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    Gene therapy method for reducing risk of atherosclerosis
    2.
    发明授权
    Gene therapy method for reducing risk of atherosclerosis 失效
    降低动脉粥样硬化风险的基因治疗方法

    公开(公告)号：US06784162B1

    公开(公告)日：2004-08-31

    申请号：US08817192

    申请日：1997-07-10

    申请人： Michael R. Hayden ,  Yuanhong Ma ,  Suzanne Lewis ,  Guoquing Liu

    发明人： Michael R. Hayden ,  Yuanhong Ma ,  Suzanne Lewis ,  Guoquing Liu

    IPC分类号： A61K4800

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  C12N9/20 ,  C12N2799/022 ,  C12N2799/027 ,  C12Q1/683 ,  C12Q2600/156 ,  C12Y301/01003 ,  Y10S435/81

    摘要： A single point mutation in the human lipoprotein lipase gene which results in an A→G nucleotide change at codon 291 (nucleotide 1127) of the lipoprotein lipase gene, and a substitution of serine for the normal asparagine in the lipoprotein lipase gene product is seen with increased frequency in patients with coronary artery disease, and is associated with an increased susceptibility to coronary artery disease, including in particular premature atherosclerosis. This is expressed as a diminished catalytic activity of lipoprotein lipase, lower HDL-cholesterol levels and higher triglyceride levels. Thus, susceptibility of a human individual to premature atherosclerosis can be evaluated by: (a) obtaining a sample of DNA from the individual; and (b) evaluating the sample of DNA for the presence of nucleotides encoding a serine residue as amino acid 291 of the lipoprotein lipase gene product. The presence of a serine residue is indicative of increased susceptibility in the patient. This method may be performed using a kit which contains a pair of primers selected to amplify a region of a human lipoprotein lipase gene spanning amino acid 291 of human lipoprotein lipase. Appropriate additional reagents may also be included in the kit such as polymerase enzymes, nucleoside stock solutions and the like. Patients found to be suffering from or likely to suffer from premature atherosclerosis and other forms of coronary artery disease as a result of a lipoprotein lipase deficiency can be treated using gene therapy. This may be accomplished using adenovirus-mediated or retrovirus-mediated gene therapy, and can be performed using either an in vivo or an ex vivo approach.

    摘要翻译： 人脂蛋白脂肪酶基因中的单点突变导致脂蛋白脂肪酶基因的291密码子（核苷酸1127）的A→G核苷酸变化，以及脂蛋白脂肪酶基因产物中丝氨酸取代正常的天冬酰胺。 冠状动脉疾病患者的频率增加，并且与冠状动脉疾病的易感性增加相关，特别是早产动脉粥样硬化。 这表达为脂蛋白脂肪酶的催化活性降低，HDL-胆固醇水平降低，甘油三酯水平升高。 因此，人类对早产动脉粥样硬化的易感性可以通过以下方式来评估：（a）从个体获得DNA样品; 和（b）评估DNA样品中编码丝氨酸残基的核苷酸的存在，作为脂蛋白脂肪酶基因产物的氨基酸291。 丝氨酸残基的存在表明患者易感性增加。 该方法可以使用包含选择用于扩增跨越人类脂蛋白脂肪酶的氨基酸291的人类脂蛋白脂肪酶基因的区域的一对引物的试剂盒来进行。 试剂盒中还可以包括合适的另外的试剂，例如聚合酶，核苷储备溶液等。 发现由于脂蛋白脂肪酶缺乏而发现患有或可能患有过早动脉粥样硬化和其他形式的冠状动脉疾病的患者可以使用基因治疗来治疗。 这可以使用腺病毒介导的或逆转录病毒介导的基因治疗来实现，并且可以使用体内或离体方法进行。

    Staging support
    3.
    发明授权
    Staging support 失效
    分期支持

    公开(公告)号：US5938364A

    公开(公告)日：1999-08-17

    申请号：US949828

    申请日：1997-10-14

    申请人： Michael R. Hayden

    发明人： Michael R. Hayden

    IPC分类号： E04H3/28 ,  F16B7/00

    CPC分类号： E04H3/28 ,  Y10T403/342 ,  Y10T403/347 ,  Y10T403/44

    摘要： One-piece staging support for use in staging which can be horizontally collapsed. Cylindrical pivot supports are supported at a common level about a centrally located cylindrical body for the support of pivoted stage support members.

    摘要翻译： 用于分段的单件分段支持，可以水平折叠。 圆柱形枢轴支撑件在围绕中心定位的圆柱形主体的共同水平面处支撑，用于支撑枢转平台支撑构件。

    Multipurpose adjustable panel system
    5.
    发明授权
    Multipurpose adjustable panel system 有权
    多用途可调面板系统

    公开(公告)号：US07971395B1

    公开(公告)日：2011-07-05

    申请号：US11331326

    申请日：2006-01-12

    申请人： Todd S Vigil ,  Steven J. Zechmeister ,  Michael R. Hayden

    发明人： Todd S Vigil ,  Steven J. Zechmeister ,  Michael R. Hayden

    IPC分类号： E04H3/12

    CPC分类号： E04H3/12 ,  E04G11/48 ,  E04H4/08 ,  E04H2003/145

    摘要： A multipurpose adjustable panel system having support beams continuously adjustable between zero pitch and a pitch exceeding zero, wherein support beam pitch is influenced by vertical adjustment of support post assemblies and by horizontal spacing of support post assemblies. Multiple mounting fixtures are incorporated to accommodate beam pitch adjustment including pivotable beam support fixtures adjustably and positionably secured along the bottoms of the beams and pivotable panel support node fixtures adjustably and positionably secured along the tops of the beams, the pivotable beam support fixtures and the pivotable panel support node fixtures enabling ready adjustment of the pitch of the beams.

    摘要翻译： 一种多用途可调节面板系统，其具有在零间距和间距超过零之间连续可调的支撑梁，其中支撑梁节距受支撑柱组件的垂直调整和支撑柱组件的水平间距的影响。 结合多个安装固定装置以适应波束俯仰调节，包括可枢转的梁支撑固定装置，其可沿着梁的底部可调节地且可定位地固定，并且可枢转的支撑节点固定装置可沿梁的顶部可调节和定位地固定，可枢转的梁支撑固定装置和可枢转的支撑装置 面板支撑节点固定装置，能够准确地调整横梁的间距。

    Stage system with connectable corner
    7.
    发明授权
    Stage system with connectable corner 失效
    舞台系统可连接角

    公开(公告)号：US07624540B1

    公开(公告)日：2009-12-01

    申请号：US10842703

    申请日：2004-05-10

    申请人： Michael R. Hayden ,  Danny D. Scott

    发明人： Michael R. Hayden ,  Danny D. Scott

    IPC分类号： E04H3/12

    CPC分类号： E04H3/24 ,  E04H3/28

    摘要： A portable platform-support provides an external platform corner for supporting a platform surface structure. The external platform corner employs a rigid corner-support apparatus that is connectable to other components. The rigid corner-support apparatus includes a non-integrating outer-facing portion with opposing outer edges and an inner portion. A channel member has an elongated shape and an upper surface adapted to provide support to the platform surface structure, and a reinforcement member is securely coupled to and extending from the inner portion with the reinforcement member being adapted to securely support the channel member.

    摘要翻译： 便携式平台支架提供了一个支撑平台表面结构的外部平台角。 外部平台角采用可连接到其他部件的刚性拐角支撑装置。 刚性角支撑装置包括具有相对的外边缘和内部部分的非整合外向部分。 通道构件具有细长形状和适于向平台表面结构提供支撑的上表面，并且加强构件牢固地联接到内部部分并且从内部部分延伸，而加强构件适于牢固地支撑通道构件。

    Treatment of Vascular, Autoimmune and Inflammatory Diseases Using Low Dosages of IMPDH Inhibitors
    10.
    发明申请
    Treatment of Vascular, Autoimmune and Inflammatory Diseases Using Low Dosages of IMPDH Inhibitors 审中-公开
    使用低剂量的IMPDH抑制剂治疗血管，自身免疫和炎症疾病

    公开(公告)号：US20090088427A1

    公开(公告)日：2009-04-02

    申请号：US12115464

    申请日：2008-05-05

    申请人： Richard GLICKMAN ,  Michael R. Hayden ,  Noel Hall

    发明人： Richard GLICKMAN ,  Michael R. Hayden ,  Noel Hall

    IPC分类号： A61K31/5377

    CPC分类号： A61K31/365 ,  A61K31/343 ,  A61K31/5377

    摘要： The disclosure provides methods and compositions for treating a vascular, autoimmune, and/or inflammatory disease, or a condition associated therewith, with a dose of an inosine monophosphate dehydrogenase (IMPDH) inhibitor effective to treat the vascular, autoimmune and/or inflammatory disease, or associated condition but that does not produce immunosuppression sufficient to reduce the risk of allograft rejection. These lower doses of the immunosuppressant avoid the adverse consequences of severe immunosuppression while providing effective treatment of the vascular, autoimmune and/or inflammatory disease.

    摘要翻译： 本公开提供用于治疗血管，自身免疫和/或炎性疾病或与其相关的病症的方法和组合物，其中一种剂量的有效治疗血管，自身免疫和/或炎性疾病的肌苷一磷酸脱氢酶（IMPDH）抑制剂， 或相关状况，但不产生足以降低同种异体移植排斥风险的免疫抑制。 这些较低剂量的免疫抑制剂避免严重免疫抑制的不良后果，同时提供对血管，自身免疫和/或炎性疾病的有效治疗。