摘要:
A system for monitoring a position of an instrument in a subject includes a light transmission medium configured to transmit light pulses to a desired region to produce an acoustic signal, at least one ultrasound sensor configured to receive the acoustic signal and to produce a transduced signal from the acoustic signal, and a processing unit connected to the at least one ultrasound sensor and configured to locate a source of the acoustic signal using the transduced signal.
摘要:
Apparatus for assaying an analyte of blood in a patient's blood vessel comprising: a mounting module adapted so that it can be adhered to the skin of the patient overlying a tissue region comprising the blood vessel; a sensor unit mounted to the module that generates signals responsive to characteristics of the tissue region; and a controller that receives the signals and uses received signals to assay the analyte and to determine a degree to which the sensor unit is aligned with the blood vessel.
摘要:
Apparatus for assaying an analyte in blood in a patient's blood vessel comprising: a light provider comprising at least one light source that illuminates a tissue region in which a blood vessel is located with light that stimulates photoacoustic waves in the region; at least one acoustic transducer that generates signals responsive to the photoacoustic waves; a controller that receives the signals and processes them to determine which are responsive to photoacoustic waves that originate in the blood vessel and uses the determined signals to assay the analyte; wherein, the light provider and at least one transducer define a field of view that overlaps the blood vessel, said field of view having a central region and a lateral extent greater than about 4 mm.
摘要:
A method of determining a portion of light at a given wavelength which is incident on a material that is absorbed by the material, the method comprising: transmitting a pulse of light at the given wavelength so that the pulse traverses a path through the material; generating a first signal responsive to light in the light pulse that traverses the path length without being absorbed by the material; generating a second signal responsive to energy that the material emits responsive to a portion of the light from the light pulse that is absorbed by the material as the light pulse traverses the path; and using the first and second signals to determine the absorbed portion.
摘要:
Apparatus (20, 100) for assaying a target analyte in a localized tissue region (22) that may include the target and other analytes comprising: a light source (34, 104) that illuminates the region with light at each of a plurality of wavelengths at which light is absorbed and/or scattered by tissue in the region wherein light at a least one of the wavelengths is absorbed or scattered by the target analyte; a signal generator (40) that generates signals responsive to intensity of the light from the light source (34, 104) at different locations in the localized region (22); and a controller (32, 102) that: receives the generated signals; processes the signals to determine an extinction coefficient for light in the localized region at each wavelength; and determines the concentration of the target analyte responsive to a solution of a set of simultaneous equations having as unknown variables concentrations of a plurality of analytes in the region (22), one of which is the target analyte, wherein each equation in the set expresses a relationship between the extinction coefficient, the absorption coefficient and/or the reduced scattering coefficient for light at a different one of the plurality of wavelengths and at least one of the equations expresses a relationship between the extinction coefficient and the reduced scattering coefficient.
摘要:
A tissue viability monitor (TVM) for determining viability of a biological tissue comprising: at least one light source controllable to illuminate the tissue with light that generates photoacoustic waves therein; at least one acoustic transducer that generates signals responsive to the photoacoustic waves; and a controller that receives the signals and processes the signals to determine at least one characteristic of the tissue and a measure of viability responsive to the determined at least one characteristic.
摘要:
A method of assaying an analyte in a body part comprising: illuminating the body part with at least one pulse of light at each of first and second wavelengths that stimulates photoacoustic waves in a first, target, region and a second, reference, region of the body part, wherein the reference region interfaces with the target region and has at least one known optoacoustic property and wherein light at the first wavelength is absorbed by the analyte; sensing pressure in the photoacoustic waves from the target and reference regions stimulated by the light at the first and second wavelengths; and using the sensed pressures and the at least one known optoacoustic property to assay the analyte in the target region.
摘要:
Apparatus for forming a hole in a region of the heart muscle wall of a patient undergoing myocardial revascularization comprising: means for removing tissue from the region to form the hole; a light source that illuminates the region with light that generates photoacoustic waves therein; at least one acoustic sensor that generates signals responsive to the photoacoustic waves; and a controller that receives the signals and processes them to determine a characteristic of the region useable to control the means for removing tissue.
摘要:
Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
摘要:
The present invention relates generally to systems, apparatuses, and methods for obtaining a fluid sample from a patient. In particular, the present invention relates to a various types of fluid access interfaces for enabling contact between a patient blood sample and blood parameter sensors for the measurement of physiological parameters and blood constituents.