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    Devices and Methods for Photodynamically Modulating Neural Function in a Human
    6.
    发明申请
    Devices and Methods for Photodynamically Modulating Neural Function in a Human 审中-公开
    用于光动力调制人类神经功能的装置和方法

    公开(公告)号：US20150133904A1

    公开(公告)日：2015-05-14

    申请号：US14573291

    申请日：2014-12-17

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Robert J. Melder ,  Ayala Hezi-Yamit ,  Christopher W. Storment ,  Carol M. Sullivan

    IPC: A61B18/18 ,  A61N5/06

    CPC classification number: A61B18/18 ,  A61B2018/0022 ,  A61B2018/00434 ,  A61B2018/00791 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0661 ,  A61N2005/0666

    Abstract: Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.

    Abstract translation: 用于人类神经功能的治疗光动力学调制的装置和方法。 根据该技术的方法的一个实施方案包括向人施用光敏剂，其中相比于血管的非神经组织，光敏剂优先在血管附近的神经处累积。 该方法还可以包括使用位于人体内的辐射发射体照射光敏剂，其中辐射具有使光敏剂反应并改变至少一部分神经的波长，从而提供交感神经活性的治疗性降低。 该技术的几个实施方案可用于破坏肾神经，例如肾去神经支配，用于治疗高血压，糖尿病，充血性心力衰竭和其它适应症。

    Devices and methods for photodynamically modulating neural function in a human
    10.
    发明授权
    Devices and methods for photodynamically modulating neural function in a human 有权
    用于光动力调制人类神经功能的装置和方法

    公开(公告)号：US08951296B2

    公开(公告)日：2015-02-10

    申请号：US13826604

    申请日：2013-03-14

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Robert J. Melder ,  Ayala Hezi-Yamit ,  Christopher W. Storment ,  Carol M. Sullivan

    IPC: A61N5/00 ,  A61N5/06 ,  A61N5/067 ,  A61B18/00

    CPC classification number: A61B18/18 ,  A61B2018/0022 ,  A61B2018/00434 ,  A61B2018/00791 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0661 ,  A61N2005/0666

    Abstract: Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.

    Abstract translation: 用于人类神经功能的治疗光动力学调制的装置和方法。 根据该技术的方法的一个实施方案包括向人施用光敏剂，其中相比于血管的非神经组织，光敏剂优先在血管附近的神经处累积。 该方法还可以包括使用位于人体内的辐射发射体照射光敏剂，其中辐射具有使光敏剂反应并改变至少一部分神经的波长，从而提供交感神经活性的治疗性降低。 该技术的几个实施方案可用于破坏肾神经，例如肾去神经支配，用于治疗高血压，糖尿病，充血性心力衰竭和其它适应症。

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