人类神经功能的治疗光动力学调制的装置和方法。 根据该技术的方法的一个实施方案包括向人施用光敏剂，其中相比于血管的非神经组织，光敏剂优先在血管附近的神经处累积。 该方法还可以包括使用位于人体内的辐射发射体照射光敏剂，其中辐射具有使光敏剂反应并改变至少一部分神经的波长，从而提供交感神经活性的治疗性降低。 该技术的几个实施方案可用于破坏肾神经，例如肾去神经支配，用于治疗高血压，糖尿病，充血性心力衰竭和其它适应症。
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6.发明申请Biomarker Sampling in the Context of Neuromodulation Devices, Systems, and Methods 审中-公开在神经调节装置，系统和方法的背景下的生物标记取样公开(公告)号：US20130237780A1
公开(公告)日：2013-09-12
申请号：US13791751
申请日：2013-03-08
CPC分类号： A61B5/157 , A61B5/1405 , A61B5/14503 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150992 , A61B5/20 , A61B5/201 , A61B5/4035 , A61B5/4836 , A61B5/4848 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/6858 , A61B10/0045 , A61B10/007 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00279 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00875 , A61B2018/0212 , A61N1/05 , A61N1/32 , A61N1/36007 , A61N1/3605 , A61N1/40 , A61N7/02 , G01N33/68 , G01N2800/347
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.
摘要翻译： 本文公开了使用治疗性肾神经调节和相关联的装置，系统和方法治疗患者的方法。 本技术的一个方面涉及在神经调节装置，系统和方法的背景下的生物标志物采样。 例如，一些实施例涉及导管，导管系统和用于对生物标志物进行取样的方法，所述生物标志物响应于神经调节而改变。 系统可以包括例如细长轴和具有神经调节和采样元件的神经调节和采样组件。
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公开(公告)号：US10729365B2
公开(公告)日：2020-08-04
申请号：US15424575
申请日：2017-02-03
IPC分类号： A61B5/15 , A61B5/157 , A61B5/20 , A61B5/00 , A61N7/02 , A61N1/36 , A61N1/40 , A61B10/00 , A61B18/14 , A61B5/145 , A61N1/05 , A61B18/00 , A61B18/18 , A61N1/32 , G01N33/68 , A61B18/02
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.
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公开(公告)号：US10368791B2
公开(公告)日：2019-08-06
申请号：US15296925
申请日：2016-10-18
发明人： Ayala Hezi-Yamit , Rudy Beasley , Susan Thornton Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
IPC分类号： A61B5/145 , A61B18/14 , A61B18/02 , A61B5/00 , A61B5/157 , A61N1/36 , A61N1/05 , A61B10/00 , A61B5/15 , A61B5/20 , A61B18/18 , A61N1/32 , G01N33/68 , A61N1/40 , A61N7/02 , A61B18/00
摘要： Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.
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公开(公告)号：US20180042535A1
公开(公告)日：2018-02-15
申请号：US15667901
申请日：2017-08-03
发明人： Ayala Hezi-Yamit , Rudy Beasley , Susan Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
CPC分类号： A61B5/157 , A61B5/1405 , A61B5/14503 , A61B5/14546 , A61B5/15 , A61B5/15003 , A61B5/150229 , A61B5/150992 , A61B5/20 , A61B5/201 , A61B5/4035 , A61B5/4836 , A61B5/4848 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/6858 , A61B10/0045 , A61B10/007 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00279 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00875 , A61B2018/0212 , A61N1/05 , A61N1/0551 , A61N1/32 , A61N1/36007 , A61N1/3605 , A61N1/3606 , A61N1/36135 , A61N1/40 , A61N7/02 , G01N33/68 , G01N2800/347
摘要： Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.
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公开(公告)号：US20170202500A1
公开(公告)日：2017-07-20
申请号：US15424575
申请日：2017-02-03
IPC分类号： A61B5/157 , A61B5/15 , A61B5/20 , A61B5/00 , A61N7/02 , A61N1/36 , A61N1/40 , A61B10/00 , A61B18/14 , A61B5/145 , A61N1/05
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.
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