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    Photoacoustic Assay Method and Apparatus
    1.
    发明申请
    Photoacoustic Assay Method and Apparatus 审中-公开
    光声测定方法和装置

    公开(公告)号：US20080194929A1

    公开(公告)日：2008-08-14

    申请号：US10551543

    申请日：2004-03-29

    申请人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

    发明人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

    IPC分类号： A61B5/1455 ,  A61B8/00

    CPC分类号： A61B5/0066 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/1702 ,  G01N2021/1706

    摘要： Apparatus (20, 100) for assaying a target analyte in a localized tissue region (22) that may include the target and other analytes comprising: a light source (34, 104) that illuminates the region with light at each of a plurality of wavelengths at which light is absorbed and/or scattered by tissue in the region wherein light at a least one of the wavelengths is absorbed or scattered by the target analyte; a signal generator (40) that generates signals responsive to intensity of the light from the light source (34, 104) at different locations in the localized region (22); and a controller (32, 102) that: receives the generated signals; processes the signals to determine an extinction coefficient for light in the localized region at each wavelength; and determines the concentration of the target analyte responsive to a solution of a set of simultaneous equations having as unknown variables concentrations of a plurality of analytes in the region (22), one of which is the target analyte, wherein each equation in the set expresses a relationship between the extinction coefficient, the absorption coefficient and/or the reduced scattering coefficient for light at a different one of the plurality of wavelengths and at least one of the equations expresses a relationship between the extinction coefficient and the reduced scattering coefficient.

    摘要翻译： 用于测定局部组织区域（22）中可能包括目标物和其它分析物的靶分析物的装置（20,100），包括：光源（34,104），其以多个波长中的每一个的光照射该区域 在该区域中的组织被光吸收和/或散射，其中至少一个波长的光被靶分析物吸收或散射; 信号发生器（40），其在所述局部区域（22）中的不同位置处产生响应于来自所述光源（34,104）的光的强度的信号; 以及控制器（32,102），其接收所生成的信号; 处理信号以确定每个波长处的局部区域中的光的消光系数; 并且确定目标分析物的浓度，其响应于在区域（22）中具有多个分析物浓度的未知变量的一组联立方程（其中一个是目标分析物）的溶液的溶液，其中集合中的每个方程表示 在多个波长中的不同一个波长处的光的消光系数，吸收系数和/或减小的散射系数之间的关系以及至少一个等式表示消光系数和降低的散射系数之间的关系。

    Photoacoustic assay method and apparatus
    2.
    发明申请
    Photoacoustic assay method and apparatus 审中-公开
    光声测定方法和装置

    公开(公告)号：US20060264717A1

    公开(公告)日：2006-11-23

    申请号：US10542600

    申请日：2004-01-13

    申请人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

    发明人： Benny Pesach ,  Gabriel Bitton ,  Michal Balberg

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/0095 ,  A61B5/14532 ,  G01N21/1702 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/4427

    摘要： A method of assaying an analyte in a body part comprising: illuminating the body part with at least one pulse of light at each of first and second wavelengths that stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property and wherein light at the first wavelength is absorbed by the analyte; sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light at the first and second wavelengths; and using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region.

    摘要翻译： 一种测定身体部位中的分析物的方法，包括：用在第一和第二波长中的每一个处的至少一个脉冲光照射身体部分，以刺激第一，目标，区域和第二参考区域中的光声波 其中所述参考区域与所述目标区域接合并且具有至少一个已知的光声特性，并且其中所述第一波长处的光被所述分析物吸收; 感测来自由第一和第二波长的光刺激的目标和参考区域的光声波中的压力; 以及使用感测到的压力和至少一种已知的光声特性来测定目标区域中的分析物。

    Drug delivery device with sensor for closed-loop operation
    4.
    发明授权
    Drug delivery device with sensor for closed-loop operation 有权
    带传感器的药物输送装置用于闭环操作

    公开(公告)号：US08409133B2

    公开(公告)日：2013-04-02

    申请号：US12809425

    申请日：2008-12-18

    申请人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar ,  Ram Weiss

    发明人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar ,  Ram Weiss

    IPC分类号： A61N1/08

    CPC分类号： A61M5/1723 ,  A61M5/14248 ,  A61M2005/14296 ,  A61M2005/1726 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/60 ,  A61M2230/201 ,  A61M2230/50 ,  A61M2230/63

    摘要： An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.

    摘要翻译： 一种用于控制和/或管理药物对患者体内的药物的装置和系统。 该装置包括药物输注装置，其配置成在患者体内的预定位置输送药物，至少一个传感器设置在药物输注装置中并且被配置为测量a。 与患者相关的并且选自生理特性，生物化学性质，环境特性和药物相关性质的对应性质，设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据 相应的财产，并根据收到的数据，确定药物递送率。 药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。

    DEVICE AND METHOD FOR DRUG DELIVERY TO A TARGETED SKIN LAYER
    5.
    发明申请
    DEVICE AND METHOD FOR DRUG DELIVERY TO A TARGETED SKIN LAYER 审中-公开
    用于药物递送至目标皮肤层的装置和方法

    公开(公告)号：US20120203164A1

    公开(公告)日：2012-08-09

    申请号：US13499704

    申请日：2010-10-04

    申请人： Gabriel Bitton ,  Ron Nagar ,  Benny Pesach

    发明人： Gabriel Bitton ,  Ron Nagar ,  Benny Pesach

    IPC分类号： A61M37/00

    CPC分类号： A61M5/422 ,  A61M5/3287 ,  A61M5/425 ,  A61M5/44 ,  A61M2205/058

    摘要： The present invention relates to a device and method for the controlled delivery of a drug to a targeted layer of the skin in a human or animal subject. In particular, the present invention relates to such a device, system and method for selective drug delivery to the cutaneous or subcutaneous layer of skin to enhances the effectiveness of the drug delivery.

    摘要翻译： 本发明涉及用于在人或动物受试者中将药物控制递送至皮肤目标层的装置和方法。 特别地，本发明涉及用于选择性药物递送至皮肤皮下或皮下层的装置，系统和方法，以提高药物递送的有效性。

    Method and apparatus for performing optical measurements of a material
    6.
    发明申请
    Method and apparatus for performing optical measurements of a material 有权
    用于进行材料的光学测量的方法和装置

    公开(公告)号：US20070052965A1

    公开(公告)日：2007-03-08

    申请号：US11355434

    申请日：2006-02-16

    申请人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar

    发明人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar

    IPC分类号： G01N21/00

    CPC分类号： G01N21/1702 ,  G01N21/314 ,  G01N21/64 ,  G01N2021/6491

    摘要： A method of determining an optical parameter or function thereof for a liquid, the method comprising: flowing the liquid through a flow cell; transmitting a pulse of light into the liquid in the flow cell; generating a signal responsive to energy that the material emits responsive to a portion of the light from the light pulse that is absorbed by the liquid; and using the signal to determine the optical parameter or function thereof.

    摘要翻译： 一种确定液体的光学参数或其功能的方法，所述方法包括：使液体流过流动池; 将光脉冲传输到流动池中的液体中; 产生响应于材料发射的能量的信号，所述能量响应于来自由液体吸收的光脉冲的光的一部分; 并使用该信号来确定其光学参数或功能。

    DEVICE AND METHOD FOR DRUG DELIVERY
    8.
    发明申请
    DEVICE AND METHOD FOR DRUG DELIVERY 有权
    用于药物递送的装置和方法

    公开(公告)号：US20110288527A1

    公开(公告)日：2011-11-24

    申请号：US13127823

    申请日：2009-11-06

    申请人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar ,  Ram Weiss

    发明人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar ,  Ram Weiss

    IPC分类号： A61M37/00

    CPC分类号： A61M5/44 ,  A61B2018/00005 ,  A61B2090/0803 ,  A61F7/007 ,  A61F7/02 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61F2007/0226 ,  A61M5/003 ,  A61M5/20 ,  A61M5/427 ,  A61M2205/273 ,  A61M2205/3368 ,  A61M2205/3653 ,  A61M2209/00

    摘要： A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.

    摘要翻译： 公开了一种治疗装置，系统和方法，用于在药物注射部位改善对患者体内的组织中的感温药物的给药。 该装置包括具有可控加热元件的处理元件，其与邻近药物注射部位的组织温度交互接触。 可控制加热元件被配置为将邻近药物注射部位的组织加热到可控温度，但是不将注射的药物加热到预定的极限温度以上，在该极限温度以上可能发生注射药物的降解。

    DRUG DELIVERY DEVICE WITH SENSOR FOR CLOSED-LOOP OPERATION
    9.
    发明申请
    DRUG DELIVERY DEVICE WITH SENSOR FOR CLOSED-LOOP OPERATION 有权
    具有传感器的药物递送装置用于闭环操作

    公开(公告)号：US20110184342A1

    公开(公告)日：2011-07-28

    申请号：US12809425

    申请日：2008-12-18

    申请人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar ,  Ram Weiss

    发明人： Benny Pesach ,  Gabriel Bitton ,  Ron Nagar ,  Ram Weiss

    IPC分类号： A61M5/00

    CPC分类号： A61M5/1723 ,  A61M5/14248 ,  A61M2005/14296 ,  A61M2005/1726 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/60 ,  A61M2230/201 ,  A61M2230/50 ,  A61M2230/63

    摘要： An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.

    摘要翻译： 一种用于控制和/或管理药物对患者体内的药物的装置和系统。 该装置包括药物输注装置，其配置成在患者体内的预定位置输送药物，至少一个传感器设置在药物输注装置中并且被配置为测量a。 与患者相关的并且选自生理特性，生物化学性质，环境特性和药物相关性质的对应性质，设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据 相应的财产，并根据收到的数据，确定药物递送率。 药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。

    METHOD AND DEVICE FOR SUBSTANCE MEASUREMENT
    10.
    发明申请
    METHOD AND DEVICE FOR SUBSTANCE MEASUREMENT 审中-公开
    用于物质测量的方法和装置

    公开(公告)号：US20100292557A1

    公开(公告)日：2010-11-18

    申请号：US12450250

    申请日：2008-03-19

    申请人： Benny Pesach ,  Gabriel Bitton ,  Ram Weiss ,  Ron Nagar

    发明人： Benny Pesach ,  Gabriel Bitton ,  Ram Weiss ,  Ron Nagar

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/1491

    摘要： Embodiments of the present disclosure present systems, devices and methods for ISF glucose monitoring that more accurately reflects the blood glucose levels by introducing a treatment element allowing stable and accurate prediction of blood glucose levels based measured glucose levels from interstitial fluid.

    摘要翻译： 本公开的实施例提供了用于ISF葡萄糖监测的系统，装置和方法，其通过引入治疗元件更准确地反映血糖水平，所述治疗元件允许基于来自间质液的测量的葡萄糖水平来稳定和准确地预测血糖水平。